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Highly effective design of high GFA alloys with different metalbased and various components by machine learning

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Science China(Technological Sciences) 2024年第5期67卷 1431-1442页

作者： TANG YiChuan HE YiFan FAN ZhuoQun WANG ZhongQi TANG chengying Guangxi Key Laboratory for Informational Materials School of Materials Science and EngineeringGuilin University of Electronic TechnologyGuilin541004China

The glass-forming ability(GFA)is of great significance for the development of novel functional metal-based metallic *** this study,seven popular machine learning(ML)algorithms were employed to design novel M-based(M=Fe,Co,Ni,Ti,Zr,and rare earth metal(RE))and X-component(X=2,3,4,5,6,and>6)alloys with excellent GFA.A GFA containing 6957 data points with structural analysis was *** engineering was used to analyze the importance and correlation of *** algorithms were utilized for GFA prediction,revealing that Xtreme Gradient Boosting Trees exhibited the strongest predictive capability,achieving a high accuracy of 94.0%,a true positive rate of 97.6%,and a root mean squared error of 0.3705 across the entire ***,the GFA of ternary to hexahydroxy alloys based on Fe,Co,Ni,Zr,Ti,and Y was predicted using all possible compositions generated through ***,a series of alloys with good GFA was successfully designed and *** present work suggests that the proposed ML method can be utilized to design novel multiple-M-based amorphous alloys with high GFA.

关键词： machine learning amorphous alloy feature engineering materials design glass forming ability

Mapping multiple phases in curcumin binary solid dispersions by fluorescence contrasting

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Chinese Chemical Letters 2024年第9期35卷 266-272页

作者： Ying Xu chengying Shen Hailong Yuan Wei Wu Key Laboratory of Smart Drug Delivery of MOE School of PharmacyFudan UniversityShanghai 201203China Center for Medical Research and Innovation Shanghai Pudong HospitalFudan University Pudong Medical CenterShanghai 201399China Department of Pharmacy Air Force Medical CenterPLABeijing 100142China Jiangxi Provincial People’s Hospital The First Affiliated Hospital of Nanchang Medical CollegeNanchang 330006China

The microphases and miscibility in binary curcumin(Cur)solid dispersions(SDs)with amorphous polyvinylpyrrolidone K30(PVP K30)and semi-crystalline poloxamer(P407)and poly(ethylene glycol)6000(PEG6000)as carriers were investigated by fluorescence contrasting utilizing confocal laser scanning microscopy.A super sensitive fluorophore P4 with typical aggregation-caused quenching properties was employed to stain the continuous polymer phases and contrasted with the autofluorescence of the model drug *** addition,differential scanning calorimetry(DSC)and powder X-ray diffraction(PXRD)were utilized to assist in explanation of the fluorescence *** all three SD systems,there is always a homogenous polymer phase stained by P4 and it is difficult to adulterate Cur crystals by ***-enriched rather than polymer-enriched domains could be *** the Cur-PVP K30 system,Cur exists in an amorphous form at a Cur loading level of 50%and below,while Cur crystallines phase out and continuously grow with the increase of Cur loading from 60%to 90%.The phase behaviors in the Cur-P407 and Cur-PEG 6000 systems are similar but with minor *** both systems,Cur phases out as clusters of drug-enriched domains at a loading level of 20%and below,which however cannot be correlated with crystallization,as evidenced by both DSC and *** is a transition from an amorphous to a crystalline state from 20%to 30%Cur loading,above which Cur crystallines can be *** is interesting that a co-mix phase of both Cur-and PEG 6000-enriched domains can be identified at Cur loading levels of 10%and *** together,it is concluded that contrasting Cur autofluorescence with the signals of P4 proves to be a functional strategy to reveal multiple phases in the binary SD systems investigated.

关键词： Solid dispersion Curcumin PEG PVP Poloxamer Fluorescence Environment-responsive Confocal laser scanning microscopy

All-optical nanoscale thermometry with silicon carbide color centers

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Photonics Research 2024年第8期12卷 1696-1702页

作者： chengying LIU HAIBO HU ZHENGTONG LIU SHUMIN XIAO JUNFENG WANG YU ZHOU QINGHAI SONG Ministry of Industry and Information Technology Key Laboratory of Micro-Nano Optoelectronic Information System Guangdong Provincial Key Laboratory of Semiconductor Optoelectronic Materials and Intelligent Photonic SystemsHarbin Institute of TechnologyShenzhen 518055China Pengcheng Laboratory Shenzhen 518055China Quantum Science Center of Guangdong-Hong Kong-Macao Greater Bay Area Shenzhen-Hong Kong International Science and Technology ParkShenzhen 518045China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China College of Physics Sichuan UniversityChengdu 610065China

All-optical thermometry plays a crucial role in precision temperature measurement across diverse *** defects in solids are one of the most promising sensors due to their excellent sensitivity,stability,and ***,it faces limitations,such as the microwave heating effect and the complexity of spectral *** these challenges,we introduce a novel approach to nanoscale optical thermometry using quantum defects in silicon carbide(SiC),a material compatible with complementary metal-oxide-semiconductor(CMOS)*** method leverages the intensity ratio between anti-Stokes and Stokes emissions from SiC color centers,overcoming the drawbacks of traditional techniques such as optically detected magnetic resonance(ODMR)and zero-phonon line(ZPL)*** technique provides a real-time,highly sensitive(1.06%K^(-1)),and diffraction-limited temperature sensing protocol,which potentially helps enhance thermal management in the future miniaturization of electronic components.

关键词： carbide optical centers

ISOLATION AND CHARACTERIZATION OF BACTERIA FOR REMOVAL OF SULFUR IN ORGANIC COMPOUNDS

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化工学报 2000年第S1期51卷 272-275页

作者： Jiang chengying, xie Yuchun, Liu Huizhou and Chen Jiayong (Young Scientist Laboratory of Separation Science & Engineering, State Key Laboratory of Biochemical Engineering, Institute of Chemical Metallurgy, Chinese Academy of Sciences, Beijing 100080,)

Four bacterial strains have been isolated for their ability to growth on dibenzothiophene (DBT), dibenzothiophene sulfone (DBTO2). The results show that different bacteria strains oxidize the DBT to different products through different pathways. R-6 and R-16 metabolize DBT to DBTO2 and HBP; they are identified as species of Bacillus brevis and Bacillus sphaericus. For long time storage, R-9 identified as Nocardia globerula oxidizes DBT to DBT-sulfone (DBTO2) and benzenamine n-phenyl. The optimum temperature and pH for growth of R-16 are 32℃ and 7.02 respectively. The pH of broth decreases during the processes.

关键词： biodegradation biodesulfurization dibenzothiophene

The hydrophobic cluster on the surface of protein is the key structural basis for the SDS-resistance of chondroitinase VhChlABC

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Marine Life Science & Technology 2024年第1期6卷 93-101页

作者： Juanjuan Su Hao Wu chengying Yin Fengchao Zhang Feng Han Wengong Yu School of Medicine and Pharmacy Ocean University of ChinaQingdao 266003China Laboratory for Marine Drugs and Bioproducts Qingdao Marine Science and Technology CenterQingdao 266237China Key Laboratory of Marine Drugs Ministry of EducationQingdao 266003China Shandong Provincial Key Laboratory of Glycoscience and Glycoengineering Qingdao 266003China

The application of chondroitinase requires consideration of the complex microenvironment of the *** previous research reported a marine-derived sodium dodecyl sulfate(SDS)-resistant chondroitinase *** study further investigated the mechanism of VhChlABC resistance to *** on the hydrophobic cluster on its strong hydrophilic surface,it was found that the reduction of hydrophobicity of surface residues Ala181,Met182,Met183,Ala184,Val185,and Ile305 significantly reduced the SDS resistance and *** dynamics(MD)simulation and molecular docking analysis showed that I305G had more conformational flexibility around residue 305 than wild type(WT),which was more conducive to SDS insertion and *** affinity of A181G,M182A,M183A,V185A and I305G to SDS was significantly higher than that of *** conclusion,the surface hydrophobic microenvironment composed of six residues was the structural basis for SDS *** feature could prevent the binding of SDS and the destruction of hydrophobic packaging by increasing the rigid conformation of protein and reducing the binding force of *** study provides a new idea for the rational design of SDS-resistant proteins and may further promote chondroitinase research in the targeted therapy of lung diseases under the pressure of pulmonary surfactant.

关键词： Hydrophobic cluster Protein surface SDS-resistance Chondroitinase

RON confers lapatinib resistance in HER2-positive breast cancer cells

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RON confers lapatinib resistance in HER2-positive breast can...

In vivo flow cytometry reveals a circadian rhythm of circulating tumor cells

2013医学前沿论坛暨第十三届全国肿瘤药理与化疗学术会议

作者： Quanren Wang Haitian Quan Jie Zhao chengying xie Lei Wang Liguang Lou Shanghai Institute of Materia Medica Chinese Academy of Sciences

Lapatinib-resistance is a major problem for HER2-positive breast cancer treatment. SK-BR-3-LR,a lapatinib-resistant cell clone,was established from HER2-positive SK-BR-3 breast cancer cells following chronic exposure ... 详细信息

关键词： RON lapatinib resistance HER2 HER2-targeted agents

来源： cnki会议评论

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Light(Science & Applications) 2021年第6期10卷 1112-1121页

作者： Xi Zhu Yuanzhen Suo Yuting Fu Fuli Zhang Nan Ding Kai Pang chengying xie Xiaofu Weng Meilu Tian Hao He Xunbin Wei State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer InstituteMed-X Research Institute and School of Biomedical EngineeringShanghai Jiao Tong University200030 ShanghaiChina Biomedical Pioneering Innovation Center Peking University100871 BeijingChina School of Life Sciences Peking University100871 BeijingChina School of Instrument Science and Optoelectronics Engineering Beijing Information Science and Techno logy University100192 BeijingChina Biomedical Engineering Department Peking University100081 BeijingChina Key Laboratory of Carcinogenesis and Translatiorial Research(Ministry of Education/Beijing) Peking University Cancer Hospital and Institute100142 BeijingChina

Circulating tumor cells(CTCs)is an established biomarker of cancer *** circulation dynamics of CTCs are important for understanding the mechanisms underlying tumor cell *** studies have revealed that the circadian rhythm may disrupt the growth of tumors,it is generally unclear whether the circadian rhythm controls the release of *** clinical examinations,the current in vitro methods for detecting CTCs in blood samples are based on a fundamental assumption that CTC counts in the peripheral blood do not change significantly over time,which is being challenged by recent *** it is not practical to draw blood from patients repeatedly,a feasible strategy to investigate the circadian rhythm of CTCs is to monitor them by in vivo detection *** nee in vivo flow cytometry(IVFC)is a powerful optical technique that is able to detect fluoresce nt circulating cells directly in living animals in a noninvasive manner over a long period of *** this study,we applied fluorescence IVFC to monitor CTCs noninvasively in an orthotopic mouse model of human prostate *** observed that CTCs exhibited stochastic bursts over cancer *** probability of the bursting activity was higher at early stages than at late *** longitudinally monitored CTCs over a 24-h period,and our results revealed striking daily oscillations in CTC counts that peaked at the onset of the night(active phase for rodents),suggesting that the release of CTCs might be regulated by the circadian rhythm.

关键词： vivo flow release

Reply to Comment on “In vivo flow cytometry reveals a circadian rhythm of circulating tumor cells”

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Light(Science & Applications) 2021年第10期10卷 2000-2001页

作者： Xi Zhu Yuanzhen Suo Yuting Fu Fuli Zhang Nan Ding Kai Pang chengying xie Xiaofu Weng Meilu Tian Hao He Xunbin Wei State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer InstituteMed-X Research Institute and School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghai 200030China Biomedical Pioneering Innovation Center Peking UniversityBeijing 100871China School of Life Sciences Peking UniversityBeijing 100871China School of Instrument Science and Optoelectronics Engineering Beijing Information Science&Technology UniversityBeijing 100192China Biomedical Engineering Department Peking UniversityBeijing 100081China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Peking University Cancer Hospital&InstituteBeijing 100142China

Dear Editor,We thank Niedre et *** their correspondence regarding our recent *** proposed a point that the temporal distribution of circulating tumor cells(CTCs)monitored by diffuse in vivo flow cytometry in a multiple myeloma mouse model in their previous work2 might be different from our *** et *** that CTC detection statistics deviated from Poisson but did not found circadian variations in CTC numbers in a multiple myeloma mouse *** also cite another literature by *** al.3,in which the authors reported that CTC numbers did not always correlate with tumor size during cancer ***,by establishing an orthotopic mouse model of prostate cancer and utilizing the technology in vivo flow cytometry(IVFC),we found CTCs exhibited bursting activity and daily oscillation in an orthotopic model of prostate cancer.

关键词： al. vivo flow

Actin-depolymerizing factors 8 and 11 promote root hair elongation at high pH

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Plant Communications 2024年第3期5卷 232-247页

作者： Dong Qian Tian Li Chen Zheng Yue Niu Yingzhi Niu chengying Li Muxuan Wang Yang Yang Lizhe An Yun Xiang Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations School of Life SciencesLanzhou UniversityLanzhou 730000China These authors contributed equally to this article

A root hair is a polarly elongated single-celled structure that derives from a root epidermal cell and func-tions in uptake of water and nutrients from the surrounding *** reports have demon-strated that short periods of high pH inhibit root hair extension;but the effects of long-term high-pH treat-ment on root hair growth are still ***,we report that the duration of root hair elongation is signicantly prolonged with increasing external pH,which counteracts the effect of decreasing root hair elongation rate and ultimately produces longer root hairs,whereas loss of actin-depolymerizing factor 8 and 11(ADF8/11)function causes shortening of root hair length at high pH(pH 7.4).Accumulation of ADF8/11 at the tips of root hairs is inhibited by high pH,and increasing environmental pH affects the actinlament(F-actin)meshwork at the root hair *** high pH,the tip-focused F-actin meshwork is absent in root hairs of the adf8/11 mutant,actinlaments are disordered at the adf8/11 root hair tips,and actin turn-over is *** and recycling vesicles do not aggregate in the apical region of adf8/11 root hairs at high ***,our results suggest that,under long-term exposure to high extracellular pH,ADF8/11 may establish and maintain the tip-focused F-actin meshwork to regulate polar trafcking of secretory/recycling vesicles at the root hair tips,thereby promoting root hair elongation.

关键词： pH ADF actin Rab GTPase vesicle root hair