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neural Regeneration Research 2025年第8期20卷 2264-2278页

作者： You Wu Lijie Yang Wanrong Jiang Xinyuan Zhang Zhaohui yao Department of Geriatrics Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Alzheimer's disease poses a significant global health challenge owing to the progressive cognitive decline of patients and absence of curative *** current therapeutic strategies,primarily based on cholinesterase inhibitors and n-methyl-Daspartate receptor antagonists,offer limited symptomatic relief without halting disease progression,highlighting an urgent need for novel research directions that address the key mechanisms underlying Alzheimer's *** studies have provided insights into the critical role of glycolysis,a fundamental energy metabolism pathway in the brain,in the pathogenesis of Alzheimer's *** in glycolytic processes within neurons and glial cells,including microglia,astrocytes,and oligodendrocytes,have been identified as significant contributors to the pathological landscape of Alzheimer's *** changes impact neuronal health and function,thus offering promising targets for therapeutic *** purpose of this review is to consolidate current knowledge on the modifications in glycolysis associated with Alzheimer's disease and explore the mechanisms by which these abnormalities contribute to disease onset and *** focus on the pathways through which glycolytic dysfunction influences Alzheimer's disease pathology should provide insights into potential therapeutic targets and strategies that pave the way for groundbreaking treatments,emphasizing the importance of understanding metabolic processes in the quest for clarification and management of Alzheimer's disease.

关键词： Alzheimer’s disease glial cells glycolysis neuronal metabolism pathogenesis therapeutic targets

An Unprecedented Efficiency with Approaching 21%Enabled by Additive‑Assisted Layer‑by‑Layer Processing in Organic Solar Cells

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nano-Micro Letters 2025年第2期17卷 372-375页

作者： Shuai Xu Youdi Zhang Yanna Sun Pei Cheng Zhaoyang yao ning Li Long Ye Lijian Zuo Ke Gao Key Laboratory of Advanced Green Functional Materials College of ChemistryChangchun Normal UniversityChangchun 130032People’s Republic of China Shandong Provincial Key Laboratory for Science of Material Creation and Energy Conversion School of Chemistry and Chemical EngineeringShandong UniversityQingdao 266237People’s Republic of China College of Polymer Science and Engineering Sichuan UniversityChengdu 610065People’s Republic of China State Key Laboratory and Institute of Elemento‑Organic Chemistry Centre of Nanoscale Science and Technology and Key Laboratory of Functional Polymer MaterialsRenewable Energy Conversion and Storage Center(RECAST)College of ChemistryNankai UniversityTianjin 300071People’s Republic of China Institute of Polymer Optoelectronic Materials and Devices State Key Laboratory of Luminescent Materials and Devices South China University of TechnologyGuangzhou 510640People’s Republic of China Tianjin Key Laboratory of Molecular Optoelectronic Sciences School of Materials Science and EngineeringTianjin UniversityTianjin 300350People’s Republic of China State Key Laboratory of Silicon Materials MOE Key Laboratory of Macromolecular Synthesis and FunctionalizationDepartment of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China

Recently published in Joule,Feng Liu and colleagues from Shanghai Jiaotong University reported a record-breaking 20.8%power conversion efficiency in organic solar cells(OSCs)with an interpenetrating fibril network active layer morphology,featuring a bulk p-in structure and proper vertical segregation achieved through additive-assisted layer-by-layer *** optimized hierarchical gradient fibrillar morphology and optical management synergistically facilitates exciton diffusion,reduces recombination losses,and enhances light capture *** approach not only offers a solution to achieving high-efficiency devices but also demonstrates the potential for commercial applications of OSCs.

关键词： Organic solar cells Additive-assisted layer-by-layer processing Three-dimensional fibril morphology Bulk p-i-n structure Optical management

An Efficient Boron Source Activation Strategy for the Low‑Temperature Synthesis of Boron nitride nanotubes

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nano-Micro Letters 2025年第1期17卷 548-558页

作者： Ying Wang Kai Zhang Liping Ding Liyun Wu Songfeng E Qian He nanyang Wang Hui Zuo Zhengyang Zhou Feng Ding Yue Hu Jin Zhang Yagang yao national Laboratory of Solid State Microstructures College of Engineering and Applied SciencesJiangsu Key Laboratory of Artificial Functional Materialsand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093People’s Republic of China School of Electronic Information and Artificial Intelligence Shaanxi University of Science&TechnologyXian 710000People’s Republic of China College of Bioresources Chemical and Materials Engineering Shaanxi University of Science&TechnologyXian 710000People’s Republic of China Key Laboratory of Carbon Materials of Zhejiang Province College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325000People’s Republic of China Shenzhen Institutes of Advanced Technology Chinese Academy of SciencesShenzhen 518000People’s Republic of China College of Chemical and Molecular Engineering Peking UniversityBeijing 100871People’s Republic of China

Lowering the synthesis temperature of boron nitride nanotubes(BnnTs)is crucial for their *** primary reason for adopting a high temperature is to enable the effective activation of highmelting-point solid *** this study,we developed a novel approach for efficiently activating boron by introducing alkali metal compounds into the conventional MgO–B *** approach can be adopted to form various low-melting-point AM–Mg–B–O growth *** growth systems have improved catalytic capability and reactivity even under low-temperature conditions,facilitating the synthesis of BnnTs at temperatures as low as 850℃.In addition,molecular dynamics simulations based on density functional theory theoretically demonstrate that the systems maintain a liquid state at low temperatures and interact with n atoms to form Bn *** findings offer novel insights into the design of boron activation and are expected to facilitate research on the low-temperature synthesis of BnnTs.

关键词： Boron nitride nanotubes Low-temperature Boron activation Density functional theory

Male infertility： lifestyle factors and holistic, complementary, and alternative therapies

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Asian Journal of Andrology 2016年第3期18卷 410-418,I0008,I0009页

作者： David F yao Jesse n Mills Department of Urology UCLA 1260 15^th St #1200 Santa Monica CA 90404 USA.

While we may be comfortable with an allopathic approach to male infertility, we are also responsible for knowledge about lifestyle modifications and holistic, complementary, and alternative therapies that are used by many of our patients. This paper provides an evidence-based review separating fact from fiction for several of these therapies. There is sufficient literature to support weight reduction by diet and exercise, smoking cessation, and alcohol moderation. Supplements that have demonstrated positive effects on male fertility on small randomized controlled trial （RCT） include aescin, coenzyme Qlo, glutathione, Korean red ginseng, L-carnitine, nigella sativa, omega-3, selenium, a combination of zinc and folate, and the Menevit antioxidant. There is no support for the use of Vitamin C, Vitamin E, or saffron. The data for Chinese herbal medications, acupuncture, mind-body practice, scrotal cooling, and faith-based healing are sparse or inconclusive.

关键词： alcohol antioxidants caffeine faith-based healing male infertility obesity scrotal cooling sperm tobacco traditional Chinese medicine

Exploring the vacuum ultraviolet photochemistry of astrochemically important triatomic molecules

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national Science Review 2023年第8期10卷 243-259页

作者： yao Chang Michael n.R. Ashfold Kaijun Yuan Xueming Yang State Key Laboratory of Molecular Reaction Dynamics and Dalian Coherent Light Source Dalian Institute of Chemical Physics Chinese Academy of Sciences School of Chemistry University of Bristol University of Chinese Academy of Sciences Hefei national Laboratory Department of Chemistry College of Science Southern University of Science and Technology

The recently constructed vacuum ultraviolet(VUV) free electron laser(FEL) at the Dalian Coherent Light Source(DCLS) is yielding a wealth of new and exquisitely detailed information about the photofragmentation dynamics of many small gas-phase molecules. This review focuses particular attention on five triatomic molecules—H2O, H2S, CO2, OCS and CS2. Each shows excitation wavelength-dependent dissociation dynamics, yielding photofragments that populate a range of electronic and(in the case of diatomic fragments) vibrational and rotational quantum states, which can be characterized by different translational spectroscopy methods. The photodissociation of an isolated molecule from a well-defined initial quantum state provides a lens through which one can investigate how and why chemical reactions occur, and provides numerous opportunities for fruitful, synergistic collaborations with high-level ab initio quantum chemists. The chosen molecules, their photofragments and the subsequent chemical reaction networks to which they can contribute are all crucial in planetary atmospheres and in interstellar and circumstellar environments. The aims of this review are 3-fold: to highlight new photochemical insights enabled by the VUV-FEL at the DCLS, notably the recently recognized central atom elimination process that is shown to contribute in all of these triatomic molecules; to highlight some of the potential implications of this rich photochemistry to our understanding of interstellar chemistry and molecular evolution within the universe; and to highlight other and future research directions in areas related to chemical reaction dynamics and astrochemistry that will be enabled by increased access to VUV-FEL sources.

关键词： vacuum ultraviolet photochemistry photodissociation free electron laser interstellar chemistry chemistry of planetary atmospheres

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论健康数据科学研究合法性基础的证成与适用

科技与法律（中英文） 2025年第1期 57-67页

作者：姚旭鑫华东政法大学卫生健康法治与政策研究院上海200042 安特卫普大学法学院安特卫普2000

现有的个人信息处理合法性基础框架难以满足健康数据科学研究的需要。将科学研究作为健康数据处理的合法性基础,是国家促进、实现科学研究自由和健康权的要求,并可通过对“公共利益”的解释得到证成。科学研究主体应当隶属于以科学研究... 详细信息

现有的个人信息处理合法性基础框架难以满足健康数据科学研究的需要。将科学研究作为健康数据处理的合法性基础,是国家促进、实现科学研究自由和健康权的要求,并可通过对“公共利益”的解释得到证成。科学研究主体应当隶属于以科学研究为主要目的范围的组织机构。科学研究不排斥商业目的,但商业程度的不同,决定了研究主体是否需要向数据主体付酬。科学研究主体对健康数据的访问需要依托健康数据协调机构加以实现。在适用科学研究这一合法性基础对健康数据进行处理时,应将对数据主体的影响控制在最小范围。原则上对健康数据去标识化,对科学研究有重要意义的标识符可依申请予以保留。标识符的保留和健康数据科学研究的黑箱属性,决定了要对健康数据科学研究课以更高标准的公开透明要求。同时相关规则具有较大自由裁量空间,自由裁量应以风险收益平衡原则为基本遵循。科学研究和其他合法性基础可能存在重合或冲突,只有在数据主体未明示反对的前提下,才可适用科学研究这一合法性基础。当科学研究与其他法定数据处理情形相重合时,科学研究作为特别情形,应优先于一般情形的适用。

关键词：健康数据科学研究合法性基础适用规则

A theoretical analysis of the electromigration-induced void morphological evolution under high current density

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Acta Mechanica Sinica 2017年第5期33卷 868-878页

作者： Yuexing Wang yao yao School of Mechanics and Civil Engineering Northwestern Polytechnical University

In this work, analysis of electromigration-induced void morphological evolution in solder interconnects is performed based on mass diffusion theory. The analysis is conducted for three typical experimentally observed void shapes: circular, ellipse, and cardioid. Void morphological evolution is governed by the competition between the electric field and surface capillary force. In the developed model, both the electric field and capillary force on the void's surface are solved analytically. Based on the mass conversation principle, the normal velocity on the void surface during diffusion is obtained. The void morphological evolution behavior is investigated, and a physical model is developed to predict void collapse to a crack or to split into sub-voids under electric current. It is noted that when the electric current is being applied from the horizontal direction, a circular void may either move stably along the electric current direction or collapse to a finger shape, depending on the relative magnitude of the electric current and surface capillary force. However, the elliptical-shaped void will elongate along the electric current direction and finally collapse to the finger shape. On the other hand, the cardioid-shaped void could bifurcate into two sub-voids when the electric current reaches a critical value. The theoretical predictions agree well with the experimental observations.

关键词： Electromigration Analytical solution Void evolution High current density Mass diffusion

Experimental and Statistical Analysis of Fatigue Behavior in Zr-based Bulk Metallic Glass

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稀有金属材料与工程 2024年第11期53卷 3010-3016页

作者： yao Zhifeng Qiao Jichao Pelletier Jean-Marc yao yao School of Civil Engineering Xi'an University of Architecture&TechnologyXi'an 710055China Dongguan Sanhang Innovation Institute Dongguan 523808China School of Mechanics Civil Engineering and ArchitectureNorthwestern Polytechnical UniversityXi'an 710072China Institut national des Sciences Appliquées de Lyon Universitéde LyonLyon F-69621France School of Materials and Chemical Engineering Xi'an Technological UniversityXi'an710021China

Three-point bending fatigue experiments were conducted on a typical Zr-based bulk metallic glass(BMG)at ambient temperature to investigate the fatigue behavior under cyclic loading *** show that the stress amplitude-cycles to failure(S-n)curve of the Zr-based BMG is determined,and the fatigue endurance limit is 442 MPa(stress amplitude).To evaluate the probability-stress amplitude-cycles to failure(P-S-n)curve,an estimation method based on maximum likelihood was proposed,which relies on statistical principles to estimate the fatigue life of the material and allows for a reduction in the number of samples required,offering a cost-effective and efficient alternative to traditional testing *** experimental results align with the American Society for Testing and Materials(ASTM)standard,indicating the reliability and accuracy of this estimation method in evaluating the fatigue behavior of Zr-based BMG.

关键词： bulk metallic glass P-S-n curve fatigue test statistical analysis

Convergence Analysis of Iterative Sequences for a Pair of Mappings in Banach Spaces

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Acta Mathematica Sinica,English Series 2008年第3期24卷 463-470页

作者： Liu Chuan ZEnG n.C.WOnG J.C.yao Department of Mathematics Shanghai Normal University Shanghai 200234 P. R. China Department of Applied Mathematics National Sun Yat-Sen University Kaohsiung Taiwan 80424

Let C be a nonempty closed convex subset of a real Banach space E. Let S ： C→ C be a quasi-nonexpansive mapping, let T ： C→C be an asymptotically demicontractive and uniformly Lipschitzian mapping, and let F ：= {x ∈C ： Sx = x and Tx = x}≠Ф Let {xn}n≥0 be the sequence generated irom an arbitrary x0∈Cby xn＋i=（1-cn）Sxn＋cnT^nxn, n≥*** prove the necessary and sufficient conditions for the strong convergence of the iterative sequence {xn} to an element of F. These extend and improve the recent results of Moore and nnoli.

关键词： quasi-nonexpansive mapping asymptotically demicontractive type mapping iterative sequence convergence analysis

Convergence of Hybrid Steepest-Descent Methods for Generalized Variational Inequalities

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Acta Mathematica Sinica,English Series 2006年第1期22卷 1-12页

作者： Liu Chuan ZEnG n. C. Wong J. C. yao Department of Mathematics Shanghai Normal University Shanghai 200234 P. R. China Department of Applied Mathematics National Sun Yat-sen University Kaohsiung Taiwan 804

In this paper, we consider the generalized variational inequality GVI（F, g, C）, where F and g are mappings from a Hilbert space into itself and C is the fixed point set of a nonexpansive mapping. We propose two iterative algorithms to find approximate solutions of the GVI（F,g, C）. Strong convergence results are established and applications to constrained generalized pseudo-inverse are included.

关键词： iterative algorithms hybrid steepest-descent methods nonexpansive mappings Hilbert space Constrained generalized pseudo-inverse