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过程体裁教学法促进五年级小学生写作能力的实验研究

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滁州职业技术学院学报 2019年第2期18卷 72-76页

作者：王欣程小云嵇奕麟李兴雅吕元婧马琳岳品青天津师范大学心理学部天津300387 天津市河西区天津小学天津300220

如何提高小学生的写作能力是语文教学中的一个热点问题。通过考察过程体裁教学法对小学生作文能力的促进,以天津小学五年级学生为研究对象,设置实验组和对照组,使用过程体裁教学法对实验组进行一学期的标准化作文训练。结果表明,与传统... 详细信息

如何提高小学生的写作能力是语文教学中的一个热点问题。通过考察过程体裁教学法对小学生作文能力的促进,以天津小学五年级学生为研究对象,设置实验组和对照组,使用过程体裁教学法对实验组进行一学期的标准化作文训练。结果表明,与传统教学相比,过程体裁教学能够有效地促进小学生写作能力的发展。

关键词：过程体裁教学法小学写作写作心理

Drug repurposing for cancer treatment through global propagation with a greedy algorithm in a multilayer network

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Cancer Biology & Medicine 2022年第1期19卷 74-89页

作者： Xi cheng Wensi Zhao Mengdi Zhu Bo Wang Xuege Wang xiaoyun Yang Yuqi Huang Minjia Tan Jing Li Department of Bioinformatics and Biostatistics School of Life Sciences and BiotechnologyShanghai Jiao Tong UniversityShanghai 200240China The Chemical Proteomics Center and State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Tissue Microenvironment and Tumor Shanghai Institute of Nutrition and HealthShanghai Institutes for Biological SciencesUniversity of Chinese Academy of SciencesChinese Academy of Sciences(CAS)Shanghai 200031China

Objective:Drug repurposing,the application of existing therapeutics to new indications,holds promise in achieving rapid clinical effects at a much lower cost than that of de novo drug *** aim of our study was to perform a more comprehensive drug repurposing prediction of diseases,particularly ***:Here,by targeting 4,096 human diseases,including 384 cancers,we propose a greedy computational model based on a heterogeneous multilayer network for the repurposing of 1,419 existing drugs in Drug *** performed additional experimental validation for the dominant repurposed drugs in ***:The overall performance of the model was well supported by cross-validation and literature *** on the top-ranked repurposed drugs in cancers,we verified the anticancer effects of 5 repurposed drugs widely used clinically in drug sensitivity *** of the distinctive antitumor effects of nifedipine(an antihypertensive agent)and nortriptyline(an antidepressant drug)in prostate cancer,we further explored their underlying mechanisms by using quantitative *** analysis revealed that both nifedipine and nortriptyline affected the cancer-related pathways of DNA replication,the cell cycle,and RNA ***,in vivo experiments demonstrated that nifedipine and nortriptyline significantly inhibited the growth of prostate tumors in a xenograft ***:Our predicted results,which have been released in a public database named The Predictive Database for Drug Repurposing(PAD),provide an informative resource for discovering and ranking drugs that may potentially be repurposed for cancer treatment and determining new therapeutic effects of existing drugs.

关键词： Database drug repurposing machine learning network random walk proteomics analysis

Relationships between Interannual and Intraseasonal Variations of the Asian–Western Pacific Summer Monsoon Hindcasted by BCC CSM 1.1(m)

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Advances in Atmospheric Sciences 2014年第5期31卷 1051-1064页

作者： LIU Xiangwen WU Tongwen YANG Song LI Qiaoping cheng Yanjie LIANG xiaoyun FANG Yongjie JIE Weihua NIE Suping National Climate Center China Meteorological Administration Department of Atmospheric Sciences Sun Yat-sen University

Using hindcasts of the Beijing Climate Center Climate System Model, the relationships between interannual variability （IAV） and intraseasonal variability （ISV） of the Asian-western Pacific summer monsoon are diagnosed. Predictions show reasonable skill with respect to some basic characteristics of the ISV and IAV of the western North Pacific summer monsoon （WNPSM） and the Indian summer monsoon （ISM）. However, the links between the seasonally averaged ISV （SAISV） and seasonal mean of ISM are overestimated by the model. This deficiency may be partially attributable to the overestimated frequency of long breaks and underestimated frequency of long active spells of ISV in normal ISM years, although the model is capable of capturing the impact of ISV on the seasonal mean by its shift in the probability of phases. Furthermore, the interannual relationships of seasonal mean, SAISV, and seasonally averaged long-wave variability （SALWV; i.e., the part with periods longer than the intraseasonal scale） of the WNPSM and ISM with SST and low-level circulation are examined. The observed seasonal mean, SAISV, and SALWV show similar correlation patterns with SST and atmospheric circulation, but with different details. However, the model presents these correlation distributions with unrealistically small differences among different scales, and it somewhat overestimates the teleconnection between monsoon and tropical central-eastern Pacific SST for the ISM, but underestimates it for the WNPSM, the latter of which is partially related to the too-rapid decrease in the impact of E1 Nifio-Southern Oscillation with forecast time in the model.

关键词： interannual variability intraseasonal variability western North Pacific summer monsoon Indian summer monsoon

Synthesis and Antitumor Activities of 1,3,4-Thiadiazole Derivatives Possessing Benzisoselenazolone Scaffold

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Chemical Research in Chinese Universities 2014年第5期30卷 764-769页

作者： ZHAO Jie XUAN Lina ZHAO Haichuan cheng Ji FU xiaoyun LI Sha JING Fen LIU Yuming CHEN Baoquan School of Chemistry and Chemical Engineering Tianjin University of Technology Tianjin 300384 P. R. China

A series of novel 1,3,4-thiadiazole derivatives possessing benzisoselenazolone scaffold were designed and synthesized, and their antitumor activities against human cervix adenocarcinoma（HeLa）, human liver cancer cell（SMMC-7721）, human breast cancer cell（MCF-7） and human lung cancer cell（A549） lines were evaluated by CCK-8 assay, The bioassay results demonstrate that most of the tested compounds showed potent antiproliferative effects against various cell lines. Furthermore, compounds 7c, 7e, 7h, 7i and 7k showed significant antiproliferative activities against SMMC-7721 cells, with IC5o values of 2.38, 2.67, 1.35, 2.75 and 2.48 μmol/L, respectively. Com- pounds 7a, 7e, 7j and 71 exhibited highly effective antitumor activities against MCF-7 cells, with IC50 values of 2.89, 2.95, 1.12 and 2.75 μmol/L, respectively. Compound 7j was found to be the most potent compound against A549 cells, with an IC50 value of 1.25 μmol/L. The pharmacological results suggest that the substituents of benzylthio-moiety at position 2 on 1,3,4-thiadiazole are vital for modulating antitumor activities against various cancer cell lines.

关键词： 1,3,4-Thiadiazole derivative Benzisoselenazolone Antitumor activity

Structural basis of Zika virus helicase in recognizing its substrates

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Protein & Cell 2016年第8期7卷 562-570页

作者： Hongliang Tian xiaoyun Ji xiaoyun Yang Zhongxin Zhang zuoku Lu Kailin Yang cheng Chen Qi Zhao Heng Chi Zhongyu Mu Wei Xie Zefang Wang Huiqiang Lou Haitao Yang Zihe Rao School of Life Sciences Tianjin University Tianjin 300072 China Tianjin Intemational Joint Academy of Biotechnology and Medicine Tianjin 300457 China The State Key Laboratory of Pharmaceutical Biotechnology School of Life Sciences Nanjing University Nanjing 210023 China State Key Laboratory of Agro-Biotechnology College of Biological Sciences China Agricultural University Beijing 100193 China College of Life Sciences Nankai University Tianjin 300071 China Cleveland Clinic Lemer College of Medicine of Case Western Reserve University Cleveland OH 44195 USA Department of Molecular Biophysics and Biochemistry Yale University New Haven CT 06520 USA

The recent explosive outbreak of Zika virus （ZlKV） infection has been reported in South and Central America and the Caribbean. Neonatal microcephaly associated with ZIKV infection has already caused a public health emergency of international concern. No specific vaccines or drugs are currently available to treat ZIKV infection. The ZIKV helicase, which plays a pivotal role in viral RNA replication, is an attractive tar- get for therapy. We determined the crystal structures of ZIKV helicase-ATP-Mnz＋ and ZlKV helicase-RNA. This is the first structure of any flavivirus helicase bound to ATP. Comparisons with related flavivirus helicases have shown that although the critical P-loop in the active site has variable conformations among different species, it adopts an identical mode to recognize ATPIMn2＋. The structure of ZlKV helicase-RNA has revealed that upon RNA binding, rotations of the motor domains can cause significant conformational changes. Strikingly, although ZlKV and dengue virus （DENV） apo-helicases share conserved residues for RNA binding, their different manners of motor domain rotations result in distinct individual modes for RNA recognition. It suggests that flavivirus helicases could have evolved a conserved engine to convert chemical energy from nucleoside triphosphate to mechanical energy for RNA unwinding, but different motor domain rotations result in variable RNA recognition modes to adapt to individual viral replication.

关键词： Zika virus helicase ATP crystal structure,flavivirus

Investigating the ENSO prediction skills of the Beijing Climate Center climate prediction system version 2

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Acta Oceanologica Sinica 2022年第5期41卷 99-109页

作者： Yanjie cheng Youmin Tang Tongwen Wu Xiaoge Xin Xiangwen Liu Jianglong Li xiaoyun Liang Qiaoping Li Junchen Yao Jinghui Yan CMA Earth System Modeling and Prediction Centre China Meteorological Administration(CMA)Beijing100081China State Key Laboratory of Severe Weather China Meteorological AdministrationBeijing100081China College of Environmental Science and Engineering University of Northern British ColumbiaPrince GeorgeV2N 4Z9Canada

The El Niño-Southern Oscillation(ENSO)ensemble prediction skills of the Beijing Climate Center(BCC)climate prediction system version 2(BCC-CPS2)are examined for the period from 1991 to *** upper-limit ENSO predictability of this system is quantified by measuring its“potential”predictability using information-based metrics,whereas the actual prediction skill is evaluated using deterministic and probabilistic skill *** show that:(1)In general,the current operational BCC model achieves an effective 10-month lead predictability for ***,prediction skills are up to 10–11 months for the warm and cold ENSO phases,while the normal phase has a prediction skill of just 6 months.(2)Similar to previous results of the intermediate coupled models,the relative entropy(RE)with a dominating ENSO signal component can more effectively quantify correlation-based prediction skills compared to the predictive information(PI)and the predictive power(PP).(3)An evaluation of the signal-dependent feature of the prediction skill scores suggests the relationship between the“Spring predictability barrier(SPB)”of ENSO prediction and the weak ENSO signal phase during boreal spring and early summer.

关键词： ENSO ensemble prediction skill potential predictability measure BCC-CPS2 climate model

Genomic instability and eye diseases

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Advances in Ophthalmology Practice and Research 2023年第3期3卷 103-111页

作者： Hongyan Liu Jun cheng xiaoyun Zhuang Benxiang Qi Fenfen Li Bining Zhang Eye Institute of Shandong First Medical University Qingdao Eye Hospital of Shandong First Medical UniversityQingdaoChina School of Ophthalmology Shandong First Medical UniversityQingdaoChina State Key Laboratory Cultivation Base Shandong Provincial Key Laboratory of OphthalmologyQingdaoChina Eye Institute of Shandong First Medical University Eye Hospital of Shandong First Medical University(Shandong Eye Hospital)JinanChina Department of Ophthalmology School of Clinical MedicineWeifang Medical UniversityWeifangChina The Eye Hospital of Wenzhou Medical University HangzhouChina

Background:Genetic information is stored in the bases of double-stranded ***,the integrity of DNA molecules is constantly threatened by various mutagenic agents,including pollutants,ultraviolet light(UV),and *** counteract these environmental damages,cells have established multiple mechanisms,such as producing molecules to identify and eliminate damaged DNA,as well as reconstruct the original DNA *** or insufficiency of these mechanisms can cause genetic ***,the role of genome stability in eye diseases is still under-researched,despite extensive study in cancer *** text:As the eye is directly exposed to the external environment,the genetic materials of ocular cells are constantly under *** of the proteins essential for DNA damage repair,such as pRb,p53,and RAD21,are also key during the ocular disease *** this review,we discuss five ocular diseases that are associated with genomic *** and pterygium are linked to abnormal cell ***’corneal endothelial dystrophy and age-related macular degeneration are related to the accumulation of DNA damage caused by oxidative damage and *** mutation of the subunit of the cohesin complex during eye development is linked to ***:Failure of DNA damage detection or repair leads to increased genomic *** the role of genomic instability in ocular diseases can lead to the development of new treatments and strategies,such as protecting vulnerable cells from risk factors or intensifying damage to unwanted cells.

关键词： Genomic instability Ocular diseases Retinoblastoma Cornea Pterygium

The protective effects of Levilactobacillus brevis FZU0713 on lipid metabolism and intestinal microbiota in hyperlipidemic rats

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Food Science and Human Wellness 2023年第5期12卷 1646-1659页

作者： xiaoyun Fan Qing Zhang Weiling Guo Qi Wu Jinpeng Hu Wenjian cheng Xucong Lü Pingfan Rao Li Ni Youting Chen Lijiao Chen Institute of Food Science and Technology College of Biological Science and EngineeringFuzhou UniversityFuzhou 350108China College of Food Science Fujian Agriculture and Forestry UniversityFuzhou 350002China Jinjiang Food Engineering Research Center School of Advanced ManufacturingFuzhou UniversityJinjiang 362200China Department of Hepatopancreatobiliary Surgery Fujian Research Institute of Abdominal SurgeryThe First Affi liated Hospital of Fujian Medical UniversityFuzhou 350005China

Levilactobacillus brevis FZU0713, a potential probiotic previously isolated from the traditional brewing process of Hongqu rice wine, may have the beneficial effects on improving lipid metabolism. This study aimed to evaluate the in vivo protective effects and possible mechanism of L. brevis FZU0713 on the disturbance of lipid metabolism in hyperlipidemic rats fed a high-fat diet(HFD). Results showed that oral administration of L. brevis FZU0713 could significantly inhibit obesity, ameliorate the lipid metabolism disorder, including serum/liver biochemical parameters and hepatic oxidative stress in HFD-fed rats. Histopathological result also indicated that dietary intervention of L. brevis FZU0713 could reduce the accumulation of lipid droplets in liver induced by 8 weeks HFD feeding. Furthermore, L. brevis FZU0713 intervention significantly increased the fecal levels of short-chain fatty acids(SCFAs, including acetate, propionate, butyrate, isobutyrate, valerate and isovalerate)in HFD-fed rats, which may be closely related to the changes of intestinal microbial composition and metabolic function. Intestinal microbiota profiling by 16S rRNA gene sequencing revealed that L. brevis FZU0713 intervention significantly altered the relative abundance of Coprococcus, Butyricicoccus, Intestinimonas, Lachnospiraceae FCS020 group, Ruminococcaceae_NK4A214 group, Ruminococcaceae_UCG-005 and UCG-014 at genus levels. Based on Spearman's rank correlation coefficient, serum and liver lipid metabolism related biochemical parameters were positively correlated with genera Ruminococcus, Pediococcus and Lachnospiraceae, but negatively correlated with genera Pseudoflavonifractor, Butyricicoccus and Intestinimonas. Furthermore, liver metabolomics analysis demonstrated that L. brevis FZU0713 had a significant regulatory effect on the composition of liver metabolites in hyperlipidemic rats, especially the levels of some important biomarkers involved in the metabolic pathways of arachidonic

关键词： Levilactobacillus brevis FZU0713 Lipid metabolism Hyperlipidemia Intestinal microbiota Liver metabolomics mRNA expression

Supporting and retaining competent primary care workforce in low-resource settings:lessons learned from a prospective cohort study

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Family Medicine and Community Health 2023年第4期11卷 13-35页

作者： Mingyue Li Haoqing Tang Huixian Zheng Yiran Tian Xiaoran cheng Haozhe cheng Xiaotian Zhang Dan Hu xiaoyun Liu School of Public Health Peking UniversityBeijingChina China Center for Health Development Studies Peking UniversityBeijingChina School of Health Policy and Management Nanjing Medical UniversityNanjingJiangsuChina

Objective Assess whether local health facilities can adequately support the performance of general practitioners(GPs)trained by China’s national compulsory services programme(CSP).Design Prospective cohort *** Health facilities in middle and western rural areas in China,2015–*** Cohorts of CSP graduates from 2015 to 2019 in four major medical *** outcomes Job performance measured by a 12-item Job Performance Scale;productivity measured by outpatient volume per day;turnover measured by ever changing jobs within the past *** 91.2%,92.0%and 90.5%GPs working in township health centres reported inadequate medication,equipment and external assistance from higher level hospitals,while CSP graduates working in secondary or tertiary hospitals reported a lower rate of less than 60%.The top three tests reported as lacking were blood gases(67.7%),microbiology(61.6%)and cancer biomarkers(49.7%);the top three lacked procedures were CT scan(64.8%),MRI scan(58.1%)and ambulatory BP monitoring(55.8%);and the top three lacked drugs were drugs for cardiovascular diseases(23.3%),systematic hormonal preparations(17.7%)and traditional Chinese medicines(13.0%).Multivariable analysis showed that facility support was positively associated with job performance—adequate medication increased job performance by 2.2 points(95%CI 0.7to 3.8),and adequate external assistance increased job performance by 3.3 points(95%CI 1.8to 4.8).Facility support was also positively associated with productivity—adequate medication increased outpatients seen per day by 20%(95%CI 0.1to 0.3),and adequate equipment increased outpatients seen per day by 12%(95%CI 0.0to 0.2).Facility support did not have significant impact on turnover,but GPs who changed jobs in the past year were 1.9–2.3 times more likely to report adequate facility *** GPs in township health centres experienced a high prevalence of shortage in facility *** identification of a positiv

关键词： retaining adequate facility