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Study on Mechanism of Bushen Yugong Granule(补肾育宫冲剂) in Treating Uterine Dysgenesia

Chinese Journal of Integrative Medicine 2000年第2期6卷 96-100页

作者： Zuqi Qian Huijuan Lu Ping Wu xilian liu Leina Xin Haili Dai Kejing Zhang Rongfa Lu Maternity and Child Care Centre of Nanshi District Shanghai Obstetrics and Gynaecology Hospital Shanghai Medical University China Shanghai Institute of Materia Medica Chinese Academy of Sciences China

Objective: To explore the therapeutic mechanism of Bushen Yugong Granule (BSYGG, a Chinese medicinal preparation) in treating infertility due to uterine dysgenesia. Methods: (1) Clinical study: Serum level of sex hormone and endometrial contents of estradial receptor (ER) and progesterone receptor (PR) in follicle period of 60 patients (the tested group) were measured and compared before and after treatment, and also compared with those of 70 normal women (the control group). (2) Experimental study: Rats were divided into the control group and 3 tested groups fed with different doses of BSYGG. Pathologic examination of pituitary, ovary and uterus of rats after BSYGG treatment were performed,and serum levels of ER, PR measu red. Also, an estrogen activity experiment was conducted in some young oophorectomized rats. Results: (1) Clinical study showed the difference of serum sex hormone levels between the tested and control group was insignificant. The percentage of patients in the tested groups with endometrial ER content over  was lower than that in the control group (46.9% vs 72.4%) significantly (P<0.05), after treatment, it rose to 65.4%,a nd the change was significant, P<0.05. (2) Experimental study showed that the number of follicle, weight of uterus and serum E2 level increased significantly after BSYGG treatment. The endometrial content of ER in the control group was 29.25±17.03%, while in the tested groups, it was 67.75±24.56% to 83.00±9.87% after treatment, the difference between the two groups was significant (P<0.005). Conclusion: BSYGG has an estrogen-like activity, it could increase the endometrial content of ER, enhance the effect of estrogen on uterus and promote the development of uterus, so as to elevate fertilization rate.

关键词： Bushen Yugong Granule uterine dysgenesia infertility sex hormone receptor

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Robust and tunable Weyl phases by coherent infrared phonons in ZrTe_(5)

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npj Computational Materials 2022年第1期8卷 1063-1071页

作者： Niraj Aryal xilian Jin Qiang Li Mengkun liu A.M.Tsvelik Weiguo Yin Condensed Matter Physics and Materials Science Division Brookhaven National LaboratoryUptonNY11973USA State Key Laboratory of Superhard Materials College of PhysicsJilin UniversityChangchun130012China Department of Physics and Astronomy Stony Brook UniversityStony BrookNY11794USA

Ultrafast control of structural and electronic properties of various quantum materials has recently sparked great *** particular,photoinduced switching between distinct topological phases has been considered a promising route to realize quantum *** we use first-principles and effective Hamiltonian methods to show that in ZrTe_(5),lattice distortions corresponding to all three types of zone-center infrared optical phonon modes can drive the system from a topological insulator to a Weyl *** achieved Weyl phases are robust,highly tunable,and one of the cleanest due to the proximity of the Weyl points to the Fermi level and a lack of other *** also find that Berry curvature dipole moment,induced by the dynamical inversion symmetry breaking,gives rise to various nonlinear effects that oscillate with the amplitude of the phonon *** nonlinear effects present an ultrafast switch for controlling the Weyltronics-enabled quantum system.

关键词： quantum topological phonon

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凯博-75 钢框胶合板模板体系

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施工技术 1999年第3期28卷 48-48页

作者：袁必勤金治勇刘锡莲中国建筑科学研究院建筑机械化分院

ＣＡＢＲ－７５Ｓｔｅｅｌ－ｆｒａｍｅｄ－ｐｌｙｗｏｏｄ－ｆｏｒｍｗｏｒｋＳｙｓｔｅｍＹｕａｎＢｉｑｉｎＪｉｎＺｈｉｙｏｎｇＬｉｕＸｉｌｉａｎ表１平面模板规格ｍｍ项目高度宽度长度尺寸７５２００２５０３００４５０６００９... 详细信息

ＣＡＢＲ－７５Ｓｔｅｅｌ－ｆｒａｍｅｄ－ｐｌｙｗｏｏｄ－ｆｏｒｍｗｏｒｋＳｙｓｔｅｍＹｕａｎＢｉｑｉｎＪｉｎＺｈｉｙｏｎｇＬｉｕＸｉｌｉａｎ表１平面模板规格ｍｍ项目高度宽度长度尺寸７５２００２５０３００４５０６００９００１２００１５００１８００２４０...

关键词：钢框胶合板模板平面模板连接角模支撑配件

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Research on colored lyotropic liquid crystals

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Chinese Science Bulletin 2005年第15期50卷 1586-1591页

作者： WEI xilian YIN Baolin SUN Dezhi liu Jie WANG Zhongni LI Ganzuo Department of Chemistry Liaocheng University Liaocheng 252059China Key Laboratory of Colloid and Interface Chemistry Ministry of Education Shandong University Jinan 250100 China

Splendidly colored lyotropic liquid crystals formed in the ternary system of a novel cationic surfactant, 3-p-nonylphenoxy-2-hydroxypropyl trimethyl ammonium bromide (NPTAB)-n-butanol-water system, had been ob-served under polarized light microscope. Small-angle X-ray scattering (SAXS), 2H (deuterium) quadrupolar splitting (2H NMR) were employed to confirm the structures of these liq-uid crystals. The structural transformation of these special lyotropic liquid crystals had been confirmed by differential scanning calorimetry (DSC). The influences of liquid crystal film thickness, temperature and conserving time on the color of liquid crystals have been investigated. It is also theoreti-cally discussed for forming and changing of liquid crystal color.

关键词：有色液态晶体三甲基色氨酸溴化物丁醇

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BP小波神经网络自适应调节步长的改进算法

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济南大学学报（自然科学版） 2001年第4期15卷 315-318页

作者：何苗刘希莲李金屏杨波济南大学信息科学与工程学院山东济南250022 潍坊医学院附属医院山东潍坊261031

在BP小波神经网络的训练过程中 ,自适应调节步长是对算法效率起重要作用的步骤之一。深入讨论了自适应调节步长的改进算法 ,从而得到更加方便合理的实时步长调整方法 ,进一步提高了局部搜索速度。多种情况下的仿真结果表明 ,该算法能够... 详细信息

在BP小波神经网络的训练过程中 ,自适应调节步长是对算法效率起重要作用的步骤之一。深入讨论了自适应调节步长的改进算法 ,从而得到更加方便合理的实时步长调整方法 ,进一步提高了局部搜索速度。多种情况下的仿真结果表明 ,该算法能够提高局部搜索速度 ,具有较广泛的应用价值。

关键词： BP小波神经网络自适应调节步长改进算法梯度下降法

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Clinical practices s of Traditional Chinese Medicine for acute upper respiratory tract infection in children

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Journal of Traditional Chinese Medicine 2018年第4期38卷 504-510页

作者： Rong Ping Li Li Zhang xilian liu Quanhui Yan Huimin Xin Deli Xue Zheng Ren Xianqing Wu Zhenqi Ma Rong Zhang Junhua Department of Pediatrics First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Traditional Chinese Medicine Prevention and Treatment of Infectious Disease Research Office Institute of Basic Research in Clinical MedicineChina Academy of Chinese Medical Sciences Department of Traditional Chinese Medicine Beijing Children's HospitalCapital Medical University Department of Pediatrics Beijing Friendship HospitalCapital Medical University Department of Pediatrics Shanghai Municipal Hospital of Traditional Chinese Medicine Department of Pediatrics The First Affiliated Hospital of Henan University of Traditional Chinese Medicine Department of Pediatrics The First Clinical CollegeLiaoning Hospital of Traditional Chinese Medicine Department of Internal Medicine Tianjin University of Traditional Chinese Medicine

OBJECTIVE:To develop Clinical practice s of Traditional Chinese Medicine(TCM) for acute upper respiratory tract infection(AURI) in children;TCM is usedalone or administered together with ***:Under the guidance of evidence-based medicine concept,in strict accordance with the rules of international s development,as well as on the basis of evidence of clinical research of TCM,the s solicited opinions from clinical experts and methodologists in TCM and Western *** standard was applied to form experts' ***:The s standardized classification of TCM patterns and TCM treatments in children with AURI,including prescription,Chinese patent medicine,non-drug treatment and ***:Follows the principle of "evidence based,consensus supplemented,and experience referred",these s were formulated,but the quality of evidence of included studies were relatively *** refinement of the s should be needed as deeper clinical studies as available in future.

关键词： Traditional Chinese Medicine Children Upper respiratory tract infection Clinical practice s

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First Assessment of the Thermodynamic Properties for an Aqueous Two-Phase Systems bath on Ionic Liquid

First Assessment of the Thermodynamic Properties for an Aque...

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中国化学会第十九届全国化学热力学和热分析学术会议

作者： Qi liu Suxu Wang Xiaoxiao Chen Yan Guo Jie liu xilian Wei Liaocheng University

Aqueous two-phase system(ATPS) have been widely used as an extremely promising primary separation unit operation in the downstream biological engineering .A conventional ATPS is composed of two structurally different polymers or one salt and a hydrophilic *** recent years,many new ATPS based on surfactants or ionic solution have been *** new ATPS have been successfully applied in the extraction of biological analysis and have opened a new vista for purification and isolation of *** a later study,a new kind of ATPS’s formed by different ILs and anionic or cationic surfactants in aqueous media were reported by our research *** can be used to separate and purify different biomaterials and to retain the activity of the separated materials as much as *** this basis,we choose a ternary system composed of an ionic liquid [Bmim]BF,Sodium Alkylbenzene Sulfonate(SDBS) and *** phase diagram was drawn based on experimental data at 298.15 *** got a narrow aqueous two-phase region near the side of water-ionic liquid.A series of samples with different compositions around the phase diagram were *** enthalpy change of these systems after injecting triply distilled water into these samples has been studied by using isothermal titration microcalorimetry(ITC).It is found that with increasing the water content there are weak endothermic and exothermic processes appearing,separately,which matches perfectly with the location of the formation and disappearance of the aqueous two-phase in the ternary phase *** suggests the ITC is a feasible and effective method for the thermodynamic study of aqueous two-phase systems(ATPS) and was first *** experimental results show that the formation of the aqueous two-phase system is endothermic(ΔH>0),but the process of disappearing is exothermic(ΔH<0).Due to the formation of aqueous two-phase is a thermodynamic spontaneous process under the isothermal constant pressure,we can

关键词： Ternary phase diagram Aqueous two-phase system Sodium dodecylbenzene Sulfonate Isothermal titration microcalorimetry

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Viscoelastic Properties and Molecular Dynamics Simulation of Cationic Surfactant/Aromatic Salt Mixed Solutions

Viscoelastic Properties and Molecular Dynamics Simulation of...

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中国化学会第十九届全国化学热力学和热分析学术会议

作者： Yao Chunhong liu Qi Wang Suxu Jia Lihan Lv Dongmei Wei xilian College of Chemistry and Chemical Engineering Liaocheng University

Surfactant molecules tend to form various self-aggregates in aqueous media,such as spherical or wormlike micelles,vesicle and liquid crystal(lamellar,hexagonal and cubic structure).Among these various microstructures,wormlike micelles have attracted much interest in fundamental research and practical applications over the past several decades due to their peculiar micellar structure and fascinatingly rich nonlinear rheological *** understand how wormlike micellar structure is related to the chemical composition of the surfactant solutions,and in turn,how the structural characters of the aggregates can be adjusted by specific control parameters,and how these direct the bulk properties,offers a considerable research ***,we choose a cationic surfactant 3-hexadecyloxy-2-hydroxy-propyl trimethyl ammonium bromide(RHTAB) and is mixed with different aromatic co-solutes(sodium salicylate,sodium 1-hydroxynaphthalene-2-carboxylate and sodium 2-hydroxynaphthalene-3-carboxylate) as additives to construct a series of wormlike micellar *** effects of three aromatic salts on the morphological transformation of RHTAB micelles in solution were investigated by means of rheology,(Cryo-TEM,1 H NMR and molecular dynamics simulation MDS).According to the molecular structure of added salts,the influence of hydroxyl substituent position on formation and growth of wormlike micelles was discussed by the rheological parameters and the calculated results,and the change in micellar structure resulting from increasing additive concentrations was observed using *** weak interaction between counterions and surfactant molecules was analyzed by using steady state and dynamic rheological curve,1 H NMR spectrogram and a RDG *** main objectives of this study were to understand the differences in the self-assembly RHTAB into wormlike micelles in the presence of different salts,and to examine how the properties and molecular structure of the added salts,in partic

关键词： Cationic surfactant dynamics simulation Rheology properties

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马融运用五脏辨证体系论治小儿抽动障碍经验

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中医杂志 2020年第8期61卷 672-675页

作者：刘璇张喜莲马融(指导) 天津中医药大学第一附属医院天津市300193

总结马融教授运用五脏辨证体系论治小儿抽动障碍的临证经验。小儿抽动障碍病位在肝,与脾、肺、心、肾密切相关。通过分析不同患儿的临床主症、兼证及体质特点,确定五脏致病的主次,判断病性虚实,从而提炼出核心病机--肝气郁滞、脾虚生痰... 详细信息

总结马融教授运用五脏辨证体系论治小儿抽动障碍的临证经验。小儿抽动障碍病位在肝,与脾、肺、心、肾密切相关。通过分析不同患儿的临床主症、兼证及体质特点,确定五脏致病的主次,判断病性虚实,从而提炼出核心病机--肝气郁滞、脾虚生痰、感受外风、心血不足、肾精亏虚,均可导致气机逆乱,引动肝风。并在此基础上选方用药,采用柴胡桂枝龙骨牡蛎汤从肝论治,涤痰汤从脾论治,银翘散从肺论治,酸枣仁汤从心论治,六味地黄丸从肾论治。

关键词：小儿抽动障碍五脏辨证名医经验马融

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马融治疗小儿难治性哮喘经验

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中医杂志 2020年第21期61卷 1871-1875页

作者：刘璇张喜莲宋娜马融(指导) 天津中医药大学第一附属医院天津市南开区300193

总结马融教授治疗小儿难治性哮喘的临证经验。认为小儿难治性哮喘发作期和缓解期不应按照是否有喘息发作而截然分开,缓解期患儿即使无明显喘息症状,但如肺功能异常也可以按照发作期辨治。小儿难治性哮喘病程日久,也有实邪因素存在,所以... 详细信息

总结马融教授治疗小儿难治性哮喘的临证经验。认为小儿难治性哮喘发作期和缓解期不应按照是否有喘息发作而截然分开,缓解期患儿即使无明显喘息症状,但如肺功能异常也可以按照发作期辨治。小儿难治性哮喘病程日久,也有实邪因素存在,所以治疗时要标本同治。根据患儿的临床症状,提出了病程中的"气闭""痰阻""血瘀""肺痉""肾虚"五大病理因素,并分别采用麻黄、炒苦杏仁、蜜桑白皮、煅赭石、白果等宣肃开闭;瓜蒌、清半夏、细辛等涤痰逐饮;郁金、当归、红花等活血化瘀;地龙、炒僵蚕、钩藤等祛风解痉;熟地黄、阿胶、肉桂等补肾固本。

关键词：小儿难治性哮喘名医经验马融

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