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TCR-mimic antibody-drug conjugates targeting intracellular tumor-specific mutant antigen KRAS G12V mutation

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Asian Journal of Pharmaceutical Sciences 2020年第6期15卷 777-785页

作者： Ying Shen xiaoyue Wei Shijie Jin Yue Wu Wenbin zhao Yingchun Xu Liqiang Pan Zhan Zhou Shuqing Chen College of Pharmaceutical Sciences Zhejiang UniversityHangzhou 310058China Huabo Biopharm Co. Ltd.Shanghai 201203China

Limited clinical application of antibody-drug conjugates(ADCs)targeting tumor associated antigens(TAAs)is usually caused by on-target off-tumor side effect.Tumor-specific mutant antigens(TSMAs)only expressed in tumor cells which are ideal targets for ADCs.In addition,intracellular somatic mutant proteins can be presented on the cell surface by human leukocyte antigen class I(HLA I)molecules forming tumor-specific peptide/HLA I complexes.KRAS G12 V mutation frequently occurred in varied cancer and was verified as a promising target for cancer therapy.In this study,we generated two TCR-mimic antibodydrug conjugates(TCRm-ADCs),2E8-MMAE and 2 A5-MMAE,targeting KRAS G12 V/HLAA*0201 complex,which mediated specific antitumor activity in vitro and in vivo without obvious toxicity.Our findings are the first time validate the strategy of TCRm-ADCs targeting intracellular TSMAs,which improves the safety of antibody-based drugs and provides novel strategy for precision medicine in cancer therapy.

关键词： TCR-mimic antibody-drug conjugates Tumor-specific mutant antigens KRAS G12V Human leukocyte antigen classⅠ

Evaluation of the sustainable development level of countries along the Belt and Road and its impact factors:Empirical analysis based on the Super-efficiency slacks-based measure and Tobit measure models

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Chinese Journal of Population,Resources and Environment 2021年第2期19卷 162-170页

作者： Tianhang Huang Xiaoyu zhao Chi-Han Ai Shaofeng Chen Yi Wang xiaoyue Hu School of Public Policy and Management University of Chinese Academy of SciencesBeijing100190China Tamkang University Lanyang Campus New Taipei City251301China Institutes of Science and Development Chinese Academy of SciencesSchool of Public Policy and ManagementUniversity of Chinese Academy of SciencesBeijing100190China School of Sociology and Population Studies Renmin University of ChinaBeijing102249China

Sustainable development is an important component of the Belt and Road Initiative(BRI)and is of great significance for evaluating the levels of sustainable development of countries along this route(henceforth,BRI countries).Therefore,this study aims to identify the factors that influence the levels of sustainable development of BRI countries in a reasonable and objective manner.Eventually,this study employs the super efficiency slacks-based measure(Super-SBM)model,which considers unexpected outputs to measure the level of sustainable development of BRI countries.The dynamic change and composition of the sustainable development level of these countries are calculated using the global Malmquist-Luenberger index.Furthermore,the Tobit model is used to identify the factors influencing the level of sustainable development of BRI countries in general and in various categories.The empirical results suggest the following points.(a)The overall level of sustainable development of BRI countries is low,whereas those of high-income and middle-and high-income countries are relatively high.(b)The overall sustainable development levels of BRI countries declined to a certain extent in 2008 owing to the effect of the financial crisis,.However,the sustainable development level of other countries,barring low-income countries,has gradually increased since 2011.(c)Since 2008,technological progress has replaced technical efficiency as the main driving force behind the improvement of the sustainable development level of BRI countries.(d)A U-shaped relationship is observed between the economic and sustainable development levels of these countries.(e)The level of science and technology and the proportion of renewable energy consumption can promote the sustainable development of these countries.Moreover,a negative correlation exists between the level of opening to the outside world and that of sustainable development of countries that mainly export resource-based products and are dominated by labor-intensive export industries.Barring low-in

关键词： Belt and Road Initiative Sustainable development level Super-efficiency slacks-based measure model Global Malmquist-Luenberger Index Tobit model

Machining deformation of single-sided component based on finishing allowance optimization

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Chinese Journal of Aeronautics 2020年第9期33卷 2434-2444页

作者： xiaoyue LI Liang LI Yinfei YANG Guolong zhao Ning HE Xiaocen DING Yaowen SHI Longxin FAN Hui LAN Muhammad JAMIL National Key Laboratory of Science and Technology on Helicopter Transmission Nanjing University of Aeronautics and AstronauticsNanjing 210016China AVIC Jiangxi Hongdu A viation Industry Group Company Ltd Nanchang 330000China

Owing to reliability and high strength-to-weight ratio,large thin-walled components are widely used in the aviation and aerospace industry.Due to the complex features and sequence involved in the machining process of large thin-walled components,machining deformation of component is easy to exceed the specification.In order to address the problem,it is important to retain the appropriate finishing allowance.To find the overall machining deformation,finishing allowance-induced deformation(web finishing allowance,sidewall finishing allowance)and initial residual stress-induced deformation were considered as major factors.Meanwhile,machined surface residual stress-induced deformation,clamping stress-induced deformation,thermal deformation,gravity-induced deformation and inertial force-induced deformation were neglected in the optimization model.Six-peak Gaussian function was introduced to fit the initial residual stress.Based upon the obtained function of initial residual stress,a deformation prediction model between initial residual stress and finishing allowance was established to attain the finishing allowanceinduced deformation.In addition,linear programming optimization model based on the simplex algorithm was developed to optimize the overall machining deformation.Results have concluded that the overall machining deformation reached the minimum value when sidewall finishing allowance and web finishing allowance varied between 1 and 2 mm.Additionally,web finishing allowance-induced deformation and sidewall finishing allowance-induced deformation were1.05 mm and 0.7 mm.Furthermore,the machining deformation decreased to 0.3–0.38 mm with the application of optimized finishing allowance allocation strategy,which made 39–56%reduction of the overall machining deformation compared to that in conventional method.

关键词： Finishing allowance Linear programming Machining deformation Residual stresses Simplex algorithm

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基于用户偏好特征的微博转发预测

武汉大学学报（工学版） 2023年第6期56卷 749-756页

作者：郑聪江昊赵小月武汉大学电子信息学院湖北武汉430072

在线社交网络为信息的传播提供了渠道,但同时也加快了不良信息的传播速度。针对真实场景下新浪微博社交网络中的转发现象,分析了微博网络中用户之间的相互影响关系,以及微博文本内容等特征对受众用户的影响,证明了这些信息对于预测微博... 详细信息

在线社交网络为信息的传播提供了渠道,但同时也加快了不良信息的传播速度。针对真实场景下新浪微博社交网络中的转发现象,分析了微博网络中用户之间的相互影响关系,以及微博文本内容等特征对受众用户的影响,证明了这些信息对于预测微博转发序列的有效性。提出了一种综合微博用户偏好信息及关系信息的微博转发序列预测方法,该方法使用Transformer编码器分析了微博发布之后的早期转发序列,随后,使用注意力机制处理微博文本信息和其他信息对转发过程的影响,预测下一步可能会转发的用户。从真实社交网络中提取得到微博的转发序列,共涉及14891位用户,使用提出的方法处理该数据集,实验结果表明,所提方法的概率排名TOP500的准确率达到71%,对比当前同类型预测方法,所提方法的性能提升了约10%。

关键词：在线社交网络微博转发预测用户偏好特征深度学习

A comprehensive analysis of the Bencao(herbal)small RNA Atlas reveals novel RNA therapeutics for treating human diseases

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Science China(Life Sciences) 2023年第10期66卷 2380-2398页

作者： Yinghao Cao Yexuan Lin Na Sun Xinyi Du Yixin Dong Song Mei Xingyu Deng Xiaobei Li Shaoting Guo Kegong Tang Jiaqi Liu Xiangyu Qiao Dandan zhao Yuhao Qin Cong Zhang Tianyi Xin Xiaohu Shi Congzhao Zhou Tao Dong De-an Guo Benedikt MKessler Dong Xu Jingyuan Song Fengming Huang xiaoyue Wang Chengyu Jiang State Key Laboratory of Common Mechanism Research for Major Diseases Department of BiochemistryInstitute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing 100005China Key Laboratory of Chinese Medicine Resources Conservation State Administration of Traditional Chinese Medicine of ChinaEngineering Research Center of Chinese Medicine Resource of Ministry of EducationInstitute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100193China Department of Traditional Chinese Medicine Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100005China Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences University of Science and Technology of ChinaHefei 230027China MRC Human Immunology Unit MRC Weatherall Institute of Molecular MedicineRadcliffe Department of MedicineUniversity of OxfordOxford OX37FZUK Chinese Academy of Medical Sciences(CAMS) CAMS Oxford Institute(COI)Nuffield Department of MedicineUniversity of OxfordOxfordOX37FZUK Shanghai Research Center for Modernization of Traditional Chinese Medicine National Engineering Laboratory for TCM Standardization TechnologyShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Target Discovery Institute Centre for Medicines DiscoveryNuffield Department of MedicineUniversity of OxfordOxfordOX37FZUK Department of Electrical Engineering and Computer Science and Christopher S.Bond Life Sciences CenterUniversity of MissouriColumbia MO 65211USA

Cross-kingdom herbal mi RNA was first reported in 2012.Using a modified herbal extraction protocol,we obtained 73,677,287sequences by RNA-seq from 245 traditional Chinese Medicine(TCM),of which 20,758,257 were unique sequences.We constructed a Bencao(herbal)small RNA(s RNA)Atlas(http://***),annotated the sequences by sequence-based clustering,and created a nomenclature system for Bencao s RNAs.The profiles of 21,757 mi RNAs in the Atlas were highly consistent with those of plant mi RNAs in mi RBase.Using software tools,our results demonstrated that all human genes might be regulated by s RNAs from the Bencao s RNA Atlas,part of the predicted human target genes were experimentally validated,suggesting that Bencao s RNAs might be one of the main bioactive components of herbal medicines.We established roadmaps for oligonucleotide drugs development and optimization of TCM prescriptions.Moreover,the decoctosome,a lipo-nano particle consisting of 0.5%–2.5%of the decoction,demonstrated potent medical effects.We propose a Bencao(herbal)Index,including small-molecule compounds(SM),protein peptides(P),nucleic acid(N),non-nucleic and non-proteinogenic large-molecule compounds(LM)and elements from Mendeleev's periodic table(E),to quantitatively measure the medical effects of botanic medicine.The Bencao s RNA Atlas is a resource for developing gene-targeting oligonucleotide drugs and optimizing botanical medicine,and may provide potential remedies for the theory and practice of one medicine.

关键词： small RNA herbal decoction cross-kingdom regulation traditional Chinese medicine RNA oligonucleotide drug RNA therapeutics Bencao small RNA Atlas

Self-Assembly of Luminescent Twisted Fibers Based on Achiral Quinacridone Derivatives

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Nano Research 2009年第6期2卷 493-499页

作者： Yunfeng zhao Yan Fan xiaoyue Mu Hongze Gao Jia Wang Jingying Zhang Wensheng Yang Lifeng Chi Yue Wang State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012China Physikalisches Institut and Center for Nanotechnology(CeNTech) Universität MünsterMünster 48149Germany

It is a great challenge to spontaneously assemble achiral molecules into twisted nanostructures in the absence of chiral substances.Here we show that two achiral centrosymmetric quinacridone(QA)derivatives,N,N’-di(n-hexyl)-1,3,8,10-tetramethylquinacridone(C6TMQA)and N,N’-di(n-decyl)-1,3,8,10-tetramethylquinac ridone(C10TMQA),can be employed as building blocks to fabricate well-defi ned twisted nanostructures by controlling the solvent composition and concentration.Bowknot-like bundles with twisted fiber arms were prepared from C6TMQA,whilst uniform twisted fibers were generated from C10TMQA in ethanol/THF solution.Spectroscopic characterization and molecular simulation calculations revealed that the introduction of ethanol into the solution could induce a staggered aggregation of C6TMQA(or C10TMQA)molecules and the formation of twisted nanostructures.Such twisted materials generated from achiral organic functional molecules may be valuable in the design and fabrication of new materials for optoelectronic applications.

关键词： Twisted fi ber quinacridone self-assembly luminescence

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基于C-DGCN的信息流行度预测

武汉大学学报（工学版） 2023年第4期56卷 506-514页

作者：赵小月曾园园江昊武汉大学电子信息学院先进网络与智能系统实验室湖北武汉430072

提出了一种基于上下文依赖的动态图卷积网络(context dependent dynamic graph convolutional network,CDGCN)对在线社交网络进行信息流行度预测,即根据信息的历史转发动态预测将来的流行度。根据信息转发动态构建转发网络,并将转发文... 详细信息

提出了一种基于上下文依赖的动态图卷积网络(context dependent dynamic graph convolutional network,CDGCN)对在线社交网络进行信息流行度预测,即根据信息的历史转发动态预测将来的流行度。根据信息转发动态构建转发网络,并将转发文本嵌入作为节点属性。C-DGCN基于扩散核的图卷积网络对转发网络进行嵌入,得到空间依赖表示,并输入循环神经网络(recurrent neural network,RNN)学习实时依赖表示。在2020年1月的微博数据集上进行了实验,并将C-DGCN与传统的基于特征设计、基于生成模型、基于深度学习的方法进行了比较。CDGCN的优势在于:1)充分考虑了文本内容对信息传播的驱动作用,建模表示了语义特性变化的影响,捕获了上下文依赖特性;2)扩散核是基于时间延迟特性的,循环神经网络能够捕获实时特性,充分建模表示了信息传播的时-空依赖。

关键词：上下文依赖图卷积网络信息流行度扩散核深度学习时-空依赖

考虑综合需求响应的虚拟电厂日前调度优化策略

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现代电力 2023年第6期40卷 976-984页

作者：赵书豪王进张孝跃长沙理工大学电气与信息工程学院湖南省长沙市410000

为有效缓解三北地区高比例可再生能源并网所存在的大规模弃风问题,将火电机组、热电联产机组、光热电站、风电厂和电热负荷聚合为虚拟电厂。首先采用场景分析法对日前风光场景进行随机优化,降低风光预测误差;利用综合需求响应机制充分... 详细信息

为有效缓解三北地区高比例可再生能源并网所存在的大规模弃风问题,将火电机组、热电联产机组、光热电站、风电厂和电热负荷聚合为虚拟电厂。首先采用场景分析法对日前风光场景进行随机优化,降低风光预测误差;利用综合需求响应机制充分调动电热柔性负荷资源。然后综合考虑系统运行成本、弃风成本和需求响应成本构建虚拟电厂(virtual power plant,VPP)系统日前调度优化模型,并在多种运行模式下求解以获得最优日前调度计划。最后通过算例分析验证所提方案在提高系统经济性的同时能有效促进风电消纳。

关键词：虚拟电厂光热电站场景分析综合需求响应日前调度

基于随机优化的虚拟电厂热电联合经济优化调度

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太阳能学报 2023年第9期44卷 57-65页

作者：李嘉森王进杨蒙赵书豪张孝跃长沙理工大学电气与信息工程学院长沙410114 国网河南省电力公司超高压公司郑州450000

针对三北地区现有能源结构调节能力不足而导致的弃风问题,将风电场、光热电站、火电机组和热电联产机组聚合为虚拟电厂。采用随机优化处理风光不确定性问题,通过拉丁超立方抽样生成大量随机风光场景,并在充分考虑风光相关性和分布随机... 详细信息

针对三北地区现有能源结构调节能力不足而导致的弃风问题,将风电场、光热电站、火电机组和热电联产机组聚合为虚拟电厂。采用随机优化处理风光不确定性问题,通过拉丁超立方抽样生成大量随机风光场景,并在充分考虑风光相关性和分布随机特性的基础上,利用Kantorovich距离削减与K-均值聚类算法对随机场景进行降维优化,获得风电、太阳直接辐照度典型预测场景。结合光热电站的灵活性与供能惯性,构建含光热虚拟电厂热电联合优化调度模型,并建立系统总运行成本最小的目标函数。最后在算例部分验证所提随机优化方法在计算效率、预测精度和处理风光随机问题的优越性;对不同运行模式下的目标函数进行求解,验证所提出的优化调度策略能够在满足系统运行经济性的同时实现风电的最大消纳。

关键词：虚拟电厂不确定性随机优化场景生成优化调度