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Inhibitory gamma-aminobutyric acidergic neurons in the anterior cingulate cortex participate in the comorbidity of pain and emotion

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Neural Regeneration Research 2025年第10期20卷 2838-2854页

作者： Lu Guan Mengting Qiu Na Li Zhengxiang Zhou Ru Ye Liyan Zhong Yashuang Xu Junhui Ren Yi Liang Xiaomei Shao Jianqiao fang Junfan fang Junying Du Department of Neurobiology and Acupuncture Research Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Key Laboratory for Research of Acupuncture Treatment and Transformation of Emotional Diseases Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Fuchun Community Health Service Center of Fuyang District HangzhouZhejiang ProvinceChina

Pain is often comorbid with emotional disorders such as anxiety and *** of the anterior cingulate cortex has been implicated in pain and pain-related negative emotions that arise from impairments in inhibitory gamma-aminobutyric acid *** review primarily aims to outline the main circuitry(including the input and output connectivity)of the anterior cingulate cortex and classification and functions of different gamma-aminobutyric acidergic neurons;it also describes the neurotransmitters/neuromodulators affecting these neurons,their intercommunication with other neurons,and their importance in mental comorbidities associated with chronic pain *** understanding on their role in pain-related mental comorbidities may facilitate the development of more effective treatments for these ***,the mechanisms that regulate gamma-aminobutyric acidergic systems remain *** is also unclear as to whether the mechanisms are presynaptic or *** exploration of the complexities of this system may reveal new pathways for research and drug development.

关键词： anterior cingulate cortex anxiety chronic pain circuit communication comorbidity depression gamma-aminobutyric acidergic neurons parvalbumin neurons synaptic transmission

Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

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Nano-Micro Letters 2025年第2期17卷 134-168页

作者： Yijie Wang Congrui Liu Chao fang Qiuxia Peng Wen Qin Xuebing Yan Kun Zhang Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Department of Stomatology and Central Laboratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential for preventing and treating disease,especially cancer nanovaccines,which have gained considerable interest recently for their strong anti-tumor immune *** can prompt the immune system to generate antibodies and activate various immune cells,leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and *** enhance the flexibility and targeting of vaccines,nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level,enabling more controlled and precise drug delivery to enhance immune *** nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within *** small size of these nanomaterials allows for precise targeting of T cells,dendritic cells,or cancer cells,thereby eliciting a more potent anti-tumor *** this paper,we focus on the classification of carriers for cancer nanovaccines,the roles of different target cells,and clinically tested cancer nanovaccines,discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation,while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.

关键词： Cancer nanovaccines Immunotherapy Nanobiotechnology Immune targets Signaling pathway

生物菌肥与化肥配施对水稻生长特性及产量的影响

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杂交水稻 2023年第4期38卷 134-139页

作者：屈成刘芬傅爱斌徐一兰方希林王悦湖南生物机电职业技术学院湖南长沙410127 怀化职业技术学院湖南怀化418000 湖南农业大学农学院湖南长沙410128

以籼型两系杂交水稻恒两优金龙丝苗为材料,研究了生物菌肥与化肥配合施用对水稻生长特性及产量的影响。结果表明,生物菌肥与化肥配合施用能提高水稻产量,与对照相比,其千粒重、理论产量和实际产量分别提高4.41%~9.41%、11.92%~21.41%和2... 详细信息

以籼型两系杂交水稻恒两优金龙丝苗为材料,研究了生物菌肥与化肥配合施用对水稻生长特性及产量的影响。结果表明,生物菌肥与化肥配合施用能提高水稻产量,与对照相比,其千粒重、理论产量和实际产量分别提高4.41%~9.41%、11.92%~21.41%和2.47%~13.46%;水稻叶片叶面积指数和SPAD值增加,生育期缩短,以T2处理(复合肥900kg/hm^(2)+生物菌肥9L/hm^(2))最佳;另外,生物菌肥可提高水稻叶片过氧化物歧化酶(SOD)、过氧化物酶(POD)和过氧化氢酶(CAT)的活性,从而提高水稻抗性。总之,生物菌肥与化肥配合施用能有效改善水稻的农艺性状,提高水稻抗性和产量,尤以T2施肥方式最佳。本试验研究结果可为水稻生产中科学配施生物菌肥提供理论参考。

关键词：生物菌肥水稻生长特性产量抗氧化酶

Isobaric enzymatic assays reveal depth-dependent variation in microbial ectoenzyme activities in the deepest ocean on Earth

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Science China Earth Sciences 2025年第1期68卷 185-194页

作者： Junwei CAO Jiahua WANG Hongge ZHANG Junhao DENG Binbin PAN Jiawang CHEN Li ZHANG Jiasong fang College of Oceanography and Ecological Science Shanghai Ocean University Ocean College Zhejiang University Laboratory for Marine Biology and Biotechnology Qingdao National Laboratory for Marine Science and Technology

Microbial ectoenzymes play essential roles in the transformation and mineralization of organic matter in the ***, conventional methods for measuring microbial ectoenzyme activities(MEAs) in the deep ocean under atmospheric conditions can misrepresent the metabolic activities of indigenous microbial communities. To overcome this limitation, we measured the activities of three microbial ectoenzymes(aminopeptidase, α-glucosidase, and β-glucosidase) under both atmospheric and in situ pressure conditions in seawater collected using pressure-retaining and non-pressure-retaining samplers in the Challenger Deep, Mariana Trench. In the case of aminopeptidase and α-glucosidase, the highest isobaric MEAs were observed in the surface layer(50 m), followed by those at abyssopelagic depths(4,000–6,000 m) for aminopeptidase, hadal realm(10,903 m)for α-glucosidase, while β-glucosidase activity exhibited the highest value at 10,903 m. Furthermore, the isobaric MEAs in hadal waters were commonly found to be higher than the decompressed counterparts, highlighting the importance of pressure-retaining sampling and isobaric enzymatic assays. The half-saturation constant(Km) showed a general decreasing trend with depth,suggesting that the deep ocean microbes might have adapted to the high-pressure and oligotrophic environment by increasing their ectoenzyme's affinity to substrate. Furthermore, particle-free MEAs contribute more to the total MEAs in the deep ocean than particle-associated MEAs, suggesting the significance of cell-associated and dissolved ectoenzymes in ocean *** study provides a foundation for future investigations of MEAs in the ocean and has important implications for understanding the dynamics of microbially mediated biogeochemical cycling in marine ecosystems.

关键词： Pressure-retaining sampling Microbial ectoenzyme activity Deep-sea microbes High pressure Mariana Trench

High Fe‑Loading Single‑Atom Catalyst Boosts ROS Production by Density Effect for Efficient Antibacterial Therapy

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Nano-Micro Letters 2025年第2期17卷 187-203页

作者： Si Chen fang Huang Lijie Mao Zhimin Zhang Han Lin Qixin Yan Xiangyu Lu Jianlin Shi Department of Cardiology Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200092People’s Republic of China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 200050People’s Republic of China Shanghai Frontiers Science Center of Nanocatalytic Medicine School of MedicineTongji UniversityShanghai 200092People’s Republic of China

The current single-atom catalysts(SACs)for medicine still suffer from the limited active site ***,we develop a synthetic method capable of increasing both the metal loading and mass-specific activity of SACs by exchanging zinc with *** constructed iron SACs(h^(3)-FNC)with a high metal loading of 6.27 wt%and an optimized adjacent Fe distance of~4 A exhibit excellent oxidase-like catalytic performance without significant activity decay after being stored for six months and promising antibacterial ***,a“density effect”has been found at a high-enough metal doping amount,at which individual active sites become close enough to interact with each other and alter the electronic structure,resulting in significantly boosted intrinsic activity of single-atomic iron sites in h^(3)-FNCs by 2.3 times compared to low-and medium-loading ***,the overall catalytic activity of h^(3)-FNC is highly improved,with mass activity and metal mass-specific activity that are,respectively,66 and 315 times higher than those of commercial Pt/*** addition,h^(3)-FNCs demonstrate efficiently enhanced capability in catalyzing oxygen reduction into superoxide anion(O_(2)·^(−))and glutathione(GSH)*** in vitro and in vivo assays demonstrate the superior antibacterial efficacy of h^(3)-FNCs in promoting wound *** work presents an intriguing activity-enhancement effect in catalysts and exhibits impressive therapeutic efficacy in combating bacterial infections.

关键词： Nanocatalytic medicine Single-atom catalysts Reactive oxygen species(ROS) High metal loading Oxidase catalysis

双季早稻养分积累分配特征及其与产量构成的相关性

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热带作物学报 2022年第7期43卷 1431-1439页

作者：李宇飞方希林刘玉喜刘鹏杨文菊王悦陈光辉湖南农业大学农学院湖南长沙410128

三熟制模式下南方双季稻茬口衔接季节紧张是协调双季稻周年增产中存在的主要问题。虽然前人在三熟制模式下水稻品种搭配以及肥料利用率方面做了大量研究,但是三熟制模式下南方双季早稻产量及其养分积累分配相关性的研究鲜有报道。为了... 详细信息

三熟制模式下南方双季稻茬口衔接季节紧张是协调双季稻周年增产中存在的主要问题。虽然前人在三熟制模式下水稻品种搭配以及肥料利用率方面做了大量研究,但是三熟制模式下南方双季早稻产量及其养分积累分配相关性的研究鲜有报道。为了比较南方双季早稻养分积累分配特征,本文以15个水稻早稻品种为研究对象,对不同水稻品种的秧苗素质、基本苗及分蘖动态、经济性状、营养元素积累及分配、产量及产量构成因素进行比较分析。结果表明,不同品种间秧苗素质存在显著差异,‘株两优819’的叶龄、苗高、百株鲜重等多项指标优于其他品种,秧苗素质表现佳。分蘖动态调查表明不同品种达到分蘖峰值的时间不同,其中以‘株两优929’的高峰苗最大,1 hm^(2)达616.65万茎蘖数,‘株两优929’与‘中早39’高峰苗差异最为显著,‘株两优929’较‘中早39’显著增加33.62%。氮、磷、钾总养分的积累方面,‘株两优929’和‘陵两优942’养分积累量显著高于其他品种,分别为311.88 kg/hm^(2)和376.35 kg/hm^(2)。‘陵两优942’的地上部干物质积累量最高,为12028.09 kg/hm^(2)。‘株两优929’的实际产量最高,为7873.01 kg/hm^(2)。成熟期水稻品种养分积累量与子粒产量的相关性分析表明,氮、磷积累与有效穗均呈显著正相关(r=0.62^(*),r=0.50^(*)),株高与千粒重之间呈极显著正相关(r=0.80^(**)),有效穗数与每穗粒数之间呈极显著负相关(r=-0.76^(**)),结实率与千粒重之间呈极显著负相关(r=-0.68^(**))。通过关联度分析表明,‘陵两优942’和‘株两优929’的综合表现明显优于其他品种。本研究对南方多熟制稻区早稻品种筛选及高效栽培具有重要意义。

关键词：三熟制早稻养分积累产量构成

湖北省鹤峰县走马地区南华系“大塘坡式”锰矿的发现及其地质意义初探

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资源环境与工程 2018年第3期32卷 345-350页

作者：陈林王红军方喜林曹文胜湖北省地质局第二地质大队湖北恩施445000 河南省地质矿产勘查开发局第一地质矿产调查院河南洛阳471023

在鹤峰县走马地区南华系大塘坡组黑色含碳质泥(页)岩中发现了"大塘坡式"锰矿。地表和钻孔揭示含锰岩系厚度在0.3~4 m,矿(化)体中Mn品位在2%~29.71%。目前已知该类型锰矿在黔湘渝地区和宜昌长阳地区均有发现,锰矿体均赋存于大塘坡组地层... 详细信息

在鹤峰县走马地区南华系大塘坡组黑色含碳质泥(页)岩中发现了"大塘坡式"锰矿。地表和钻孔揭示含锰岩系厚度在0.3~4 m,矿(化)体中Mn品位在2%~29.71%。目前已知该类型锰矿在黔湘渝地区和宜昌长阳地区均有发现,锰矿体均赋存于大塘坡组地层中。走马地区"大塘坡式"锰矿的发现,揭示了南华系大塘坡组地层在黔湘渝鄂地区沉积较为连续,锰矿成矿范围较广,层控性明显,厚度变化不一,局部出现间断;走马地区大塘坡组地层中火山凝灰岩的发现,说明在沉积过程中,海底火山活动可能作为其中一种锰质来源且参与了成矿作用;根据目前邻区及周边该类型锰矿的成矿规模和潜力推断,走马地区锰矿的发现具有重要的指示意义。今后锰矿勘查的主要方向是寻找控制锰矿形成和赋存的南华纪早期同沉积断层及其控制的断陷盆地的位置,在此基础上通过深部工程控制,寻找成锰盆地有利区,进而圈定锰矿找矿靶区。

关键词： “大塘坡式”锰矿南华纪同沉积断层断陷盆地王家界锰矿

外源多效唑、ABA、2,4-D和NAA对水稻秧苗生长特性的影响

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分子植物育种 2020年第8期18卷 2687-2694页

作者：杜逸凡方希林曾红丽于玉凤张露倩王悦湖南农业大学农学院长沙410128 湖南农业大学水稻油菜抗病育种湖南省重点实验室长沙410128

为了探讨不同植物生长调节剂对水稻幼苗生长特性的影响,筛选适宜水稻机插的植物生长调节剂类型及其浓度,本研究以‘株两优189’和‘中嘉早17’为试验材料,研究外源多效唑、ABA、2,4-D和NAA对水稻幼苗叶龄、绿叶数、苗高、白根数、总根... 详细信息

为了探讨不同植物生长调节剂对水稻幼苗生长特性的影响,筛选适宜水稻机插的植物生长调节剂类型及其浓度,本研究以‘株两优189’和‘中嘉早17’为试验材料,研究外源多效唑、ABA、2,4-D和NAA对水稻幼苗叶龄、绿叶数、苗高、白根数、总根数、茎基宽、秧苗鲜重及干重等的影响。试验结果表明:多效唑对水稻秧苗苗高抑制作用最为显著,ABA、2,4-D次之;NAA在一定程度上能够提高秧苗苗高;四种植物生长调节剂均能有效提高水稻秧苗的白根数,其中以ABA处理提高作用最显著,并且四种植物生长调节剂对茎基宽均表现为促进作用,呈现随浓度增加,秧苗茎基宽增加的趋势。综上来看,C2浓度多效唑浸种和C4浓度ABA浸种均能有效培育矮壮秧苗。本研究为培育适宜机械化生产的水稻育秧技术提供了理论指导。

关键词：水稻机插秧植物生长调节剂秧苗素质

鹤峰县大典河滑石矿床地质特征及区域找矿潜力分析

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资源环境与工程 2019年第4期33卷 464-468页

作者：黄强方喜林孔繁河李哲武湖北省地质局第二地质大队

鹤峰县大典河滑石矿床位于走马-东山峰背斜南西段之南东翼,其赋矿层位为上震旦统-下寒武统灯影组二段。矿体空间形态呈似层状、透镜状大致与围岩整合产出,形态简单,边界规则。通过初步分析,矿床成因与地层、构造及动力变质作用有关,属... 详细信息

鹤峰县大典河滑石矿床位于走马-东山峰背斜南西段之南东翼,其赋矿层位为上震旦统-下寒武统灯影组二段。矿体空间形态呈似层状、透镜状大致与围岩整合产出,形态简单,边界规则。通过初步分析,矿床成因与地层、构造及动力变质作用有关,属于沉积-变质型矿床。本区与湖南省石门县清官渡滑石矿区相邻,均位于走马-东山峰背斜南东翼,两者赋矿层位相同,矿石质量特征也基本相似。在大典河-清官渡一带,灯影组地层分布广泛,走向断层发育,成矿地质条件优越,故沿赋矿层位寻找滑石矿潜力巨大,是今后找矿和勘查的工作重点。

关键词：滑石矿地质特征找矿潜力大典河