检索结果-南通市图书馆

Efficacy of Lycium barbarum polysaccharide in adolescents with subthreshold depression: interim analysis of a randomized controlled study

引用

Neural Regeneration Research 2022年第7期17卷 1582-1587页

作者： xiaoyue li Xuan Mo Tao liu Robin Shao Kayla Teopiz Roger S.McIntyre Kwok-Fai So Kangguang lin Department of Affective Disorders The Affiliated Brain Hospital of Guangzhou Medical University(Guangzhou Huiai Hospital)GuangzhouGuangdong ProvinceChina Laboratory of Emotion and Cognition The Affiliated Hospital of Guangzhou Medical University(Guangzhou Huiai Hospital)GuangzhouGuangdong ProvinceChina Department of Psychiatry The Fifth Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Canadian Rapid Treatment Center of Excellence MississaugaONCanada Mood Disorders Psychopharmacology Unit Poul Hansen Family Centre for DepressionUniversityHealth NetworkTorontoONCanada Department of Psychiatry University of TorontoTorontoONCanada Brain and Cognition Discovery Foundation TorontoONCanada Ministry of Education Joint International Research Laboratory of CNS Regeneration Jinan UniversityGuangzhouGuangdong ProvinceChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Subthreshold depression is a highly prevalent condition in adolescents who are at high risk for developing major depressive *** preclinical models of neurological and psychiatric diseases,Lycium barbarum polysaccharide(LBP)extracted from Goji berries had antidepressant effects including but not limited to anti-oxidative and anti-inflammatory ***,the effect of LBP on subthreshold depression is *** investigate the clinical efficacy and safety of LBP for treating subthreshold depression in adolescents,we conducted a randomized,double-blind,placebo-controlled trial(RCT)with 29 adolescents with subthreshold depression recruited at The Fifth Affiliated Hospital of Guangzhou Medical *** participants were randomly assigned to groups where they received either 300 mg LBP(LBP group,n=15,3 boys and 12 girls aged 15.13±2.17 years)or a placebo(placebo group,n=14,2 boys and 12 girls aged 15±1.71 years)for 6 successive *** analyses revealed that the LBP group exhibited a greater change in Hamilton Depression Scale(HAMD-24)scores relative to the baseline and a higher remission rate(HAMD-24 total score≤7)at 6 weeks compared with the placebo *** on the Beck Depression Inventory-II(BDI-II),Pittsburgh Sleep Quality Index(PSQI),Kessler Psychological Distress Scale(Kessler),and Screen for Child Anxiety-Related Emotional Disorders(SCARED)were similar between the LBP and placebo *** side effects related to the intervention were reported in either *** results indicate that LBP administration reduced depressive symptoms in adolescents with subthreshold ***,LBP was well tolerated with no treatment-limiting adverse *** trials involving a larger sample size are needed to further confirm the anti-depressive effects of LBP in adolescents with subthreshold *** study was approved by the Medical Ethics Committee of the Fifth Affiliated Hospital of Guangzhou Medical University(Guangzho

关键词： adolescents efficacy Goji berry Lycium barbarum polysaccharide randomized clinical trial safety subthreshold depression tolerance

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effects of hydroxyproline supplementation in low fish meal diets on collagen synthesis, myofiber development and muscular texture of juvenile Pacific white shrimp(litopenaeus vannamei)

引用

Animal Nutrition 2024年第2期17卷 428-437页

作者： Menglin Shi Haoming li Tianyu Chen Bocheng Huang xiaoyue li Xiaohui Dong Shuyan Chi Qihui Yang Hongyu liu Junming Deng Beiping Tan Shuang Zhang Shiwei Xie Laboratory of Aquatic Nutrition and Feed College of Fisheries Guangdong Ocean University Aquatic Animals Precision Nutrition and High-Efficiency Feed Engineering Research Centre of Guangdong Province Key Laboratory of Aquatic Livestock and Poultry Feed Science and Technology in South China Ministry of Agriculture Guangdong Provincial Key Lab of Aquatic Animals Disease Control and Healthy Culture

This experiment aimed to evaluate the impact of dietary hydroxyproline(Hyp) supplementation on the muscle quality of juvenile Pacific white shrimp(litopenaeus vannamei) fed a low fishmeal diet. Six formulated diets included one high fishmeal(HF; 25% fishmeal content) and five low fishmeal diets(10%fishmeal content) with 0%, 0.2%, 0.4%, 0.6% and 0.8% Hyp(LF0, LF2, LF4, LF6 and LF8, respectively). Each diet was assigned to four replicates, and 40 shrimp(0.32 ± 0.00 g) per replicate were fed four times a day for 8 weeks. Dietary Hyp supplementation had little effects on growth performance, but increased the contents of Hyp, prolyl 4-hydroxylases(P4Hs), and collagen. The meat yield, springiness, hardness,chewiness, and cohesiveness of muscle were the highest in the LF4 group among the low fishmeal groups(P lity of L. vannamei.

关键词： Hydroxyproline Collagen Muscle quality litopenaeus vannamei

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Analysis of Noise under Regime Switching

引用

Applied Mathematics 2011年第7期2卷 836-842页

作者： ling Bai xiaoyue li 不详

In this paper we consider a stochastic nonlinear system under regime switching. Given a system x(t)=f(x(t),r(t),t) in which f satisfies so-called one-side polynomial growth condition. We introduce two Brownian noise feedbacks and stochastically perturb this system into dx(t)=(x(t),r(t),t)dt+ σ (r(t))|x(t)|βx(t)dW1(t)+q(r(t))x(t)dW2(t) . It can be proved that appropriate noise intensity may suppress the potentially explode in a finite time and ensure that this system is almost surely exponentially stable although the corresponding system without Brownian noise perturbation may be unstable system.

关键词： Hybrid System One-Side Polynomial Growth Condition Ito Formula Stochastic Ultimate Boundedness

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effects of Lycium barbarum polysaccharide on cytokines in adolescents with subthreshold depression:a randomized controlled study

引用

Neural Regeneration Research 2024年第9期19卷 2036-2040页

作者： xiaoyue li Tao liu Xuan Mo Runhua Wang Xueyan Kong Robin Shao Roger S.Mclntyre Kwok-Fai So Kangguang lin Department of Affective Disorders The Affiliated Brain Hospital of Guangzhou Medical University(Guangzhou Huiai Hospital)GuangzhouGuangdong ProvinceChina Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Psychiatry The Fifth Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Mood Disorders Psychopharmacology Unit Poul Hansen Family Centre for DepressionUniversity Health NetworkTorontoONCanada Department of Psychiatry University of TorontoTorontoONCanada Brain and Cognition Discovery Foundation TorontoCanada Ministry of Education Joint International Research Laboratory of CNS Regeneration Jinan UniversityGuangzhouGuangdong ProvinceChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Strong evidence has accumulated to show a correlation between depression symptoms and inflammatory ***,anti-inflammatory treatment has shown partial effectiveness in alleviating depression *** barbarum polysaccharide(LBP),derived from Goji berries,exhibits notable antioxidative and anti-inflammatory *** our recent double-blinded randomized placebo-controlled trial,we found that LBP significantly reduced depressive symptoms in adolescents with subthreshold *** is presumed that the antidepressant effect of LBP may be associated with its influence on inflammatory *** the double-blinded randomized controlled trial,we enrolled 29 adolescents with subthreshold depression and randomly divided them into an LBP group and a placebo *** the LBP group,adolescents were given 300 mg/d LBP.A 6-week follow up was completed by 24 adolescents,comprising 14 adolescents from the LBP group(15.36±2.06 years,3 men and 11 women)and 10 adolescents from the placebo group(14.9±1.6 years,2 men and 8 women).Our results showed that after 6 weeks of treatment,the interleukin-17A level in the LBP group was lower than that in the placebo *** analysis showed that LBP reduced the correlations and connectivity between inflammatory factors,which were associated with the improvement in depressive *** findings suggest that 6-week administration of LBP suppresses the immune response by reducing interleukin-17A level,thereby exerting an antidepressant effect.

关键词： adolescents cytokines efficacy Goji berry inflammatory responses interleukin-17A Lycium barbarum polysaccharide randomized controlled study subthreshold depression

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Simulation study on the active layer thickness and the interface of a-IGZO-TFT with double active layers

引用

Frontiers of Optoelectronics 2015年第4期8卷 445-450页

作者： xiaoyue li Sheng YIN Dong XU School of Optical and Electronic Information Huazhong University of Science and Technology Wuhan 430074 China

In this paper, ATLAS 2D device simulator of SILVACO was used for device simulation of inverted- staggered thin film transistor using amorphous indium gallium zinc oxide as active layer （a-IGZO-TFT） with double active layers, based on the density of states （DOS） model of amorphous material. The change of device performance induced by the thickness variation of each active layer was studied, and the interface between double active layers was analyzed. The best performance was found when the interface was near the edge of the channel, by optimizing the thickness of each active layers, the high performance device of threshold voltage （Vth） = -0.89 V, sub-threshold swing （SS）= 0.27, on/off current ratio （IoN/IoFF） = 6.98 × 10^14 was obtained.

关键词： amorphous indium gallium zinc oxide (a-IGZO) double active layers interface density of states(DOS) ATLAS

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

DFast Beam Diagnostic System to Measure Nanosecond Pulsed Beam

引用

IMP & HIRFL Annual Report 2017年第1期 170-171页

作者： Guo Jinlong li xiaoyue Du Guanghua 不详

Recently,a laser plasma accelerator has been constructed at Peking *** energy proton beam was produced after laser hitting a thin *** beam energy ranges from 1 to 15 MeV,and the length of beam pulse in time is less than 2 *** proton beam can be used to irradiate samples not only in vacuum but also in air,both macro and micro beam are optional[1].It’s a critical diagnostic that the accurately measurement of the ion beam’s current which was longitudinally compressed to a few nanoseconds *** it’s really essential to set up such diagnostic system in order to know the real fluence in every beam bunch,and to corroborate relative measurement methods such as optical ones[2](Fig.1).A faraday cup diagnostic system whose rise time is less than 0.4 ns is a convenient and precise way to achieve the purpose of directly measuring nanosecond pulsed beam[3].However,a fast read out circuit is essential and it will be the main problem that need to be solved in this work.

关键词： beam system precise

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Sea cucumber derived sulfated sterols alter glucose metabolism by promoting gluconeogenesis and reducing glycogenesis in healthy mice

引用

Food Science and Human Wellness 2024年

作者： Shanyun Yu Teng Wang Yingcai Zhao xiaoyue li Changhu Xue Yuming Wang Tiantian Zhang SKL of Marine Food Processing & Safety Control， College of Food Science and Engineering， Ocean University of China Sanya Institute of Oceanography， Ocean University of China

Sea cucumber derived sulfated sterols (SS) significantly ameliorated insulin resistance and decreased lipid accumulation compared to plant sterols. Interestingly， our recent study found that intervention with sea cucumber sulfated sterols could significantly increase blood glucose levels of healthy mice in the presence of glucose， while cholesterol sulfate， as one of sulfated sterols， did not have the same effect. However， the exact mechanism of SS on glucose metabolism is still unknown. In the present study， we investigated the potential mechanism by which SS influenced blood glucose homeostasis in healthy mice. Results showed that intervention with sea cucumber sulfated sterols did not affect the levels of hormones related to glucose metabolism， while led to a significant decrease in the synthesis of liver glycogen and muscle glycogen. Besides， the expression of proteins associated with the promotion of gluconeogenesis dramatically increased in the mice intervened with sea cucumber sulfated sterols. These findings suggested that sea cucumber sulfated sterols might change blood glucose metabolism in healthy mice by reducing glycogenesis and promoting gluconeogenesis.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

数字孪生驱动的机械工艺系统研究进展

引用

航空学报 2024年第21期45卷 26-58页

作者：戚浩李晓月陶强李亮青岛大学机电工程学院青岛266075 南京航空航天大学机电学院南京210016

数字孪生技术以数字化方式创建物体虚拟模型,基于数据模拟物体现实中的行为,借助虚实反馈、数据融合分析、决策迭代优化等方式,达到缩短产品研发周期、降低成本的目的。机械工艺系统中存在诸多问题如加工过程监测实时性和交互性差、设... 详细信息

数字孪生技术以数字化方式创建物体虚拟模型,基于数据模拟物体现实中的行为,借助虚实反馈、数据融合分析、决策迭代优化等方式,达到缩短产品研发周期、降低成本的目的。机械工艺系统中存在诸多问题如加工过程监测实时性和交互性差、设备故障难以诊断、加工误差影响大等,数字孪生技术是解决这些问题的有效手段。本文阐述了数字孪生的基本概念和数字孪生驱动的机械工艺系统技术路线;归纳了基于数字孪生技术建立虚实交互系统、实现多模型融合以及数据感知、算法预测和智能决策的关键技术等;从产品设计、产品制造、产品服务3个阶段总结了数字孪生驱动的机械工艺系统在产品全生命周期各阶段的具体应用,实现了产品的方案制定、加工状态监测及预测、加工参数优化、设备预测性维护和加工工艺评价等功能;探讨了新兴使能技术为数字孪生驱动的机械工艺系统带来的机遇和挑战。从关键技术、应用方向和数据利用3方面展望了未来发展趋势,以期为后续研究提供参考。

关键词：数字孪生机械工艺系统产品全生命周期孪生模型使能技术

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Pd(0)-Catalyzed Regioselective C(sp3)-H Bond Acyloxylation Assisted by Bidentate Directing Groups

Pd(0)-Catalyzed Regioselective C(sp3)-H Bond Acyloxylation A...

引用

中国化学会·第十六届全国有机合成化学学术研讨会

作者： xiaoyue li Qingdong Hu Feifan Wang 张武 College of Chemistry and Materials Science Anhui Normal University 安徽师范大学

Over the last two decades,the use of metal-mediated direct C-H functionalization has grown rapidly as it enables the conversion of ubiquitous C-H bonds of organic molecules into diverse functional groups in a single synthetic *** an important structure in organic compounds,amides and esters are commonly found in natural products,pharmaceuticals and material ***,a practical and efficient Pd(0)-catalyzed region-and cnemoselective activation/acyloxylation of unactivated C(sp)-H bonds of aliphatic amides using a bidentate system has been *** reaction demonstrates excellent reactivity,high reusability,good functional-group tolerance and a broad substrate range.A preliminary study was conducted to evaluate relative directing-group abilities of various functionalities.

关键词： 2-quinolinamide C-H activation acyloxylation heterogeneous catalysis

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

线粒体DNA在急性呼吸窘迫综合征中的研究进展

引用

中华危重病急救医学 2023年第5期35卷 558-560页

作者：韩静李小悦张杰遵义医科大学珠海校区广东珠海519000 遵义医科大学第五附属(珠海)医院重症医学科广东珠海519000

急性呼吸窘迫综合征(ARDS)是急危重症患者常见的死亡原因之一。目前ARDS发病机制尚未阐明,主要与过度炎症反应、内皮和上皮通透性增加、肺泡表面活性物质减少等有关。近年来,许多研究表明线粒体DNA(mtDNA)可以通过诱导炎症、激活免疫反... 详细信息

急性呼吸窘迫综合征(ARDS)是急危重症患者常见的死亡原因之一。目前ARDS发病机制尚未阐明,主要与过度炎症反应、内皮和上皮通透性增加、肺泡表面活性物质减少等有关。近年来,许多研究表明线粒体DNA(mtDNA)可以通过诱导炎症、激活免疫反应参与ARDS的发生发展,且具有作为ARDS生物标志物的应用价值。本文就mtDNA在ARDS发病机制中的作用进行综述,将有助于为ARDS治疗提供新策略,最终降低ARDS患者的病死率。

关键词：急性呼吸窘迫综合征线粒体DNA 发病机制

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：