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人工智能在阿尔茨海默病临床诊疗中的研究热点及前沿趋势分析

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中国全科医学 2024年第26期27卷 3218-3226页

作者：余如霞姜婧王湫澄王越赵小月北京中医药大学护理学院北京市100029 北京中医药大学针灸推拿学院北京市100029

背景目前,人工智能应用于阿尔茨海默病(AD)领域的研究论文数量增幅较大,明确该领域最新研究热点和未来发展趋势十分重要。目的通过应用文献计量学分析,总结人工智能应用于AD领域的相关研究,阐明2004-2023年的研究热点和未来研究趋势。... 详细信息

背景目前,人工智能应用于阿尔茨海默病(AD)领域的研究论文数量增幅较大,明确该领域最新研究热点和未来发展趋势十分重要。目的通过应用文献计量学分析,总结人工智能应用于AD领域的相关研究,阐明2004-2023年的研究热点和未来研究趋势。方法在Web of Science核心数据库中检索了2004年1月-2023年6月关于人工智能应用于AD领域的文献。采用Microsoft Office Excel、CiteSpace和VOSviewer软件对发文量、国家、作者、机构、关键词和共引网络进行可视化分析。结果最终纳入了3189篇文献。自2004年以来有关人工智能应用于AD领域的文献数量稳步增加,并从2015年起进入快速增长阶段,最高突破600篇。共有94个国家、3930家机构、13563位作者以及52019位被引作者参与了此研究。其中,美国和中国在这一领域中处于领先地位;韩国大学发文量位列第一;此外,ZHANG DAOQIANG、LIU MINGXIA、SUK HEUNG-IL和CLIFFFORD *** Jr不仅是高产的作者还是被引次数最多的作者。根据关键词和文献被引结果的可视化分析,发现AD的诊断与病程分类、预测AD的风险因素是当前的研究热点,任务分析是未来人工智能应用于AD领域中的研究趋势。结论人工智能应用于AD领域已经引起了全球研究者的广泛关注,AD的诊断与病程分类、预测AD的风险因素是当前的研究热点,而任务分析中的辅助药物的研发、个性化治疗和护理以及提升人工智能的算法性能可能会成为未来的研究趋势。

关键词：阿尔茨海默病痴呆人工智能 CiteSpace VOSviewer 文献计量学

Influences of spherical tree canopy on thermal radiation disturbance to exterior wall under the condition of no shade cast on the wall

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Building Simulation 2022年第7期15卷 1367-1383页

作者： Tailong Zhang xiaoyue zhao Yu zhao Derek Lukolongo Mwewa Chabi Feng Qi School of Landscape Architecture Zhejiang A&F UniversityLin'an 371300China

Research on the influence of thermal radiation of tree canopies to adjacent exterior walls has relevance to the selection of tree species and the spatial arrangement of trees for urban *** the last decade,there have been many studies on the influence of tree shadows on the thermal environment and energy consumption of ***,there is a lack of research on how trees affect the thermal radiation of adjacent buildings,when they do not cast direct shadows on the *** view of this,a combination of experiment and simulation was used to explore the influence of spherical canopy on the intensity changes of net long-wave thermal radiation(T_(RDL))and net short-wave thermal radiation(T_(RDS))absorbed by the adjacent *** measured and simulated results show that the tree canopy has a T_(RD)(the sum of T_(RDL) and T_(RDS))effect on the south wall of adjacent buildings in *** peak of T_(RD) from the tree to the adjacent wall was obtained by ENVI-met under 27 scenarios.A functional relationship was further given between the peak T_(RD) and the canopy diameter(D_(C)),the minimum distance between wall and tree canopy(D_(W-T)).Moreover,the influence of D_(C),D_(W-T) and leaf area density(LAD)on T_(RD) was discussed by ***,the Trd of canopy decays exponentially in the horizontal direction and linearly in the vertical direction of the *** above methods and results can guide the selection of tree species,green space design around buildings and the evaluation of the influence of trees on indoor cooling energy consumption in summer.

关键词： tree canopy thermal radiation disturbance exterior wall ENVI-met

Protective effects of VMY-2-95 on corticosterone-induced injuries in mice and cellular models

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Acta Pharmaceutica Sinica B 2021年第7期11卷 1903-1913页

作者： Ziru Yu Dewen Kong Yu Liang xiaoyue zhao Guanhua Du State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Beijing Key Laboratory of Drug Target and Screening ResearchInstitute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

Nicotinicα4β2 receptor antagonists have drawn increasing attention in the development of new *** this study,we aimed to investigate the protective effect of VMY-2-95,the new selective antagonist ofα4β2 nicotinic acetylcholine receptor(nAChR)on corticosterone(CORT)injured mice and cellular *** was applied as a positive control,and the effects of VMY-2-95 were investigated with three different doses or concentrations(1,3,10 mg/kg in mice,and 0.003,0.03,0.1μmol/L in cells).As a result,VMY-2-95 showed significant antidepressant-like effects in the CORT injured mice by improving neuromorphic function,promoting hippocampal nerve proliferation,and regulating the contents of monoamine ***,VMY-2-95 exhibited protective effects on cell viability,cell oxidant,cell apoptosis,and mitochondrial energy metabolism on corticosterone-impaired SH-SY5 Y ***,the PKA-CREB-BDNF signaling pathway was up-regulated by VMY-2-95 both in vitro and in vivo,and pathway blockers were also combined with VMY-2-95 to verify the effects ***,we preliminarily proved that VMY-2-95 had protective effects in depressed mice and SH-SY5 Y cells against injuries induced by *** work indicated that the application of VMY-2-95 is a potential pharmacological solution for *** study also supported the development ofα4β2 nAChR antagonists towards neuropsychiatric dysfunctions.

关键词： α4β2 nAChR antagonist VMY-2-95 Cholinergiceadrenergic theory Depression Corticosterone SH-SY5Y cells PKA-CREB-BDNF signaling pathway

Author correction to‘Protective effects of VMY-2-95 on corticosterone-induced injuries in mice and cellular models’[Acta Pharmaceutica Sinica B 11(2021)1903-1913]

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Acta Pharmaceutica Sinica B 2023年第8期13卷 899-901页

The authors regret that there was a picture error in Fig.5F owing to the inappropriate data statistics—forgetting gating when data collecting and a picture error in Fig.6F owing to the data copy mistake when drawing ... 详细信息

关键词： correction injuries getting

China Cultural Center in Moscow:Shared World,Shared Moon,Shared Happiness

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China & The World Cultural Exchange 2020年第10期86卷 13-14页

作者： zhao xiaoyue 不详

From September 28 to October 5,2020,online cultural week event of Mid-Autumn Festival:A Moonmoment to Remember lunched by China Cultural Center in Moscow,greeted the Russians online for the first time.

关键词： Moscow Moon Russian

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中国壳斗科植物属的水平地带性及其成因研究

太原师范学院学报（自然科学版） 2024年第2期23卷 72-78页

作者：邱丽氚岳晓英赵晓月李雅丽王建太原师范学院地理科学学院山西晋中030619

栗属、锥属、青冈属、水青冈属、柯属、栎属均具有水平地带性.锥属、柯属、青冈属、水青冈属主要分布在亚热带,在107°~109°E分界处将经度地带性分为西部、东部,主要受冬季降水量影响,冬季降水量在西部低于52 mm,东部则高于167 mm,西... 详细信息

栗属、锥属、青冈属、水青冈属、柯属、栎属均具有水平地带性.锥属、柯属、青冈属、水青冈属主要分布在亚热带,在107°~109°E分界处将经度地带性分为西部、东部,主要受冬季降水量影响,冬季降水量在西部低于52 mm,东部则高于167 mm,西部比东部更干燥.柯属、锥属、青冈属、水青冈属、栗属在23°~25°N、28°~33°N分界处,将纬度地带性分为南部、中部、北部,主要受冬季平均温度的影响,冬季平均温度分别是高于11℃、6~10.5℃、低于5℃.栎属边界线的年降水量为486mm,冬季的降水量及平均温度分别是11.4 mm、-9.4℃.

关键词：壳斗科属经度地带性纬度地带性气候因素

Identification of Motor Nuclei in the Medulla Oblongata of Carp for Biological Control

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Journal of Bionic Engineering 2024年第2期21卷 842-851页

作者： Yang zhao Yong Peng Yudong Wen Lingjun Han Yanhong Yan Xueying Dong Hui Zhang Zheng zhao xiaoyue Liu School of Electrical Engineering Yanshan UniversityQinhuangdao066004China School of Mechanical Engineering Yanshan UniversityQinhuangdao066004China Key Laboratory of National Defense of Mechanical Structure and Material Science Under Extreme Conditions Yanshan UniversityQinhuangdao066004China Institute of Marine Science and Engineering Yanshan UniversityQinhuangdao066004China Shijiazhuang University Shijiazhuang050035China

Brain-controlled technology is the key technology in biological control,and the corresponding relationship between animal brain nuclei and motor behavior is the *** purpose of this study was to explore the motor nuclei of the medulla oblongata in *** carps were subjected to electrical stimulation and chemical stimulation experiments,respectively,in the water-free state,and the effective chemical stimulation sites were injected with the pontamine sky blue *** brain tissue sections were obtained by paraffin tissue section technology and the neutral red staining *** comparing the positions of the brain nuclei shown in earlier studies,the motor nerve nuclei in the medulla oblongata were *** brain electrode was implanted into the motor nucleus of the medulla oblongata,and the underwater control experiment and behavioral tests were carried out with different electrical stimulation *** results showed that the abducens nucleus(NVI)was the motor nucleus that controls the ipsilateral steering,and the facial nucleus(NVII)was the motor nucleus that controls the forward *** adjusting the stimulation voltage and the stimulation pulse number,the carp can be stably controlled to achieve a left–right steering motion of 30°–180°and a forward motion of more than 80 cm/*** study indicated that the quantitative control of the steering and forward behavior of the carp can be achieved by electrical stimulation of the NVI and NVII,which provided a certain experimental basis for the accurate control of the carp robot.

关键词： Biological control Carp Medulla oblongata motor nucleus Electrical stimulation technique Chemical stimulation technique

Mechanism study and uric acid reduce effects of theaflavin on potassium oxonate induced hyperuricemia in mice

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Mechanism study and uric acid reduce effects of theaflavin o...

Sea cucumber derived sulfated sterols alter glucose metabolism by promoting gluconeogenesis and reducing glycogenesis in healthy mice

第十一届海峡两岸心血管科学研讨会、2017年全国心脑血管药理学术会议、中国卒中学会第一次新药研讨会

作者： Zhou Qimeng Wang Haigang zhao xiaoyue Yang Haiguang Du Guanhua Institute of Materia Medica Chinese Academy of medical science and Peking Union Medical College

Background:Hyperuricemia is an independent risk factor for cardiovascular ***,it's also tightly relative with hypertension and metabolic *** were reported as materials that has anti-hyperlipidemia,anti-inflammatory,antioxidant and anti-tumor *** study observes theaflavins' effect of reducing uric acid level and its mechanism in hyperuricemia mice induced by potassium oxonate.

关键词： Mechanism study and uric acid reduce effects of theaflavin on potassium oxonate induced hyperuricemia in mice

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Food Science and Human Wellness 2024年

作者： Shanyun Yu Teng Wang Yingcai zhao xiaoyue Li Changhu Xue Yuming Wang Tiantian Zhang SKL of Marine Food Processing & Safety Control， College of Food Science and Engineering， Ocean University of China Sanya Institute of Oceanography， Ocean University of China

Sea cucumber derived sulfated sterols (SS) significantly ameliorated insulin resistance and decreased lipid accumulation compared to plant sterols. Interestingly， our recent study found that intervention with sea cucumber sulfated sterols could significantly increase blood glucose levels of healthy mice in the presence of glucose， while cholesterol sulfate， as one of sulfated sterols， did not have the same effect. However， the exact mechanism of SS on glucose metabolism is still unknown. In the present study， we investigated the potential mechanism by which SS influenced blood glucose homeostasis in healthy mice. Results showed that intervention with sea cucumber sulfated sterols did not affect the levels of hormones related to glucose metabolism， while led to a significant decrease in the synthesis of liver glycogen and muscle glycogen. Besides， the expression of proteins associated with the promotion of gluconeogenesis dramatically increased in the mice intervened with sea cucumber sulfated sterols. These findings suggested that sea cucumber sulfated sterols might change blood glucose metabolism in healthy mice by reducing glycogenesis and promoting gluconeogenesis.

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