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nanotechnology’s frontier in combatting infectious and inflammatory diseases:prevention and treatment

Signal Transduction and Targeted Therapy 2024年第3期9卷 998-1047页

作者： Yujing Huang Xiaohan Guo Yi Wu Xingyu Chen Lixiang Feng na xie Guobo Shen Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China Hospitaland West China School of Basic Medical Sciences and Forensic MedicineSichuan Universityand Collaborative Innovation Center for BiotherapyChengdu 610041China

Inflammation-associated diseases encompass a range of infectious diseases and non-infectious inflammatory diseases,which continuously pose one of the most serious threats to human health,attributed to factors such as the emergence of new pathogens,increasing drug resistance,changes in living environments and lifestyles,and the aging population.Despite rapid advancements in mechanistic research and drug development for these diseases,current treatments often have limited efficacy and notable side effects,necessitating the development of more effective and targeted anti-inflammatory therapies.In recent years,the rapid development of nanotechnology has provided crucial technological support for the prevention,treatment,and detection of inflammation-associated diseases.Various types of nanoparticles(NPs)play significant roles,serving as vaccine vehicles to enhance immunogenicity and as drug carriers to improve targeting and bioavailability.NPs can also directly combat pathogens and inflammation.In addition,nanotechnology has facilitated the development of biosensors for pathogen detection and imaging techniques for inflammatory diseases.This review categorizes and characterizes different types of NPs,summarizes their applications in the prevention,treatment,and detection of infectious and inflammatory diseases.It also discusses the challenges associated with clinical translation in this field and explores the latest developments and prospects.In conclusion,nanotechnology opens up new possibilities for the comprehensive management of infectious and inflammatory diseases.

关键词： prevention inflammatory treatment

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Insights and implications of sexual dimorphism in osteoporosis

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Bone Research 2024年第1期12卷 20-49页

作者： Yuan-Yuan Zhang na xie Xiao-Dong Sun Edouard C.Nice Yih-Cherng Liou Canhua Huang Huili Zhu Zhisen Shen Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province Sichuan Research Center for Drug Precision Industrial TechnologyWest China School of PharmacySichuan UniversityChengdu 610041China West China School of Basic Medical Sciences&Forensic Medicine Sichuan UniversityChengdu 610041China Department of Biochemistry and Molecular Biology Monash UniversityClaytonVIC 3800Australia Department of Biological Sciences Faculty of ScienceNational University of SingaporeSingapore 117543Republic of Singapore Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China Hospitaland West China School of Basic Medical Sciences&Forensic MedicineSichuan UniversityChengdu 610041China Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education Department of Reproductive MedicineWest China Second University Hospital of Sichuan UniversityChengduChina Department of Otorhinolaryngology and Head and Neck Surgery The Affiliated Lihuili HospitalNingbo University315040 NingboZhejiangChina

Osteoporosis,a metabolic bone disease characterized by low bone mineral density and deterioration of bone microarchitecture,has led to a high risk of fatal osteoporotic fractures worldwide.Accumulating evidence has revealed that sexual dimorphism is a notable feature of osteoporosis,with sex-specific differences in epidemiology and pathogenesis.Specifically,females are more susceptible than males to osteoporosis,while males are more prone to disability or death from the disease.To date,sex chromosome abnormalities and steroid hormones have been proven to contribute greatly to sexual dimorphism in osteoporosis by regulating the functions of bone cells.Understanding the sex-specific differences in osteoporosis and its related complications is essential for improving treatment strategies tailored to women and men.This literature review focuses on the mechanisms underlying sexual dimorphism in osteoporosis,mainly in a population of aging patients,chronic glucocorticoid administration,and diabetes.Moreover,we highlight the implications of sexual dimorphism for developing therapeutics and preventive strategies and screening approaches tailored to women and men.Additionally,the challenges in translating bench research to bedside treatments and future directions to overcome these obstacles will be discussed.

关键词： osteoporosis epidemiology overcome

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Predictive model for non-malignant portal vein thrombosis associated with cirrhosis based on inflammatory biomarkers

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1213-1226页

作者： Guo-Le Nie Jun Yan Ying Li Hong-Long Zhang Dan-na xie Xing-Wang Zhu Xun Li The First School of Clinical Medicine Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of General Surgery The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina

BACKGROUND Portal vein thrombosis(PVT),a complication of liver cirrhosis,is a major public health concern.PVT prediction is the most effective method for PVT diagnosis and treatment.AIM To develop and validate a nomogram and network calculator based on clinical indicators to predict PVT in patients with cirrhosis.METHODS Patients with cirrhosis hospitalized between January 2016 and December 2021 at the First Hospital of Lanzhou University were screened and 643 patients with cirrhosis who met the eligibility criteria were retrieved.Following a 1:1 propensity score matching 572 patients with cirrhosis were screened,and relevant clinical data were collected.PVT risk factors were identified using the least absolute shrinkage and selection operator(LASSO)and multivariate logistic regression analysis.Variance inflation factors and correlation matrix plots were used to analyze multicollinearity among the variables.A nomogram was constructed to predict the probability of PVT based on independent risk factors for PVT,and its predictive performance was verified using a receiver operating characteristic curve(ROC),calibration curves,and decision curve analysis(DCA).Finally,a network calculator was constructed based on the nomograms.RESULTS This study enrolled 286 cirrhosis patients with PVT and 286 without PVT.LASSO analysis revealed 13 variables as strongly associated with PVT occurrence.Multivariate logistic regression analysis revealed nine indicators as independent PVT risk factors,including etiology,ascites,gastroesophageal varices,platelet count,D-dimer,portal vein diameter,portal vein velocity,aspartate transaminase to neutrophil ratio index,and platelet-to-lymphocyte ratio.LASSO and correlation matrix plot results revealed no significant multicollinearity or correlation among the variables.A nomogram was constructed based on the screened independent risk factors.The nomogram had excellent predictive performance,with an area under the ROC curve of 0.821 and 0.829 in the training and testing groups,respectively.Calibr

关键词： Portal vein thrombosis Liver cirrhosis Nomogram Inflammatory markers Aspartate aminotransferase to neutrophil ratio index Platelet-to-lymphocyte ratio

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Population dynamics and protection strategies of Litsea coreana Levl.var.sinensis with Guizhou Province in China as an example

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Journal of Mountain Science 2023年第4期20卷 1090-1101页

作者： YUAN Gang-yi GUO Qi-qiang xie na ZHANG Ya-qin LUO Si-qiong GUI Qin YAO Shan Institute for Forest Resources and Environment of Guizhou College of ForestryGuizhou UniversityGuiyang550025China

Studying the dynamics of plant populations is crucial to the conservation and management of endangered plants.The diameter at breast height(DBH),tree height,crown width,and environmental factors of a total of 15 plots in five populations in Guizhou Province,China were measured in this study.The method of substituting diameter at breast height for age was used to divide the population into 7 age classes.The age structure,static life table,and relationship between the population characteristics and environmental factors of the Litsea coreana Levl.***.sinensis population were studied.Moreover,the time series model was used to predict the population dynamics.Results showed that the age structure of population in Zhengan County(Population ZA)had an inverted Jshape with abundant seedlings and insufficient middle-aged and elderly individuals.The age structures of populations in Daozhen County(Population DZ),Kaiyang County(KY),Meitan County(Population MT),and Xishui County(Population XS)were spindle-shaped with few young individuals and many middle-aged and elderly individuals.The mortality rate of each population fluctuated with the increase in age class,and the populations were extremely unstable.The survival curve was close to the Deevey III type,and the degree of deviation was related to the lack of young individuals.After the age stages II,IV,and VI,the number of aged plants in the different populations initially increased then decreased,and population stability was difficult to maintain.Redundancy analysis showed that the DBH,tree height and crown width of the population decreased with the increase of annual mean temperature,and the population density was restricted by soil nutrient conditions to a certain extent.The results of this work provide scientific basis for the conservation and sustainable utilization of natural populations of L.coreana var.sinensis in Guizhou Province,China.

关键词： Litsea coreana var.sinensis Age structure Survival curve Time series prediction Environmental factor

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习近平文化思想与中国艺术学自主知识体系建构

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艺术传播研究 2024年第2期 4-13页

作者：谢纳宋伟上海交通大学人文艺术研究院

习近平文化思想开辟了中国化时代化的马克思主义文化理论的崭新境界。作为新时代的重大理论创新成果,习近平文化思想对新时代中国艺术学自主知识体系建构提出了更高的要求。建构中国艺术学自主知识体系,已成为当代中国艺术学界的学术使... 详细信息

习近平文化思想开辟了中国化时代化的马克思主义文化理论的崭新境界。作为新时代的重大理论创新成果,习近平文化思想对新时代中国艺术学自主知识体系建构提出了更高的要求。建构中国艺术学自主知识体系,已成为当代中国艺术学界的学术使命和文化任务。从经典继承上看,马克思主义文化理论是历史唯物主义的重要组成部分,习近平文化思想坚持唯物史观的立场、观点与方法,继承、发展和丰富了马克思主义文化理论。从体系建构上看,马克思主义文化理论为当代艺术理论建构奠定了文化哲学基础,习近平文化思想为新时代中国艺术学自主知识体系建构提供了整体视域、理论指南和方法路径。

关键词：习近平文化思想马克思主义文化理论中国艺术学艺术文化学新时代学科建设

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A Studyof Political Discourse from the Perspective of CDA

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学术界 2016年第8期 304-311页

作者： xie na School of Foreign Languages Fuyang Normal University

Critical Discourse Analysis derives from traditional critical linguistics.It is a new language theory in western language study emerging between 1970 s and1980s.This theory aims to analyze the non-literary discourse from the angle of criticism.Starting from the definition of critical discourse analysis and political discourse,this papers describes the current development of critical analysis approach for political discourse,explores this critical analysis course,and anticipates the tendency of critical political discourse analysis in our country.

关键词：话语政治语言学发展趋势批判性

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耳部毛囊皮脂腺囊性错构瘤2例并文献复习

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临床皮肤科杂志 2024年第4期53卷 215-217页

作者：李影黄幼生解娜海南医学院第一附属医院病理科海南海口570102

报告2例耳部毛囊皮脂腺囊性错构瘤。2例患者均为先天性,皮损发生于耳部。例1.患者男,20岁。左耳前反复出现溢脓,伴瘙痒和疼痛近20年。皮肤科检查:左侧耳轮脚前方一瘘口,皮肤表面可见一约1cm破溃口,表面红肿。例2.患者女,31岁。出生后即... 详细信息

报告2例耳部毛囊皮脂腺囊性错构瘤。2例患者均为先天性,皮损发生于耳部。例1.患者男,20岁。左耳前反复出现溢脓,伴瘙痒和疼痛近20年。皮肤科检查:左侧耳轮脚前方一瘘口,皮肤表面可见一约1cm破溃口,表面红肿。例2.患者女,31岁。出生后即发现右耳郭后方肿物。皮肤科检查:右耳郭后方一隆起的2.0cm×1.2cm类圆形肿物,表面皮肤完整,质中,界清。2例患者皮损组织病理检查均表现为真皮内毛囊漏斗部扩张,毛囊周围皮脂腺呈结节状增生,毛囊及皮脂腺周围的胶原纤维增生、硬化;其中例1可见软骨成分及一些粗大的神经。2例患者均诊断为毛囊皮脂腺囊性错构瘤。

关键词：错构瘤囊性毛囊皮脂腺

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宁夏供港蔬菜田土壤重金属分布特征及生态风险评价

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环境科学 2024年第6期45卷 3512-3522页

作者：姬丽马琨谢铁娜陈林李虹贾彪宁夏大学农学院银川750021 宁夏大学生态环境学院银川750021 宁夏大学科学技术研究院银川750021 宁夏回族自治区农业环境保护监测站银川750002

农田土壤重金属污染会影响蔬菜作物的生长发育及产量,同时也会影响蔬菜的品质与口感,长期以来通过食物链传递和富集,最终对人体健康造成一定危害.因此为探明宁夏多年多茬种植供港蔬菜后其土壤重金属分布特征,预测其生态风险,分析其污染... 详细信息

农田土壤重金属污染会影响蔬菜作物的生长发育及产量,同时也会影响蔬菜的品质与口感,长期以来通过食物链传递和富集,最终对人体健康造成一定危害.因此为探明宁夏多年多茬种植供港蔬菜后其土壤重金属分布特征,预测其生态风险,分析其污染形成原因,于2019~2021年连续3 a采集了477个宁夏供港蔬菜田表层土壤样本,分析As、Cd、Cr、Hg、Pb、Cu、Zn和Ni这8种重金属含量和分布特征,采用单因子污染指数法、内梅罗综合污染指数法、地累积指数法和潜在生态风险指数法对宁夏供港蔬菜田土壤重金属污染状况进行评价,利用Pearson相关分析和主成分分析法解析了宁夏供港蔬菜田重金属来源.结果表明,宁夏供港蔬菜田土壤中As、Cd、Cr、Hg、Cu和Zn含量均值高于宁夏土壤背景值,但8种重金属含量均低于国内农用地土壤风险筛选值;在空间分布上,As、Cr和Ni在研究区西北部、中部以及南部出现连片高值区,Pb、Zn、Cd、Hg和Cu在研究区西北部与南部出现高值响应;单因子指数法和内梅罗综合污染指数法表明,宁夏供港蔬菜田土壤整体处于清洁水平;地累积指数法结果显示研究区污染以Hg和Cd污染为主,污染区域主要集中在研究区西北部和南部;潜在生态风险指数显示Hg和Cd为主要风险元素,其中Hg以中等、较强和很强生态风险为主,分别占比44.65%、44.65%和1.26%,Cd以中等、较强为主,占比65.83%和3.56%;综合Pearson相关分析和主成分分析表明,8种重金属污染来源可划分为3类,Ⅰ为自然源:Cu、Zn、Pb、As、Ni和Cr;Ⅱ为农业源:Cd;Ⅲ为工业源和农业源:Hg.综合来看,供港蔬菜田土壤重金属均无超标现象,土壤环境条件良好,宁夏供港蔬菜生产整体处于安全水平.研究结果可为宁夏供港菜田土壤安全利用和供港蔬菜安全生产、合理施肥、农艺运筹以及种植结构调整等提供帮助.

关键词：宁夏供港蔬菜土壤重金属空间分布生态风险评价来源解析

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Simulation and Analysis of Electromagnetic Force in Laser Melting Deposition by Electromagnetic Impact

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Transactions of nanjing University of Aeronautics and Astronautics 2018年第4期35卷 702-709页

作者： xie na Zhao Jianfeng xie Deqiao Sun Jie Tian Zongjun Shen Lida College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and Astronautics

Magnetic field was introduced in laser melting deposition to reduce the pores in workpieces.Finite 3-D model of the coil-deposition layer-substrate was established.Simulation results show that the electromagnetic force in deposition layer mainly concentrates in the projection area of the coil.Axial electromagnetic force shows repulsion in one cycle.The experimental results indicate that the magnetic field is beneficial for grain refinement,microhardness increasement and decline of quantities and average sizes of pores.

关键词： laser melting deposition(LMD) finite element method electromagnetic force coil microstructure

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语域视角下重大突发事件对外话语建构策略探究

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蚌埠学院学报 2024年第3期13卷 68-72页

作者：谢娜安徽建筑大学外国语学院安徽合肥230601

重大突发事件对外话语建构具有塑造形象、提升话语权和增强软实力的意义。梳理了国内外重大突发事件对外话语研究的现状,概述了当前重大突发事件面临的困境,以韩礼德的系统功能语言学中的语域理论为框架,强调重大突发事件对外话语建构... 详细信息

重大突发事件对外话语建构具有塑造形象、提升话语权和增强软实力的意义。梳理了国内外重大突发事件对外话语研究的现状,概述了当前重大突发事件面临的困境,以韩礼德的系统功能语言学中的语域理论为框架,强调重大突发事件对外话语建构应注重语域,整合重大突发事件对外话语传播内容;明确语场,提升重大突发事件对外话语主导权;厘清语旨,增强我国应对重大突发事件时的对外话语权。

关键词：语域重大突发事件对外话语策略

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