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Preparation of yttrium oxide coating with enhanced thermal shock resistance on refractories used for titanium alloy melting and casting

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Journal of Iron and Steel Research International 2024年第6期31卷 1411-1422页

作者： Ao Chen Yan Ma Zhou-fu Wang Hao Liu Xi-tang Wang Sen-na Chen Chen-xin Zhang Zi-yi Tang Wei-dong fu Wei Cheng The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina Xiangyang Juli High Technology Material Co. Ltd.Xiangyang 441705HubeiChina Xiangyang Public Inspection and Testing Center Xiangyang 441000HubeiChina

In order to enhance the service life of refractories for melting and casting of titanium alloy,preparation of yttrium oxide coatings on the refractories surface is an effective *** improvement of thermal shock stability of the coating is beneficial to its spalling resistance during the high-temperature service,and the available slurry with good performance is the *** effects of the varieties and contents of dispersant(sodium tripolyphosphate,sodium hexametaphosphate,sodium pyrophosphate,citric acid and polycarboxylate ammonium salt)and binder(aluminum dihydrogen phosphate,zirconium acetate and yttria sol)on the stability,rheological and thixotropic properties of yttrium oxide waterbased slurry were investigated,and the effects of slurry composition design on the thermal shock resistance of the coating were *** results showed that the introduction of polycarboxylate ammonium salt as dispersant significantly improved the stability of the slurry,and the varieties of the binders had significant effects on the dispersibility of the *** aluminum dihydrogen phosphate and polycarboxylate ammonium salt were used as binder and dispersant,respectively,the slurry had better stability,suitable rheological and thixotropic *** using aluminum dihydrogen phosphate as binder,the coating had good thermal shock resistance and no obvious cracks were observed for the coating after thermal shock,which was attributed to the yttrium aluminate binding phase generated in the *** effective method was provided for preparing yttrium oxide coatings with enhanced thermal shock resistance applied in the process of titanium alloy melting and casting.

关键词： Yttrium oxide-Slurry Stability Rheological property Thixotropic property-Coating Thermal shock resistance

A novel multi-state bogie system reliability evaluation approach by extended d-MC model for high-speed trains

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Transportation Safety and Environment 2024年第3期6卷 35-46页

作者： Yong fu Ruoqu Liu Jisheng Dai Wenlong Zhu xin Liu Yong Qin Zhuzhou CRRC Times Electric Co. Ltd.Times RoadShifeng DistrictZhuzhouHunan 412001China Department of Statistics University of WarwickCoventry CV47ALUnited Kingdom State Key Lab of Rail Traffic Control&Safety Beijing Jiaotong UniversityHaidian DistrictBeijing 100044China

Bogie is a pivotal system and plays a critical part in the safety and reliability management of high-speed ***,the available bogie system reliability analysis methods lack the consideration of multi-state characteristics,and the common multi-state reliability analysis methods,being an NP-hard problem,lead to low *** order to overcome these drawbacks,this paper proposes a novel multi-state rail train bogie system reliability analysis approach based on the extended d-MC *** different function interactions within the bogie system are considered to build the multi-state bogie system flow network ***,an extended d-MC model is established to remove unnecessary d-MC candidates and duplicates,which greatly enhances the computing *** bogie system reliability is calculated,and examples are *** experiments are carried out for the different operational conditions of the bogie system and are used to test the practicability of the method proposed in this article;it is found that this method outperforms a newly developed method in solving multi-state reliability problems.

关键词： multi-state system reliability bogie flow network extended d-MC model

Biological Evaluation of Lysionotin:a Novel Inhibitor of 5-Lipoxygenase for Anti-glioma

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Chinese Journal of Integrative Medicine 2024年第9期30卷 826-834页

作者： SHAO xin-xin CHEN Cong LIU Jie LI Qing-jun HE Shan QI Xiang-hua fu Xian-jun WANG Zhen-guo The First Clinical College of Medicine Shandong University of Traditional Chinese MedicineJinan250355China Institute for Literature and Culture of Chinese Medicine Shandong University of Traditional Chinese MedicineJinan250355China Key Laboratory of Classical Theory of Traditional Chinese Medicine Ministry of EducationShandong University of Traditional Chinese MedicineJinan250355China College of Pharmacy Shandong University of Traditional Chinese MedicineJinan250355China Experimental Center Shandong University of Traditional Chinese MedicineJinan250355China Neurology Department Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinan250014China Marine Traditional Chinese Medicine Research Center Qingdao Academy of Traditional Chinese MedicineShandong University of Traditional Chinese MedicineQingdao266114Shandong ProvinceChina

Objective:To explore the potential mechanism of lysionotin in treating ***:First,target prediction based on Bernoulli Naïve Bayes profiling and pathway enrichment was used to predict the biological activity of *** binding between 5-lipoxygenase(5-LO)and lysionotin was detected by surface plasmon resonance(SPR)and molecular docking,and the inhibitory effects of lysionotin on 5-LO and proliferation of glioma were determined using enzyme inhibition assay in vitro and cell viability analysis,***,the pharmaceutical effect of lysionotin was explored by cell survival rate analysis and liquid chromatography with tandem mass spectrometry(LC-MS/MS).The protein expression,intracellular calcium ion concentration and cytoskeleton detection were revealed by Western blot,flow cytometry and fluorescence labeling,***:Target prediction and pathway enrichment revealed that lysionotin inhibited 5-LO,a key enzyme involved in the arachidonic acid metabolism pathway,to inhibit the proliferation of *** docking results demonstrated that 5-LO can be binding to lysionotin through hydrogen bonds,forming bonds with His600,Gln557,Asn554,and *** analysis further confirmed the interaction between 5-LO and ***,enzyme inhibition assay in vitro and cell survival rate analysis revealed that 50%inhibition concentration of lysionotin and the median effective concentration of lysionotin were 90 and 16.58µmol/L,respectively,and the results of LC-MS/MS showed that lysionotin inhibited the production of 5S-hydroperoxy-eicosatetraenoic acid(P<0.05),and moreover,the LC-MS/MS results indicated that lysionotin can enter glioma cells well(P<0.01)and inhibit their *** blot analysis demonstrated that lysionotin can inhibit the expression of 5-LO(P<0.05)and downstream leukotriene B4 receptor(P<0.01).In addition,the results showed that lysionotin affected intracellular calcium ion concentration by inh

关键词： 5-lipoxygenase inhibitor lysionotin 5-lipoxygenase leukotriene B4 calcium ion cytoskeleton

Metochalcone induces senescence-associated secretory phenotype via JAK2/STAT3 pathway in breast cancer

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Oncology Research 2024年第5期32卷 943-953页

作者： JIANBO ZHOU FENG WAN BIN XIAO xin LI CHENG PENG fu PENG Department of Pharmacology West China School of PharmacySichuan UniversityChengduChina State Key Laboratory of Southwestern Chinese Medicine Resources Chengdu University of Traditional Chinese MedicineChengduChina Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial TechnologySichuan UniversityChengduChina Chengdu No.1 Pharmaceutical Co. Ltd.PengzhouChina Chengdu Push Bio-Technology Co. Ltd.ChengduChina

Breast and lung cancers are the leading causes of mortality and most frequently diagnosed cancers in women and men,respectively,*** the antitumor activity of chalcones has been extensively studied,the molecular mechanisms of isoliquiritigenin analog 2',4',4-trihydroxychalcone(metochalcone;TEC)against carcinomas remain less well *** this study,we found that TEC inhibited cell proliferation of breast cancer BT549 cells and lung cancer A549 cells in a concentration-dependent *** induced cell cycle arrest in the S-phase,cell migration inhibition in vitro,and reduced tumor growth in ***,transcriptomic analysis revealed that TEC modulated the activity of the JAK2/STAT3 and P53 *** triggered the senescence-associated secretory phenotype(SASP)by repressing the JAK2/STAT3 *** mechanism of metochalcone against breast cancer depended on the induction of SASP via deactivation of the JAK2/STAT3 pathway,highlighting the potential of chalcone in senescence-inducing therapy against carcinomas.

关键词： Metochalcone Breast cancer Lung cancer SASP JAK2/STAT3

A folic acid-decorated nanoparticles loaded JQ1 for oral squamous cell carcinoma therapy

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Chinese Chemical Letters 2024年第3期35卷 332-336页

作者： Dequan Zeng Zhongkai Ma xin Zan Ting Luo Xiang Wang Xiang Gao Xianghui fu School of Health Management Xihua UniversityChengdu 610039China State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesWest China College of StomatologySichuan UniversityChengdu 610041China Department of Neurosurgery and Institute of Neurosurgery State Key Laboratory of Biotherapy and Cancer CenterWest China HospitalWest China Medical SchoolSichuan University and Collaborative Innovation Center for BiotherapyChengdu 610041China Breast Disease Center Cancer CenterWest China HospitalSichuan UniversityChengdu 610041China

Oral squamous cell carcinoma(OSCC)is known as one of the most malignant tumors with high recurrence and fatality *** poor tumor-targeting ability of traditional chemotherapeutic drugs has been a grand challenge for anti-OSCC *** that,a large quantity of tumor associated macrophages in OSCC tissues further diminish the anti-tumor effects of these ***,we produced a therapeutic nano drug delivery system(FA-PEG-PLA-JQ1)through encapsulating JQ1[a small-molecule inhibitor of bromodomain containing protein 4(BRD4)]into the folic acid(FA)-modified nanoparticle(PEG-PLA),which could prolong the half-life of JQ1 and target the tumor *** then,JQ1 released from this nanoparticle could prevent OSCC growth inducing tumor cell apoptosis,inhibiting tumor angiogenesis and the polarization of M2 type *** conclusion,our date demonstrated the therapeutic benefits of FA-PEG-PLA-JQ1 against OSCC in vivo or in vitro,which could be a novel treatment strategy for OSCC in coming days.

关键词： Folic acid Nanoparticles JQ1 Oral squamous cell carcinoma Macrophages

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Effective utilization of dolomitic lead-zinc waste rock by replacing dolomite as flux in iron ore sintering process

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Journal of Iron and Steel Research International 2024年第8期31卷 1861-1872页

作者： xin Wang Cong-cong Yang Jian pan De-qing Zhu Zheng-qi Guo Guang-hui Xia Shi-juan Qu School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083HunanChina Low-Carbon and Hydrogen Metallurgy Research Center Central South UniversityChangsha 410083HunanChina

With increasingly stringent environmental protection policies,cost-effective and value-added treatment of massive lead-zinc waste rock(LZWR)generated from the preconcentration process has attracted substantial attention.A type of dolomitic LZWR with 18 wt.%MgO,27 wt.%CaO,0.29 wt.%Zn and 1.43 wt.%S was used as a replacement flux in the iron ore sintering *** sinter pot tests were carried out based on an industrial ore *** results show that replacing 0%-60%of dolomite with LZWR does not adversely affect the sintering productivity,fuel consumption rate,and the quality of the sinter products,while the Zn and S elements contained in LZWR can be effectively removed with the residual Zn and S contents of the resultant sinter products being less than 0.02 and 0.055 wt.%,***,substituting LZWR for dolomite as a flux inevitably increases the SO_(2) concentration in the sintering flue gas due to its high sulfur *** the processing capacity of the sintering flue gas desulfurization system,the replacement ratio of dolomite can reach 40%,equal to LZWR consumption of 24.3 kg per ton of *** SO_(2) in sintering flue gas can be recovered to produce(NH_(4))_(2)SO_(4) or HSO_(4),while the volatilized Zn collected into the zinc-containing dust can be subsequently recycled by the rotary hearth furnace ***,it is technologically and economically feasible to use the LZWR as a replacement flux in the iron ore sintering process,providing a new way for the safe,large-scale and low-cost treatment of LZWR.

关键词： Lead Zinc waste rock Dolomite Sintering Flue gas Sinter product

REGIOSELECTIVE OXIDATION OF KETONE BY AN OXIDATIVE REAGENT SYSTEM KH/O_2/18-CROWN-6/THF:APPLICATION TO SYNTHESIS OF VARIOUS LACTONES

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Chinese Chemical Letters 1991年第7期2卷 505-508页

作者： Wei Shan ZHOU Biao JIANG Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,345 Lingling Lu,Shanghai 200032.xin fu pan Department of Chemistry,Lanzhou University,Lanzhou 730000.

the regioselectivity in the oxidation of different types of ketone compounds 1--6 with an oxidative reagent system,KH/O_2/18- Crown-6/THF is *** these oxidative products,the various lactones have been prepared.

关键词： THF REGIOSELECTIVE OXIDATION OF KETONE BY AN OXIDATIVE REAGENT SYSTEM KH/O2/18-CROWN-6/THF KH

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Application of fusobacterium nucleatum as a biomarker in gastrointestinal malignancies

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2271-2283页

作者： Long-Chen Yu Ya-Ping Li Yue-Ming xin Mai Mao Ya-xin pan Yi-Xuan Qu Zheng-Dong Luo Yi Zhang xin Zhang Department of Clinical Laboratory Qilu Hospital of Shandong UniversityShandong Engineering Research Center of Biomarker and Artificial Intelligence ApplicationJinan 250012Shandong ProvinceChina

The morbidity and mortality of gastrointestinal(GI)malignancies are among the highest in the world,posing a serious threat to human *** of the insidious onset of the cancer,it is difficult for patients to be diagnosed at an early stage,and it rapidly progresses to an advanced stage,resulting in poor treatment and *** nucleatum(***)is a gram-negative,sporefree anaerobic bacterium that primarily colonizes the oral cavity and is implicated in the development of colorectal,esophageal,gastric,and pancreatic cancers via various intricate *** development in novel research suggests that *** may function as a biomarker in GI *** the abundance of *** in stool,saliva,and serum samples of patients may aid in the diagnosis,risk assessment,and prognosis monitoring of GI *** editorial systematically describes the biological roles and mechanisms of *** in GI malignancies focusing on the application of *** as a biomarker in the diagnosis and prognosis of GI malignancies to promote the clinical translation of *** and GI tumors-related research.

关键词： Gastrointestinal malignancies fusobacterium nucleatum Biomarker Diagnosis Prognosis

Electrochemical chemoselective thiocarbamylation of late-stage Tyr-containing drugs and peptides

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Science China Chemistry 2024年第10期67卷 3382-3388页

作者： Wan-Jie Wei xin-Yu Wang Hai-Tao Tang Fei-Hu Cui Yun-Qi Wu Ying-Ming pan State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China)Collaborative Innovation Center for Guangxi Ethnic MedicineSchool of Chemistry and Pharmaceutical SciencesGuangxi Normal University

The synthesis and modification of peptides occupy a unique position in the field of drug development, and the functionalization of amino acids is a valuable strategy as an alternative to peptide modification. Currently, the development of tyrosine(Tyr) as a target amino acid is a major challenge in the field of chemistry. Herein, we report an electrochemical radical coupling reaction of labeling tyrosine-containing active drugs and peptides with thiocarbamate derivatives for the first time. This tri-component, onepot reaction can be performed smoothly under simple, gentle, and clean electrochemical conditions and is suitable for the functionalization of various Tyr-containing drug molecular derivatives and peptides.

关键词： tyrosine electrochemical radical coupling chemical modification peptides

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