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New Lower Bounds to Wrap-around L2-discrepancy for U-type Designs with Three-level

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Acta Mathematicae Applicatae Sinica 2019年第3期35卷 513-520页

作者： Zheng-hong WANG hong QIN School of Mathematics and Statistics South-Central University for NationalitiesWuhan 430074China Faculty of Mathematics and Statistics Central China Normal UniversityWuhan 430079China

The objective of this paper is to study the issue of uniformity on three-level U-type designs in terms of the wrap-around *** on the known formula,we present a new lower bound of wrap-around L2-discrepancy for three-level U-type designs and compare it with those existing ones through figures,numerical simulation and illustrative examples.

关键词： U-type designs wrap-around L2-discrepancy lower bound

绿原酸对中性粒细胞功能及胞外诱捕网形成的影响及机制

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中国药理学通报 2025年第1期41卷 101-107页

作者：杨运刘娅王翠彭春红贵州中医药大学第二临床医学院贵州贵阳550025 七星关区中医妇幼集团医院贵州毕节551700 毕节市中医医院贵州毕节551700 贵州医科大学临床医学院贵州贵阳550025 贵州省人民医院呼吸与危重医学科贵州贵阳550002 国家卫健委肺脏免疫性疾病重点实验室贵州贵阳550002

目的探究绿原酸(chlorogenic acid,CGA)对中性粒细胞(neutrophil,NEU)功能及中性粒细胞胞外诱捕网(neutrophil extracellular traps,NETs)形成的影响及机制。方法从小鼠骨髓中分离并纯化NEU;将NEU与CGA共培养,通过CCK-8法筛选共培养适合的干预浓度;检测NEU迁移能力、髓过氧化物酶(MPO)以及脱颗粒弹性蛋白酶(NE)、基质金属蛋白酶9(MMP-9)的水平观察CGA对NEU功能的影响;免疫荧光法观察NETs的主要结构组蛋白H3及DNA骨架,以及检测NEU释放的游离DNA(cf-DNA)含量,观察NETs的形成情况;检测NEU产生的活性氧(ROS)水平,以确定CGA是否影响NEU释放NETs过程中的ROS的生成。结果CGA在浓度为100、200、400μmol·L^(-1)时对NEU活性有明显抑制作用(P<0.01)。与空白组(Blank)相比,CGA(100、200、400μmol·L^(-1))干预后,细胞迁移能力及MPO、NE、MMP-9分泌量增加(P<0.05),组蛋白H3及DNA骨架、cf-DNA的释放量明显增加(P<0.01),细胞产生的ROS也明显增加(P<0.01),上述作用在一定范围内具有浓度依赖性。结论CGA能够增强NEU功能及促进NETs的形成,可能与促进细胞内ROS水平增加有关。

关键词：绿原酸中性粒细胞胞外诱捕网免疫抗菌活性氧

中药治疗腰椎椎体间融合术后发热的炎症信号通路

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中国组织工程研究 2025年第21期29卷 4568-4575页

作者：方雨婷彭宏庞玉洁南阳市中医院河南省南阳市473000

背景:术后发热是后路腰椎椎体间融合后常见临床症状之一,目前没有明确的病因病机,患者术后体温易反复,病程较久,西药治疗效果欠佳,影响患者术后恢复。目的:综述总结炎症信号通路和术后发热的关联及中药防治后路腰椎椎体间融合后发热的机... 详细信息

背景:术后发热是后路腰椎椎体间融合后常见临床症状之一,目前没有明确的病因病机,患者术后体温易反复,病程较久,西药治疗效果欠佳,影响患者术后恢复。目的:综述总结炎症信号通路和术后发热的关联及中药防治后路腰椎椎体间融合后发热的机制,为研究术后发热继续探索新的治疗药物。方法:检索CNKI中国期刊全文数据库、万方数据库和PubMed数据库2006年6月至2023年12月收录的文献,中文检索词为“中药,术后发热,炎症,白细胞介素1,白细胞介素6,白细胞介素8,干扰素γ,肿瘤坏死因子,前列腺素E2,p38丝裂原活化蛋白激酶,核因子κB,Toll样受体,Janus激酶/信号转导和转录激活因子,Notch信号通路”;英文检索词为“medicinal herb,postoperative fever,inflammation,interleukin-1,interleukin-6,interleukin-8,γ-interferon,tumor necrosis factor,Prostaglandin E2,p38 mitogen-activated protein kinase,nuclear factor-κB,toll-like receptor,janus kinases/signal transducer and activator of transcription,notch signaling pathway”。阅读文章剔除研究内容不相关、质量差的文献,纳入100篇文献进行归纳总结。结果与结论:(1)手术造成软组织创伤促使机体释放炎症因子,促炎因子作用于下丘脑前部的体温调节中心,促使发热;(2)术后切口内出血及渗液等的吸收,吞噬细胞吞噬坏死细胞的蛋白分解产物后,产生内生致热原(白细胞介素、肿瘤坏死因子、干扰素等)导致发热;(3)细胞因子通过炎症信号通路发挥致炎作用,促使发热;(4)中药或中药复方可以调控炎症信号通路发挥抗炎解热作用防治术后发热;目前中药作用机制尚无定论,应深入研究阐明中医药防治术后发热的相关信号通路,运用现代技术把细胞分子技术与中医药药理作用机制联系起来,以便指导临床医生用药,促进患者术后恢复;(5)中药联合西药治疗术后发热是未来的研究热点,应充分发挥中医药优势,明确不同证型应用中药单体或有效成分提取物和中药汤剂的靶点作用机制。

关键词：中药腰椎椎体间融合术后发热炎症白细胞介素干扰素γ 肿瘤坏死因子信号通路

Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang Zeng Jun-hong Wu Dan-Dan Xu Kang He Chang-Qing Liu Li-Fei Song Zheng-Zhi Wu Qian-Qian Jiang Shao-Yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

Interception time and uncertainty optimization for tangent-impulse orbit interception problem

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Defence Technology（防务技术） 2022年第3期18卷 418-440页

作者： Yang hong Li Xin-hong Ding Wen-zhev Department of Aerospace Science and Technology Space Engineering UniversityNo.1 BaYi RoadHuaiRou DistrictBeijing101416China

The traditional tangent impulse interception problem does not consider the influence of actual ***,by taking the actual state deviation of the interceptor into the orbit design process,an interception orbit that is more robust than the nominal orbit can be ***,we study the minimum time interception problem and the minimum terminal interception error problem under tangent impulse conditions and give an orbit optimization method that considers the interception time and the interception ***,we express the interceptor's transfer time equation as a form of flight path angle,establish a global optimization model for solving the minimum time tangent impulse interception and give a hybrid optimization algorithm based on Augmented Lagrange Genetic Algorithm-Sequential Quadratic Programming(ALGA-SQP).Secondly,we use the universal time equation and Bootstrap resampling technology to calculate the interceptor's terminal error distribution and establish the relevant global optimization model by using the circumscribed cuboid volume of the interceptor's terminal position error ellipsoid as the optimization ***,we combined the above two singleobjective optimization models to establish a global multi-objective optimization model that considers interception time and interception uncertainty and gave a hybrid multi-objective optimization algorithm based on Non-dominated Sorting Genetic Algorithm Ⅱ-Goal Achievement Method(NSGA2-GAM).The simulation example verifies the effectiveness of this method.

关键词： Tangent impulse interception Minimum time Interception uncertainty Multi-objective optimization Hybrid optimization

Supercritical carbon dioxide as a new working medium for pneumatic launch:A theoretical study

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Defence Technology（防务技术） 2021年第4期17卷 1296-1306页

作者： hong-xin Yao Xue-zhong Wei hong Ye Department of Thermal Science and Energy Engineering University of Science and Technology of ChinaHefei230027People’s Republic of China

Compared with the conventionally gaseous or liquid working media,the specific internal energy of supercritical carbon dioxide(SCD)is higher at the same temperature and pressure,and the critical temperature of carbon dioxide is close to room temperature,making SCD a potential new working medium for pneumatic *** analyze the feasibility of this conception,an analytical model of a pneumatic catapult is established on basis of the conservations of mass and *** model consists of a high-pressure chamber and a low-pressure chamber connected by multiple valves,and there is a movable piston in the low-pressure chamber that can push an aircraft to *** effects of the launch readiness state of SCD in the high-pressure chamber,the initial volume of the low-pressure chamber and the valve control on the movement of the aircraft are *** is found that there is a restrictive relation between the temperature and pressure of the launch readiness state of SCD,i.e.,there is a maximum allowable launch readiness pressure when the launch readiness temperature is *** this restrictive relation is not satisfied,the working medium in the low-pressure chamber will drop to its triple point within a few milliseconds,leading to a launch *** to this restrictive relation,there is an optimal launch readiness state of SCD with the highest working capacity for any allowable launch readiness *** pressure of the low-pressure chamber will decrease significantly as the initial volume increases,leading to a decreased acceleration of the *** acceleration can be controlled below a critical value by a designed sequential blasting technique of multiple *** calculated results show that a 500 kg aircraft can be accelerated from 0 to 58 m/s in 0.9 s with 36 kg of carbon *** research provides a new technique for the controllable cold launch of an aircraft.

关键词： Pneumatic launch Supercritical carbon dioxide Restrictive relation of the launch readiness state Optimal launch readiness state High working capacity

Tunable edge bands and optical properties in black phosphorus nanoribbons under electric field

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Chinese Physics B 2018年第12期27卷 115-120页

作者： hong Liu Physics Department Nanjing Normal University

For several types of the applied electric field configuration on the normal-zigzag black phosphorus nanoribbon(nZZ-BPNR)we investigate the band structure and the linear optical absorption spectrum,especially for the edge states and the corresponding low-energy absorption *** obtained results show that the applied electric field can not only open another band gap at k=0.5 point,but also can change completely the spacial probabilities of edge states in the two edge *** strength of electric field can tune the two band gaps at the Γ point and 0.5 ***,one remarkable feature is that the forbidden *** lowest-excited-energy linear absorption peakfrom the transition between two edge bands at the Γ ***,in comparison with the lowest-excited-energy peaks among various configurations,the second type of electric field configuration can move this peak blue-shift larger than other configurations.

关键词： black phosphorus nanoribbon edge band linear optical absorption spectrum

Identifying Spatial Heterogeneity in the Effects of High-Tech Firm Density on Housing Prices:Evidence from Guangdong-hong Kong-Macao Greater Bay Area,China

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Chinese Geographical Science 2023年第2期33卷 233-249页

作者： WANG Yang WU Kangmin ZHANG hong’ou LIU Yi YUE Xiaoli Faculty of Geography Yunnan Normal UniversityKunming 650500China Guangzhou Institute of Geography Guangdong Academy of SciencesGuangzhou 510070China Institute of Strategy Research for Guangdong Hong Kong and Macao Greater Bay AreaGuangzhou 510070China Key Laboratory of Regional Sustainable Development Modeling Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China School of Architecture and Urban Planning Guangdong University of TechnologyGuangzhou 510090China

Innovation capitalization is a new concept in innovation geography *** research on a city scale has proven that innovation is an important factor affecting housing prices and verified that innovation has a capitalization ***,few studies investigate the spatial heterogeneity of innovation ***,case verification at the urban agglomeration scale is ***,this study proposes a theoretical framework for the spatial heterogeneity of innovation capitalization at the urban agglomeration *** the Guangdong-hong Kong-Macao Greater Bay Area(GHMGBA),China as a case study,the study investigated the spatial heterogeneity of the influence of high-tech firms,representing innovation,on housing *** work verified the spatial heterogeneity of innovation *** study constructed a data set influencing housing prices,comprising 11 factors in 5 categories(high-tech firms,convenience of living facilities,built environment,the natural environment,and the fundamentals of the districts)for 419 subdistricts in the *** the global scale,the study finds that high-tech firms have a significant and positive influence on housing prices,with the housing price increasing by 0.0156%when high-tech firm density increases by 1%.Furthermore,a semi-geographically weighted regression(SGWR)analysis shows that the influence of high-tech firms on housing prices has spatial *** areas where high-tech firms have a significant and positive influence on housing prices are mainly in the GuangzhouFoshan metropolitan area,western Shenzhen-Dongguan,north-central Zhongshan-Nansha district,and Guangzhou—all areas with densely distributed high-tech *** results confirm the spatial heterogeneity of innovation capitalization and the need for further discussion of its scale and spatial *** study offers implications for relevant GHMGBA administrative authorities for spatially differentiated development strateg

关键词： innovation capitalization high-tech firms housing prices spatial heterogeneity semi-geographically weighted regression(SGWR) Guangdong-hong Kong-Macao Greater Bay Area(GHMGBA)

Lattice structure adaptive IIR notch filter based on least square kurtosis

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Journal of Systems Engineering and Electronics 2009年第6期20卷 1188-1192页

作者： Liang hong hong Kang Yang Changsheng Coll. of Marine Northwestern Polytechnical Univ. Xi'an 710072 P. R. China

A new variable step-size algorithm for a second-order lattice form structure adaptive infinite impulse response （IIR） notch filter to detection and estimation frequency of sinusoids in Gaussian noises is proposed. Utilizing least square kurtosis of output signals as a cost function, the new gradient-based algorithm to update frequency of the adaptive IIR notch filter and the new variable step-size algorithm are given. The computer simulation results show that the proposed algorithm has better ability in suppressing colored Gaussian noises and better accuracy in estimating parameters at low SNR than previous algorithms.

关键词： adaptive IIR notch filter least square kurtosis variable step-size colored Gaussian noise.