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Aryl hydrocarbon receptor nuclear translocator 2 as a prognostic biomarker and immunotherapeutic indicator for clear cell renal cell carcinoma

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BIOCELL 2023年第11期47卷 2397-2408页

作者： RENLONG ZHOU SHUANG LI xilin xiao Department of Public Health Laboratory Sciences University of South ChinaHengyang421001China Department of Blood Transfusion Shenzhen Longhua District Central HospitalShenzhen518000China Bioinformatics R&D Department Hangzhou Mugu Technology Co.Ltd.Hangzhou310000China

Background:In many cancer types,aryl hydrocarbon receptor nuclear translocator 2(ARNT2)has been found to be associated with tumor cell proliferation and ***,the role of ARNT2 in clear cell renal cell carcinoma(ccRCC)has not been completely *** this study,the potential role of ARNT2 in ccRCC development was ***:A pan-cancer dataset(TCGA-TARGET-GTEx)was accessed from UCSC Xena Data ***2 expression in normal and tumor samples was *** Cox regression was performed to evaluate the prognostic value of *** sample gene set enrichment analysis(ssGSEA)was used to estimate the enrichment of functional pathways and gene *** and ESTIMATE methods evaluated the immune *** ARNT2 expression was determined in ccRCC tissue and cell lines using RT-qPCR and Western ***:ARNT2 expression was significantly dysregulated in 23 out of 30 cancer ***-cancer data revealed a strong correlation between ARNT2 expression and immune modulators,immune cell infiltration,and genomic *** ccRCC patients,the low-ARNT2 expression group had higher immune infiltration,CD8 T cells,and programmed cell death ligand 1 expression,as well as higher enrichment score of immunotherapeutic predictors than those in the high-ARNT2 expression ***-ARNT2 expression group was more responsive to ***,low ARNT2 expression was observed in ccRCC tissue and cell ***:Dysregulated ARNT2 expression is involved in cancer development and the modulation of the immune ***2 can be potentially used as a prognostic indicator and an immunotherapeutic indicator for ccRCC.

关键词： Pan-cancer Clear cell renal cell carcinoma Aryl hydrocarbon receptor nuclear translocator 2 Immune microenvironment Immunotherapy

Biocompatibility and in vitro antineoplastic drug-loaded trial of titania nanotubes prepared by anodic oxidation of a pure titanium

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Science China Chemistry 2009年第12期52卷 2161-2165页

作者： xiao xilin YANG LiXia GUO ManLi PAN ChunFeng CAI QingYun YAO ShouZhuo State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China College of Chemistry and Chemical Engineering University of South ChinaHengyang 421001China

TiO2 nanotube (NT) arrays have been prepared by anodic oxidation of a Ti sheet,and carbon-deposited TiO2 NT arrays have been prepared by annealing TiO2 NT arrays in carbon atmosphere. The biocompatibility of the as-prepared NT arrays was investigated by observing the growth of osteosarcoma (MG-63) cells on the NT arrays. The application of the TiO2 NT arrays as a drug delivery vehicle was investigated. Both the TiO2 NTs and the carbon-modified TiO2 NTs have good biocompatibility supporting the normal growth and adhesion of MG-63 cells with no need of extracellular matrix protein coating. The one end-opened TiO2 NTs can be easily filled with drugs,working as an efficient drug delivery vehicle.

关键词： drug delivery biocompatibility titania nanotubes cell adhesion cisplatin

Molecular engineering of self-assembled monolayers for highly utilized Zn anodes

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eScience 2024年第2期4卷 70-79页

作者： Lei Zhang Jin xiao xilin xiao Wenli Xin Yaheng Geng Zichao Yan Zhiqiang Zhu State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China Greater Bay Area Institute for Innovation Hunan UniversityGuangzhou 511300China School of Science Hunan University of TechnologyZhuzhou 412007China

Stabilizing the Zn anode under high utilization rates is highly applauded yet very challenging in aqueous Zn ***,we rationally design a zincophilic short-chain aromatic molecule,4-mercaptopyridine(4Mpy),to construct self-assembled monolayers(SAMs)on a copper substrate to achieve highly utilized Zn *** reveal that 4Mpy could be firmly bound on the Cu substrate via Cu–S bond to form compact and uniform SAMs,which could effectively isolate the water on the electrode surface and thus eliminate the water-related side *** addition,the short-chain aromatic ring structure of 4Mpy could not only ensure the ordered arrangement of zincophilic pyridine N but also facilitate charge transfer,thus enabling uniform and rapid Zn ***,the Zn/4Mpy/Cu electrode not only enables the symmetric cell to stably cycle for over 180 h at 10 mA cm^(-2) under a high depth-of-discharge of 90%,but also allows the MnO_(2)-paired pouch cell to survive for 100 cycles under a high Zn utilization rate of 78.8%.An anode-free 4Mpy/Cu||graphite cell also operates for 150 cycles without obvious capacity fading at 0.1 A g^(-1).This control of interfacial chemistry via SAMs to achieve high utilization rates of metal anodes provides a new paradigm for developing high-energy metal-based batteries.

关键词： Zn anodes Interfacial engineering Self-assembled monolayers Zincophilic aromatic molecules High utilization

Adaptive strategies of high and low nucleic acid prokaryotes in response to declining resource availability and selective grazing by protozoa

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Science China Earth Sciences 2024年第6期67卷 1872-1884页

作者： Chen HU Liuqian YU xiaowei CHEN Jihua LIU Yao ZHANG John BATT xilin xiao Qiang SHI Rui ZHANG Tingwei LUO Nianzhi JIAO Dapeng XU College of the Environment and Ecology Xiamen UniversityXiamen 361102China State Key Laboratory of Marine Environmental Science College of Ocean and Earth SciencesFujian Key Laboratory of Marine Carbon SequestrationXiamen UniversityXiamen 361102China Joint Lab for Ocean Research and Education(LORE)of Dalhousie University Canadaand Shandong University and Xiamen UniversityXiamen 361102China Earth Ocean and Atmospheric Sciences ThrustThe Hong Kong University of Science and Technology(Guangzhou)Guangzhou 510000China Institute of Marine Science and Technology Shandong UniversityQingdao 266237China Department of Oceanography Dalhousie UniversityHalifaxNova Scotia B3H 4R2Canada Institute for Advanced Study Shenzhen UniversityShenzhen 518060China Carbon Neutral Innovation Research Center Xiamen UniversityXiamen 361102China

Prokaryotes play a fundamental role in global ocean biogeochemical ***,how the abundance and metabolic activity of ecologically distinct subgroups(i.e.,high nucleic acid(HNA)and low nucleic acid(LNA)cells),and their regulating factors,change in response to changing marine environmental conditions remains poorly ***,we delved into the time-evolving dynamic responses of the HNA and LNA prokaryotic subgroups to declining resource availability and selective grazing by protozoa by conducting a 73-day incubation experiment in a large-volume(117,000 L)macrocosm that facilitates community-level *** found that the metabolic activity of the HNA subgroup was higher than that of the LNA subgroup when the macrocosm was resource replete but that the HNA subgroup declined more rapidly than the LNA subgroup as the resources became increasingly scarce,leading to a steadily increasing contribution of LNA cells to prokaryotic ***,as resources in the macrocosm became limited,protozoan grazing preference shifted from the HNA to the LNA subgroup and the contributions of the LNA subgroup to the carbon flow within the macrocosm *** findings highlight the resilience of LNA cells in resource-limited environments,illuminate the critical role of selective grazing by protozoa in balancing distinct prokaryotic subgroups under changing resource conditions,and demonstrate the complex and adaptive interactions between protozoa and prokaryotes across diverse environmental contexts.

关键词： Microbial loop Macrocosm experiment Prokaryote Top-down and bottom-up controls Carbon flow

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液相链烷烃热导率与其结构定量关系

化工学报 2011年第3期62卷 604-610页

作者：彭国文肖方竹聂长明廖力夫杨胜园肖锡林南华大学化学化工学院湖南衡阳421001 南华大学公共卫生学院湖南衡阳421001 图卢兹第三大学量子化学与物理实验室法国图卢兹31077 湖南大学化学生物传感与计量学国家重点实验室湖南长沙410082

应用密度泛函理论(DFT),在B3LYP/6-31+G(d)水平上对含有5～24个碳原子的部分液相链烷烃进行结构优化和量化计算其分子中各个原子间空间拓扑距离,并构建拓扑距离矩阵。结合分子中各原子的支化度,应用原子的平衡电负性对分子图进行着色,... 详细信息

应用密度泛函理论(DFT),在B3LYP/6-31+G(d)水平上对含有5～24个碳原子的部分液相链烷烃进行结构优化和量化计算其分子中各个原子间空间拓扑距离,并构建拓扑距离矩阵。结合分子中各原子的支化度,应用原子的平衡电负性对分子图进行着色,得到新型结构拓扑指数PXm(m=1,2,3)。采用多元线性回归技术建立液相链烷烃热导率λ与PXm(m=1,2,3)的定量关系拓扑模型,并用该模型对热导率λ进行预测与估算,结果表明实验值与预测值、估算值均很吻合。同时,采用留一法(leave-one-out)和外检验方法测试模型的内部稳定性和外部预测能力。与文献结果比较,本文所用参数少,计算简便,为液相链烷烃导热的研究提供了一种新方法。

关键词：液相链烷烃热导率平衡电负性拓扑模型定量关系

Tumor inflammation-specific self-amplifying fluorescent molecular probes induce an anti-tumor immune response

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Science China Chemistry 2025年第1期68卷 273-287页

作者： Shuguang Yang Lijun Hu Hong xiao Zecong xiao Xintao Shuai PCFM Lab of Ministry of Education School of Materials Science and Engineering Sun Yat-sen University Department of Ultrasound The Fifth Affiliated Hospital Sun Yat-sen University Department of Medical Ultrasound The Third Affiliated Hospital of Sun Yat-sen University Nanomedicine Research Center The Third Affiliated Hospital of Sun Yat-sen University

Enhancing the concentration of exogenous molecular drugs within the tumor microenvironment through enzyme-catalyzed polymerization presents a novel strategy for cancer therapy. Nonetheless, the optimization of the catalytic efficiency is often impeded by the inefficient expression of enzymes. Herein, we reported a self-amplifying fluorescent molecular probe, Bis-HTPICG, for photodynamic therapy(PDT) and subsequent PDT-induced immunoreaction. The Bis-HTP-ICG probe possesses a noticeable enzyme-catalyzed polymerization facilitated by myeloperoxidase(MPO), a crucial enzyme secreted by neutrophils at inflammation sites. Upon exposure to laser irradiation, Bis-HTP-ICG showed a high PDT efficacy, inducing an acute inflammatory response that stimulates further recruitment of neutrophils and then elevated MPO secretion. The heightened level of MPO enhances the accumulation of the Bis-HTP-ICG via self-polymerization or binding with intratumoral proteins following MPO enzyme catalysis, instigating a self-amplifying chain reaction cycle involving Bis-HTP-ICG, neutrophils and ***, PDT efficiently incites immunogenic cell death(ICD) in tumor cells, initiating an anti-tumor immune response including dendritic cells(DCs) maturation, T cell proliferation and reprogramming of tumor-associated neutrophils(TANs). This work portrays a promising strategy for self-amplification of fluorescent molecular probes through adjustable enzyme levels,potentially offering a unique avenue to enhance the tumor accumulation of molecular drugs for improved tumor therapy.

关键词： fluorescent molecular probes self-amplifying myeloperoxidase photodynamic therapy

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海洋异养细菌利用溶解有机碳的定量评估

微生物学报 2020年第6期60卷 1090-1105页

作者：肖喜林咸淑慧张锐焦念志厦门大学海洋与地球学院近海海洋环境科学国家重点实验室福建省海洋碳汇重点实验室海洋微型生物与地球圈层研究所福建厦门361002

【目的】惰性溶解有机碳(refractory dissolved organic carbon,RDOC)是海洋总有机碳的主体组分,RDOC在深海中可保存数千年,构成了巨大的碳储库,在调节气候变化中有重要作用。但RDOC的定量评估尚未有统一的标准方法。通过测定环境中能... 详细信息

【目的】惰性溶解有机碳(refractory dissolved organic carbon,RDOC)是海洋总有机碳的主体组分,RDOC在深海中可保存数千年,构成了巨大的碳储库,在调节气候变化中有重要作用。但RDOC的定量评估尚未有统一的标准方法。通过测定环境中能被异养细菌利用的溶解有机碳(biodegradable DOC,BDOC)可以反过来评估RDOC的量。本文对BDOC测定中一些关键步骤进行验证,为制定海洋RDOC评估标准奠定基础。【方法】本文评估了3种过滤方式及5种滤膜对DOC测定的影响,并评估了瓶子效应和稀释效应对细菌生长和DOC利用的影响。【结果】研究发现,(1)GF/F滤膜、GF-75滤膜、聚四氟乙烯(PTFE)滤膜(孔径0.2μm)、聚碳酸酯(PC)滤膜(孔径0.2μm)和聚四氟乙烯材质针孔过滤器(HA)(孔径0.2μm)5种滤膜不会引入DOC污染;抽滤过滤和重力过滤方式过滤效果稳定、无污染,而在线过滤效果不稳定,易污染;(2)不同大小培养体系(30–480 mL;表面积/体积比为:1.64–0.67 cm^–1)之间的细菌生长速率和DOC利用量没有显著性差异;(3)培养体系稀释度越高,细菌生长速率越高,对数生长期细菌丰度及DOC利用量越低。【结论】综合考虑,建议BDOC和RDOC测定实验中采用抽滤过滤的方式及不进行稀释的培养体系;常用的滤膜和培养体积对BDOC评估无显著影响。结合研究结果,我们提出了评估海洋RDOC的方法。

关键词：溶解有机碳惰性溶解有机碳定量方法标准方法

MCM-41型介孔二氧化硅纳米颗粒的制备及其在DNA生物传感器中的应用

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化学进展 2021年第11期33卷 2085-2102页

作者：刘陈李强翔张迪郦瑜杰刘金权肖锡林南华大学化学化工学院衡阳421001 南华大学公共卫生学院典型环境污染与健康危害湖南省重点实验室衡阳421001 南华大学资源环境与安全工程学院衡阳421001 宁夏医科大学附属自治区人民医院银川750001

MCM-41型介孔二氧化硅纳米颗粒具有独特的结构特征和理化性质,能够与DNA、信号探针以及多种活性纳米颗粒结合,在DNA生物传感器中得到了广泛应用。其中,球形和薄膜形的MCM-41型介孔二氧化硅具有高负载量、孔口控释和高比表面积等优点,能... 详细信息

MCM-41型介孔二氧化硅纳米颗粒具有独特的结构特征和理化性质,能够与DNA、信号探针以及多种活性纳米颗粒结合,在DNA生物传感器中得到了广泛应用。其中,球形和薄膜形的MCM-41型介孔二氧化硅具有高负载量、孔口控释和高比表面积等优点,能有效装载各种信号探针、控制粒子的扩散以及固定大量活性纳米颗粒,可大大提高DNA生物传感器的灵敏度。本文就MCM-41型介孔二氧化硅在合成方式、模板剂去除、表面修饰及应用等三个方面的最新研究作了综述。首先依次介绍了球形和薄膜形MCM-41型介孔二氧化硅的常用合成方法和模板剂去除方法,并简要描述了各方法的优缺点。其次,大致介绍了其表面性质和功能化修饰的研究现状。再次介绍了现阶段将MCM-41型介孔二氧化硅作为信号探针的传递系统、分子筛和活性纳米材料的载体来提高检测灵敏度的DNA生物传感器。最后总结了目前研究中的不足之处并展望了其未来的进展方向。

关键词：介孔二氧化硅纳米颗粒 DNA生物传感器高灵敏度

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基于K-L信息量法的安徽省工业用电量预测

电网与清洁能源 2015年第11期31卷 58-62页

作者：石雪梅葛斐肖夕林国网安徽省电力公司经济技术研究院安徽合肥230022 合肥工业大学管理学院安徽合肥230009

针对区域工业用电量与经济指标的相关性,运用K-L信息量法,在月度尺度上筛选出能够指示区域工业用电量变化趋势的经济先行指标,并获得各先行指标的先行期数。以经济先行指标为自变量、区域工业用电量为被因变量建立多元回归模型,根据AIC... 详细信息

针对区域工业用电量与经济指标的相关性,运用K-L信息量法,在月度尺度上筛选出能够指示区域工业用电量变化趋势的经济先行指标,并获得各先行指标的先行期数。以经济先行指标为自变量、区域工业用电量为被因变量建立多元回归模型,根据AIC准则和BIC准则选取最佳拟合方程,得到工业用电量预测模型。运用模型预测安徽省2014年5月-12月的月用电量,结果显示预测精度较高,预测方法可以用于工业用电量预测。

关键词：经济先行指标 K-L信息量法用电量预测安徽省