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Effecacy of Biejia(Carapax Trionycis) and Ezhu(Rhizoma Curcumae Phaeocaulis) couplet medicine on epithelial-mesenchymal transition, invasion and migration of MDA-MB-231 triple negative breast cancer cells via PI3K/Akt/mTOR signaling pathway

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Journal of Traditional Chinese Medicine 2021年第6期41卷 853-861页

作者： ZHU Manjing xie su xie Qing ZHU Jiulong HUANG Yazhen Guizhou Medical University Guiyang 550004China the Affiliated Hospital of Guizhou Medical University Guiyang 550004China

OBJECTIVE:To investigate the efficacy of Biejia(Carapax Trionycis)and Ezhu(Rhizoma Curcumae Phaeocaulis)couplet medicine on epithelial-mesenchymal transition(EMT),invasion and migration of MDA-MB-231 triple negative breast cancer(TNBC)cells based on PI3K/Akt/mTOR signaling ***:MDA-MB-231 cells were treated with different medicated serum as Biejia-,Ezhu-,Biejia-Ezhu(BJ-,EZ-,BJ-EZ-)groups,intervened with no drug rat serum and paclitaxel with final concentration of 33 nM(IC50)as negative and positive control(NC and PC)***-8 assay,scratch test,and Transwell assay were used to examine cell proliferation,invasion,and *** expression of E-cadherin,N-cadherin,Vimentin,MMP-2,MMP-9,PI3K,Akt,p-Akt,mTOR,and p-mTOR was determined by Western blot,and the m RNA expression of PI3K,Akt and mTOR was determined by real-time polymerase chain ***:BJ-EZ group inhibited proliferation after 24,48,and 72 h compared with the NC group(P<0.05,<0.01 or<0.001)and reduced the invasion and migration of MDA-MB-231 cells(P<0.01 or<0.001).In addition,BJ-EZ group upregulated the expression of E-cadherin,downregulated the expression of N-cadherin,Vimentin,MMP-2,and MMP-9(P<0.05,P<0.01 or P<0.001),and inhibited the m RNA and protein expression of PI3K,Akt(p-Akt),mTOR(p-mTOR)(P<0.05,<0.01 or<0.001).CONCLUSION:Biejia(Carapax Trionycis)and Ezhu(Rhizoma Curcumae Phaeocaulis)couplet medicine can inhibit the proliferation,invasion,migration and EMT of MDA-MB-231 cells through PI3K/Akt/mTOR signaling pathway,and the effect is better than that of Biejia(Carapax Trionycis)or Ezhu(Rhizoma Curcumae Phaeocaulis)alone.

关键词： triple negative breast neoplasms epithelial-mesenchymal transition PI3K/Akt/mTOR signal transduction Biejia(Carapax Trionycis) Ezhu(Rhizoma Curcumae Phaeocaulis)

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Synthesis and optical activity of isosorbide chiral derivative containing fluorocarbon group as chiral dopant in liquid crystal materials

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Chinese Chemical Letters 2011年第12期22卷 1447-1450页

作者： Kong Liang xie Yin He su Chun Xiang Zhang College of Chemistry Chemical Engineering and Biotechnology Donghua University Shanghai 201620 China

Novel isosorbide derivative containing perfluorocarbon group,bi（perfluorooctanesulfonyl）isosorbide ester as chiral dopant in liquid crystal,was *** structure was characterized by elemental analysis,FT-IR,~1H NMR and ^（19）F *** optical texture of the mixture was observed by polarized optical microscopy（POM）.Novel chiral dopant containing perfluorocarbon group had excellent optical *** specific rotation and molar rotation were noticeable higher than those of bi（4-chloromethylbenzenecarbonic）isosorbide *** fluorocarbon group improved the molar rotation of chiral compound and did not affect optical rotation *** texture of the mixture added isosorbide derivative with fluorocarbon group showed the oily streak texture.

关键词： Optical properties surfaces Texture Liquid crystal Fluorocarbon

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Multi-objective optimisation of a vehicle energy absorption structure based on surrogate model

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Journal of Central South University 2014年第6期21卷 2539-2546页

作者：谢素超周辉 Key Laboratory of Traffic Safety on Track of Ministry of Education(School of Traffic and Transportation Engineering Central South University) School of Transportation and Logistics Central South University of Forestry and Technology

In order to optimize the crashworthy characteristic of energy-absorbing structures, the surrogate models of specific energy absorption （SEA） and ratio of SEA to initial peak force （REAF） with respect to the design parameters were respectively constructed based on surrogate model optimization methods （polynomial response surface method （PRSM） and Kriging method （KM））. Firstly, the sample data were prepared through the design of experiment （DOE）. Then, the test data models were set up based on the theory of surrogate model, and the data samples were trained to obtain the response relationship between the SEA ＆amp; REAF and design parameters. At last, the structure optimal parameters were obtained by visual analysis and genetic algorithm （GA）. The results indicate that the KM, where the local interpolation method is used in Gauss correlation function, has the highest fitting accuracy and the structure optimal parameters are obtained as： the SEA of 29.8558 kJ/kg （corresponding toa=70 mm andt= 3.5 mm） and REAF of 0.2896 （corresponding toa=70 mm andt=1.9615 mm）. The basis function of the quartic PRSM with higher order than that of the quadratic PRSM, and the mutual influence of the design variables are considered, so the fitting accuracy of the quartic PRSM is higher than that of the quadratic PRSM.

关键词： railway vehicle energy-absorbing structure surrogate model Kriging method (KM) polynomial response surface method (PRSM) structure optimization

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Effects of Jiazhu decoction in combination with cyclophosphamide on breast cancer in mice

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Journal of Traditional Chinese Medicine 2019年第5期39卷 642-648页

作者： Guan Huiting xie su Liu Shangyi xie Qing Hou Shengkai Liu Huarong Zhang Yunjie Hu Yaqing Zhang Chenyu Academy of Clinical Medicine Guizhou Medical UniversityGuiyang 550004China Department of Chinese Medicine the Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004China the First Affiliated Hospital of Guiyang University of Chinese Medicine Guiyang 550004 China Department of Chinese Medicine the Maternity and Child Health Care of ZaozhuangZaozhuang 277100China Academy of Clinical Medicine Guizhou Medical UniversityGuiyang 550004China

OBJECTIVE: To investigate the therapeutic effects of Jiazhu decoction (JZD) in combination with cyclophosphamide (CTX) on the growth of breast cancer in mice and to explore the possible molecular mechanisms of action. METHODS: BALB/c mice were randomly divided into four groups of 10 (untreated model group, JZD group, CTX group, and JZD + CTX group) and subcutaneously injected with 4T1 mouse breast cancer cells. Tumors were allowed to establish for ~7 d before initiation of treatment with CTX (100 mg/kg every week by intraperitoneal injection) and/or JZD (0.015 mL of 1.65 g/mL crude drug, administered daily by gavage). The model group received equivalent volumes of vehicle on the same schedules. Tumor volumes were measured every 3 d. Mice were sacrificed after 3 weeks of treatment, and tumors were excised and subjected to RT-qPCR and western blot analysis to evaluate expression of the Wnt/β-catenin signaling pathway components β-catenin, c-Myc, and cyclin D1 at the mRNA and protein levels. REsuLTS: The mean tumor volume was smaller and the growth rate was slower in the CTX and JZD + CTX groups compared with the model group (P < 0.05), and in the JZD + CTX group compared with the CTX and JZD groups (P < 0.05). Tumor growth was inhibited by 35.4% and 48.1% by CTX and JZD + CTX treatment, respectively (P < 0.001). The expression of β-catenin, c-Myc, and cyclin D1 mRNA and protein in tumors was significantly lower in mice treated with JZD or JZD + CTX compared with the untreated mice (P < 0.05), and was significantly lower in mice treated with JZD + CTX compared with either JZD or CTX alone (P < 0.05). CONCLUSION: JZD inhibited the growth of mouse breast cancer cells in vivo, possibly by reducing the expression of β-catenin, c-Myc, and cyclin D1. Combination therapy with JZD plus CTX had a more potent inhibitory effect on breast cancer growth compared with either agent alone.

关键词： Breast neoplasms Cyclophosphamide Wnt signaling pathway Jiazhu decoction

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Effect of bamboo charcoal filler on the performance of microbial fuel cell

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环境污染与防治 2014年第2期36卷 I0004-I0009,10页

作者： xie Beizhen su Qiang YANG Shaoqiang LIU Hong Laboratory of Environmental Biology and Life sup- port Technology School of Biological Science and Medical Engineering Beihang University Beijing 100191

微生物燃料电池（MFC）的阳极对提高MFC产电性能有至关重要的影响.利用竹炭比表面积大、吸附能力强等特性,将其作为“三合一”膜电极MFC的阳极填充材料,通过增大阳极比表面积来提高其产电能力.实验结果表明,加入竹炭至阳极室后,MFC最高... 详细信息

微生物燃料电池（MFC）的阳极对提高MFC产电性能有至关重要的影响.利用竹炭比表面积大、吸附能力强等特性,将其作为“三合一”膜电极MFC的阳极填充材料,通过增大阳极比表面积来提高其产电能力.实验结果表明,加入竹炭至阳极室后,MFC最高输出电压（外接电阻1 000Ω时）由0.280V增大到0.387V,提高了38.2％,并且输出电压更加稳定;而最大功率密度也由原来的0.22 W/m3增大到1.42 W/m3,同时内阻降低了80.85％（由235 Ω降为45 Ω）;库仑效率由15.0％增大到25.6％.说明MF℃阳极室填充竹炭可以显著促进MFC的产电性能.

关键词：摘要编辑部编辑工作读者

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Metathesis of Butylene-2 and Ethylene to Propylene over 3.0Mo/(Hβ+γ-Al_(2)O_(3))Catalysts with Differentγ-Al_(2)O_(3)Contents

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Chemical Research in Chinese Universities 2005年第2期21卷 213-216页

作者： LIU Sheng-lin HUANG Sheng-jun XIN Wen-jie BAI Jie xie su-juan XU Long-ya Laboratory of Natural Gas Utilization and Applied Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023P.R.China

A series of 3.0Mo/(Hβ+γ-Al_(2)O_(3))samples withγ-Al_(2)O_(3)contents in the range of 0_100%(mass fraction)was studied by means of XRD,NH_(3)-TPD,TPR and BET determinations for characterizing their *** Hβzeolite structure in the 3.0Mo/Hβsample can be effectively stabilized by adding someγ-Al_(2)O_(3)to Hβzeolite.γ-Al_(2)O_(3)mainly favors the formation of polymolybdate or multilayered Mo oxide,while Hβmainly forms the Al_(2)(MoO_(4))_(3)species,as evaluated by the TPR *** used as the catalyst for the metathesis of butylene-2 and ethylene to propylene,there exists a close correlation between the specific surface area and stability of the *** specific surface area of the catalyst shows the maximum when{(Hβ+}γ-Al_(2)O_(3))contains 30%γ-Al_(2)O_(3),which is in agreement with that of the time needed for the reaction *** the case of maximum surface area,the rate of coke deposition is the minimum.

关键词： Butylene-2 Ethylene Propylene Metathesis Mo-impregnated(Hβ+γ-Al_(2)O_(3))catalyst {γ-Al_(2)O_(3)}content TPR/TPD/XRD characterization

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In vivo anti-tumor effect of hybrid vaccine of dendritic cells and esophageal carcinoma cells on esophageal carcinoma cell line 109 in mice with severe combined immune deficiency

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World Journal of Gastroenterology 2008年第8期14卷 1167-1174页

作者： Guang-Hua Guo su-Zuan Chen Jing Yu Juan Zhang Li-Li Luo Li-Hua xie Zhong-Jing su Hong-Mei Dong Hong Xu Li-Biao Wu Department of Gastroenterology The First Affiliatecl Hospital of Shantou University Medical College Shantou 515041Guangdong Province China

AIM： To develop a fusion vaccine of esophageal carcinoma cells and dendritic cells （DC） and observe its protective and therapeutic effect against esophageal carcinoma cell line 109 （EC109）. METHODS： The fusion vaccine was produced by fusing traditional polyethyleneglycol （PEG）, inducing cytokine, sorting CD34＋ magnetic microbead marker and magnetic cell system （MACS）. The liver, spleen and lung were pathologically tested after injection of the fusion vaccine. To study the therapeutic and protective effect of the fusion vaccine against tumor EC109, mice were divided immune group and therapeutic group. The immune group was divided into P, E, D and ED subgroups, immunized by phosphate buffered solution （PBS）, inactivated EC109, DC and the fusion vaccine respectively, and attacked by EC109 cells. The tumor size, weight, latent period and mouse survival period were recorded and statistically analyzed. The therapeutic group was divided into four subgroups： P, inactivated EC109, D and ED subgroups, which were attacked by EC109 and then treated with PBS, inactivated EC109, DC, and EC109-DC respectively. Pathology and flow cytometry were also used to study the therapeutic effect of the fusion vaccine against EC109 cells.REsuLTS： Flow cytometry showed that the expression of folate receptor （FR）, EC109 （C）, Des （D） in human nasopharyngeal carcinoma cell line （HNE1）（B） was 78.21%, 89.50%, and 0.18%, respectively. The fusion cells （C） were highly expressed. No tumor was found in the spleen, lung and liver after injection of the fusion vaccine. Human IgG was tested in peripheral blood lymphocytes （PBL）. In the immune group, the latent period was longer in EC109-DC subgroup than in other subgroups, while the tumor size and weight were also smaller than those in ED subgroup. In the therapeutic group, the tumor size and weight were smaller in ED subgroup than in P, inactivated EC109 and DC subgroups. CONCLUSION： Fusion cells are highly expressed not only in FR but also in CD8

关键词： Dendritic cells Esophageal carcinoma cells Cell fusion Immune protection Immunotherapy

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A prediction method of rail grinding profile using non-uniform rational B-spline curves and Kriging model

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Journal of Central South University 2018年第1期25卷 230-240页

作者： YANG Yue QIU Wen-sheng ZENG Wei xie Huan xie su-chao School of Traffic and Transportation Engineering Central South University Changsha 410075 China Guangzhou Large Scale Track Maintenance Machine Running and Maintenance Division Guangzhou Railway Co. Guangzhou 511400 China School of Mechanical Engineering Xijing University Xi’an 710123 China

Non-uniform rational B-spline(NURBS)curves are combined with the Kriging model to present a prediction method of the rail grinding profile for a grinding *** a worn rail profile is a free-form curve,the parameterized model of a rail profile is constructed by using the cubic NURBS *** the removed area of the rail profile cross-section by grinding as the calculation index of the grinding amount,the grinding amount calculation model of a grinding wheel is established based on the area integral formula of the cubic NURBS *** predict the grinding amount of a grinding wheel in different modes,a Kriging model of the grinding amount is constructed,taking the travel speed of a grinding train,the grinding angle and grinding pressure of a grinding wheel as the variables,and considering the grinding amount of a grinding wheel as the *** this basis,the prediction method of the rail grinding profile is presented based on the order-forming *** effectiveness of this method is verified based on a practical application.

关键词： rail grinding NURBS Kriging worn rail target profile

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Crystallographic Understanding of Photoelectric Properties for C_(60) Derivatives Applicable as Electron Transporting Materials in Perovskite Solar Cells

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Chemical Research in Chinese Universities 2022年第1期38卷 75-81页

作者： XING Zhou LI Shu-Hui XU Piao-Yang TIAN Han-Rui DENG Lin-Long YAO Yang-Rong CHEN Bin-Wen xie Fang-Fang AN Ming-Wei YUN Da-Qin xie su-Yuan ZHENG Lan-sun State Key Lab for Physical Chemistry of Solid surfaces iChEM(Collaborative Innovation Center of Chemistry for Energy Materials)Department of ChemistryCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005P.R.China Pen-Tung Sah Institute of Micro-Nano Science and Technology Xiamen UniversityXiamen 361005P.R.China College of Energy Xiamen UniversityXiamen 361005P.R.China

Hundreds of C60 derivatives stand out as electrontransporting materials(ETMs), for example, in perovskite solar cells(PSCs), due to their properties on electron extraction or defect passivation. However, it still lacks of guidelines to update C60-based ETMs with excellent photoelectric properties. In this work, crystallographic data of eight C60-based ETMs, including pristine C60 and the well-known PCBM as well as six newly synthesized fullerenes, are analyzed to establish the connections between derivatized structures and photoelectric properties for the typical carbon cluster of C60. In terms of packing centroid-centroid distance between neighboring carbon cages, the crystallographic data are useful for probing photoelectric properties, such as electrochemical properties, electron mobility and photovoltaic performances, and therefore facilitate to design novel C60-based ETMs for PSCs with high performances.

关键词： Perovskite solar cell(PSC) Electron transporting material(ETM) Fullerene Power conversion efficiency Crystallographic understanding

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原子吸收光谱法测定翅果油树体内的八种无机元素

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光谱学与光谱分析 2006年第1期26卷 154-155页

作者：谢苏婧山西大学现代化学研究所山西太原030006

采用火焰原子吸收法测定了翅果油树体内八种微量元素,结果表明,在不同器官或不同生长阶段其无机元素含量均有显著差异。总体上看,该种植物无机元素含量丰富,尤其以根、叶和种子更为突出。

关键词：原子吸收光谱翅果油树无机元素

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