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Correlation of obstructive sleep apnea hypopnea syndrome with metabolic syndrome in snorers

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The Journal of Biomedical Research 2014年第3期28卷 222-227页

作者： Qun Zhang Xiaofeng Zhang Mengmeng Zhao Hanpeng Huang Ning Ding xilong Zhang Hong Wang Nanjing Medical University Department of Respiratory Medicine the First Affiliated HospitalNanjing Medical University

Though obstructive sleep apnea hypopnea syndrome（OSAHS） and metabolic syndrome（MS） are correlated;the contributing factors for the occurrence of MS in Chinese snorers remain largely *** aimed to investigate the associated pathogenesis of coexistence of OSAHS and MS in Chinese snorers.A total of 144 Chinese habitual snorers were divided into 3 groups,the control group（simple snorers）（n = 36）,the mild OSAHS group（n= 52）and the moderate-to-severe OSAHS group（n = 56）.The incidence of MS in the moderate-to-severe OSAHS group（26.8%） was significantly higher than that in the control group（8.3%）,the mild OSAHS group（11.1%） and all the OSAHS patients（19.45%）（all P 〈 0.05）.Homeostatic model assessment（HOMA） index and proinsulin（PI） were negatively correlated with nocturnal meanSpO2 and ***,nocturnal SpO2 were negatively correlated with body mass index,waist and neck circumferences and diastolic blood pressure,but positively correlated with total cholesterol and high-density lipoprotein *** study indicated that in Chinese snorers,moderate-to-severe OSAHS was closely associated with MS via nocturnal hypoxemia.

关键词： hypoxia insulin resistance metabolic syndrome obstructive sleep apnea hypopnea syndrome

The Problems and Solutions of Rural Labor Flowing in low Marketization Level

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International Journal of Technology Management 2015年第7期 143-146页

作者： xilong Deng Juan Chen School of Economics & Management Lanzhou University of Technology Lanzhou China 730050 Gansu Administration Institute Lanzhou China 730010

Rural labor flowing in low marketization level restricts rural production elements of effective allocation, and restricts the development of rural economy, causes the gap between urban and rural areas to continue expanding. This article has analyzed the reasons of phenomenon, and raised some solutions from abolishing the barrier of the household register, improved rural labor＇ s cultural and skills quality, and built a social security system in rural areas improve the marketization level of rural labor flow.

关键词： Rural Laborers Flowing in Low Marketization Level Reasons Solutions

Charge adaptive phytochemical-based nanoparticles for eradication of methicillin-resistant staphylococcus aureus biofilms

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Asian Journal of Pharmaceutical Sciences 2024年第3期19卷 160-176页

作者： xilong Cui Fanhui Liu Shuang Cai Tingting Wang Sidi Zheng Xinshu Zou Linlin Wang Siqi He Yanhua Li Zhiyun Zhang College of Veterinary Medicine Northeast Agricultural UniversityHarbin 150030China Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development Harbin 150030China

The intrinsic resistance of MRSA coupled with biofilm antibiotic tolerance challenges the antibiotic treatment of MRSA biofilm ***-based nanoplatform is a promising emerging approach for treatment of biofilm ***,their therapeutic efficacy was restricted by the low drug loading capacity and lack of ***,we constructed a surface charge adaptive phytochemical-based nanoparticle with high isoliquiritigenin(ISL)loading content for effective treatment of MRSA biofilm.A dimeric ISL prodrug(ISL-G2)bearing a lipase responsive ester bond was synthesized,and then encapsulated into the amphiphilic quaternized *** obtained ISL-G2loaded NPs possessed positively charged surface,which allowed cis-aconityl-D-tyrosine(CA-Tyr)binding via electrostatic interaction to obtain ISL-G2@TMDCOS-Tyr *** NPs maintained their negatively charged surface,thus prolonging the blood circulation *** response to low pH in the biofilms,the fast removal of CA-Tyr led to a shift in their surface charge from negative to positive,which enhanced the accumulation and penetration of NPs in the ***,the pH-triggered release of D-tyrosine dispersed the biofilm and lipase-triggered released of ISL effectively kill biofilm *** in vivo study was performed on a MRSA biofilm infected wound *** phytochemical-based system led to~2log CFU(>99%)reduction of biofilm MRSA as compared to untreated wound(P<0.001)with negligible biotoxicity in *** phytochemical dimer nanoplatform shows great potential for long-term treatment of resistant bacterial infections.

关键词： MRSA biofilm Isoliquiritigenin Dimer prodrug Charge adaptive Responsive nanoparticles

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基于递进动因分解的碳税减排机制研究

资源科学 2023年第7期45卷 1285-1296页

作者：姚西龙刘娜太原理工大学经济管理学院太原030024

【目的】旨在厘清碳税的具体减排机制,助其充分发挥减排功能,推动碳减排政策体系建设。【方法】本文基于多层递进动因分解视角探究碳税的减排机制,建立可计算一般均衡模型(CGE)与结构路径分解(SPD)的耦合模型,识别碳税的关键减排路径,... 详细信息

【目的】旨在厘清碳税的具体减排机制,助其充分发挥减排功能,推动碳减排政策体系建设。【方法】本文基于多层递进动因分解视角探究碳税的减排机制,建立可计算一般均衡模型(CGE)与结构路径分解(SPD)的耦合模型,识别碳税的关键减排路径,并对促进各路径减排的驱动因素进行分解分析。【结果】(1)碳税的减排作用以产业链引发的间接减排为主,占碳减排总量的80.77%,且碳税的减排效果随生产层级的增加而逐渐减弱;(2)能源效率效应是碳税促进减排的最主要动因,不同驱动因素在各生产层级、不同减排路径上的作用存在差异;(3)重工业、火电行业、煤炭行业等少数关键行业提供了主要碳减排贡献,固定资本形成的减排贡献最大,且主要通过影响建筑业对上游高耗能行业的需求这一路径实现碳减排。【结论】因此,应当充分把握和利用各关键因素对不同生产层级和路径碳减排的驱动机制,充分挖掘产业链关键环节的减排潜力,采取针对性措施促进行业间协同减排。

关键词：碳税传导机制递进动因可计算一般均衡模型结构路径分解

Oxidation of KCNB1 K^+ channels in central nervous system and beyond

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World Journal of Biological Chemistry 2014年第2期5卷 85-92页

作者： Federico Sesti xilong Wu Shuang Liu Department of Neuroscience and Cell Biology Obert Wood Johnson Medical School Rutgers University Piscataway NJ 08854 United States Department of Neurology Jinan Central Hospital

KCNB1, a voltage-gated potassium(K+) channel that conducts a major delayed rectifier current in the brain, pancreas and cardiovascular system is a key player in apoptotic programs associated with oxidative stress. As a result, this protein represents a bona fide drug target for limiting the toxic effects of oxygen radicals. Until recently the consensus view was that reactive oxygen species trigger a pro-apoptotic surge in KCNB1 current via phosphorylation and SNARE-dependent incorpora-tion of KCNB1 channels into the plasma membrane. However, new evidence shows that KCNB1 can be modified by oxidants and that oxidized KCNB1 channels can directly activate pro-apoptotic signaling pathways. Hence, a more articulated picture of the pro-apoptotic role of KCNB1 is emerging in which the protein induces cell's death through distinct molecular mechanisms and activation of multiple pathways. In this review article we discuss the diverse functional, toxic and protective roles that KCNB1 channels play in the major organs where they are expressed.

关键词： Apoptosis Kv2.1 Aging Reactive oxygen species Alzheimer’ s disease

Genome-wide identification of the CONSTANS-LIKE(COL)family and mechanism of fruit senescence regulation by PpCOL8 in sand pear(Pyrus pyrifolia)

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Journal of Integrative Agriculture 2024年第4期23卷 1222-1237页

作者： Yue Xu Shurui Song Huiying Wang xilong Cao Xinran Zhao Wenli Wang Liyue Huo Yawei Li Misganaw Wassie Bin Lu Liang Chen Haiyan Shi College of Horticulture Hebei Agricultural UniversityBaoding 071001China Wuhan Botanical Garden Chinese Academy of SciencesWuhan 430074China

Pyrus pyrifolia Nakai‘Whangkeumbae'is a sand pear fruit with excellent nutritional quality and ***,the industrial development of pear fruit is significantly limited by its short shelf *** acid(SA),a well-known phytohormone,can delay fruit senescence and improve shelf ***,the mechanism by which SA regulates CONSTANS-LIKE genes(COLs)during fruit senescence and the role of COL genes in mediating fruit senescence in sand pear are poorly *** this study,22 COL genes were identified in sand pear,including four COLs(Pp COL8,Pp COL9a,Pp COL9b,and Pp COL14)identified via transcriptome analysis and 18 COLs through genome-wide *** COL genes were divided into three subgroups according to the structural domains of the COL *** COL8,with two B-box motifs and one CCT domain,belonged to the first *** contrast,the other three Pp COLs,Pp COL9a,Pp COL9b,and Pp COL14,with similar conserved protein domains and gene structures,were assigned to the third *** four COLs showed different expression patterns in pear tissues and were preferentially expressed at the early stage of fruit ***,the expression of Pp COL8 was inhibited by exogenous SA treatment,while SA up-regulated the expression of Pp COL9a and Pp ***,Pp COL8 interacts with Pp MADS,a MADS-box protein preferentially expressed in fruit,and SA up-regulated its *** the production of ethylene and the content of malondialdehyde(MDA)were increased in Pp COL8-overexpression sand pear fruit,the antioxidant enzyme(POD and SOD)activity and the expression of Pp POD1 and Pp SOD1 in the sand pear fruits were down-regulated,which showed that Pp COL8 promoted sand pear fruit *** contrast,the corresponding changes were the opposite in Pp MADS-overexpression sand pear fruits,suggesting that Pp MADS delayed sand pear fruit *** co-transformation of Pp COL8 and Pp MADS also delayed sand pear fruit *** re

关键词： Pyrus pyrifolia CONSTANS-LIKE gene salicylic acid fruit senescence MADS

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日记视域下张舜徽的历史文献学与学术批评

史学史研究 2023年第2期 53-63页

作者：舒习龙韩山师范学院历史文化学院广东潮州521041

张舜徽先生一生钟情于历史文献学的思考与研究,所作日记蕴含有丰富的校雠学、目录学、校勘学等分支学科的分析与思考。张氏初步建构的历史文献学体制,对改变中国历史文献学研究偏狭而单一的状况,恢复历史文献学“辨章学术,考镜源流”的... 详细信息

张舜徽先生一生钟情于历史文献学的思考与研究,所作日记蕴含有丰富的校雠学、目录学、校勘学等分支学科的分析与思考。张氏初步建构的历史文献学体制,对改变中国历史文献学研究偏狭而单一的状况,恢复历史文献学“辨章学术,考镜源流”的传统,进而推动历史文献学学科发展起到了重要的作用。张氏的学术思想形成于民国时代。他对学术本原的追求、识见为高的求索、学术经世的倡导以及博学会通的强调等,都具有鲜明的特色。张氏以史学家的批评视角来评析学术发展中的得失利弊,形成独有的学术批评话语和方法。在张氏的学术思想中,历史文献学是基础,学术批评是其学术品性的表征。

关键词：日记张舜徽历史文献学学术批评

Reviews of Metallurgical Technology to Recovery Platinum Group Metals from Secondary Resource in China

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贵金属 2012年第A1期33卷 18-23页

作者： GUO Junmei HE Xiaotang WANG Huan WU xilong ZHAO Yu LI Yong LI Kun HAN Shouli Sino-Platinum Metals Resources(Yimen)Co.Ltd. State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum MetalsSino-Platinum Metals Co.Ltd.Kunming650106China

China is extremely poor in mineral resources of Platinum Group Metals (PGMs), productive output of PGMs from mineral resource is 2.5 tons per year. At the same time, China is the biggest PGMs consumption country in the world, the mineral resource of PGMs is critical shortage, it shows the importance of recycling the secondary resource of PGMs. Sino-Platinum Metals Resource (Yimen) Co., Ltd. is the leader in recycling of PGMs from secondary resource, and has made outstanding contributions to China PGMs secondary resources recycling. This article elucidates the current situation of secondary resources recovery and development of metallurgical technology for PGMs.

关键词： metallurgical technology platinum group metals secondary resource refining recovery

Thermal Degradation Kinetics of Deoxybenzoin Polymer

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Journal of Donghua University(English Edition) 2018年第1期35卷 1-5页

作者： HU xilong WANG Yan YU Junrong ZHU Jing HU Zuming State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Material Science and Engineering Donghua University Shanghai 201620 China

The thermal degradation behavior of 4, 4-bishydroxydeoxybenzoin-polyphosphonate( BHDB-PPN) was investigated by gas chromatograph-mass spectrometer( GC-MS)and thermogravimetric analysis( TGA). It was found that BHDBPPN exhibited a different char formation way from the previous proposed mechanism based on the residue analysis by Fourier transform infrared spectra( FTIR) and the gas phase analysis by GC-MS. The thermal degradation kinetics was studied through TGA at various heating rates to identify the activation energy of BHDBPPN at two decomposition stages which were mainly attributed to the evolved phenol and benzene respectively. It was demonstrated that the activation energy at the second stage was much higher than that at the first stage,indicating that more energy was required to break the P—C bond to form benzene in comparison to the formation of phenol.

关键词： thermal degradation deoxybenzoin kinetics activation energy