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Deep learning models for automatic classification ofechocardiographic views

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中国医学影像技术 2024年第8期40卷 1124-1129页

作者： CHEN Wenwen ZHU Ye ZHANG Yiwei WU Chun LI Yuman ZHANG Ziming SUN Zhenxing xie mingxing ZHANG Li Department of Ultrasound Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Clinical Research Center for Medical Imaging in Hubei Province Wuhan 430022China Hubei Province Key Laboratory of Molecular Imaging Wuhan 430022China

Objective To observe the value of deep learning (DL) models for automatic classification of echocardiographic views. Methods Totally 100 patients after heart transplantation were retrospectively enrolled and divided into training set, validation set and test set at a ratio of 7 ∶ 2 ∶ 1. ResNet18, ResNet34, Swin Transformer and Swin Transformer V2 models were established based on 2D apical two chamber view, 2D apical three chamber view, 2D apical four chamber view, 2D subcostal view, parasternal long-axis view of left ventricle, short-axis view of great arteries, short-axis view of apex of left ventricle, short-axis view of papillary muscle of left ventricle, short-axis view of mitral valve of left ventricle, also 3D and CDFI views of echocardiography. The accuracy, precision, recall, F1 score and confusion matrix were used to evaluate the performance of each model for automatically classifying echocardiographic views. The interactive interface was designed based on Qt Designer software and deployed on the desktop. Results The performance of models for automatically classifying echocardiographic views in test set were all good, with relatively poor performance for 2D short-axis view of left ventricle and superior performance for 3D and CDFI views. Swin Transformer V2 was the optimal model for automatically classifying echocardiographic views, with high accuracy, precision, recall and F1 score was 92.56%, 89.01%, 89.97% and 89.31%, respectively, which also had the highest diagonal value in confusion matrix and showed the best classification effect on various views in t-SNE figure. Conclusion DL model had good performance for automatically classifying echocardiographic views, especially Swin Transformer V2 model had the best performance. Using interactive classification interface could improve the interpretability of prediction results to some extent.

关键词： heart transplantation echocardiography deep learning

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小鼠心肌缺血再灌注损伤模型改良及评价

中华胸心血管外科杂志 2024年第4期40卷 214-221页

作者：宋远王一卉高瑭董念国谢明星华中科技大学同济医学院附属协和医院超声医学科武汉430022 湖北省影像医学临床研究中心武汉430022 分子影像湖北省重点实验室武汉430022 华中科技大学同济医学院附属协和医院心脏大血管外科武汉430022

目的改良小鼠心肌缺血再灌注损伤(MIRI)造模方法,并对其系统性评价。方法将70只SPF级雄性C57BL/6小鼠随机分为假手术组(Sham)、经典组(CM)、单圈活结组(SM)和改良活结组(MM)。通过结扎冠状动脉左前降支30 min后再灌注24 h建立MIRI模型,... 详细信息

目的改良小鼠心肌缺血再灌注损伤(MIRI)造模方法,并对其系统性评价。方法将70只SPF级雄性C57BL/6小鼠随机分为假手术组(Sham)、经典组(CM)、单圈活结组(SM)和改良活结组(MM)。通过结扎冠状动脉左前降支30 min后再灌注24 h建立MIRI模型,记录并统计各组小鼠建模时间、模型存活率及实时心电图的变化。采用2,3,5-氯化三苯基四氮唑(TTC)、HE、Masson和TUNEL染色,比较MIRI心肌组织病理改变。生化仪测定血清谷草转氨酶(AST)、肌酸激酶(CK)、肌酸激酶同工酶MB(CK-MB)和乳酸脱氢酶(LDH)水平。ELISA法分析肿瘤坏死因子α(TNF-α)、白细胞介素2(IL-2)、白细胞介素6(IL-6)和单核细胞趋化因子1(MCP-1)水平。结果MM组小鼠心电图ST段明显抬高;MM组建模时间(36.2 min)显著少于CM组(66.2 min,P<0.0001),且MM组相较于CM组存活率显著提升(P<0.05)。MM组小鼠心肌组织梗死区细胞肿胀变形,心肌纤维化程度高于其他组并明显发生凋亡。CM组和MM组小鼠心肌酶AST、CK、CK-MB、LDH水平较Sham组均显著升高,其中MM组的CK和CK-MB水平较CM组明显增加(P<0.05)。CM组和MM组小鼠炎性因子TNF-α(P<0.01)、IL-6(P<0.05)较Sham组显著升高,CM组IL-2水平显著高于Sham组和MM组(P<0.05),MCP-1水平各组间差异无统计学意义。结论与经典和单圈活结造模方式相比,利用改良活结法建立的小鼠MIRI模型,造模时间缩短,模型更稳定,小鼠存活率显著提高。

关键词：心肌缺血再灌注损伤结扎动物模型小鼠

纳米抗氧化剂减轻心肌缺血再灌注损伤的研究进展

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中华心血管病杂志 2024年第6期52卷 729-734页

作者：付文佩邓诚李诗莹张丽谢明星杨亚利华中科技大学同济医学院附属协和医院超声医学科武汉430022

心肌缺血再灌注损伤是缺血心肌恢复血流灌注过程中心肌细胞进一步损伤、坏死和凋亡的现象,严重影响冠状动脉血流再通术患者预后。氧化应激是介导心肌缺血再灌注损伤发生发展的重要机制之一,使用抗氧化剂清除活性氧可有效缓解氧化应激、... 详细信息

心肌缺血再灌注损伤是缺血心肌恢复血流灌注过程中心肌细胞进一步损伤、坏死和凋亡的现象,严重影响冠状动脉血流再通术患者预后。氧化应激是介导心肌缺血再灌注损伤发生发展的重要机制之一,使用抗氧化剂清除活性氧可有效缓解氧化应激、减轻心肌缺血再灌注损伤。纳米抗氧化剂是一种新型抗氧化剂,相较于传统抗氧化剂,可改善治疗药物药代动力学和药效学性能,提高治疗效果,减少副作用,具有良好临床应用前景。该文就纳米抗氧化剂在心肌缺血再灌注损伤治疗中的最新研究进展进行综述。

关键词：心肌缺血心肌缺血再灌注损伤纳米抗氧化剂氧化应激活性氧

Reference values of carotid intima-media thickness and arterial stiffness in Chinese adults based on ultrasound radio frequency signal: A nationwide, multicenter study

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中华医学杂志(英文版) 2024年第15期137卷 1802-1810页

作者： Xing Changyang xie Xiujing Wu Yu Xu Lei Guan Xiangping Li Fan Zhan Xiaojun Yang Hengli Li Jinsong Zhou Qi Mu Yuming Zhou Qing Ding Yunchuan Wang Yingli Wang Xiangzhu Zheng Yu Sun Xiaofeng Li Hua Zhang Chaoxue Zhao Cheng Qiu Shaodong Yan Guozhen Yang Hong Mao Yinjuan Zhan Weiwei Ma Chunyan Gu Ying Chen Wu xie mingxing Jiang Tianan Yuan Lijun Department of Ultrasound Medicine Tangdu Hospital Air Force Medical University Xi’an Shaanxi China Department of Ultrasound Medicine The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang China Department of Ultrasound Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China Department of Ultrasound Xi’an Hospital of Traditional Chinese Medicine Xi’an Shaanxi China Ultrasound Medical Diagnosis Center Shaanxi Provincial People’s Hospital Xi’an Shaanxi China Department of Ultrasound Hospital of Northwestern Polytechnical University Xi’an Shaanxi China Department of Ultrasound Xi’an No. Hospital The First Affiliated Hospital of Northwest University Xi’an Shaanxi China Department of Ultrasound Diagnosis The Second Affiliated Hospital Xi’an Medical College Xi’an Shaanxi China Department of Ultrasound Xi’an Gem Flower ChangQing Hospital Xi’an Shaanxi China Department of Ultrasound The Second Affiliated Hospital of Xi’an Jiaotong University China Xi’an Shaanxi China Department of Echocardiography First Affiliated Hospital of Xinjiang Medical University Urumqi Xinjiang China Department of Ultrasound Renmin Hospital of Wuhan University Wuhan Hubei China Department of Ultrasound Yan’an Hospital The Affiliated Hospital of Kunming Medical University Kunming Yunnan China Department of Ultrasound Yan’an University Xianyang Hospital Xianyang Shaanxi China Department of Function Examination Beijing University of Chinese Medicine Third Affiliated Hospital Beijing China Department of Ultrasound Xi’an Central Hospital Xi’an Shaanxi China Cadre’s Wards Ultrasound Department Diagnostic Ultrasound Center First Hospital of Jilin University Changchun Jilin China Department of Echocardiography Affiliated Hospital of Traditional Chinese Medicine of Xinjiang Medical University Urumqi Xinjiang China Department of Ultrasound First Affiliated Hospital of Anhui Medical University Hefei

Background: Carotid intima-media thickness (IMT) and diameter, stiffness, and wave reflections, are independent and important clinical biomarkers and risk predictors for cardiovascular diseases. The purpose of the present study was to establish nationwide reference values of carotid properties for healthy Chinese adults and to explore potential clinical ***: A total of 3053 healthy Han Chinese adults (1922 women) aged 18-79 years were enrolled at 28 collaborating tertiary centers throughout China between April 2021 and July 2022. The real-time tracking of common carotid artery walls was achieved by the radio frequency (RF) ultrasound system. The IMT, diameter, compliance coefficient, β stiffness, local pulse wave velocity (PWV), local systolic blood pressure, augmented pressure (AP), and augmentation index (AIx) were then automatically measured and reported. Data were stratified by age groups and sex. The relationships between age and carotid property parameters were analyzed by Jonckheere-Terpstra test and simple linear regressions. The major clinical determinants of carotid properties were identified by Pearson’s correlation, multiple linear regression, and analyses of ***: All the parameters of carotid properties demonstrated significantly age-related trajectories. Women showed thinner IMT, smaller carotid diameter, larger AP, and AIx than men. The β stiffness and PWV were significantly higher in men than women before forties, but the differences reversed after that. The increase rate of carotid IMT (5.5 μm/year in women and 5.8 μm/year in men) and diameter (0.03 mm/year in both men and women) were similar between men and women. For the stiffness and wave reflections, women showed significantly larger age-related variations than men as demonstrated by steeper regression slopes (allP for age by sex interaction <0.05). The blood pressures, body mass index (BMI), and triglyceride levels were identified as major clinical determinants o

关键词： Intima-media thickness Arterial stiffness Reference values Ultrasound radio frequency signal Wave reflections

翻转课堂结合PBL用于围术期床旁超声心动图规范化培训的效果

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中华麻醉学杂志 2024年第5期44卷 615-618页

作者：郭小密赵岩张丽王静谢明星孙振兴华中科技大学同济医学院附属协和医院超声医学科武汉430022 武汉亚心总医院超声科武汉430056 华中科技大学同济医学院附属协和医院麻醉科武汉430022

目的评价翻转课堂结合基于问题教学(PBL)用于围术期床旁超声心动图规范化培训的效果。方法选取2021年1月至2022年6月在华中科技大学同济医学院附属协和医院麻醉科轮转规培二年级学生64名,性别不限,采用随机数字表法分为2组(n=32):对照... 详细信息

目的评价翻转课堂结合基于问题教学(PBL)用于围术期床旁超声心动图规范化培训的效果。方法选取2021年1月至2022年6月在华中科技大学同济医学院附属协和医院麻醉科轮转规培二年级学生64名,性别不限,采用随机数字表法分为2组(n=32):对照组采用传统教学模式,试验组采用翻转课堂结合PBL模式。在为期3个月的床旁超声心动图标准切面及血流动力学评价教学结束后,比较2组超声心动图理论综合成绩和临床实践成绩(≥80分为优良),并通过发放问卷对学生的自主学习能力和主动性、学习兴趣、专业知识掌握效率、对带教工作满意度、沟通协作能力及临床思维能力进行调查。结果与对照组相比,试验组学生超声心动图理论综合成绩[(87±8)分vs(80±8)分]和临床实践成绩[(86±8)分vs(78±8)分]明显升高,超声心动图理论综合成绩优良率(88%vs 47%)和临床实践成绩优良率(84%vs 50%)明显升高(P<0.05或0.01)。共发放64份调查问卷,收回64份,回收率为100%。试验组学生超声心动图自学能力和主动性增强(94%vs 69%)、学习兴趣增强(91%vs 66%)、专业知识掌握效率提高(97%vs 75%)、对带教工作满意(94%vs 62%)、沟通协作能力增强(84%vs 62%)及临床思维能力增强(88%vs 59%)等方面明显优于对照组(P<0.05)。结论翻转课堂结合PBL用于围术期床旁超声心动图规范化培训的效果优于传统教学。

关键词：超声心动描记术围手术期教学方法基于问题教学翻转课堂

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氧化钙改性赤泥固化黄土的电阻率特性及机理

太原理工大学学报 2024年第2期55卷 331-337页

作者：宋志伟韩素丽秦鹏举苗晨曦谢明星太原理工大学土木工程学院太原030024

【目的】研究CaO改性赤泥固化黄土的电阻率特性。【方法】对不同CaO和赤泥掺量以及养护龄期条件下的电阻率进行测试,分析了电阻率的变化趋势。另外,测试了不同条件下试样的XRD、SEM、EDS和孔隙度、孔喉分布率,通过分析微观指标的差异揭... 详细信息

【目的】研究CaO改性赤泥固化黄土的电阻率特性。【方法】对不同CaO和赤泥掺量以及养护龄期条件下的电阻率进行测试,分析了电阻率的变化趋势。另外,测试了不同条件下试样的XRD、SEM、EDS和孔隙度、孔喉分布率,通过分析微观指标的差异揭示了电阻率的变化机理。【结果】研究结果表明:随着CaO和赤泥的增加,电阻率呈现降低的趋势;与水泥固化土相比,CaO改性赤泥固化土孔隙水中的导电离子在离子种类和离子浓度两方面都有所增加,这导致孔隙水的导电性增加;而CaO改性赤泥固化土的孔隙度和孔喉分布率差别不大,所以试块内部的导电通路差别不大。随着养护龄期的增加,电阻率整体呈现出对数增长的趋势;水泥固化土中的导电离子因参与反应逐渐减少;CaO改性赤泥固化土中过量的CaO未参与反应,导致孔隙水中的导电离子持续存在,因此养护龄期大于28 d时孔隙水的导电性降低幅度有限;另外,由于固化土的孔隙度和孔喉分布率均有所增加,且试块处于非饱和状态,故其内部断路增多导致导电通路减少,致使电阻率随着龄期的增加而变大。

关键词：固化土电阻率孔隙度扫描电镜 X射线衍射

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A Dynamic ID-Based Authenticated Group Key Exchange Protocol without Pairings

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Wuhan University Journal of Natural Sciences 2010年第3期15卷 255-260页

作者： xie Liyun HE mingxing School of Mathematics and Computer Engineering Xihua University Chengdu 610039 Sichuan China

So far, most of the proposed group key exchange （GKE） protocols do not consider the attack when the adversary reveals the parties＇ ephemeral private keys without their long-term private keys, so these GKE protocols are insecure on this attack. In this paper, for resisting above attack, we propose a dynamic authenticated group key exchange （AGKE） protocol in the ID-based setting. Different from previous ID-based protocols, our protocol does not utilize bilinear pairings, which makes it more efficient. At last, we analyze the security of the protocol in the cCK （enhanced Canetti-Krawczyk） security model.

关键词： group key exchange eCK security model without pairings

二尖瓣反流患者瓣膜构型的经食管三维超声心动图应用进展

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中华超声影像学杂志 2024年第3期33卷 266-270页

作者：王欢李玉曼贺林李贺吴文谦杨芸谢明星方凌云华中科技大学同济医学院附属协和医院超声医学科湖北省影像医学临床医学研究中心分子影像湖北省重点实验室武汉430022

近年来随着外科及经导管二尖瓣修复术的广泛应用,对二尖瓣反流独特的瓣膜解剖结构、功能特点的评估成为临床关注的重点,亦是指导治疗此类病变的重要基石。超声心动图是评估二尖瓣形态结构和功能的首选影像学技术,尤其是经食管三维超声... 详细信息

近年来随着外科及经导管二尖瓣修复术的广泛应用,对二尖瓣反流独特的瓣膜解剖结构、功能特点的评估成为临床关注的重点,亦是指导治疗此类病变的重要基石。超声心动图是评估二尖瓣形态结构和功能的首选影像学技术,尤其是经食管三维超声心动图在二尖瓣装置的量化评估中具有独特的作用和价值。笔者就二尖瓣反流患者瓣膜构型的经食管三维超声心动图应用与前景进行综述。

关键词：超声心动描记术,经食管,三维二尖瓣二尖瓣构型

A Rare Long Term Survival Case of Complete Pentalogy of Cantrell in Adult after One-Staged Surgery

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Congenital Heart Disease 2021年第5期16卷 513-518页

作者： Hao Hong Nianguo Dong mingxing xie Lin Li Si Chen Wengang Sun Xiaoqing Hu Department of Cardiovarscular Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Department of Ultrasound Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Department of Radiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China

Pentalogy of Cantrell is a rare congenital *** with high-quality medical care and staged corrective surgeries in professional hospitals,the mortality rate is still very high and long-term prognosis is *** is largely determined by the complexity and severity of cardiac abnormalities,the efficiency of abdominal wall closure and postoperative complications.A 24-year-old male patient with complete pentalogy of Cantrell was ***-stage surgical repair of all abnormalities were *** patient recovered well and had been follow-up for 7 *** has a good cosmetic outcome,with no signs of cardiac *** complications were noted.

关键词： Pentalogy of cantrell adult one-stage surgery