检索结果-南通市图书馆

Global Energy Interconnection 2024年第2期7卷 117-129页

作者： xiaoyun deng Yongdong Chen Dongchuan Fan Youbo Liu Chao Ma College of Electrical Engineering Sichuan UniversityChengdu 610065P.R.China State Grid Sichuan Comprehensive Energy Service Co.Ltd. Chengdu 610072P.R.China

In this study,a novel residential virtual power plant(RVPP)scheduling method that leverages a gate recurrent unit(GRU)-integrated deep reinforcement learning(DRL)algorithm is *** the proposed scheme,the GRU-integrated DRL algorithm guides the RVPP to participate effectively in both the day-ahead and real-time markets,lowering the electricity purchase costs and consumption risks for *** Lagrangian relaxation technique is introduced to transform the constrained Markov decision process(CMDP)into an unconstrained optimization problem,which guarantees that the constraints are strictly satisfied without determining the penalty ***,to enhance the scalability of the constrained soft actor-critic(CSAC)-based RVPP scheduling approach,a fully distributed scheduling architecture was designed to enable plug-and-play in the residential distributed energy resources(RDER).Case studies performed on the constructed RVPP scenario validated the performance of the proposed methodology in enhancing the responsiveness of the RDER to power tariffs,balancing the supply and demand of the power grid,and ensuring customer comfort.

关键词： Residential virtual power plant Residential distributed energy resource Constrained soft actor-critic Fully distributed scheduling strategy

2100MPa级超高强弹簧钢的组织和强韧化机理

在线全文

学校读者我要写书评

暂无评论

金属热处理 2024年第6期49卷 142-149页

作者：卢伟涂天权邓小云罗素晖邢献强骆智超广州华德汽车弹簧有限公司广东广州511339 广东省科学院新材料研究所、国家钛及稀有金属粉末冶金工程技术研究中心、广东省金属强韧化技术与应用重点实验室广东广州510650 广汽零部件有限公司广东广州510620 广州市奥赛钢线科技有限公司广东广州511450

通过合金成分与淬、回火工艺优化获得1900、2000和2100 MPa级别的超高强弹簧钢,并对比研究了这3种超高强钢的组织、性能与强化机制。结果表明,随着C和V含量的提高,钢材原奥氏体晶粒尺寸由28.8μm减小到16.0μm。2100 MPa级别钢的抗拉强... 详细信息

通过合金成分与淬、回火工艺优化获得1900、2000和2100 MPa级别的超高强弹簧钢,并对比研究了这3种超高强钢的组织、性能与强化机制。结果表明,随着C和V含量的提高,钢材原奥氏体晶粒尺寸由28.8μm减小到16.0μm。2100 MPa级别钢的抗拉强度达2130 MPa,断面收缩率为42%。进一步研究表明2100 MPa级别弹簧钢含有高达16.2%的残留奥氏体,在拉伸变形时,残留奥氏体发生相变诱发塑性(TRIP)效应使钢材加工硬化能力和均匀伸长率显著提高。2100 MPa级别弹簧钢强度主要来源于固溶强化、位错强化与沉淀强化,其强化贡献值分别为391、808和469 MPa。细化的原奥氏体晶粒以及残留奥氏体的TRIP效应是2100 MPa级别超高强弹簧钢具有优异强塑性的关键。

关键词：弹簧钢显微组织强度加工硬化韧性

Cu-Promoted Oxidative Trifluoromethylation of Terminal Alkynes with Difluoromethylene Phosphobetaine

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2014年第8期32卷 689-693页

作者： xiaoyun deng Jinhong Lin Jian Zheng Jichang Xiao Key Laboratory of Organofluorine Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China

Difluoromethylene phosphobetaine(Ph_(3)P^(+)CF_(2)CO_(2)^(-),PDFA),a known difluorocarbene reagent,was found to be able to efficiently trifluoromethylate terminal alkynes in the presence of Cu(I)and potassium *** tran... 详细信息

关键词： copper difluoromethylene phosphobetaine trifluoromethylation alkynes difluorocarbene

Tensile and fracture properties of Ti-62A alloy plate with different microstructures

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2012年第5期31卷 420-423页

作者： LIU Rui HUI Songxiao YE Wenjun YU Yang FU Yanyan SONG xiaoyun deng Xiguang State Key Laboratory of Nonferrous Metals & Processes General Research Institute for Nonferrous Metals Beijing 100088 China

Ti-62A alloy plates with three different types of microstructure, fully equiaxed, bimodal, and Widmanstatten, were obtained by various heat treatments to investigate the effects of microstructure on the tensile and fracture properties at room temperature. The results reveal that Widmanstatten microstructure exhibits good damage tolerance behavior considering strength, fracture toughness, and fatigue crack growth behavior, while the bimodal microstructure shows good comprehensive properties considering the plasticity synthetically. Optical microscopy (OM) and scanning electron microscopy (SEM) microstructure analyses on fracture and fatigue crack path demonstrate that the dependence of mechanical properties and fatigue crack growth behavior on microstructural feature are attributed to the α lamellae width and the α colony size. © The Nonferrous Metals Society of China and Springer-Verlag Berlin Heidelberg 2012.

关键词： Brittleness Damage tolerance Fatigue crack propagation Fatigue of materials Fracture toughness Microstructural evolution Optical microscopy Scanning electron microscopy Tensile properties

[^(18)F]MAGL-4-11 positron emission tomography molecular imaging of monoacylglycerol lipase changes in preclinical liver fibrosis models

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2022年第1期12卷 308-315页

作者： Tuo Shao Zhen Chen Jian Rong Vasily Belov Jiahui Chen Andre Jeyarajan xiaoyun deng Hualong Fu Qingzhen Yu Steve H.Rwema Wenyu Lin Mikhail Papisov Lee Josephson Raymond T.Chung Steven H.Liang Division of Nuclear Medicine and Molecular Imaging Department of RadiologyMassachusetts General Hospital and Harvard Medical SchoolBostonmA 02114USA Liver Center and Gastrointestinal Division Department of MedicineMassachusetts General HospitalHarvard Medical SchoolBostonA 02114USA Shriners Hospitals for Children-Boston Boston BostonMA 02114USA

Monoacylglycerol lipase(MAGL) is a pivotal enzyme in the endocannabinoid system, which metabolizes 2-arachidonoylglycerol(2-AG) into the proinflammatory eicosanoid precursor arachidonic acid(AA). MAGL and other endogenous cannabinoid(EC) degrading enzymes are involved in the fibrogenic signaling pathways that induce hepatic stellate cell(HSC) activation and ECM accumulation during chronic liver disease. Our group recently developed an;F-labeled MAGL inhibitor([18F]MAGL-4-11)for PET imaging and demonstrated highly specific binding in vitro and in vivo. In this study, we determined [18F]MAGL-4-11 PET enabled imaging MAGL levels in the bile duct ligation(BDL) and carbon tetrachloride(CCl_(4)) models of liver cirrhosis;we also assessed the hepatic gene expression of the enzymes involved with EC system including MAGL, NAPE-PLD, FAAH and DAGL that as a function of disease severity in these models;[18F]MAGL-4-11 autoradiography was performed to assess tracer binding in frozen liver sections both in animal and human. [18F]MAGL-4-11 demonstrated reduced PET signals in early stages of fibrosis and further significantly decreased with disease progression compared with control mice. We confirmed MAGL and FAAH expression decreases with fibrosisseverity, while its levels in normal liver tissue are high;in contrast, the EC synthetic enzymes NAPE-PLD and DAGL are enhanced in these different fibrosis models. In vitro autoradiography further supported that[18F]MAGL-4-11 bound specifically to MAGL in both animal and human fibrotic liver tissues. Our PET ligand [18F]MAGL-4-11 shows excellent sensitivity and specificity for MAGL visualization in vivo and accurately reflects the histological stages of liver fibrosis in preclinical models and human liver tissues.

关键词： [18F]MAGL-4-11 PET imaging Liver fibrosis MAGL

Structure-activity relationship of pyrazol-4-ylpyridine derivatives and identification of a radiofluorinated probe for imaging the muscarinic acetylcholine receptor M4

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2023年第1期13卷 213-226页

作者： Ahmed Haider xiaoyun deng Olivia Mastromihalis Stefanie K.Pfister Troels E.Jeppesen Zhiwei Xiao Vi Pham Shaofa Sun Jian Rong Chunyu Zhao Jiahui Chen Yinlong Li Theresa R.Connors April T.Davenport James B.Daunais Vahid Hosseini Wenqing Ran Arthur Christopoulos Lu Wang Celine Valant Steven H.Liang Department of Radiology Division of Nuclear Medicine and Molecular Imaging Massachusetts General Hospital and Harvard Medical SchoolBostonMA 02114USA Department of Nuclear Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Drug Discovery Biology Monash Institute of Pharmaceutical SciencesMonash UniversityParkvilleVIC 3052Australia Neuromedicines Discovery Centre Monash Institute of Pharmaceutical SciencesMonash UniversityParkvilleVIC 3052Australia Hubei Collaborative Innovation Centre for Non-power Nuclear Technology College of Nuclear Technology&Chemistry and BiologyHubei University of Science and TechnologyXianning 437100China Department of Neurology Massachusetts General HospitalHarvard Medical SchoolBostonMA 02114USA Department of Physiology and Pharmacology Wake Forest School of MedicineWinston SalemNC 27157USA Terasaki Institute for Biomedical Innovation(TIBI) Los AngelesCA 90024USA Center of Cyclotron and PET Radiopharmaceuticals Department of Nuclear Medicine and PET/CT-MRI Centerthe First Affiliated Hospital of Jinan UniversityGuangzhou 510630China

There is an accumulating body of evidence implicating the muscarinic acetylcholine receptor4(M4)in schizophrenia and dementia with Lewy bodies,however,a clinically validated M4positron emission tomography(PET)radioligand is currently *** such,the aim of this study was to develop a suitable M4PET ligand that allows the non-invasive visualization of M4in the ***-activity relationship studies of pyrazol-4-yl-pyridine derivates led to the discovery of target compound 12—a subtype-selective positive allosteric modulator(PAM).The radiofluorinated analogue,[18F]12,was synthesized in 28±10%radiochemical yield,>37 GBq/μmol and an excellent radiochemical purity>99%.Initial in vitro autoradiograms on rodent brain sections were performed in the absence of carbachol and showed moderate specificity as well as a low selectivity of[18F]12 for the M4-rich ***,in the presence of carbachol,a significant increase in tracer binding was observed in the rat striatum,which was reduced by>60%under blocking conditions,thus indicating that orthosteric ligand interaction is required for efficient binding o f[18F]12 to the allosteric ***,however,the presence of carbachol was not required for high specific binding in the non-human primate(NHP)and human striatum,and did not further improve the specificity and selectivity of[18F]12 in higher *** results pointed towards significant species-differences and paved the way for a preliminary PET study in NHP,where peak brain uptake of[18F]12 was found in the putamen and temporal *** conclusion,we report on the identification and preclinical development of the first radiofluorinated M4PET radioligand with promising *** availability of a clinically validated M4PET radioligand harbors potential to facilitate drug development and provide a useful diagnostic tool for non-invasive imaging.

关键词： Muscarinicacetylcholine receptor Positronemission tomography Neuroimaging Neuropharmacology Neurological disorders

农业面源污染防治法律制度设计模式的反思与重构

在线全文

学校读者我要写书评

暂无评论

中州学刊 2021年第10期 49-55页

作者：邓小云河南省社会科学院郑州450002

我国农业面源污染防治法律制度主要针对个体行为发力,在这种制度设计模式下,政府防控农业面源污染的活动是被动履职,成效不够显著。基于农业面源污染的特性,有必要运用总行为控制理论,提升相关立法的精准性和执法的效能。为此,应将总行... 详细信息

我国农业面源污染防治法律制度主要针对个体行为发力,在这种制度设计模式下,政府防控农业面源污染的活动是被动履职,成效不够显著。基于农业面源污染的特性,有必要运用总行为控制理论,提升相关立法的精准性和执法的效能。为此,应将总行为控制制度作为农业面源污染防治法的核心制度,将环境质量目标作为总行为控制制度的唯一目标,通过制度扬弃,形成系统、高效的农业面源污染防治制度体系。该制度体系的实施路径是:以流域为环境保护的目标单位,以目标单位水污染物容纳能力为依据,设定农业面源污染物许可排放总量,据此分配具体区域的排放量,地方政府通过执行农业环境税收、补贴等制度,使个体排放行为总量不超出区域排放量。

关键词：农业面源污染惩罚主义总行为控制环境质量目标

整体主义视域下黄河流域生态环境风险及其应对

在线全文

学校读者我要写书评

暂无评论

东岳论丛 2020年第10期41卷 150-155页

作者：邓小云河南省社会科学院中州学刊杂志社河南郑州450002

流域兼具自然属性和社会属性,其生态系统的范围和功能发挥不受行政区划限制,这决定了流域生态环境保护要从流域整体出发统筹开展。黄河流域生态环境风险涉及复杂、多元的风险类型,在整体主义视域下突出表现为产业结构性风险、跨域格局... 详细信息

流域兼具自然属性和社会属性,其生态系统的范围和功能发挥不受行政区划限制,这决定了流域生态环境保护要从流域整体出发统筹开展。黄河流域生态环境风险涉及复杂、多元的风险类型,在整体主义视域下突出表现为产业结构性风险、跨域格局性风险、系统失衡性风险。从整体生态环境观出发,黄河流域生态环境治理应当全国一盘棋,以科学合理的顶层设计统筹推进沿黄区域因地制宜地具体施策。为此,要贯彻落实新发展理念,促进黄河流域经济社会转型发展;合理规划,加强黄河流域生态空间管控;制定"黄河保护法",强力推进黄河流域生态环境协同治理;构建黄河流域生态环境保护的刚性约束机制和利益补偿机制,助力黄河流域整体生态环境质量提升。

关键词：黄河流域生态环境整体主义黄河保护法

新型城镇化进程中的隐性环境问题及其治理对策

在线全文

学校读者我要写书评

暂无评论

中州学刊 2016年第2期 79-83页

作者：邓小云河南省社会科学院中州学刊杂志社

我国环境保护一直走不出"局部改善,整体恶化"的怪圈,一个深层原因是环境治理区域化、碎片化,重城市、轻农村,重显性环境问题、轻隐性环境问题。环境问题具有整体性,必须运用法治思维,将城乡建设与环境保护统一规划,对显性环境问题和隐... 详细信息

我国环境保护一直走不出"局部改善,整体恶化"的怪圈,一个深层原因是环境治理区域化、碎片化,重城市、轻农村,重显性环境问题、轻隐性环境问题。环境问题具有整体性,必须运用法治思维,将城乡建设与环境保护统一规划,对显性环境问题和隐性环境问题统筹治理。要建立健全环境标准制度、排污权交易制度、农业面源污染防治制度、农产品质量安全监管制度、合同环境服务制度,加强基层执法体系和执法能力建设。

关键词：隐性环境问题城乡统筹制度建设

“河长+检察长”制在河道治理中的实践及其完善

在线全文

学校读者我要写书评

暂无评论

河南教育学院学报（哲学社会科学版） 2023年第4期42卷 47-51页

作者：邓小云刘源河南省社会科学院法学研究所河南大学法学院

河道治理是流域防洪工作和生态环境保护的重要环节。“河长+检察长”制是在河长制的基础上衍生出的一种新的部门协作机制,能够为河道治理提供制度保障。“河长+检察长”制通过吸纳检察机关的法律监督功能,实现行政执法与公益检察的深度... 详细信息

河道治理是流域防洪工作和生态环境保护的重要环节。“河长+检察长”制是在河长制的基础上衍生出的一种新的部门协作机制,能够为河道治理提供制度保障。“河长+检察长”制通过吸纳检察机关的法律监督功能,实现行政执法与公益检察的深度合作,形成河流管理与保护的强大合力。但是,该机制在实践中存在跨区域协作机制缺失、多部门联动不足,河道管理部门之间职责划分不清晰,公众参与程度较低等问题。为进一步发挥“河长+检察长”制在河道治理中的效能,需要完善相关法律制度,保障检察机关充分履职,构建一体化执行体系,创新跨区域联动协作机制,积极搭建公众参与平台。

关键词： “河长+检察长” 联动协作河道治理