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健肝消脂方医院制剂质量标准初步研究

云南中医中药杂志 2020年第9期41卷 73-78页

作者：房昉温伟波杨龄谢雪华陶丽玲云南中医药大学第一附属医院云南昆明650021 云南中医药大学云南昆明650500

目的初步建立健肝消脂方医院制剂的质量标准。方法采用薄层色谱法分别定性鉴别该医院制剂中的三七、赤芍、青皮、黄芪,采用高效液相色谱法定量测定该医院制剂中丹酚酸B的含量。结果在选定的薄层色谱条件下,供试品色谱与对照品色谱相应... 详细信息

目的初步建立健肝消脂方医院制剂的质量标准。方法采用薄层色谱法分别定性鉴别该医院制剂中的三七、赤芍、青皮、黄芪,采用高效液相色谱法定量测定该医院制剂中丹酚酸B的含量。结果在选定的薄层色谱条件下,供试品色谱与对照品色谱相应位置上显相同颜色的斑点,分离效果较好,专属性强。高效液相色谱法测定丹酚酸B的线性范围在0.101μg^2.525μg之间,线性关系良好(r 2=1)。平均回收率为101.7%,相对标准偏差值为0.98%。结论该方法简便可行、专属性强、重现性好,可作为初步质量标准用于控制该制剂的质量。

关键词：健肝消脂方薄层色谱法高效液相色谱法质量标准

激光诱导荧光技术与地下水重金属原位检测应用进展

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岩矿测试 2025年第1期44卷 19-34页

作者：毛康薛家奇陈卓张华中国科学院地球化学研究所环境地球化学国家重点实验室贵州贵阳550081

对地下水重金属污染进行现场检测,是快速识别重金属种类和评价污染程度的重要手段。激光诱导荧光技术(LIF)利用特定荧光探针,在目标重金属存在下,通过激光诱导荧光探针产生/猝灭荧光,从而完成对重金属的识别和检测,具有快速甄别地下水... 详细信息

对地下水重金属污染进行现场检测,是快速识别重金属种类和评价污染程度的重要手段。激光诱导荧光技术(LIF)利用特定荧光探针,在目标重金属存在下,通过激光诱导荧光探针产生/猝灭荧光,从而完成对重金属的识别和检测,具有快速甄别地下水重金属污染特性和无损获取其价态的优势。本文在简述LIF检测重金属原理和LIF原位检测地下水重金属装备基础上,重点从荧光探针合成及其在重金属传感检测方法的构建上总结了基于不同荧光探针的LIF现场检测重金属的研究进展。目前可用于重金属检测的荧光探针包括以小分子探针、有机大分子和聚集诱导发光为主的有机荧光探针和以金纳米簇、量子点和金属有机框架材料为代表的纳米荧光探针。这些探针的合成及其对应的传感检测方法的构建表明LIF技术在地下水重金属检测中具有巨大优势。而针对地下水重金属检测的LIF设备研发方面的成果虽不如荧光传感检测方法丰富,但已研制出部分重金属的传感器和检测装备,表现出良好的应用前景。未来研究将会聚焦在地下水重金属主控因子识别和抗干扰技术研发、荧光探针合成与LIF检测方法构建、重金属传感部件和检测装备集成研制,以及检测技术标准化,为后续场地地下水典型重金属LIF检测技术的研究提供参考。

关键词：地下水重金属激光诱导荧光荧光探针现场检测

Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3287-3301页

作者： Ziwei Fan Mengxian Jia Jian Zhou Zhoule Zhu Yumin Wu Xiaowu Lin Yiming Qian Jiashu Lian Xin hua Jianhong Dong Zheyu Fang Yuqing Liu Sibing Chen Xiumin xue Juanqing Yue Minyu Zhu Ying Wang Zhihui huang Honglin Teng Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Neurology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina

The M1/M2 phenotypic shift of microglia after spinal cord injury plays an important role in the regulation of neuroinflammation during the secondary injury phase of spinal cord *** of shifting microglia polarization from M1(neurotoxic and proinflammatory type)to M2(neuroprotective and anti-inflammatory type)after spinal cord injury appears to be *** possesses an anti-inflammatory biological ***,its roles and the underlying molecular mechanisms in spinal cord injury remain *** this study,we found that tryptanthrin inhibited microglia-derived inflammation by promoting polarization to the M2 phenotype in *** promoted M2 polarization through inactivating the cGAS/STING/NF-κB ***,we found that targeting the cGAS/STING/NF-κB pathway with tryptanthrin shifted microglia from the M1 to M2 phenotype after spinal cord injury,inhibited neuronal loss,and promoted tissue repair and functional recovery in a mouse model of spinal cord ***,using a conditional co-culture system,we found that microglia treated with tryptanthrin suppressed endoplasmic reticulum stress-related neuronal *** together,these results suggest that by targeting the cGAS/STING/NF-κB axis,tryptanthrin attenuates microglia-derived neuroinflammation and promotes functional recovery after spinal cord injury through shifting microglia polarization to the M2 phenotype.

关键词： cGAS/STING functional recovery microglia neuroinflammation neuroprotection nuclear factor-κB polarization spinal cord injury tryptanthrin

Passivation and dissociation of P_(b)-type defects at a-SiO_(2)/Si interface

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Chinese Physics B 2021年第9期30卷 49-55页

作者： xue-hua Liu Wei-Feng xie Yang Liu Xu Zuo College of Electronic Information and Optical Engineering Nankai UniversityTianjin 300350China Microsystem and Terahertz Research Center China Academy of Engineering PhysicsChengdu 610200China Institute of Electronic Engineering China Academy of Engineering PhysicsMianyang 621999China Key Laboratory of Photoelectronic Thin Film Devices and Technology of Tianjin Nankai UniversityTianjin 300350China Engineering Research Center of Thin Film Optoelectronics Technology Ministry of EducationNankai UniversityTianjin 300350China

It is well known that in the process of thermal oxidation of silicon,there are P_(b)-type defects at amorphous silicon dioxide/silicon(a-SiO_(2)/Si)interface due to *** defects have a very important impact on the performance and reliability of semiconductor *** the process of passivation,hydrogen is usually used to inactivate P_(b)-type defects by the reaction P_(b)+H_(2)→P_(b)H+*** the same time,P_(b)H centers dissociate according to the chemical reaction P_(b)H→P_(b)+***,it is of great significance to study the balance of the passivation and *** this work,the reaction mechanisms of passivation and dissociation of the P_(b)-type defects are investigated by first-principles *** reaction rates of the passivation and dissociation are calculated by the climbing image-nudged elastic band(CI-NEB)method and harmonic transition state theory(HTST).By coupling the rate equations of the passivation and dissociation reactions,the equilibrium density ratio of the saturated interfacial dangling bonds and interfacial defects(P_(b),P_(b)0,and P_(b)1)at different temperatures is calculated.

关键词： first-principles calculation a-SiO_(2)/Si interface P_(b)-type defects equilibrium density

Ensemble-based optimization of hydraulically fractured horizontal well placement in shale gas reservoir through Hough transform parameterization

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Petroleum Science 2021年第3期18卷 839-851页

作者： Liang xue Shao-hua Gu xie-Er Jiang Yue-Tian Liu Chen Yang State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum(Beijing)Beijing 102249China Department of Oil-Gas Field Development Engineering College of Petroleum EngineeringChina University of Petroleum(Beijing)Beijing 102249China State Key Laboratory of Shale Oil and Gas Enrichment Mechanisms and Efective Development Beijing 100083China Sinopec Petroleum Exploration and Production Research Institute Beijing 100083China School of Water Conservancy North China University of Water Resources and Electric PowerZhengzhou 450046HenanChina

Shale gas reservoirs have been successfully developed due to the advancement of the horizontal well drilling and multistage hydraulic fracturing ***,the optimization design of the horizontal well drilling,hydraulic fracturing,and operational schedule is a challenging *** ensemble-based optimization method(EnOpt)is proposed here to optimize the design of the hydraulically fractured horizontal well in the shale gas *** objective is to maximize the net present value(NPV)which requires a simulation model to predict the cumulative shale gas *** accurately describe the geometry of the hydraulic fractures,the embedded discrete fracture modeling method(EDFM)is used to construct the shale gas simulation *** efects of gas absorption,Knudsen difusion,natural and hydraulic fractures,and gas-water two phase fow are considered in the shale gas production *** improve the parameter continuity and Gaussianity required by the EnOpt method,the Hough transformation parameterization is used to characterize the horizontal *** results show that the proposed method can efectively optimize the design parameters of the hydraulically fractured horizontal well,and the NPV can be improved greatly after optimization so that the design parameters can approach to their optimal values.

关键词： Shale gas Ensemble optimization Embedded discrete fracture model Hough transformation

基于microRNA-92a-3p靶向SIRT1调控氧糖剥夺再灌注诱导脑微血管内皮细胞炎症反应的作用机制研究

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中国现代医学杂志 2022年第24期32卷 26-33页

作者：林丽斌魏伟陆璐李永旭李惠红丁琳琳周阳杰卢陶陶薛偕华福建中医药大学康复医学院福建福州350122 福建省认知功能康复重点实验室福建福州350003 福建中医药大学附属康复医院脑病康复一科福建福州350003

目的探讨基于microRNA-92a-3p(miR-92a-3p)靶向调控SIRT1氧糖剥夺再灌注(OGD/R)诱导小鼠脑微血管内皮细胞(bEnd.3)炎症反应的作用机制。方法实时荧光定量聚合酶链反应(qRT-PCR)测定miR-92a-3p、SIRT1、肿瘤坏死因子α(TNF-α)、白细胞介... 详细信息

目的探讨基于microRNA-92a-3p(miR-92a-3p)靶向调控SIRT1氧糖剥夺再灌注(OGD/R)诱导小鼠脑微血管内皮细胞(bEnd.3)炎症反应的作用机制。方法实时荧光定量聚合酶链反应(qRT-PCR)测定miR-92a-3p、SIRT1、肿瘤坏死因子α(TNF-α)、白细胞介素1β(IL-1β)mRNA的表达;Western blotting明确SIRT1、核转录因子-κB(NF-κB)p65、磷酸化NF-κB(p-NF-κB)p65、TNF-α和IL-1β蛋白的表达;双荧光素酶报告基因验证miR-92a-3p与SIRT1靶向关系;划痕实验检测bEnd.3细胞的迁移能力。结果OGD/R组miR-92a-3p相对表达量较对照组升高(P<0.05)。M_SIRT1 WT+mimics+TK组荧光素酶活性较M_SIRT1 WT+mimics NC+TK组低(P<0.05)。OGD/R组SIRT1蛋白和mRNA相对表达量较对照组降低(P<0.05),OGD+92a抑制剂组较OGD+92a抑制剂内参组升高(P<0.05)。miR-92a-3p模拟物组NF-κBp65/p-NF-κBp65蛋白较模拟物内参组高,SIRT1蛋白和mRNA表达较模拟物内参组低(P<0.05)。miR-92a-3p模拟物组IL-1β、TNF-α蛋白和mRNA相对表达量较模拟物内参组高(P<0.05)。miR-92a-3p模拟物组伤口愈合率较模拟物内参组低(P<0.05)。结论miR-92a-3p通过靶向抑制SIRT1表达,促进OGD/R诱导的脑微血管内皮细胞炎症反应。

关键词： MicroRNA-92a-3p 脑微血管内皮细胞氧糖剥夺/再灌注 SIRT1 炎症反应小鼠

Synthesis and antibacterial activity of brominated 2′(4′)-nitro-3-hydroxy diphenyl ethers

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Chinese Chemical Letters 2009年第4期20卷 435-438页

作者： xue Tang Min xie Yong xue Sun Jian hua Li Zhi Cheng Zhong Yu Liang Wang Department of Chemistry Sichuan University Chengdu 610064 China College of Veterinary Medicine South China Agricultural University Guangzhou 510642 China

Eight new brominated 2＇（4＇）-nitro-3-hydroxy diphenyl ethers have been designed and synthesized. The structures of new compounds were confirmed by ^1H NMR, IR and HRMS. The bioactivity tests showed that these compounds possessed antibacterial activities against the tested bacteria. These new compounds cannot be transformed into dioxins when they were manufactured and used.

关键词： Brominated 2'(4')-nitro-3-hydroxy diphenyl ether Synthesis Antibacterial activity

A novel multistage anoxic/aerobic process with sludge regeneration zone (R-MAO) for advanced nitrogen removal from domestic sewage

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Journal of Environmental Sciences 2023年第2期124卷 758-768页

作者： Lin Cao Rong Sun Wenyi Dong Hongjie Wang Zhongyi Dai xue Wang Jin xie hua Li School of Chemical Engineering Huaqiao UniversityXiamen 361021China State Key Laboratory of Urban Water Resource and Environment School of Environment Harbin Institute of TechnologyHarbin 150090China School of Civil and Environmental Engineering Harbin Institute of Technology ShenzhenShenzhen 518055China Central and Southern China Municipal Engineering Design&Research Institute Co. Ltd.Wuhan 430010China Shenzhen Water Group Co. Ltd.Shenzhen 518000China

To achieve advanced nitrogen removal from actual municipal sewage,a novel multistage anoxic/aerobic process with sludge regeneration zone(R-MAO)was *** reactor was used to treat actual domestic sewage and the nitrogen removal capacity of the sludge regeneration zone(R zone)was investigated during the long-term *** best performance was obtained at the R zone’s Oxidation-Reduction Potential(ORP)of-50±30 mV and hydraulic residence times(HRT)of 1.2 *** average effluent COD,TN,NH_(4)^(+)-N and NO_(3)^(−)-N of the R-MAO process were 18.0±2.3,7.5±0.6,1.0±0.5 and 4.6±0.4 mg/L,respectively,with the corresponding removal efficiency of COD,TN and NH_(4)^(+)-N were 92.9%±1.0%,84.1%±1.5% and 97.5%±1.1%.Compared to the sole MAO system,the TN removal efficiency of the R-MAO increased by 10.1%.Besides,under the optimal conditions,the contribution of the R zone in the R-MAO that removal COD,TN,NH_(4)^(+)-N and NO_(3)^(−)-N were 0.36,0.15,0.032 and 0.82 g/***-throughput sequencing results showed that uncultured_bacterium_f_Burkholderiaceae(5.20%),OLB8(1.04%)and Ottowia(1.03%)played an important role in denitrification in the R *** study provided effective guidance for the design and operation of the R-MAO process in domestic sewage treatment.

关键词： Advanced nitrogen removal Multistage anoxic/aerobic process Sludge regeneration zone(R zone) Microbial community

Halogen bonding in the co-crystallization of potentially ditopic diiodotetrafluorobenzene:a powerful tool for constructing multicomponent supramolecular assemblies

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National Science Review 2020年第12期7卷 1906-1932页

作者： xue-hua Ding Yong-Zheng Chang Chang-Jin Ou Jin-Yi Lin Ling-Hai xie Wei huang Key Laboratory of Flexible Electronics(KLOFE) & Institute of Advanced Materials(IAM) Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM)Nanjing Tech University(Nanjing Tech) Key Laboratory for Organic Electronics &Information Displays(KLOEID) and Institute of Advanced Materials (IAM) Jiangsu National Synergistic Innovation Center for Advanced Materials (SICAM)Nanjing University of Posts & Telecommunications(NUPT) Shaanxi Institute of Flexible Electronics(SIFE) Northwestern Polytechnical University (NPU)

Halogen bonding is emerging as a significant driving force for supramolecular self-assembly and has aroused great interest during the last two *** the various halogen-bonding donors,we take notice of the ability of 1,4-diiodotetrafluorobenzene(1,4-DITFB) to co-crystallize with diverse halogen-bonding acceptors in the range from neutral Lewis bases(nitrogen-containing compounds,N-oxides,chalcogenides,aromatic hydrocarbons and organometallic complexes) to anions(halide ions,thio/selenocyanate ions and tetrahedral oxyanions),leading to a great variety of supramolecular architectures such as discrete assemblies,1 D infinite chains and 2 D/3 D *** of them act as promising functional materials(***,phosphorescence,optical waveguide,laser,non-linear optics,dielectric and magnetism)and soft materials(*** crystal and supramolecular gel).Here we focus on the supramolecular structures of multicomponent complexes and their related physicochemical properties,highlight representative examples and show clearly the main directions that remain to be developed and improved in this *** the point of view of crystal engineering and supramolecular chemistry,the complexes summarized here should give helpful information for further design and investigation of the elusive category of halogen-bonding supramolecular functional materials.

关键词： halogen bond co-crystal physicochemical properties supramolecular chemistry crystal engineering