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Menstrual cycle characteristics as an indicator of fertility outcomes:evidence from prospective birth cohort study in China

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Journal of Traditional Chinese Medicine 2022年第2期42卷 272-278页

作者： LIU Xiping wu xiaqiu BAO Lirong PENG Jin Ka-Kit Hui School of Public Health Zhejiang Chinese Medical UniversityHangzhou 310053China Zhejiang Chinese Medical University Hangzhou 310053China Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100700China

OBJECTIVE:To evidently assess the applicability of regulate menstrual cycle(MC)characteristics in Traditional Chinese Medicine(TCM)as an indicator for ***:A community-based prospective cohort study was conducted in *** January 2010 and December 2012,women who were willing to conceive within 2 years were enrolled in the *** than the MC length pattern,a well-adopted MC characteristic,menstrual blood color and clots were specifically concerned for women *** participants were followed up in 2 years by trained *** rate,fecundability odds ratio(FOR)and risk of miscarriage were assessed as fertility ***:A total of 2109 women were effectively included in this cohort for *** show that women with irregular MC length were less likely to achieve conception(FOR_(irregular)=0.59;95%CI=0.45-0.77,P<0.001).Menstrual blood in bright red color was also associated with decline in likelihood of conception(FOR=0.79;95%CI=0.63-0.98,P=0.04).Women with menstrual blood in light red were at higher risk of miscarriage(OR=2.39;95%CI=0.91-6.28,P=0.08).No significant impact was found between menstrual blood clots and fertility outcomes(FOR=1.02,95%CI=0.83-1.25,P=0.88;OR=1.2695%CI=0.77-2.07,P=0.35).CONCLUSIONS:MC characteristics can be an effective and simple indicator for women’s *** the knowledge of MC characteristics for women in reproductive ages would bring great benefits to their preconception health conditions.

关键词： menstrual cycle fertility odds ratio abortion spontaneous medicine Chinese traditional preconception care

Efficacy evaluation of summer acupoint application treatment on asthma patients: a two-year follow-up clinical study

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Journal of Traditional Chinese Medicine 2015年第1期35卷 21-27页

作者： wu xiaqiu Peng Jin Li Guoqin Zhang Wei Liu Guangxia Liu Baoyan Department of Preventive Medicine Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical Science Department of Respiratory Guanganmen Hospital China Academy of Chinese Medical Science Department of Acupuncture and Massage The First Hospital of Hunan University of Chinese Medicine Department of Acupuncture The Second Hospital of Anhui University of Chinese Medicine China Academy of Chinese Medical Science

OBJECTIVE: To evaluate the self-efficacy and satisfaction of asthma patients subjected to summer acupoint application treatment(SAAT).METHODS: A two-year follow-up clinical study was conducted. Patients with asthma were treated by applying a herbal paste onto the Feishu(BL 13) and Fengmen(BL 12) acupoints on the three hottest days of summer, according to the traditional Chinese calendar, from 2008 to 2010. During a two-year follow-up, these patients were asked tofill out a questionnaire evaluating asthma degree,exacerbation frequency, concomitant medications and self-satisfaction. The self-rate and doctor-report outcomes obtained in parallel were evaluated to assess the efficacy of ***: A total of 527 asthma patients were initially enrolled in this study, of which 97 elderly patients and those with more severe cases of asthma were lost to follow-up. Thus, a total of 430 patients were valid for analysis using self-rate data. Nevertheless, occasional negative returns were obtained;almost all of the outcomes were rated as "No change", "Moderate effective", or "Very effective". In addition, 80% of the patients were satisfied with this treatment. Moreover, 391(91.4%) patients were somewhat improved after SAAT in 2009, and further improvement was observed in 2010. After SAAT, the average asthma-degree score decreased from 5.3 in 2008 to 4 in 2009 and, subsequently to3.5 in ***: With pronounced patient satisfaction, SAAT can reduce the exacerbation severity and frequency, concomitant medications and asthma degree. Prolonging the treatment course might enhance the efficacy of SAAT.

关键词： Acupoint sticking therapy Quality ofLife Self efficacy Asthma Chinese medicine, traditional

Influencing factors on efficacy of summer acupoint application treatment for allergic rhinitis:a retrospective study

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Journal of Traditional Chinese Medicine 2012年第3期32卷 377-381页

作者： Jin Peng xiaqiu wu Jingqing Hu Yigong Fang Mingjie Zi Baoyan Liu Institute of Basic Research in ClinicalMedicine China Academy of Chinese Medical Sciences Beijing 100700 China Baoyan Liu China Academy of Chinese Medical Sciences Beijing 100700 China Institute of Acupuncture and Moxibustion China Academy of Chinese Medical Sciences Beijing100700 China Xiyuan Hospital China Academy of ChineseMedical Sciences Beijing 100700 China

OBJECTIVE:Allergic rhinitis(AR) is a common health *** acupoint application treatment(SAAT) is reported to effectively treat and prevent AR from seasonal *** the present study,we aimed to evaluate its effects,especially on the course of AR,through a retrospective ***:A cross-sectional multicenter study was performed based on patients treated between 2008 and 2009 in 13 clinical centers in China.A total of 1058 outpatients aged ≥2 years with documented AR and ≥1 year SAAT were eligible for enrollment.A case report form(CRF) was completed by both patient and *** CRF was designed to collect data on the patient's history of SAAT,AR condition,and self-reported health *** outcomes(dependent variables) were incidence and intensity of AR and concomitant medications *** were analyzed with ordinal logistic regression(OLR).RESULTS:Treatment course and seasonal pattern of AR were related to all dependent variables *** controlling for sample bias and confounding factors,the findings suggested that a 3-year treatment course had better efficacy(OR/incidence of AR:2.57,95%CI:1.76-3.76;OR/intensity of AR:2.17,95%CI:1.50-3.17;OR/concomitant medications:2.20,95% CI:1.50-3.23) compared with a 2-year or less treatment ***:The results showed that:1)the length of treatment course was positively associated with the efficacy of SAAT(the longer the treatment course,the better the efficacy);and 2)SAAT was more efficacious in treating seasonal AR than non-seasonal AR.

关键词： Acupoint sticking therapy Allergic rhinitis Cross-sectional studies Traditional Chinese Medicine

基于网络药理学探讨《种福堂公选良方》辟瘟丹预防新型冠状病毒感染作用机制

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中国中医药图书情报杂志 2024年第5期48卷 53-57页

作者：吴俊仪肖静方艳张伟娜赵静吴夏秋浙江中医药大学公共卫生学院中国中医科学院中医药信息研究所中国中医科学院中医临床基础医学研究所

目的运用网络药理学方法探讨辟瘟丹预防新型冠状病毒感染（COVID-19）的作用机制。方法通过TCMSP数据库检索辟瘟丹的化学成分及作用靶点；通过GeneCards、OMIM、PharmGKB、TTD和DrugBank数据库查询COVID-19的相关靶点；借助STRING网... 详细信息

目的运用网络药理学方法探讨辟瘟丹预防新型冠状病毒感染（COVID-19）的作用机制。方法通过TCMSP数据库检索辟瘟丹的化学成分及作用靶点；通过GeneCards、OMIM、PharmGKB、TTD和DrugBank数据库查询COVID-19的相关靶点；借助STRING网站进行蛋白质互相作用分析；利用Cytoscape3.9.0软件构建药物成分-靶点网络，分析获得辟瘟丹预防COVID-19的核心靶点；利用R语言和KOBAS数据库分别进行GO和KEGG富集分析。结果辟瘟丹化学成分共115个，靶点共2 378个，辟瘟丹和COVID-19有重叠靶点101个，核心靶点为TP53、HSP90AA1、AKT1、MAPK3;KEGG富集分析得到信号通路102条，主要涉及IL-17信号通路、TNF信号通路、P53信号通路、AGE-RAGE信号通路等；GO分析后共得到生物学过程2 359个、细胞组成423个、分子功能161个。结论辟瘟丹能够通过TP53、HSP90AA1、AKT1、MAPK3靶点，IL-17、TNF、P53、AGE-RAGE信号通路途径达到调节细胞凋亡、促进机体免疫、抗病毒等作用，发挥预防COVID-19的药理作用。

关键词：辟瘟丹新冠病毒网络药理学

中药口服汤剂联合米非司酮治疗子宫肌瘤的meta分析

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世界科学技术-中医药现代化 2019年第5期21卷 1013-1020页

作者：徐嘉时珍吴夏秋浙江中医药大学基础医学院杭州310053 浙江中医药大学附属第三医院杭州310053

目的:采用meta分析评价中药口服汤剂联合米非司酮治疗子宫肌瘤的疗效性及安全性。方法:检索CNKI、维普、万方、PubMed、The Cochrane数据库自建库至2017年10月关于中药口服汤剂联合米非司酮治疗子宫肌瘤的临床研究文献,选择符合要求的... 详细信息

目的:采用meta分析评价中药口服汤剂联合米非司酮治疗子宫肌瘤的疗效性及安全性。方法:检索CNKI、维普、万方、PubMed、The Cochrane数据库自建库至2017年10月关于中药口服汤剂联合米非司酮治疗子宫肌瘤的临床研究文献,选择符合要求的随机对照试验,提取数据并进行质量评价后使用Review Manager5.3软件进行meta分析。结果:最终纳入13个研究,共1300个患者。Meta分析结果显示,①B超下子宫肌瘤体积:治疗组疗效优于对照组[MD=-7.75,95%CI(-10.39,-5.11)],差异具有统计学意义;②B超下子宫体积:治疗组疗效优于对照组[MD=-17.35,95%CI(-23.24,-11.46)],差异具有统计学意义;③临床总有效率:治疗组的临床总有效率高于对照组[RR=1.22,95%CI(1.13,1.31)],差异具有统计学意义;④血清激素水平:4项血清激素指标[卵泡刺激素(FSH)、促黄体生成素(LH)、雌二醇(E2)、孕酮(P)]:中药汤剂联合米非司酮能更好的降低E2、LH、P,但是在降低FSH方面,治疗组和对照组的差异尚不能证明有统计学意义。结论:中药汤剂联合米非司酮治疗子宫肌瘤的临床效果比单纯使用米非司酮治疗的临床效果更好,前者在缩小子宫及肌瘤体积方面有较明显的优势,且无严重不良反应发生,但由于纳入试验的质量不高,尚需要纳入更多高质量的随机对照试验来进行验证。

关键词：中药汤剂米非司酮子宫肌瘤 Meta分析

杭州市女大学生人乳头瘤病毒及其疫苗认知和接种意愿调查

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中国疫苗和免疫 2019年第3期25卷 303-307页

作者：赖江宜吴夏秋浙江中医药大学

目的了解杭州市女大学生人乳头瘤病毒(Human papillomavirus,HPV)和HPV疫苗的认知度、接种意愿及其影响因素。方法采取分层随机抽样在杭州市抽取4所大学的女大学生进行HPV和HPV疫苗知晓率、接种意愿问卷调查,分析接种意愿的影响因素。... 详细信息

目的了解杭州市女大学生人乳头瘤病毒(Human papillomavirus,HPV)和HPV疫苗的认知度、接种意愿及其影响因素。方法采取分层随机抽样在杭州市抽取4所大学的女大学生进行HPV和HPV疫苗知晓率、接种意愿问卷调查,分析接种意愿的影响因素。结果在220名调查对象中,HPV和HPV疫苗总知晓率为25.9%,其中医学和非医学专业学生分别为38.2%、 13.6%(χ~2=17.26,P<0.001);H P V疫苗接种率为3.6%,其中医学和非医学专业学生分别为4.5%、2.7%(χ~2=0.48,P=0.488);HPV疫苗接种意愿率为73.2%,其中医学和非医学专业学生分别为88.2%、 58.2%(χ~2=23.04,P<0.001)。单因素分析显示,仅专业类型是影响调查对象接种意愿的显著性因素。结论杭州市女大学生HPV和HPV疫苗相关知识的知晓率低,但接种意愿高。需要加强对非医学专业学生的健康教育工作。

关键词：人乳头瘤病毒人乳头瘤病毒疫苗认知接种意愿

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穴位贴敷疗法儿科用药规律分析

辽宁中医杂志 2015年第7期42卷 1313-1315页

作者：吴夏秋雷蕾彭锦中国中医科学院中医临床基础医学研究所养生保健研究室北京100700 中国中医科学院中医药信息研究所信息技术研究室北京100700

目的:利用文献分析方法探索穴位贴敷疗法在儿科疾病中的用药规律,为临床合理用药以及制定相关规范提供参考依据。方法:以中国生物医学文献光盘数据库、中国期刊全文数据库、中国生物医学期刊文献数据库为来源进行检索。结果:纳入符合研... 详细信息

目的:利用文献分析方法探索穴位贴敷疗法在儿科疾病中的用药规律,为临床合理用药以及制定相关规范提供参考依据。方法:以中国生物医学文献光盘数据库、中国期刊全文数据库、中国生物医学期刊文献数据库为来源进行检索。结果:纳入符合研究要求的临床文献244篇。穴位贴敷疗法以治疗儿科的呼吸系统和消化系统疾病为主,用药特点均以"辛温走窜"之品为常用药。呼吸系统常用药物为"白芥子、甘遂、延胡索、细辛",消化系统常用药物为"吴茱萸、肉桂、丁香、木香"。考虑儿童体质尚弱,贴敷选药仅局限于甘遂、吴茱萸等"有毒""小毒"药物。结论:应用文献分析方法分析穴位贴敷疗法在儿科疾病中的用药规律,对指导临床用药以及制定相关规范均具有一定的参考价值。但现有临床文献质量均不高,进一步的研究结论尚需高质量的临床研究报道。

关键词：穴位贴敷儿科用药规律

运用成本-效果分析方法评估国家自然基金项目资助效果

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中国科学基金 2008年第2期22卷 122-124页

作者：闫兴丽刘仁权吴夏秋武丹北京中医药大学北京100029

近几年来，北京中医药大学国家自然科学基金申报项目逐年增加，项目获资助率也有了较大的提高，从2003年获资助9项到2006年获资助29项。获资助项目数的增加，给依托单位基金管理工作者提出了严峻的课题，如何管理好逐年增多的课题，如... 详细信息

近几年来，北京中医药大学国家自然科学基金申报项目逐年增加，项目获资助率也有了较大的提高，从2003年获资助9项到2006年获资助29项。获资助项目数的增加，给依托单位基金管理工作者提出了严峻的课题，如何管理好逐年增多的课题，如何让每一位项目负责人认真、按计划完成课题，一个有效、可行的评估方法的产生势在必行，本文运用成本-效果分析方法来评价项目完成情况，对项目的绩效评估进行了方法学上的尝试。

关键词：国家自然科学基金项目资助效果分析运用成本评估方法北京中医药大学基金管理项目负责人

Ballistic performances of the hourglass lattice sandwich structures under high-velocity fragments

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Defence Technology（防务技术） 2024年第1期31卷 312-325页

作者： He-xiang wu Jia Qu Lin-zhi wu Key Laboratory of Advanced Ship Materials and Mechanics College of Aerospace and Civil EngineeringHarbin Engineering UniversityHarbin150001China School of Civil Engineering Northeast Forestry UniversityHarbin150040China

In this paper,the numerical simulation method is used to study the ballistic performances of hourglass lattice sandwich structures with the same mass under the vertical incidence of *** is paid to elucidating the influences of rod cross-section dimensions,structure height,structure layer,and rod inclination angle on the deformation mode,ballistic performances,and ability to change the ballistic direction of *** results show that the ballistic performances of hourglass lattice sandwich structures are mainly affected by their structural *** this respect,structural parameters optimization of the hourglass lattice sandwich structures enable one to effectively improve their ballistic limit velocity and,consequently,ballistic performances.

关键词： Hourglass lattice sandwich structures Ballistic performances high-velocity Finite element analysis