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Inhibition of Herpes Simplex Virus-1 Replication by Natural Compound Honokiol

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Virologica Sinica 2019年第3期34卷 315-323页

作者： Shuai Liu Long Li Lingbing Tan xiaozhen liang University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100039China Key Laboratory of Molecular Virology & Immunology Institut Pasteur of ShanghaiShanghai 200031China

Honokiol is a pleiotropic natural compound isolated from Magnolia and has multiple biological and clinically relevant effects,including anticancer and antimicrobial ***,the antiviral activity of honokiol has not yet been well *** we showed that honokiol had no effect on herpes simplex virus-1(HSV-1)entry,but inhibited HSV-1 viral DNA replication,gene expression and the production of new progeny *** combination of honokiol and clinical drug acyclovir augmented inhibition of HSV-1 *** results illustrate that honokiol could be a potential new candidate for clinical consideration in the treatment of HSV-1 infection alone or combination with other therapeutics.

关键词： Honokiol Herpes simplex virus-1(HSV-1) Viral replication Anti-viral activity Acyclovir

CD95-CD95L interaction mediates the growth control of MHV68 immortalized B cells by cytotoxic T cells

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Virologica Sinica 2017年第3期32卷 257-259页

作者： Sihan Dong Lingbing Tan Guifang Chen xiaozhen liang School of Life Science Shanghai University Key Laboratory of Molecular Virology & Immunology Institut Pasteur of Shanghai Chinese Academy of Sciences

Dear Editor,The main limitation of the viral pathogenesis study of human gammaherpesviruses Epstein-Barr virus(EBV)and Kaposi sarcoma-associated herpesvirus(KSHV)is the absence of animal model owing to the narrow host... 详细信息

关键词：细胞毒T细胞生长控制 B细胞介导疱疹病毒动物模型发病机制基因编码

Quantifying spatial distribution of interrill and rill erosion in a loess at different slopes using structure from motion(SfM)photogrammetry

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International Soil and Water Conservation Research 2022年第3期10卷 393-406页

作者： Tao He Yang Yang Yangzi Shi xiaozhen liang Suhua Fu Gege Xie Baoyuan Liu Yingna Liu State Key Laboratory of Earth Surface Processes and Resource Ecology Faculty of Geographical ScienceBeijing Normal UniversityBeijing100875China School of Geography Faculty of Geographical ScienceBeijing Normal UniversityBeijing100875China Beijing Key Laboratory of Environmental Remote Sensing and Digital Cities Faculty of Geographical ScienceBeijing Normal UniversityBeijing100875China State Key Laboratory of Soil Erosion and Dryland Farming on the Loess Plateau Chinese Academy of Sciences and Ministry of Water ResourcesYangling712100China

The spatial distribution of interrill and rill erosion is essential for unravelling soil erosion principles and the application of soil and water conservation *** quantify interrill and rill erosion and their spatial development,four 30-min rainfalls at 90 mm h^(-1)intensity were consecutively simulated on runoff plots packed with a loess at six slopes of 10°,15°,20°,25°,30°and 35°.The soil surface was measured using the structure from motion(SfM)photogrammetry upon each simulation run,and the runoff and sediment samples were collected and measured at every 10 *** did not develop until the third simulation *** the initial two runs,the lower third section was more severely eroded than the upper and middle thirds along the slope direction,yet the interrill erosion was statistically uniform from left to *** tended to emerge by both sidewalls and in the lower portion in the third *** corresponding rill erosion increased with slope from 10°to 20°and then decreased for the slopes steeper,which was consistent with the slope trend of the sediment yield directly *** rills expanded substantially primarily via head retreat and to a lesser extent via sideward erosion after receiving another 30-min *** erosion contributed 69.3%of the total erosion loss,and shifted the critical slope corresponding to the maximum loss from 20°to 25°.These findings demonstrate the significance of rill erosion not only in total soil loss but also in its relation to slope,as well as the effectiveness of SfM photogrammetry in quantifying interrill and rill erosion.

关键词： Interrill and rill erosion Spatial distribution Structure from motion(SfM) photogrammetry Slope Rainfall simulation

Mild Cytokine Elevation, Moderate CD4^+ T Cell Response and Abundant Antibody Production in Children with COVID-19

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Virologica Sinica 2020年第6期35卷 734-743页

作者： Ran Jia Xiangshi Wang Pengcheng Liu xiaozhen liang Yanling Ge He Tian Hailing Chang Hao Zhou Mei Zeng Jin Xu Department of Clinical Laboratory Children’s Hospital of Fudan UniversityShanghai 201102China Department of Infectious Diseases Children’s Hospital of Fudan UniversityShanghai 201102China Key Laboratory of Molecular Virology&Immunology Institut Pasteur of ShanghaiUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China Shanghai Kehua Bio-Engineering Co. Ltd.Shanghai 200233China

Children with Coronavirus Disease 2019(COVID-19) were reported to show milder symptoms and better prognosis than their adult counterparts, but the difference of immune response against SARS-CoV-2 between children and adults hasn’t been reported. Therefore we initiated this study to figure out the features of immune response in children with *** and whole blood cells from 19 children with COVID-19 during different phases after disease onset were *** cytokine concentrations, SARS-CoV-2 S-RBD or N-specific antibodies and T cell immune responses were detected respectively. In children with COVID-19, only 3 of 12 cytokines were increased in acute sera, including interferon(IFN)-cinduced protein 10(IP10), interleukin(IL)-10 and IL-16. We observed an increase in T helper(Th)-2 cells and a suppression in regulatory T cells(Treg) in patients during acute phase, but no significant response was found in the IFN-cproducing or tumor necrosis factor(TNF)-a-producing CD8?T cells in patients. S-RBD and N IgM showed an early induction, while S-RBD and N IgG were prominently induced later in convalescent phase. Potent S-RBD IgA response was observed but N IgA seemed to be inconspicuous. Children with COVID-19 displayed an immunophenotype that is less inflammatory than adults, including unremarkable cytokine elevation, moderate CD4?T cell response and inactive CD8?T cell response, but their humoral immunity against SARS-CoV-2 were as strong as adults. Our finding presented immunological characteristics of children with COVID-19 and might give some clues as to why children develop less severe disease than adults.

关键词： COVID-19 SARS-CoV-2 Cytokine T cell immune response Antibody dynamics

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基于光幕约束和分段调整的去雾算法

光子学报 2021年第5期50卷 241-250页

作者：杨燕梁小珍兰州交通大学电子与信息工程学院兰州730070

针对雾天条件下成像设备采集到的图像目标主体不清晰,细节信息不明显,可辨识度低等问题,提出了一种基于光幕约束和分段调整的图像去雾算法。首先将大气光幕的基本不等条件映射至正方形及其内切圆平面模型中,得到约束后的初始大气光幕;... 详细信息

针对雾天条件下成像设备采集到的图像目标主体不清晰,细节信息不明显,可辨识度低等问题,提出了一种基于光幕约束和分段调整的图像去雾算法。首先将大气光幕的基本不等条件映射至正方形及其内切圆平面模型中,得到约束后的初始大气光幕;然后利用饱和度逼近构造粗糙大气光幕,以模糊无用的边缘信息,并通过梯度约束求取边缘代价对初始大气光幕进行修正。为了改善近景失真和远景去雾不彻底,建立自适应分段调整函数对大气光幕进行优化;最后通过复原模块得到清晰图像。实验结果表明:与一些经典的去雾算法相比,所提算法可以应用于各类图像,去雾效果良好,不仅保留了原图像特性而且得到的复原图像色彩明亮,清晰自然,各项指标优势明显。

关键词：图像复原光幕约束分段调整大气散射模型图像去雾

基于奇异谱分析的我国航空客运量集成预测模型

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系统工程理论与实践 2017年第6期37卷 1479-1488页

作者：梁小珍乔晗汪寿阳张珣上海大学管理学院上海200444 中国科学院大学经济与管理学院北京100190 中国科学院数学与系统科学研究院北京100190

针对时间序列包含噪声以及单一模型可能存在预测表现不稳定的问题,本文提出了一个基于奇异谱分析(SSA)的集成预测模型,并将其运用于我国年度航空客运量的预测中.首先,采用SSA方法对原始时间序列进行分解和重构,得到一个剔除噪声的时间序... 详细信息

针对时间序列包含噪声以及单一模型可能存在预测表现不稳定的问题,本文提出了一个基于奇异谱分析(SSA)的集成预测模型,并将其运用于我国年度航空客运量的预测中.首先,采用SSA方法对原始时间序列进行分解和重构,得到一个剔除噪声的时间序列,然后将其作为单整自回归移动平均模型(ARIMA)、支持向量回归模型(SVR)、Holt-Winters方法(HW)等单一模型的输入并进行预测,接着再采用加权平均集成预测方法(WA)将三种单一模型的预测结果进行综合集成.通过与各单一模型、基于经验模态分解方法(EMD)的模型以及简单平均集成预测方法(SA)的预测结果进行对比发现,本文所建模型具有较高的预测精度和较稳定的预测表现.最后,采用本文的模型对我国2014-2016年年度航空客运量进行了预测.

关键词：航空客运量奇异谱分析(SSA) 单整自回归移动平均模型(ARIMA) 支持向量回归模型(SVR) Holt—Winters方法集成预测

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基于阶梯网络与交叉融合的端到端图像去雾

光子学报 2022年第2期51卷 218-229页

作者：杨燕张金龙梁小珍兰州交通大学电子与信息工程学院兰州730070

针对卷积神经网络类图像去雾方法存在的细节丢失、颜色失真、去雾不彻底等问题,提出一种基于阶梯网络与注意力交叉融合的端到端图像去雾算法。整体网络模型包含特征提取、特征融合、图像重建三个模块,其中特征提取包括有雾图像细节和轮... 详细信息

针对卷积神经网络类图像去雾方法存在的细节丢失、颜色失真、去雾不彻底等问题,提出一种基于阶梯网络与注意力交叉融合的端到端图像去雾算法。整体网络模型包含特征提取、特征融合、图像重建三个模块,其中特征提取包括有雾图像细节和轮廓特征的提取,由阶梯网络的不同阶梯层提取实现;特征融合模块以注意力机制的交叉融合实现,并结合自适应残差处理获得最终的融合特征;最后在图像重建模块,通过非线性映射的方式获得去雾图像。实验结果表明,所提方法去雾彻底,去雾图像细节丰富,有效地解决了颜色失真和细节丢失问题,同时阶梯网络在很大程度上克服了深度网络的训练耗时问题。

关键词：图像去雾阶梯网络特征融合注意力机制细节恢复

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Influence of solidification agent and perturbance on the phosphorus release from sediment of Dianchi Lake

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Chinese Journal Of Geochemistry 2006年第B08期25卷 134-135页

作者： Shaoyong LU Weiguang XIN Xiangcan JIN xiaozhen HU Lili liang Research Center of Lake Environment Chinese Research Academy of Environmental Sciences State Environmental Protection Key Laboratory for Lake Pollution Control Beijing 100012 China

Multi-valent mRNA vaccines against monkeypox enveloped or mature viron surface antigens demonstrate robust immune response and neutralizing activity

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Science China(Life Sciences) 2023年第10期66卷 2329-2341页

作者： Niubing Zhang Xiang Cheng Yilong Zhu Ouyang Mo Huiqing Yu Liqi Zhu Juan Zhang Linlin Kuang Ying Gao Ruiyuan Cao xiaozhen liang Haikun Wang Honglin Li Song Li Wu Zhong Xuan Li Xiao Li Pei Hao Key Laboratory of Synthetic Biology CAS Center for Excellence in Molecular Plant SciencesInstitute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200032China Changchun Veterinary Research Institute Chinese Academy of Agricultural SciencesChangchun 130122China Key Laboratory of Molecular Virology and Immunology Institut Pasteur of ShanghaiChinese Academy of SciencesShanghai 200031China National Engineering Research Center for the Emergency Drug Beijing Institute of Pharmacology and ToxicologyBeijing 100850China Academicians Workstation of Jilin Province Changchun University of Chinese MedicineChangchun 130117China East China University of Science and Technology Shanghai 200237China Lingang Laboratory Shanghai 200031China University of Chinese Academy of Sciences Beijing 100049China

Monkeypox was declared a global health emergency by the World Health Organization,and as of March 2023,86,000 confirmed cases and 111 deaths across 110 countries have been *** causal agent,monkeypox virus(MPV)belongs to a large family of double-stranded DNA viruses,Orthopoxviridae,that also includes vaccinia virus(VACV)and *** produces two distinct forms of viral particles during its replication cycles:the enveloped viron(EV)that is released via exocytosis,and the mature viron(MV)that is discharged through lysis of host *** study was designed to develop multi-valent m RNA vaccines against monkeypox EV and MV surface proteins,and examine their efficacy and mechanism of *** m RNA vaccines were produced with different combinations of surface proteins from EV(A35R and B6R),MV(A29L,E8L,H3L and M1R),or EV and MV,and were administered in Balb/c mice to assess their immunogenicity potentials.A dynamic immune response was observed as soon as seven days after initial immunization,while a strong Ig G response to all immunogens was detected with ELISA after two *** higher number of immunogens contributed to a more robust total Ig G response and correlating neutralizing activity against VACV,indicating the additive potential of each immunogen in generating immune response and nullifying VACV ***,the m RNA vaccines elicited an antigen-specific CD4^(+)T cell response that is biased towards *** m RNA vaccines with different combinations of EVand MV surface antigens protected a mouse model from a lethal dose VACV challenge,with the EV and MV antigens-combined vaccine offering the strongest *** findings provide insight into the protective mechanism of multi-valent m RNAvaccines against MPV,and also the foundation for further development of effective and safe m RNA vaccines for enhanced protection against monkeypox virus outbreak.

关键词： monkeypox virus enveloped and mature viron multi-valent mRNA vaccines immune response neutralizing antibody