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RIPK3 promotes hantaviral replication by restricting JAK-STAT signaling without triggering necroptosis

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Virologica Sinica 2023年第5期38卷 741-754页

作者： Yue Si Haijun zhang Ziqing Zhou Xudong Zhu Yongheng Yang He Liu Liang zhang Linfeng Cheng Kerong Wang Wei Ye Xin Lv xijing zhang Wugang Hou Gang Zhao Yingfeng Lei Fanglin zhang Hongwei Ma Department of Microbiology School of Basic MedicineAir Force Medical UniversityXi'an710032China Department of Neurology Xijing HospitalAir Force Medical UniversityXi'an710032China Center of Clinical Aerospace Medicine School of Aerospace MedicineKey Laboratory of Aerospace Medicine of Ministry of EducationAir Force Medical UniversityXi'an710032China Department of Anesthesiology&Critical Care Medicine Xijing HospitalAir Force Medical UniversityXi'an710032China The College of Life Sciences and Medicine Northwest UniversityXi'an710069China

Hantaan virus(HTNV)is a rodent-borne virus that causes hemorrhagic fever with renal syndrome(HFRS),resulting in a high mortality rate of 15%.Interferons(IFNs)play a critical role in the anti-hantaviral immune response,and IFN pretreatment efficiently restricts HTNV infection by triggering the expression of a series of IFNstimulated genes(ISGs)through the Janus kinase-signal transducer and activator of transcription 1(JAK-STAT)***,the tremendous amount of IFNs produced during late infection could not restrain HTNV replication,and the mechanism remains ***,we demonstrated that receptor-interacting protein kinase 3(RIPK3),a crucial molecule that mediates necroptosis,was activated by HTNV and contributed to hantavirus evasion of IFN responses by inhibiting STAT1 ***-seq analysis revealed the upregulation of multiple cell death-related genes after HTNV infection,with RIPK3 identified as a key modulator of viral ***3 ablation significantly enhanced ISGs expression and restrained HTNV replication,without affecting the expression of pattern recognition receptors(PRRs)or the production of type I ***,exogenously expressed RIPK3 compromised the host's antiviral response and facilitated HTNV ***3^(-/-)mice also maintained a robust ability to clear HTNV with enhanced innate immune ***,we found that RIPK3 could bind STAT1 and inhibit STAT1 phosphorylation dependent on the protein kinase domain(PKD)of RIPK3 but not its kinase ***,these observations demonstrated a noncanonical function of RIPK3 during viral infection and have elucidated a novel host innate immunity evasion strategy utilized by HTNV.

关键词： Hantaan virus(HTNV) RIPK3 Interferons IFN-stimulated genes STAT1 Innate immune response

STING strengthens host anti-hantaviral immunity through an interferon-independent pathway

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Virologica Sinica 2023年第4期38卷 568-584页

作者： Kerong Wang Jian zhang Yongheng Yang Yue Si Ziqing Zhou Xudong Zhu Sushan Wu He Liu Hui zhang Liang zhang Linfeng Cheng Wei Ye Xin Lv Yingfeng Lei xijing zhang Shilin Cheng Lixin Shen Fanglin zhang Hongwei Ma College of Life Sciences Northwest UniversityXi'an 710069China Department of Microbiology School of Basic MedicineFourth Military Medical UniversityXi'an 710032China College of Medicine Yan'an UniversityYan'an 716000China Department of Anesthesiology&Critical Care Medicine Xijing HospitalFourth Military Medical UniversityXi'an710032China Medical Genetics and Developmental Biology School of Basic MedicineFourth Military Medical UniversityXi'an 710032China

Hantaan virus(HTNV),the prototype virus of hantavirus,could escape innate immunity by restraining type I interferon(IFN)*** is largely unknown whether there existed other efficient anti-hantaviral tactics in host ***,we demonstrate that the stimulator of interferon genes(STING)strengthens the host IFNindependent anti-hantaviral *** infection activates RIG-I through IRE1-XBP 1-mediated ER stress,which further facilitates the subcellular translocation and activation of *** this process,STING triggers cellular autophagy by interacting with Rab7A,thus restricting viral *** note,the anti-hantaviral effects of STING are independent of canonical IFN ***,neither application of the pharmacological antagonist nor the agonist targeting STING could improve the outcomes of nude mice post HTNV challenge in ***,the administration of plasmids exogenously expressing the mutant C-terminal tail(ΔCTT)STING,which would not trigger the type I IFN responses,protected the nude mice from lethal HTNV *** summary,our research revealed a novel antiviral pathway through the RIG-I-STING-autophagy pathway,which offered novel therapeutic strategies against hantavirus infection.

关键词： Hantaan virus(HTNV) IRE1 RIG-I STING Autophagy Innate immunity

Cannabinoid 1 receptor mediates spinal cord ischemic tolerance induced by limb remote ischemia preconditioning in rats

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Cannabinoid 1 receptor mediates spinal cord ischemic toleran...

2009国际麻醉学基础与临床研究论坛

作者： Bingxiao Su Hailong Dong Rui Ma xijing zhang Qian Ding Lize Xiong Department of Anesthesiology Xijing HospitalFourth Military Medical University

＜正＞Objective:The aim of this study is to examine the contribution of endogenous cannabinoids to neuroprotection on spinal cord afforded by limb remote ischemic preconditioning（RIPC）

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镀锌薄板中氧氮含量分析探讨

冶金标准化与质量 2018年第6期56卷 44-48页

作者：张希静首钢股份公司迁安钢铁公司河北迁安064404

对测定镀锌板中氧、氮含量过程中可能存在的干扰因素进行分析,通过对锌层的去除、砂带材质的选择、清洗液和清洗时间的选择、样品的制备等进行研究确保了样品制样过程中不被氧化及保证试样不受污染;通过对石墨坩埚的选择、试剂有效性的... 详细信息

对测定镀锌板中氧、氮含量过程中可能存在的干扰因素进行分析,通过对锌层的去除、砂带材质的选择、清洗液和清洗时间的选择、样品的制备等进行研究确保了样品制样过程中不被氧化及保证试样不受污染;通过对石墨坩埚的选择、试剂有效性的检查、设置合适的分析时间参数、称样量和功率的选择、空白值的控制等进行研究确保了各个分析环节均得到了较好的控制。通过对上述因素进行控制最终得到了较低的检出限和测定下限,保证了镀锌薄板中氧、氮含量分析结果的准确度和精密度。

关键词：镀锌薄板氧氮分析

Influence of early postoperative complication on the operative results in elderly intertrochanteric fractured patients

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Journal of Nanjing Medical University 2007年第5期21卷 341-344页

作者： Chun zhang xijing He Binshang Lan Haopeng Li Department of Orthopedics the Second Affiliated Hospital of Xi＇ an Jiao Tong University Xi＇ an 710004 Shanxi china

Objective： Early complications were analyzed in those with Evans Ⅲ type of intertrochanteric fracture treated with operation or nonoperative approaches. Methods：59 cases with Evans Ⅲ type of intertrochanteric fracture between June, 1999 to July, 2006 were admitted in our department. 38 patients were complicated with cardiovascular diseases, such as hypertension and arrhythmia. All the cases were operated. Results：58 cases were operated successfully. One died of pulmonary interstitial fibrosis. Grade data of different age brackets indicated that early infective complications had apparent differences between the operation and the control group. Compared with the control group, the operation group had benefits such as fewer complications, especially the infective complications, and incidence of lower extremities venous thrombosis, and the results showed notable differences. Conclusion：In elderly patients with Evans Ⅲ type of intertrochanteric fracture, the incidence of pulmonary infection was the highest. Venous thrombosis in lower extremities was the most serious complication. So it will be helpful to perform the quadriceps femories function exercise. The postoperative effect is also related with the operation approach.

关键词： elderly intertrochanteric fracture complications

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建构反腐败体系重惩更要重“教”

湛江师范学院学报 2010年第1期31卷 127-130页

作者：张西京湛江师范学院法政学院广东湛江524048

建构反腐败制度体系重惩更要重教,因为教育是有效预防腐败的出发点和落脚点。事实上,现行的惩防因素也主张教育的基础地位;西方国家的惩防经验也凸显着教育的基础地位;随着经济社会的发展必然强化教育的基础地位。防治腐败要坚持治标和... 详细信息

建构反腐败制度体系重惩更要重教,因为教育是有效预防腐败的出发点和落脚点。事实上,现行的惩防因素也主张教育的基础地位;西方国家的惩防经验也凸显着教育的基础地位;随着经济社会的发展必然强化教育的基础地位。防治腐败要坚持治标和治本、惩治和预防两手抓、两手都要硬。

关键词：防治腐败重教治标治本

重型和危重型新型冠状病毒肺炎诊断和治疗专家共识(修订版)

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中华危重病急救医学 2020年第3期32卷 269-274页

作者：无孙同文张西京余追尚游中国研究型医院学会危重医学专业委员会中国研究型医院学会危重医学专委会青年委员会不详

新型冠状病毒肺炎(新冠肺炎)疫情形势严峻,尚无特效治疗药物。为了降低重型和危重型新冠肺炎患者的病死率,组织全国一线相关领域专家对武汉等重灾区重症患者的诊断及治疗措施进行分析、探讨、总结,制定相应专家共识,于2020年2月22日发... 详细信息

新型冠状病毒肺炎(新冠肺炎)疫情形势严峻,尚无特效治疗药物。为了降低重型和危重型新冠肺炎患者的病死率,组织全国一线相关领域专家对武汉等重灾区重症患者的诊断及治疗措施进行分析、探讨、总结,制定相应专家共识,于2020年2月22日发布了第一版,2020年3月4日为修订版。

关键词：新型冠状病毒肺炎专家共识

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浅谈煤工业分析注意事项

冶金标准化与质量 2022年第2期60卷 34-36,51页

作者：张希静陈宇首钢股份公司迁安钢铁公司河北迁安064404

工业分析可以确定煤的组成,在限定的实验条件下,可将煤的工业组成分为水分、灰分、挥发分和固定碳四种,组分的测定数据对于研究煤的性质和合理用途起到了非常重要的作用。参照国标方法,进行工业分析测试的过程,由于不同检测人员对于检... 详细信息

工业分析可以确定煤的组成,在限定的实验条件下,可将煤的工业组成分为水分、灰分、挥发分和固定碳四种,组分的测定数据对于研究煤的性质和合理用途起到了非常重要的作用。参照国标方法,进行工业分析测试的过程,由于不同检测人员对于检测细节操控的差异,实验得到的数据有时差异比较大。针对这种情况,本文通过实践经验总结出煤工业分析的影响因素并提出相应的应对措施。

关键词：煤工业分析影响因素措施

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新型冠状病毒肺炎合并症处置专家建议

中国中西医结合急救杂志 2020年第1期27卷 1-5页

作者：无宋立强张西京张侃空军军医大学西京医院赴武汉重症医疗队不详

新型冠状病毒肺炎(简称新冠肺炎)的合并症涉及全身多个系统,是导致患者病情恶化的重要病因,主要包括急性心肌损伤、急性胃肠炎和急性肝损伤、急性脑炎、淋巴细胞减少和弥散性血管内凝血(DIC)、急性肾损伤、孕妇感染、横纹肌溶解症、营... 详细信息

新型冠状病毒肺炎(简称新冠肺炎)的合并症涉及全身多个系统,是导致患者病情恶化的重要病因,主要包括急性心肌损伤、急性胃肠炎和急性肝损伤、急性脑炎、淋巴细胞减少和弥散性血管内凝血(DIC)、急性肾损伤、孕妇感染、横纹肌溶解症、营养不良、发热、心理异常及呼吸功能受损等.及时准确地诊断和治疗这些合并症是重症患者救治成功的重要环节.本建议分别描述合并症的发病现状,并推荐诊治原则、主要监测指标及主要处置方案.本建议是工作在武汉抗疫一线的空军军医大学西京医院重症医疗队基于临床救治经验及文献编写的,对于提高新冠肺炎救治成功率的全身管理方案制定具有参考意义.

关键词：新型冠状病毒肺炎合并症诊断治疗