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Journal of Pharmaceutical Analysis 2024年第6期14卷 851-862页

作者： Qianlin Song Chao Song Xin Chen Yunhe Xiong Ziqi He xiaozhe su Jiawei Zhou Hu Ke Caitao Dong Wenbiao Liao Sixing Yang Department of Urology Renmin Hospital of Wuhan UniversityWuhan430060China Department of Obstetrics and Gynecology Renmin Hospital of Wuhan UniversityWuhan430060China

Oxalate is an organic dicarboxylic acid that is a common component of plant *** kidneys are essential organs for oxalate excretion,but excessive oxalates may induce kidney *** microtubule associated homolog 2(JPT2)is a critical molecule in Ca^(2+)mobilization,and its intrinsic mechanism in oxalate exposure and kidney stones remains *** study aimed to reveal the mechanism of JPT2 in oxalate exposure and kidney *** approaches were used to control JPT2 expression in cells and mice,and the JPT2 mechanism of action was analyzed using transcriptomics and untargeted *** results showed that oxalate exposure triggered the upregulation of JPT2,which is involved in nicotinic acid adenine dinucleotide phosphate(NAADP)-mediated Ca^(2+)*** analysis revealed that cell adhesion and macrophage inflammatory polarization were inhibited by JPT2 knockdown,and these were dominated by phosphatidylinositol 3-kinase(PI3K)/AKT signaling,*** metabolomics indicated that JPT2 knockdown inhibited the production of succinic acid semialdehyde(SSA)in ***,JPT2 deficiency in mice inhibited kidney stones *** conclusion,this study demonstrates that oxalate exposure facilitates kidney stones by promoting crystal-cell adhesion,and modulating macrophage metabolism and inflammatory polarization via JPT2/PI3K/AKT signaling.

关键词： Oxalate Kidney stones JPT2 Crystal-cell adhesion Immunoregulation

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逆行肾内手术治疗肾下盏结石的新评分系统

临床泌尿外科杂志 2024年第4期39卷 339-344,348页

作者：王川苏潇哲杨嗣星武汉大学人民医院泌尿外科武汉430060

目的:定义针对逆行肾内手术治疗肾下盏结石清石率(stone-free rate, SFR)的新评分系统,同时探讨其预测价值,并与其他评分系统进行比较。方法:以泌尿系CT平扫为依据来测量肾下盏解剖结构和肾下盏结石特征参数,采用上述数据建立排石难度... 详细信息

目的:定义针对逆行肾内手术治疗肾下盏结石清石率(stone-free rate, SFR)的新评分系统,同时探讨其预测价值,并与其他评分系统进行比较。方法:以泌尿系CT平扫为依据来测量肾下盏解剖结构和肾下盏结石特征参数,采用上述数据建立排石难度评分系统。回顾性分析2021年9月—2023年2月武汉大学人民医院收治的82例因单纯肾下盏结石行逆行肾内手术治疗的患者临床资料。根据患者术后复查的影像学结果,将患者分为高SFR组与低SFR组。使用统计学方法分析各因素与SFR的关系。分别计算新定义的排石难度评分系统及其他评分系统得分,并用受试者工作特征曲线(ROC)下的面积将排石难度评分系统与另外3种结石评分系统进行对比。结果:排石难度评分系统成功建立,按照选取的结石参数特征的不同分别记为排石难度MAX评分和排石难度AVE评分。本研究82例,高SFR组49例(59.76%),低SFR组33例(40.24%)。2组患者一般资料差异无统计学意义,在结石最大CT值(P<0.001)、结石平均CT值(P=0.034)以及结石体积(P=0.029)上的差异均有统计学意义。与术后SFR显著相关的评分系统ROC曲线下面积分别为0.68(排石难度MAX评分)、0.675(排石难度AVE评分)、0.672(ln排石难度MAX评分)、0.676(ln排石难度AVE评分)、0.643(R.I.R.S.评分)和0.623(***.评分)。结论:对于肾下盏结石,排石难度评分系统能更好地预测逆行肾内手术的SFR,其中排石难度MAX评分预测效果最好。

关键词：逆行肾内手术肾下盏结石清石率结石评分系统

hELP3 subunit of the Elongator Complex Regulates the Transcription of HSP70 Gene in Human Cells

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Acta Biochimica et Biophysica Sinica 2007年第6期39卷 453-461页

作者： Qiuju HAN, xiaozhe HOU, Dongmei su, Lina PAN, Jizhou DUAN, Liguo CUI, Baiqu HUANG, and Jun LU~* Institute of Genetics and Cytology, Northeast Normal University, Changchun 130024, China Institute of Genetics and Cytology Northeast Normal UniversityChangchun 130024 China

The human Elongator complex is remarkably similar to its yeast counterpart in several aspects. In a previous study, we analyzed the functions of the human elongation protein 3 (hELP3) subunit of the human Elongator by using an in vivo yeast complementation system. However, direct evidence for hELP3 functions in regulating gene expression in human cells was not obtained. In this study, we used hELP3 antisense oligonucleotide inhibitors to knock down hELP3 gene expression to investigate its function in human 293T cells. The results showed that specific reduction of hELP3 mRNA and protein caused a significant suppression of HSP70-2 gene expression, and this was accompanied by histone H3 hypoacetylation and decreased RNA polymerase Ⅱ density at the HSP70-2 gene. Moreover, the data also showed that hELP3 exerted the transcriptional regulatory function directly through its presence on the HSP70-2 gene. Data presented in this report provide further insight and direct evidence of the functions of hELP3 in HSP70-2 gene transcriptional elongation in human cells.

关键词： hELP3 histone acetylation transcription elongation antisense

Geobacter sulfurreducens promoted the biosynthesis of reduced graphene oxide and coupled it for nitrobenzene reduction

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Journal of Environmental Sciences 2024年第4期138卷 458-469页

作者： Shoujuan Zhang Qi Liu Linrui Zhong Jianhong Jiang xiaozhe Luo Xingxin Hu Qian Liu Yue Lu College of Environmental Science and Engineering Hunan UniversityChangsha 410082China Shenzhen Research Institute Hunan UniversityShenzhen 510082China Key Laboratory of Environment Biology and Pollution Control Hunan UniversityMinistry of EducationChangsha 410082China China Machinery International Engineering Design&Research Institute Co. LtdChangsha 410007China Hunan Engineering Research Center for Water Treatment Process&Equipment Changsha 410007China

In order to explore an efficient and green method to deal with nitrobenzene(NB)pollutant,reduced graphene oxide(r GO)as an electron shuttle was applied to enhance the extracellular electron transfer(EET)process of Geobacter sulfurreducens,which was a typical electrochemically active bacteria(EAB).In this study,r GO biosynthesis was achieved via the reduction of graphene oxide(GO)by *** PCA within 3 ***,the r GOPCA combining system completely reduced 50-200μmol/L of NB to aniline as end product within one *** characterization revealed that PCA cells were partly wrapped by rGO,and therefore the distance of electron transfer between strain PCA and r GO material was ***,the ID/IGof GO,r GO,and r GO-PCA combining system were 0.990,1.293 and 1.31,***,highest currents were observed in r GO-PCA-NB as 12.950μA/-12.560μA at -408 m V/156 m V,attributing to the faster electron transfer efficiency in EET ***,the NB reduction was mainly due to:(I)direct EET process from *** PCA to NB;(II)r GO served as electron shuttle and accelerated electron transfer to NB,which was the main degradation ***,the biosynthesis of r GO via GO reduction by Geobacter promoted the NB removal process,which provided a facile strategy to alleviate the problematic nitroaromatic pollution in the environment.

关键词： Reduced graphene oxide Geobacter Nitrobenzene Removal Extracellular electron transfer

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肾结石微观结构和晶体结构的研究现状与进展

中华泌尿外科杂志 2022年第12期43卷 953-956页

作者：苏潇哲宋钱林杨嗣星武汉大学人民医院泌尿外科武汉430060

肾结石是由各种无机盐和有机物按照一定规律混合生长而成。晶体成核、生长和聚集等过程是肾结石形成的关键步骤。晶体结构的不同会带来肾结石形成过程和结石理化性质的不同。研究肾结石的晶体结构及晶体形成特点,对阐明肾结石的成因和... 详细信息

肾结石是由各种无机盐和有机物按照一定规律混合生长而成。晶体成核、生长和聚集等过程是肾结石形成的关键步骤。晶体结构的不同会带来肾结石形成过程和结石理化性质的不同。研究肾结石的晶体结构及晶体形成特点,对阐明肾结石的成因和预防肾结石的复发具有重要意义。本文着重从肾结石的微观结构和晶体结构两方面出发,就近年来对肾结石中晶体形态、不同组分的分布、构成肾结石的晶体成核、生长过程,以及基于晶体结构的不同治疗方法的研究作一综述。

关键词：肾结石晶体结构防治

Analysis and Monitoring of Indoor Radon Concentrations of 37 Kindergartens — Beijing Municipality, China, 2023

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China CDC weekly 2024年第13期6卷 272-276页

作者： Meinan Yao Kuke Ding xiaozhe Tang Yunyun Wu Yanchao Song Shuyuan Liu Bin Bai Li Zhang Yongzhong Ma Institute for Radiation Hygiene Protection Beijing Center for Disease Prevention and ControlBeijingChina Chinese Center for Disease Control and Prevention BeijingChina Key Laboratory of Radiological Protection and Nuclear Emergency&National Institute for Radiological Protection Chinese Center for Disease Control and PreventionBeijingChina

Introduction:Radon(222Rn or 222radon)is a radioactive gas emitted from building materials,foundations,and *** are especially susceptible to radon exposure,underscoring the need to assess indoor radon levels in *** study monitored radon concentrations in 37 Beijing kindergartens from June to October ***:A random sample of 37 kindergartens was selected from 18 administrative districts in *** indoor radon concentration was measured using the solid track accumulation method,with radon detectors continuously monitored over a 3-month ***:The mean indoor radon level in 37 kindergartens,observed at 252 monitoring points,was 84.3 Bq/m3,with values varying from 12.9 to 263.5 Bq/*** 20.2%of points showed radon levels between 100.0 and 200.0 Bq/m3,while 2.4%exceeded 200.0 Bq/***,radon levels were significantly elevated on the ground floor compared to the upper ***:Indoor radon levels in 37 kindergartens remained below the national standard limit of 300.0 Bq/m3 for buildings(GB/T 16146-2015).Nonetheless,18.9%of the kindergartens exceeded the 100.0 Bq/m3 limit set for new *** is advised to improve radon monitoring in kindergartens and consider developing a national standard for maximum permissible radon levels in such facilities.

关键词： Radon limit floor

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双有源全桥变换器无电流传感器鲁棒预测控制

电工技术学报 2024年第10期39卷 3093-3104,3140页

作者：孙孝哲张祯滨韩明昊李真刘晓哲山东大学电气工程学院济南250061

该文以双有源全桥(DAB)DC-DC变换器为主要研究对象,针对传统比例积分控制动态响应慢及采用既有预测控制对量测噪声和参数敏感的缺陷,提出一种基于无电流传感器模型预测控制(CS-MPC)策略。首先构建双有源全桥DC-DC变换器的预测模型,分别... 详细信息

该文以双有源全桥(DAB)DC-DC变换器为主要研究对象,针对传统比例积分控制动态响应慢及采用既有预测控制对量测噪声和参数敏感的缺陷,提出一种基于无电流传感器模型预测控制(CS-MPC)策略。首先构建双有源全桥DC-DC变换器的预测模型,分别针对变换器启动阶段与暂态过程提出基于模型预测控制(MPC)的动态优化策略;然后定量分析DAB变换器对模型参数和采样精度的敏感性,结合卡尔曼滤波算法构建其状态空间模型,在无电流传感器的情况下实现系统的鲁棒预测控制;最后在实验样机上通过实验验证所提方法的有效性。实验结果表明:与传统控制策略相比,所提方法能够实现低电流应力下的快速启动,且动态响应性能明显改善。此外,所提方法无需电流传感器数据,即对测量噪声脱敏;在参数变化下的鲁棒性能较传统预测控制显著提升。

关键词：双有源全桥 DC-DC 变换器模型预测控制动态响应提升无电流传感器控制鲁棒控制

Parents'Perceptions of Online Teaching During the Pandemic:A Shanghai survey Report

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ECNU Review of Education 2024年第1期7卷 164-173页

作者：荣佳妮陈霜叶杨晓哲 Institute of Curriculum&Instruction East China Normal University

●This survey report outlined parents'evaluation of the Shanghai online learning program during the pandemic.●According to the survey results,most parents favorably accepted the Shanghai online learning initiative,while some parents held some concerns about the forms and impacts.●This report reveals nuanced analysis of parents'perception and their education backgrounds,stresses,and expectations.

关键词： China home-based online learning parents Shanghai initiative

1990—2019年中国尿路结石疾病负担和变化趋势分析

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临床泌尿外科杂志 2023年第8期38卷 627-631页

作者：苏潇哲赵延春杨嗣星武汉大学人民医院泌尿外科武汉430060 国药葛洲坝中心医院三峡大学第三临床医学院泌尿外科

目的描述和分析1990—2019年中国居民尿路结石疾病负担变化趋势,为预防和诊治尿路结石提供参考。方法基于2019年全球疾病负担数据,选取发病数、发病率、死亡数、死亡率、伤残调整生命年(disability-adjusted life years,DALYs)、伤残寿... 详细信息

目的描述和分析1990—2019年中国居民尿路结石疾病负担变化趋势,为预防和诊治尿路结石提供参考。方法基于2019年全球疾病负担数据,选取发病数、发病率、死亡数、死亡率、伤残调整生命年(disability-adjusted life years,DALYs)、伤残寿命年(years lived with disability,YLDs)、早死引起的生命损失年(years of life lost with premature death,YLLs)及DALYs率等指标,计算不同年份和不同性别之间的变化趋势,对尿路结石的疾病负担进行描述。结果相对于1990年,2019年中国居民尿路结石年龄标准化发病率、年龄标准化死亡率和年龄标准化DALYs率分别下降44.8%、83.3%和68.6%;而2019年全球居民尿路结石年龄标准化发病率、年龄标准化死亡率和年龄标准化DALYs率分别下降17.8%、33.3%和36.7%。在中国,相对于1990年,2019年尿路结石年龄标准化发病率、年龄标准化死亡率和年龄标准化DALYs率男性分别下降48.2%、70.7%和66.9%,女性分别下降34.2%、78.4%和72.4%。结论自1990年以来,我国尿路结石疾病负担逐渐减轻,但发病率仍处于较高水平,且男性在发病率、死亡率和DALYs率方面远高于女性,我们需要采取多方面的策略来解决尿石症的预防和治疗问题。

关键词：尿路结石疾病负担发病率死亡率伤残调整寿命年

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中国民法典评注:理论基础与愿景使命

交大法学 2024年第4期 31-47页

作者：朱晓喆上海财经大学法学院

当代对于大陆法系产生深远影响的法律评注兴起于德国。典型的法律评注作品根据法典的结构和顺序展开法律的逐条评释,以解释说明现行法及其适用为目的。与此不同,法学教科书以阐述法学基本原理为宗旨,侧重学术讨论;立法释义书以说明立法... 详细信息

当代对于大陆法系产生深远影响的法律评注兴起于德国。典型的法律评注作品根据法典的结构和顺序展开法律的逐条评释,以解释说明现行法及其适用为目的。与此不同,法学教科书以阐述法学基本原理为宗旨,侧重学术讨论;立法释义书以说明立法目的为主,但缺少司法裁判规则的整理和归纳。一部理想的法律评注,应当汇集和整合制定法、法学理论和司法裁判,体系地反映现行法的状况。法律评注与法教义学具有同构共生的关系,是法教义学的重要载体。法律评注比法教义学更加依赖实证法,当代编撰中国民法典评注的条件已经基本具备。编撰中国民法典评注应当融合法教义学与司法实务,注重体系思维与论题思维的互补。民法典评注的完成,将对我国民法教学事业和民法学术话语体系的建设起到至关重要的作用。在当今信息科技日新月异发展的时代,法律评注在专业分析、知识创新、价值判断等方面具有相对的优势,暂时不会被人工智能所取代。

关键词：民法典法律评注法教义学话语体系法律科技