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Fabrication of carboxylic graphene oxide-composited polypyrrole film for neurite growth under electrical stimulation

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Frontiers of Materials Science 2019年第3期13卷 258-269页

作者： Chaoyuan LIU Zhongbing huang ximing PU Lei SHANG Guangfu YIN Xianchun CHEN Shuang CHENG College of Materials Science and Engineering Sichuan UniversityChengdu 610065China

An aligned composite film was fabricated via the deposition of carboxylic graphe ne oxide(C-GO)and polypyrrole(PPy)nano particles on alig ned poly(L-lactic acid)(PLLA)fiber-films(named as C-GO/PPy/PLLA),which has the core(PLLA)-sheath(C-GO/PPy)structure,and the composition of C-GO(~4.8 wt.%of PPy sheath)significantly enhanced the tensile strength and the conductivity of the PPy/PLLA film?Especially,after 4 weeks of immersion in the PBS solution,the conductivity and the tensile strength of CGO/PPy/PLLA films still remained-6.10 S/cm and 28.9 MPa,respectively,which could meet the need of the sustained electrical stimulation(ES)therapy for nerve ***,the neurite length and the neurite alignment were significantly in creased through exerting ES on C-GO/PPy/PLLA films due to their sustained conductivity in the fluid of cell *** results indicated that C-GO/PPy/PLLA with sustained conductivity and mechanical property possessed great potential of nerve repair by exerting lasting-ES.

关键词： sustained conductivity electrical stimulation carboxylic graphene oxide polypyrrole

A novel akermanite/poly (lactic-co-glycolic acid) porous composite scaffold fabricated via a solvent casting-particulate leaching method improved by solvent self-proliferating process

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Regenerative Biomaterials 2017年第4期4卷 233-242页

作者： Yao Deng Mengjiao Zhang Xianchun Chen ximing Pu Xiaoming Liao Zhongbing huang Guangfu Yin College of Materials Science and Engineering Sichuan UniversityChengdu 610064PR China

Desirable scaffolds for tissue engineering should be biodegradable carriers to supply suitablemicroenvironments mimicked the extracellular matrices for desired cellular interactions and to providesupports for the formation of new tissues. In this work, a kind of slightly soluble bioactiveceramic akermanite (AKT) powders were aboratively selected and introduced in the PLGA matrix,a novel L-lactide modified AKT/poly (lactic-co-glycolic acid) (m-AKT/PLGA) composite scaffold wasfabricated via a solvent casting-particulate leaching method improved by solvent self-proliferatingprocess. The effects of m-AKT contents on properties of composite scaffolds and on MC3T3-E1 cellularbehaviors in vitro have been primarily investigated. The fabricated scaffolds exhibited threedimensionalporous networks, in which homogenously distributed cavities in size of 300–400 lmwere interconnected by some smaller holes in a size of 100–200 lm. Meanwhile, the mechanicalstructure of scaffolds was reinforced by the introduction of m-AKT. Moreover, alkaline ionic productsreleased by m-AKT could neutralize the acidic degradation products of PLGA, and the apatitemineralizationability of scaffolds could be largely improved. More valuably, significant promotionson adhesion, proliferation, and differentiation of MC3T3-E1 have been observed, which implied thecalcium, magnesium and especially silidous ions released sustainably from composite scaffoldscould regulate the behaviors of osteogenesis-related cells.

关键词： akermanite PLGA composite scaffolds solvent self-proliferating process

Fabrication of doxorubicin and chlorotoxin-linked Eu-Gd2O3 nanorods with dual-model imaging and targeted therapy of brain tumor

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Chinese Chemical Letters 2020年第1期31卷 285-291页

作者： Weina Zhang Zhongbing huang ximing Pua Xianchun Chen Guangfu Yin Lei Wang Fei Zhang Fabao Gao College of Materials Science and Engineering Sichuan UniversityChengdu 610065China Molecular Imaging Center Department of RadiologyWest China Hospital of Sichuan UniversityChengdu 610093China

It is urgent to find a technology accurately to better diagnose and treat to brain ***-doped Gd2 O3 nanorods(Eu-Gd2 O3 NRs)with paramagnetic and fluorescent properties were conjugated with doxorubicin(Dox)and chlorotoxin(CTX)via PEGylation,hydrazone bond and sulfur bond(named as CTXNRs-Dox),and these NRs could release more Dox in lower pH *** results of cell experiments indicated that CTX-NRs-Dox had obvious targeting and toxic effects on U251 cells,as well as good fluorescence imaging *** orthotopic glioma-transplanted mice models were constructed via the intracranial injection of glioma cells(U87 MG).The result of experiments after the tail-vein injection of the prepared NRs suggested that CTX-NRs-Dox could target to brain tumors via the long-time blood circulation,leading to their obvious contrast enhancement of MR imaging of the intracranial tumor and their significant inhibitory effect on the growth and metastasis of brain tumors.A mechanism of synergistic effect of CTX-NRs-Dox on targeting and inhabiting the brain tumor was *** research suggested that CTX-NRs-Dox had potential application prospect in the detection and treatment of glioma.

关键词： Brain tumor Dual-model imaging Doxorubicin Chlorotoxin Eu-Gd2O3 nanorods Targeted therapy

运用倾向匹配评分分析盆腔淋巴结转移对早期宫颈癌患者生存的影响

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现代肿瘤医学 2024年第15期32卷 2857-2865页

作者：黄凤仙高晖陈庆芬曹席明赵淑红陕西省人民医院放疗科陕西西安710068 西北大学第一医院妇科陕西西安710043

目的:通过使用倾向匹配评分(propensity score matching analysis, PSM)进一步验证和评估盆腔淋巴结转移(pelvic lymph node metastasis, PLNM)对早期宫颈癌患者的生存影响。方法:共纳入2009年01月01日至2016年12月31日间陕西省人民医... 详细信息

目的:通过使用倾向匹配评分(propensity score matching analysis, PSM)进一步验证和评估盆腔淋巴结转移(pelvic lymph node metastasis, PLNM)对早期宫颈癌患者的生存影响。方法:共纳入2009年01月01日至2016年12月31日间陕西省人民医院宫颈癌根治术后患者533例,其中429例盆腔淋巴结阴性(N0组)、104例盆腔淋巴结阳性(N1组患者)。采用1∶1进行PSM,共104对进入匹配后分析。结果:在PSM前,N0组及N1组在宫颈间质浸润深度(cervical stromal invasion, DSI)、淋巴血管间隙侵犯(lymphovascular space invasion, LVSI)、肿瘤大小及2009 FIGO分期上存在明显差异(P0.05)。在PSM前,N0组5年总生存期(overall survival, OS)(85.8%)明显优于N1组(72.1%),经PSM后,匹配后N0组5年OS (83.7%)仍明显优于N1组(72.1%),以上差异均具有统计学意义(P<0.05)。PSM前Cox单因素及多因素分析结果显示:DSI、LVSI、盆腔淋巴结状态及肿瘤大小是宫颈癌患者独立预后影响因素。PSM后Cox单因素及多因素分析结果显示:DSI、LVSI、盆腔淋巴结状态仍是宫颈癌患者独立预后影响因素。结论:无论在PSM前还是在PSM后,盆腔淋巴结转移与早期宫颈癌患者较差的5年OS相关。

关键词：宫颈癌盆腔淋巴结转移倾向匹配评分总生存期

基于LDAP与Struts的数字校园门户统一身份申请系统

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计算机应用与软件 2008年第3期 173-175页

作者：李涛张波张晓鹏鹿海涛钟焯荣李西明巫莉莉黄志宏华南农业大学现代教育技术中心华南农业大学现代教育技术中心广东广州510642

数字校园是推动教育信息化的重要系统工程,LDAP(Lightweight Directory Access Protocol)在数字校园门户统一身份认证中得到广泛应用。在讨论轻量级目录访问协议LDAP、Java Web开发技术的基础上,设计并实现了一个数字校园统一身份申请... 详细信息

数字校园是推动教育信息化的重要系统工程,LDAP(Lightweight Directory Access Protocol)在数字校园门户统一身份认证中得到广泛应用。在讨论轻量级目录访问协议LDAP、Java Web开发技术的基础上,设计并实现了一个数字校园统一身份申请系统。该系统结合数字校园门户来进行邮件帐号和国际访问帐号的申请,具有较好的可移植性、可扩充性和安全性。

关键词： LDAP Struts 门户 Java Web

Joint Trajectory and Passive Beamforming Optimization in IRS-UAV Enhanced Anti-Jamming Communication Networks

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China Communications 2022年第5期19卷 191-205页

作者： Zhifeng Hou Jin Chen Yuzhen huang Yijie Luo ximing Wang Jiangchun Gu Yifan Xu Kailing Yao PLA Army Engineering University Nanjing 210007China Artificial Intelligence Research Center Defense Innovation InstituteBeijing 100166China School of Information and Communication Beijing University of Posts and TelecommunicationsBeijing 100876China College of Information and Communication National University of Defense TechnologyWuhan 430010China

This paper investigates the anti-jamming communication scenario where an intelligent reflecting surface(IRS)is mounted on the unmanned aerial vehicle(UAV)to resist the malicious jamming *** from existing works,we consider the dynamic deployment of IRS-UAV in the environment of the mobile user and unknown ***,a joint trajectory and passive beamforming optimization approach is proposed in the IRS-UAV enhanced *** detail,the optimization problem is firstly formulated into a Markov decision process(MDP).Then,a dueling double deep Q networks multi-step learning algorithm is proposed to tackle the complex and coupling decision-making ***,simulation results show that the proposed scheme can significantly improve the anti-jamming communication performance of the mobile user.

关键词： intelligent reflecting surface unmanned aerial vehicle deep reinforcement learning trajectory optimization

超声滚压GCr15表面性能模型建立及工艺参数优化

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表面技术 2024年第5期53卷 156-165页

作者：黄鹏程王燕霜程勇杰王高峰袁锡铭齐鲁工业大学(山东省科学院)机械工程学院济南250353 洛阳轴研科技有限公司河南洛阳471039 山东金帝精密机械科技股份有限公司山东聊城252035

目的基于超声滚压后GCr15试样表面粗糙度和表面硬度与工艺参数之间的数学模型,获取超声滚压GCr15的最佳工艺参数。方法首先,通过单因素试验筛选4个工艺参数的取值范围;其次,建立基于响应曲面的超声滚压GCr15表面硬度及表面粗糙度预测模... 详细信息

目的基于超声滚压后GCr15试样表面粗糙度和表面硬度与工艺参数之间的数学模型,获取超声滚压GCr15的最佳工艺参数。方法首先,通过单因素试验筛选4个工艺参数的取值范围;其次,建立基于响应曲面的超声滚压GCr15表面硬度及表面粗糙度预测模型;再次,基于遗传算法对2个预测模型进行多目标复合优化,得到最佳工艺参数;最后,针对多目标优化结果进行试验验证。结果在超声滚压处理GCr15时,滚压静压力及滚压次数对试样表面硬度及表面粗糙度的影响极显著,转速的影响不显著;进给量对表面硬度有显著影响,对表面粗糙度的影响不显著。粗糙度模型受到静压力和滚压次数双因子交互作用的影响,硬度模型不受交互作用的影响。基于遗传算法进行多目标优化得到的最佳工艺参数如下:转速为207 r/min,进给量为0.34 mm/r,静压力为0.49 MPa,滚压次数为3。在最佳工艺参数下得到试样的最低表面粗糙度为0.34μm、最高硬度为60.5HRC。结论基于响应曲面法的GCr15超声滚压表面性能预测模型准确有效。采用最优工艺参数能够获得最优表面质量。

关键词：超声滚压轴承钢响应曲面法 Box-Behnken设计遗传算法工艺参数优化

一种基于VoIP技术的呼叫中心综合服务平台设计方案

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微计算机应用 2005年第1期26卷 63-65页

作者：李西明刘伟平黄红斌郑力明陈舜儿暨南大学电子系广州510632

本文首先介绍呼叫中心的概念和当前的发展,并介绍了CTI技术和VoOP技术的发展现状,然后提出了一种基于VoIP技术和CTI技术的呼叫中心综合服务平台设计方案。本文也对本方案的应用作了一些探讨。

关键词：综合服务平台呼叫中心 VoIP技术 CTI技术发展现状概念方案

球囊辅助技术帮助指引导管通过桡动脉夹层段76例临床分析

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广西医科大学学报 2021年第8期38卷 1586-1589页

作者：韦恒巫相宏朱海马国添张小新黄锡明欧传杰赖美声赵英艺广西医科大学第一附属医院心血管病研究所南宁530021 北海市人民医院心内科北海536000 广西医大开元琅东医院心内科南宁530021 贺州市人民医院心内科贺州542800 平南县人民医院心内科平南537300 合浦县人民医院心内科合浦536100 浦北县人民医院心内科浦北535300

目的:探讨应用球囊辅助技术帮助指引导管通过桡动脉夹层段的可行性和安全性。方法:回顾性分析2016年1月至2019年12月在广西医科大学第一附属医院等7家医院住院治疗的76例冠心病患者在经桡动脉路径行冠状动脉介入过程中发生桡动脉损伤引... 详细信息

目的:探讨应用球囊辅助技术帮助指引导管通过桡动脉夹层段的可行性和安全性。方法:回顾性分析2016年1月至2019年12月在广西医科大学第一附属医院等7家医院住院治疗的76例冠心病患者在经桡动脉路径行冠状动脉介入过程中发生桡动脉损伤引起夹层时,应用球囊辅助技术帮助指引导管通过夹层段的成功率、手术并发症和预后情况。结果:74例行冠状动脉介入治疗患者的指引导管能顺利通过桡动脉夹层段,2例患者因导丝进入假腔未成功,成功率为97.4%;手术过程需要平均耗时约3 min左右;住院期间无严重出血并发症和支架内血栓事件发生。结论:经桡动脉路径行冠状动脉介入发生血管损伤夹层时应用球囊辅助技术可安全有效地帮助指引导管通过血管损伤夹层段并继续行冠状动脉介入治疗。

关键词：经桡动脉路径介入治疗桡动脉夹层导丝球囊