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Interventricular Septal Hematoma after Congenital Cardiac Defects Repair at a Single Institution

Congenital Heart Disease 2022年第6期17卷 687-695页

作者： Yuan Hu Xiaohui Yang Jie Dong Peng Huang Jinwen Luo Guangxian Yang James D.StLouis xicheng deng Department of Echocardiography and Ultrasound Hunan Children’s HospitalChangshaChina Heart Center Hunan Children’s HospitalChangshaChina Pediatrics Research Institute of Hunan Province Hunan Children’s HospitalChangshaChina Departments of Surgery and Pediatrics Children’s Hospital of GeorgiaAugusta UniversityAugustaGeorgiaUSA

Background: Interventricular septal hematoma is a rare complication after congenital cardiac repair. The managementvaries according to the literature. We present our experience with this rare complication. Methods:Echocardiography database were reviewed with the term ‘‘hematoma’’ or “hypoechoic mass” for patients whounderwent congenital heart surgery from January 2018 to December 2021 at our institution to identify potentialinterventricular septal hematoma cases. Relevant data of the patients identified were collected. Focus was put onthe presentation, management, outcomes according to patent medical charts and serial echocardiographic reportdata. Results: In total, there were 5 patients included. The mean age and weight at surgery were 5.5 ± 3.6 monthsand 5.5 ± 1.4 kg, respectively. Four patients were diagnosed with ventricular septal defect and the other one beingdouble outlet of the right ventricle. While all patients had intraoperative transesophageal echocardiography, 80%(4 of 5) of Interventricular septal hematoma were revealed intraoperatively. Only one patient received hematomadrainage intraoperatively while the other 3 identified in the operating room were only closely observed. One afterventricular septal defect repair presented continuous dysfunction of the left ventricle at the last follow-up, whilethe others were doing well. All hematomas resolved completely with a mean time to interventricular septal hematomaresolution of 35.8 ± 16.9 days. Conclusion: Infants seem to be at a higher risk for Interventricular septalhematoma following congenital heart surgery. While the majority of interventricular septal hematoma has abenign postoperative course, some may result in ventricular dysfunction. Management strategies may be chosenon a case-by-case basis.

关键词： Interventricular septal hematoma ventricular septal defect double outlet right ventricle transesophageal echocardiography high-pressure waterjet

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In situ plasmonic & electrochemical fiber-optic sensor for multi-metal-ions detection

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Science China(Information Sciences) 2024年第1期67卷 292-302页

作者： Xiaoling PENG Zhiyong YANG Bo PENG Zhi LI Zhicong REN xicheng WANG Jiahai LI Zhencheng LI Liang CHEN Daotong YOU Kaiwei LI Jianqing LI Tuan GUO Institute of Photonics Technology Jinan University School of Computer Science and Engineering Macau University of Science and Technology Institute for Environmental and Climate Research Jinan University Key Laboratory of Bionic Engineering of Ministry of Education Jilin University

High precision and high throughput detection of heavy metal ions is essential for water quality monitoring and ***,we propose a plasmonic & electrochemical dual-mode fiber sensing probe for label-free and real-time detection of multiple ions(Pb2+and Cu2+as examples).This sensor comprises a multimode fiber-single mode fiber reflection probe,the outer surface of which is coated with a gold nanofilm to excite the surface plasmon resonance(SPR) optically and simultaneously serves as an electrochemical working *** traditional electrochemical detection,the enrichment of ions cannot be detected in ***,by utilizing the plasmonic & electrochemical dual-mode detection method,various kinds of metal ions can be deposited onto the gold nanofilm and selectively oxidized during forward potential scanning,and the entire electrochemical process can be monitored by SPR *** experimentally demonstrate that the sensor can simultaneously detect Pb2+and Cu2+in a mixed solution in real-time,providing a linear response over the ion concentration range from 10-12to 10-7M and offering an excellent detection limit(1.69×10-14–5.49×10-13M).The proposed dual-mode fiber sensor has the benefits of remote sensing,compact footprint,and cost-effectiveness and shows excellent potential for water quality risk management in difficult-to-reach environments.

关键词： optical fiber sensor surface plasmon resonance electrochemical measurement ions detection water pollution

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Helicobacter pylori and immunotherapy for gastrointestinal cancer

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The Innovation 2024年第2期5卷 51-60页

作者： Keren Jia Yang Chen Yi Xie xicheng Wang Yajie Hu Yu Sun Yanshuo Cao Liyan Zhang Yakun Wang Zhenghang Wang Zhihao Lu Jian Li Xiaotian Zhang Lin Shen Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Gastrointestinal OncologyPeking University Cancer Hospital&InstituteBeijing 100142China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of PathologyPeking University Cancer Hospital&InstituteBeijing 100142China

Helicobacter pylori infection is associated with the risk of gastrointestinal(GI)cancers;however,its impact on immunotherapy for GI cancers remains *** this study,we included 10,122 patients who underwent ^(13)C-urea breath *** 636 patients with Epstein-Barr virus–negative microsatellite-stable gastric cancer(GC)who were treated with anti-PD-1/PD-L1 therapy,***–positive patients exhibited significantly longer immune-related progression-free survival(irPFS)compared with ***–negative patients(6.97 months versus 5.03 months,p<0.001,hazard ratio[HR]0.76,95%confidence interval[CI]0.62–0.95,p=0.015).Moreover,the ***–positive group demonstrated a trend of 4 months longer median immune-related overall survival(irOS)than the ***–negative ***–positive GC displayed higher densities of PD-L1+cells and nonexhausted CD8+T cells,indicative of a“hot”tumor *** analysis revealed that ***–positive GC shared molecular characteristics similar to those of immunotherapy-sensitive ***,***–positive patients with DNA mismatch repair–deficient(dMMR)/microsatellite instability–high(MSI-H)colorectal adenocarcinoma and esophageal squamous cell carcinoma(ESCC)had shorter irPFS compared with ***–negative patients(16.13 months versus not reached,p=0.042,HR 2.26,95%CI 1.13–4.50,p=0.021 and 5.57 months versus 6.97 months,p=0.029,HR 1.59,95%CI 1.14–2.23,p=0.006,respectively).The difference in irOS between ***–positive and–negative patients had the same trend as that between dMMR/MSI-H colorectal adenocarcinoma and ESCC *** also identified a trend of shorter irPFS and irOS in ***–positive liver cancer and pancreatic cancer *** summary,our findings supported that *** infection is a beneficial factor for GC immunotherapy by shaping hot tumor ***,in dMMR/MSI-H colorectal adenocarcinoma and ESCC patients,*** adversely affects the efficacy of immunothera

关键词： immunotherapy gastrointestinal pylori

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玻璃生产线碎玻璃粉尘处理现状及优化

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玻璃与搪瓷 2019年第4期47卷 32-38页

作者：邓析成苏莉珊许靖琨中国建材国际工程集团有限公司

梳理了玻璃生产线碎玻璃系统粉尘处理的现状和出现的问题,根据设计和实践中的经验,提出一些改进措施和方向,为大家提供一些设计思路,以期根据不同生产线情况采取合理措施,减少碎玻璃系统粉尘对生产线的影响,提高玻璃产品质量。

关键词：玻璃生产线碎玻璃系统收尘系统

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儿童先天性漏斗胸合并先天性心脏病的同期手术治疗策略探讨

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中华小儿外科杂志 2020年第2期41卷 150-155页

作者：阳广贤易立文向金星王敬华邓喜成湖南省儿童医院心胸外科长沙410007 湖南省儿童医院心血管内科长沙410007

目的探讨儿童先天性心脏病(congenital heart disease,CHD)合并漏斗胸最佳的治疗策略。方法回顾性分析2007年7月到2018年5月间于湖南省儿童医院住院治疗的17例先天性CHD合并漏斗胸患儿的资料,男10例,女7例,年龄(4.5±2.7)岁,年龄范围1~1... 详细信息

目的探讨儿童先天性心脏病(congenital heart disease,CHD)合并漏斗胸最佳的治疗策略。方法回顾性分析2007年7月到2018年5月间于湖南省儿童医院住院治疗的17例先天性CHD合并漏斗胸患儿的资料,男10例,女7例,年龄(4.5±2.7)岁,年龄范围1~12.7岁,体重(14.5±5.2)kg,体重范围7.5~27.5 kg。其中单纯室间隔缺损4例,单纯房间隔缺损8例,室间隔缺损合并房间隔缺损3例,室间隔缺损合并房间隔缺损、动脉导管未闭1例,室间隔缺损合并肺动脉高压1例。根据年龄及漏斗胸程度,分别接受游离提拉胸骨、自制胸骨抬举装置、NUSS钢板的治疗,CHD分别接受体外循环下心内直视手术(经胸骨正中切口或右腋下直切口)或经皮及经心导管封堵治疗。结果17例患儿均接受同期手术矫治,心内畸形矫治及漏斗胸均矫治成功,住院时间(13.2±4.8)d,住院时间范围为(8~25)d。有2例切口延期愈合,1例术后左侧少量胸腔积液,无手术死亡、大出血及胸腔脏器损伤、排异反应等并发症。结论依据患儿的特点,选择个体化的方案予以同期矫治儿童CHD合并漏斗胸,可避免多次手术、麻醉的风险,安全有效。

关键词：漏斗胸心脏病,先天性儿童

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巨大甲状舌管囊肿合并慢性阻塞性肺疾病致呼吸困难1例

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中华耳鼻咽喉头颈外科杂志 2024年第6期59卷 633-635页

作者：宋昊柳忠禄宋西成滨州医学院第二临床医学院烟台264000 青岛大学附属烟台毓璜顶医院耳鼻咽喉头颈外科烟台264000 山东省耳鼻喉疾病临床医学研究中心烟台264000 烟台市耳鼻喉疾病重点实验室烟台264000

本文报道1例烟台毓璜顶医院经手术成功解除巨大甲状舌管囊肿合并慢性阻塞性肺疾病致呼吸困难患者的诊治过程。术中见患者左侧甲状软骨板受压变形且部分吸收,肿物突入喉前庭、会厌前间隙,完整切除肿物及所连部分舌骨,同期行气管切开术。... 详细信息

本文报道1例烟台毓璜顶医院经手术成功解除巨大甲状舌管囊肿合并慢性阻塞性肺疾病致呼吸困难患者的诊治过程。术中见患者左侧甲状软骨板受压变形且部分吸收,肿物突入喉前庭、会厌前间隙,完整切除肿物及所连部分舌骨,同期行气管切开术。患者术后恢复好,随访2年未见呼吸困难复发。

关键词：甲状舌管囊肿烟台毓璜顶医院呼吸困难患者喉前庭受压变形合并慢性阻塞性肺疾病完整切除诊治过程

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先天性漏斗胸合并先天性心胸疾病的同期手术治疗

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中南大学学报（医学版） 2019年第12期44卷 1385-1390页

作者：阳广贤王敬华邓喜成易立文黄鹏杨一峰湖南省儿童医院心胸外科长沙410007 中南大学湘雅二医院心血管外科长沙410011

目的:研究先天性漏斗胸(pectus excavatum,PE)合并先天性心胸疾病患儿同期手术治疗的方法及原则。方法:回顾性分析2007年1月至2018年9月于湖南省儿童医院住院治疗的27例先天性PE合并先天性心胸疾病患儿的资料,分为PE合并先天性心脏病(co... 详细信息

目的:研究先天性漏斗胸(pectus excavatum,PE)合并先天性心胸疾病患儿同期手术治疗的方法及原则。方法:回顾性分析2007年1月至2018年9月于湖南省儿童医院住院治疗的27例先天性PE合并先天性心胸疾病患儿的资料,分为PE合并先天性心脏病(congenital heart disease,CHD)组(n=17)及PE合并胸科疾病组(n=10)。PE合并CHD组中,PE接受自制胸骨抬举装置及Nuss手术矫治,CHD分别接受体外循环下心内直视手术(经胸骨正中切口或右腋下直切口)或经皮及经心导管封堵治疗;PE合并胸科疾病组接受同期胸部手术矫治+Nuss手术。结果:27例患儿均接受同期手术矫治。PE合并CHD组住院时间为8.0~25.0(13.2±4.8) d,2例并发切口延期愈合,1例术后左侧少量胸腔积液;PE合并胸科疾病组住院时间为10.0~34.0(19.9±7.5) d,1例并发乳糜胸,2例胸腔积液。两组患者心胸疾病及PE矫治均满意,无手术死亡、大出血及胸腔脏器损伤、排异反应等并发症。结论:依据病人的特点选择个体化的方案予以同期矫治儿童PE合并心胸疾病,可避免多次手术和麻醉风险,安全有效,同时可减少家属的经济负担。

关键词：漏斗胸先天性心胸疾病同期修复 Nuss手术

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Molecular features of gastroenteropancreatic neuroendocrine carcinoma: A comparative analysis with lung neuroendocrine carcinoma and digestive adenocarcinomas

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Chinese Journal of Cancer Research 2024年第1期36卷 90-102页

作者： Jianwei Zhang Hanxiao Chen Junli Zhang Sha Wang Yanfang Guan Wenguang Gu Jie Li Xiaotian Zhang Jian Li xicheng Wang Zhihao Lu Jun Zhou Zhi Peng Yu Sun Yang Shao Lin Shen Minglei Zhuo Ming Lu Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Gastrointestinal OncologyPeking University Cancer Hospital&InstituteBeijing 100142China Department of Radiation Therapy National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital&Shenzhen HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeShenzhen 518172China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department I of Thoracic OncologyPeking University Cancer Hospital&InstituteBeijing 100142China Medical Department Nanjing Geneseeq Technology Inc.Nanjing 210061China Geneplus-Beijing Beijing 102200China State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers Beijing Key Laboratory of Carcinogenesis and Translational ResearchDepartment of Gastrointestinal OncologyPeking University Cancer Hospital&InstituteBeijing 100142China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of PathologyPeking University Cancer Hospital&InstituteBeijing 100142China

Objective: There is an ongoing debate about whether the management of gastroenteropancreatic(GEP)neuroendocrine carcinoma(NEC) should follow the guidelines of small-cell lung cancer(SCLC). We aim to identify the genetic differences of GEPNEC and its ***: We recruited GEPNEC patients as the main cohort, with lung NEC and digestive adenocarcinomas as comparative cohorts. All patients undergone next-generation sequencing(NGS). Different gene alterations were compared and analyzed between GEPNEC and lung NEC(LNEC), GEPNEC and adenocarcinoma to yield the remarkable ***: We recruited 257 patients, including 99 GEPNEC, 57 LNEC, and 101 digestive *** the mutations, KRAS, RB1, TERT, IL7R, and CTNNB1 were found to have different gene alterations between GEPNEC and LNEC samples. Specific genes for each site were revealed: gastric NEC(TERT amplification),colorectal NEC(KRAS mutation), and bile tract NEC(ARID1A mutation). The gene disparities between small-cell NEC(SCNEC) and large-cell NEC(LCNEC) were KEAP1 and CDH1. Digestive adenocarcinoma was also compared with GEPNEC and suggested RB1, APC, and KRAS as significant genes. The TP53/RB1 mutation pattern was associated with first-line effectiveness. Putative targetable genes and biomarkers in GEPNEC were identified in22.2% of the patients, and they had longer progression-free survival(PFS) upon targetable treatment [12.5 months vs. 3.0 months, HR=0.40(0.21-0.75), P=0.006].Conclusions: This work demonstrated striking gene distinctions in GEPNEC compared with LNEC and adenocarcinoma and their clinical utility.

关键词： Neuroendocrine carcinoma gastroenteropancreatic lung genetic alterations molecular markers

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学术短评:两项关于胆道闭锁的实践与技术

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临床小儿外科杂志 2020年第9期19卷 856-857页

作者： Patrick Chung Paul Tam 邓喜成(翻译) 香港大学李嘉诚医学院玛丽医院外科香港特别行政区810000 湖南省儿童医院湖南省长沙市410007

2019年第12期的《Journal of Pediatric Surgery》刊登了两项来自日本的相关胆道闭锁诊治的临床研究[1,2]。其中一项主题是“肝穿刺活检有可能延迟葛西肝门肠吻合术的实施,在腹腔镜技术时代用其诊断胆道闭锁已经过时”;另一项的主题是... 详细信息

2019年第12期的《Journal of Pediatric Surgery》刊登了两项来自日本的相关胆道闭锁诊治的临床研究[1,2]。其中一项主题是“肝穿刺活检有可能延迟葛西肝门肠吻合术的实施,在腹腔镜技术时代用其诊断胆道闭锁已经过时”;另一项的主题是“胆道闭锁手术中使用近红外荧光胆管造影结合吲哚菁绿实时评估胆道流量的结果”。

关键词：胆道闭锁吲哚菁绿肝穿刺活检腹腔镜技术胆管造影 Surgery 肝门肠吻合术近红外荧光

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上转换发光纳米材料对钙钛矿太阳能电池迟滞效应和离子迁移动力学的影响

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无机材料学报 2024年第4期39卷 359-366,I0001,I0002页

作者：于嫚高荣耀秦玉军艾希成西安航空学院材料工程学院西安710077 中国人民大学化学系北京100872

迟滞效应是影响钙钛矿太阳能电池性能和稳定性的重要问题,离子迁移和由此产生的界面离子积累是引起迟滞效应最重要的原因之一。本研究采用上转换发光纳米材料(Upconversion Luminescent Nanoparticles,UCNP)修饰电子传输层/钙钛矿活性... 详细信息

迟滞效应是影响钙钛矿太阳能电池性能和稳定性的重要问题,离子迁移和由此产生的界面离子积累是引起迟滞效应最重要的原因之一。本研究采用上转换发光纳米材料(Upconversion Luminescent Nanoparticles,UCNP)修饰电子传输层/钙钛矿活性层的界面及本征钙钛矿活性层,系统探究了UCNP对钙钛矿的形貌、结构、光谱/光电性能和离子迁移动力学的影响。结果表明:钙钛矿活性层经过UCNP修饰后器件的光电转换效率(Power Conversion Efficiency,PCE)最佳(16.27%),而且迟滞因子(Hysteresis Factor,HF)得到显著改善(0.05)。进一步采用回路切换瞬态光电技术系统探究了钙钛矿太阳能电池不受光生载流子干扰的离子迁移动力学过程,证明UCNP在光电转换过程中起到抑制离子累积和迁移的双重作用:一方面UCNP可以形成阻隔层,阻碍离子累积;另一方面,UCNP可以在退火过程中进入到钙钛矿体相晶界处,阻碍离子迁移,使恢复电压从0.43 V降低到0.28 V。极化诱导缺陷态模型解释了离子-载流子相互作用机制,阐释了UCNP抑制钙钛矿光伏器件迟滞效应的机理。本研究可以为调控钙钛矿太阳能电池迟滞提供一种有效的解决方案。

关键词：上转换发光纳米材料钙钛矿太阳能电池迟滞效应离子迁移

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