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Tumor size as a prognostic factor in patients with advanced gastric cancer in the lower third of the stomach

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World Journal of Gastroenterology 2012年第38期18卷 5470-5475页

作者： Hong-Mei Wang, Chang-Ming Huang, Chao-Hui Zheng, Ping Li, Jian-Wei xie, Jia-Bin Wang, Jian-Xian Lin, Jun Lu, Department of Gastric Surgery, Affiliated Union Hospital of Fujian Medical University, Fuzhou 350001, Fujian Province, China Author contributions: Wang HM and Huang CM conceived of the study, analyzed the data, and drafted the manuscript Zheng CH, Li P and xie jw helped revise the manuscript critically for important intellectual content Wang JB, Lin JX and Lu J helped collect data and design the study and all authors read and approved the final manuscript. Department of Gastric Surgery Affiliated Union Hospital of Fujian Medical University Fuzhou 350001 Fujian Province China.

AIM: To explore the impact of tumor size on outcomes in patients with advanced gastric cancer in the lower third of the stomach. METHODS: We retrospectively analyzed the clinical records of 430 patients with advanced gastric cancer in the lower third of the stomach who underwent distal subtotal gastrectomy and D2 lymphadenectomy in our hospital from January 1998 to June 2004. Receiver-operating characteristic (ROC) curve analysis was used to determine the appropriate cutoff value for tumor size, which was measured as maximum tumor diameter. Based on this cutoff value, patients were divided into two groups: those with large-sized tumors (LSTs) and those with small-sized tumors (SSTs). The correlations between other clinicopathologic factors and tumor size were investigated, and the 5-year overall survival (OS) rate was compared between the two groups. Potential prognostic factors were evaluated by univariate KaplanMeier survival analysis and multivariate Cox's propor-tional hazard model analysis. The 5-year OS rates in the two groups were compared according to pT stage and pN stage. RESULTS: The 5-year OS rate in the 430 patients with advanced gastric cancer in the lower third of the stomach was 53.7%. The mean ± SD tumor size was 4.9 ± 1.9 cm, and the median tumor size was 5.0 cm. ROC analysis indicated that the sensitivity and specificity results for the appropriate tumor size cutoff value of 4.8 cm were 80.0% and 68.2%, respectively (AUC=0.795, 95%CI: 0.751-0.839, P=0.000). Using this cutoff value, 222 patients (51.6%) had LSTs (tumor size ≥ 4.8 cm) and 208 (48.4%) had SSTs (tumor size<4.8 cm). Tumor size was significantly correlated with histological type (P=0.039), Borrmann type (P=0.000), depth of tumor invasion (P=0.000), lymph node metastasis (P=0.000), tumor-nodes metastasis stage (P=0.000), mean number of metastatic lymph nodes (P=0.000) and metastatic lymph node ratio (P=0.000). Patients with LSTs had a significantly lower 5-year OS rate than those with SS

关键词： Gastric carcinoma Prognosis Receiver operating characteristic curve The lower third of stomach Tumor size

Perilipin-2 mediates ferroptosis in oligodendrocyte progenitor cells and myelin injury after ischemic stroke

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Neural Regeneration Research 2025年第7期20卷 2015-2028页

作者： Jian Yang Jiang Wu Xueshun xie Pengfei Xia Jinxin Lu Jiale Liu Lei Bai Xiang Li Zhengquan Yu Haiying Li Department of Neurosurgery&Brain and Nerve Research Laboratory The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Stroke Research Soochow UniversitySuzhouJiangsu ProvinceChina

Differentiation of oligodendrocyte progenitor cells into mature myelin-forming oligodendrocytes contributes to *** of remyelination due to oligodendrocyte progenitor cell death can result in severe nerve *** is an iron-dependent form of regulated cell death caused by membrane rupture induced by lipid peroxidation,and plays an important role in the pathological process of ischemic ***,there are few studies on oligodendrocyte progenitor cell *** analyzed transcriptome sequencing data from GEO databases and identified a role of ferroptosis in oligodendrocyte progenitor cell death and myelin injury after cerebral *** analysis suggested that perilipin-2(PLIN2)was involved in oligodendrocyte progenitor cell ***2 is a lipid storage protein and a marker of hypoxia-sensitive lipid droplet *** further investigation,we established a mouse model of cerebral ischemia/*** found significant myelin damage after cerebral ischemia,as well as oligodendrocyte progenitor cell death and increased lipid peroxidation levels around the infarct *** ferroptosis inhibitor,ferrostatin-1,rescued oligodendrocyte progenitor cell death and subsequent myelin *** also found increased PLIN2 levels in the peri-infarct area that co-localized with oligodendrocyte progenitor ***2 knockdown rescued demyelination and improved neurological *** findings suggest that targeting PLIN2 to regulate oligodendrocyte progenitor cell ferroptosis may be a potential therapeutic strategy for rescuing myelin damage after cerebral ischemia.

关键词： bioinformatics bulk RNA sequencing ferroptosis ischemic stroke myelin injury oligodendrocyte progenitor cell perilipin-2 single-cell RNA sequencing

Portal vein embolization by fine needle ethanol injection :experimental and clinicalstudies

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World Journal of Gastroenterology 1999年第6期5卷 506-510页

作者： Lu MD Chen jw xie XY Liang LJ Huang JF Sun Yat Sen Univ Med Sci Affiliated Hosp 1 Dept Hepatobiliary Surg Guangzhou 510080 Guangdong Prov Peoples R China

AIM To improve the technique of intraportal embolization (PVE) therapy, a new embolic method, was devised and the safety, effectiveness and feasibility were evaluated. METHODS PVE with intraportal ethanol injection via a fine needle was performed in 28 normal dogs, 22 SD rats, and 24 cirrhotic SD rats. After PVE, portography, histological and functional alteration of the liver were evaluated in dogs and rats, and the changes in portal hemodynamics as well as hepatic anatomy were observed in rats. In the clinical study, PVE by ethanol injection was performed in 61 patients with hepatocellular carcinoma under the guidance of portoechography with intraportal injection of CO 2. The effect of PVE was evaluated by ultrasonography and laparotomy. RESULTS The effectiveness and toxicity were dependent on the dose of ethanol. In the dogs, 0 25*!mg/*!kg of ethanol caused incomplete embolization with least liver damage, while 1 0*!mg/*!kg induced complete embolization with a high mortality of 57 1% (4/*!7) due to respiratory arrest. The dose of 0 5*!mg/*!kg resulted in complete embolization with slight toxicity to the liver. In the rats, the survival rate was 100% in normal group but 40 9% in cirrhotic models after ethanol injection by dose of 0 05*!mg/*!100*!g . PVE for cirrhotic rats with 0 03*!mg/*!100*!g of ethanol induced satisfactory embolization with significant hypertrophy in nonembolized lobes, and only slight damage to the hepatic parenchyma, and transient alteration in liver function, portal pressure and portal flow. In the clinical study, 12 cases with reverse portal flow were excluded judged by portoechography. Satisfactory embolization was gained in 90 2% (55/*!61) of the remaining patients determined by ultrasonography and surgery. All cases ran an uneventful postembolization course with no aberrant embolization. CONCLUSION PVE with intraportal ethanol injection of appropriate dosage via a fine needle is safe and effective and has several advantages comparing wit

关键词： liver neoplasms/therapy portal vein embolization enthanol injection carcinoma, hepatocellular/therapy

Characterization of Oxygen Species on MgO(100) Surface by XPS andSRPES

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Chinese Chemical Letters 1996年第11期7卷 1059-1060页

作者： Da, jw Shen, SK QILU PETROCHEM CO RES INSTZIBO SHANDONG 245400PEOPLES R CHINA

The present work reported the results of the characterization of the surface oxygen species on single crystal MgO(100) using surface sensitive analyzing methods ARXPS(angular resolved X-ray photoelectron spectroscopy)... 详细信息

关键词： XPS Characterization of Oxygen Species on MgO Surface by XPS andSRPES

Numerical Simulation of Thermal Stress of Shaped Casting Based on Rheological Model

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Journal of Materials Science & Technology 1999年第3期15卷 267-270页

作者： Kang, jw Liu, BC Xiong, SM Tsing Hua Univ Dept Mech Engn Beijing 100084 Peoples R China

In order to study the thermal stresses at the mushy zone, a three dimensional rheological model [H]-[H\N]-[N\S] including elastic, visco-elastic and visco-plastic elements was established, its algorithm and codes for finite element method were also developed. A FDM/FEM integrated analysis system of thermal stresses was built based on the integration of this procedure with thermal analysis by finite difference method. A steel sample casting with a hot spot was simulated in order to validate this system, and the calculated and experimental results were in good agreement.

关键词： Alloys

jw-1-283 inhibits melanoma tumor growth via stabilization of the p53 pathway

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Genes & Diseases 2024年第3期11卷 18-21页

作者： Yang xie Ruida Hou Kelli LHartman Jianxiong Jiang Zhongzhi Wu Wei Li Drug Discovery Center College of PharmacyUniversity of Tennessee Health Science CenterMemphisTN38163USA

Melanoma is a lethal skin malignancy and the fifth most diagnosed cancer in the United States.1 Currently,for unresectable melanoma,the recommended treatment options include checkpoint inhibitor immunotherapy targeting programmed cell death 1(PD-1),and inhibitors targeting the mitogen-activated protein kinase(MAPK)***,the response rate may vary among the patients,and therefore demanding the development of novel treatment *** suppressor TP53has been suggested as one of the critical regulators mediating the aggressiveness and progression of melanoma.

关键词： melanoma suppressor death

CATALYTIC　PROPERTIES　AND　SURFACE　STRUCTURE　OF　MgO　PREPARED　FROM　VARIOUS　PRECURSORS

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Chinese Chemical Letters 1995年第7期6卷 613-616页

作者： Da, jw Shen, SK Chinese Acad Sci Lanzhou Inst Chem Phys State Key Lab Oxo Synth & Select Oxidat Lanzhou 730000 Peoples R China

The calalytic perfomlances and surface surface of MgO prepared from different precursors were studied using cataytic test and pulse reaction techniques It was indicated that the MgO prepared from Ma(OH)24MgCO36H2O pretreated with distilled water exhibited the highest activity foe the oxidative coupling of methane. High lattice oxygen mobility and strong surface basicity may favor the OCM reaction.

关键词： MgO OF PREPARED STRUCTURE CATALYTIC AND

Hyaluronan Promotes Tumor Lymphangiogenesis and Intralymphantic Tumor Growth in Xenografts

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Acta Biochimica et Biophysica Sinica 2005年第9期37卷 601-606页

作者： Li-Xia GUO Ke ZOU Ji-Hang jw Hong xie Laboratory of Biotherapy,Institute of Biochemistry and Cell Biology,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Graduate School of the Chinese Academy of Sciences,Shanghai 200031,China Laboratory of Biotherapy Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Graduate School of the Chinese Academy of SciencesShanghai 200031 China

Hyaluronan (HA),a high molecular weight glycosaminoglycan in the extracellular matrix,hasbeen implicated in the promotion of malignant phenotypes,including tumor ***,little isknown about the effect of HA on tumor-associated *** this study,mouse hepatocellularcarcinoma Hca-F cells combined with or without HA were injected subcutaneously into C3H/Hej mice,thenangiogenesis and lymphangiogenesis of implanted tumors were examined by immunostaining for platelet-endothelial cell adhesion molecule-1 and lymphatic vascular endothelial hyaluronan receptor-1 ***,we found HA promotes tumor lymphangiogenesis and the occurrence of intratumoral lymphaticvessels,but has little effect on tumor ***,HA also promotes intralymphatic tumorgrowth,although it is not sufficient to potentiate lymphatic *** results suggest that HA,which is elevated in most malignant tumor stroma,may also play a role in tumor progression by promotinglymphangiogenesis.

关键词： hyaluronan tumor lymphangiogenesis intralymphatic tumor growth

Powder Microelectrodes Applied to NO_2 Detection

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Chinese Chemical Letters 1999年第1期10卷 47-50页

作者： Yan, jw Lu, JT Liu, PF Wuhan Univ Dept Chem Wuhan 430072 Peoples R China

The reduction of nitrite at Au or carbon electrode in-H_2SO_4 was found to follow achemical-electrochemical (CE) mechanism with a very thin (4×10(-8)cm) preceding reaction *** was proposed and experimentally verified that for such kind of electrode processes the totalreaction the could be effectively enhanced by using electrodes with increased true surface *** as porous electrodes. As a combination of porous electrode and microelectrode, the powdermicroclectrode shows excellent performance for nitrite detection.

关键词： Nitrite reduction microelectrode CE mechanism