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Anti-inflammatory mechanism of the non-volatile ingredients performance liquid chromatography-heated electron spray ionization-high resolution mass spectroscope and cell metabolomics

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Journal of Traditional Chinese Medicine 2024年第2期44卷 260-267页

作者： JING Wenguang lin xiaoyu LI Chu ZHAO Xiaoliang CHENG Xianlong WANG Penglong WEI Feng MA Shuangcheng Institute of Control of Chinese Traditional Medicine and Ethnic Medicine National Institutes for Food and Drug ControlBeijing 102629China School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 102488China Beijing Key Laboratory of Traditional Chinese Medicine Basic Research on Prevention and Treatment of Major Diseases Experimental Research CenterChina Academy of Chinese Medical SciencesBeijing 100700China

OBJECTIVE:To explore the anti-inflammatory components and mechanism of the non-volatile ingredients of ***:High performance liquid chromatographyheated electron spray ionization-high resolution mass spectroscope(HPLC-HESI-HRMS)was used to analyze the chemical constituents of the non-volatile ingredients of *** anti-inflammatory activity of ingredients was evaluated using lipopolysaccharide(LPS)induced RAW264.7 cell inflammation model,and the antiinflammatory mechanism was investigated using multivariate statistical analysis of cell ***:The non-volatile ingredients of patchouli were characterized by HPLC-HESI-HRMS,and 36 flavonoids and 18 other components were *** ingredients of patchouli not only had a good protective effect on the LPS-induced inflammation model of RAW264.7 cells,but also regulated the expression levels of arginine,L-leucine,cholesterol,fructose and sorbitol by down-regulating arginine metabolism,aminoacyl-tRNA biosynthesis,polyol/sorbitol pathway,so as to reduce inflammation and reduce cell ***:The non-volatile ingredients of patchouli had good anti-inflammatory effect and exerted its curative effect by regulating endogenous metabolic pathway to reduce inflammatory response.

关键词： Pogostemon non-volatile ingredients anti-inflammatory cell metabolomics

The optimization of hydrothermal process of MoS2 nanosheets and their good microwave absorption performances

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Chinese Chemical Letters 2020年第5期31卷 1124-1128页

作者： xiaoyu lin Jing Wang Zengyong Chu Dongqing Liu Taotao Guo lingni Yang Zhenyu Huang Sitong Mu Shun Li College of Liberal Arts and Sciences National University of Defense TechnologyChangsha 410073China College of Aeronautics and Astronautics National University of Defense Technology.Changsha 410073China

In this study,flower-like MoS2 constructed by nanosheets was synthesized by a simple hydrothermal *** hydrothermal process was optimized and the effects of hydrothermal condition,including reaction temperature,reaction time and the ratio of Mo source to S source(Mo:S)in precursor,on microwave absorption performances and dielectric properties were *** results showed that when the reaction temperature was 180℃,the reaction time was 18 h,and the Mo:S was 1:3.5,the synthesized MoS2 had the best performance:Its minimum reflection loss could reach-55.78 dB,and the corresponding matching thickness was 2.30 mm with a wide effective bandwidth of 5.17 *** researches on the microwave absorption mechanism revealed that in addition to the destructive interference of electromagnetic waves,various polarization phenomena such as defect dipole polarization were the main reasons for microwave *** believe that MoS2 is a candidate for a practical microwave absorbent.

关键词： MoS2 Hydrothermal preparation Microwave absorption performance Process optimization Microwave absorption mechanism

A metal ions-mediated natural small molecules carrier-free injectable hydrogel achieving laser-mediated photo-Fenton-like anticancer therapy by synergy apoptosis/cuproptosis/anti-inflammation

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Bioactive Materials 2023年第11期29卷 98-115页

作者： Wenmin Pi linying Wu Jihui Lu xiaoyu lin Xuemei Huang Zhijia Wang Zhihua Yuan Hailing Qiu Jianglan Zhang Haimin Lei Penglong Wang School of Chinese Pharmacy Beijing University of Chinese MedicineBeijing102488China School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing102488China

Tumor microenvironment (TME) plays an important role in the tumorigenesis, proliferation, invasion and metastasis. Thereby developing synergistic anticancer strategies with multiple mechanisms are urgent. Copper is widely used in the treatment of tumor chemodynamic therapy (CDT) due to its excellent laser-mediated photo- Fenton-like reaction. Additionally, copper can induce cell death through cuproptosis, which is a new modality different from the known death mechanisms and has great promise in tumor treatment. Herein, we report a natural small molecules carrier-free injectable hydrogel (NCTD Gel) consisted of Cu2+-mediated self-assembled glycyrrhizic acid (GA) and norcantharidin (NCTD), which are mainly governed by coordination and hydrogen bonds. Under 808 nm laser irradiation, NCTD Gel can produce reactive oxygen species (ROS), consume glutathione (GSH) and overcome hypoxia in TME, leading to synergistically regulate TME via apoptosis, cuproptosis and anti-inflammation. In addition, NCTD Gel’s CDT display high selectivity and good biocompatibility as it relies on the weak acidity and H2O2 overexpression of TME. Notably, NCTD Gel’s components are originated from clinical agents and its preparation process is easy, green and economical, without any excipients. This study provides a new carrier-free hydrogel synergistic antitumor strategy, which has a good prospect in industrial production and clinical transformation.

关键词： Natural small molecular ternary carrier-free hydrogel Tumor microenvironment Cuproptosis Laser-mediated photo-fenton-like reaction

Improved Electrochemical Performance Based on Nanostructured SnS_2@CoS_2–rGO Composite Anode for Sodium-Ion Batteries

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Nano-Micro Letters 2018年第3期10卷 91-102页

作者： Xia Wang Xueying Li Qiang Li Hongsen Li Jie Xu Hong Wang Guoxia Zhao Lisha Lu xiaoyu lin Hongliang Li Shandong Li College of Physics Key Laboratory of Photonics Materials and Technology in Universities of Shandong and Laboratory of Fiber Materials and Modern Textile the Growing Base for State Key Laboratory Qingdao University Institute of Materials for Energy and Environment Qingdao University

A promising anode material composed of SnS_2@CoS_2 flower-like spheres assembled from SnS_2 nanosheets and CoS_2 nanoparticles accompanied by reduced graphene oxide(rGO) was fabricated by a facile hydrothermal pathway. The presence of rGO and the combined merits of SnS_2 and CoS_2 endow the SnS_2@-CoS_2–rGO composite with high conductivity pathways and channels for electrons and with excellent properties as an anode material for sodium-ion batteries(SIBs). A high capacity of 514.0 mAh g^(-1) at a current density of200 m A g^(-1) after 100 cycles and a good rate capability can be delivered. The defined structure and good sodium-storage performance of the SnS_2@CoS_2–rGO composite demonstrate its promising application in high-performance SIBs.

关键词： SnS2 nanosheets CoS2 nanoparticles Reduced graphene oxide(rGO) Sodium-ion batteries(SIBs)

Band alignment and interlayer hybridization in monolayer organic/WSe_(2) heterojunction

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Nano Research 2022年第2期15卷 1276-1281页

作者： Yanping Guo linlu Wu Jinghao Deng linwei Zhou Wei Jiang Shuangzan Lu Da Huo Jiamin Ji Yusong Bai xiaoyu lin Shunping Zhang Hongxing Xu Wei Ji Chendong Zhang Key Laboratory of Artificial Micro-and Nano-structures of Ministry of Education and School of Physics and Technology Wuhan UniversityWuhan 430027China Department of Physics and Beijing Key Laboratory of Optoelectronic Functional Materials and Micro-Nano Devices Renmin University oj ChinaBeijing 100872China

Semiconducting heterojunctions(HJs),comprised of atomically thin transition metal dichalcogenides(TMDs),have shown great potentials in electronic and optoelectronic ***/TMD hybrid bilayers hold enhanced pumping efficiency of interfacial excitons,tunable electronic structures and optical properties,and other superior advantages to these inorganic ***,we report a direct probe of the interfacial electronic structures of a crystalline monolayer(ML)perylene-3,4,9,10-tetracarboxylic-dianhydride(PTCDA)/ML-WSe_(2) HJ using scanning tunneling microscopy,photoluminescence,and first-principle *** PTCDAAA/Se_(2) interfacial interactions lead to appreciable hybridization of the WSe_(2) conduction band with PTCDA unoccupied states,accompanying with a significant amount of PTCDA-to-WSe_(2) charge transfer(by 0.06 e/PTCDA).A type-ll band alignment was directly determined with a valence band offset of-1.69 eV,and an apparent conduction band offset of-1.57 ***,we found that the local stacking geometry at the HJ interface differentiates the hybridized interfacial states.

关键词： two-dimensional materials organic/transition metal dichalcogenide(TMD)heterojunction interlayer hybridization band diagram

二维过渡金属硫族化合物纳米材料的制备与应用研究进展

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化学学报 2017年第10期75卷 979-990页

作者：林潇羽王璟国防科技大学理学院长沙410073

二维过渡金属硫族化合物(TMDCs)纳米材料是一种新型的类石墨烯材料,具有优异的电学、光学及催化特性.简要介绍了TMDCs的晶体结构和电子特性;详细综述了常用的制备方法,主要包括机械剥离法、水(溶剂)热合成法、化学气相合成法等,并总结... 详细信息

二维过渡金属硫族化合物(TMDCs)纳米材料是一种新型的类石墨烯材料,具有优异的电学、光学及催化特性.简要介绍了TMDCs的晶体结构和电子特性;详细综述了常用的制备方法,主要包括机械剥离法、水(溶剂)热合成法、化学气相合成法等,并总结了各种方法的优缺点;归纳了二维TMDCs在电子器件、光电器件、传感器、微波吸收、储能和催化等方面的应用研究进展;最后总结了该领域存在的问题,展望了研究前景.

关键词：过渡金属硫族化合物纳米材料制备应用

Research on the Recovery of Irregular Flights under Uncertain Conditions

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World Journal of Engineering and Technology 2021年第4期9卷 755-764页

作者： Xiangfei Meng xiaoyu lin Hualei Zhao Jing Yang Department of Service Supporting Air Force Command College Beijing China

This paper mainly studies the problem of irregular flights recovery under uncertain conditions. Based on the analysis of the uncertain factors affecting the flight, taking the total delay time and the total cost of flight delay as the objective function, and considering the constraints of flight plan and passenger journey, an uncertain objective programming model is constructed. Finally, taking OVS airport temporarily closed due to bad weather as an example, the results show that better quality optimization scheme can be obtained by integrating passenger recovery with narrow sense flight recovery stage and implementing integrated recovery.

关键词： Recovery of Irregular Flights Uncertainty Theory Multi-Objective Programming

Construction of databases:advances and significance in clinical research

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Eye Science 2015年第4期30卷 184-189页

作者： Erping Long Bingjie Huang Liming Wang xiaoyu lin Haotian lin The State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen University

Widely used in clinical research, the database is a new type of data management automation technology and the most efficient tool for data management. In this article, we first explain some basic concepts, such as the definition, classification, and establishment of databases. Afterward, the workflow for establishing databases, inputting data, verifying data, and managing databases is presented. Meanwhile, by discussing the application of databases in clinical research, we illuminate the important role of databases in clinical research practice. Lastly, we introduce the reanalysis of randomized controlled trials(RCTs) and cloud computing techniques, showing the most recent advancements of databases in clinical research.

关键词：数据库建设临床随机对照试验数据管理自动化技术管理数据库输入数据工作流程

The rice miR171b–SCL6-IIs module controls blast resistance,grain yield,and flowering

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The Crop Journal 2022年第1期10卷 117-127页

作者： Yan Li Ying Tong Xiaorong He Yong Zhu Tingting Li xiaoyu lin Wei Mao Zeeshan Ghulam Nabi Gishkori Zhixue Zhao Jiwei Zhang Yanyan Huang Mei Pu Jing Fan Jing Wang Wenming Wang State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China Sichuan Agricultural UniversityChengdu 611130SichuanChina Rice Research Institute and Key Lab for Major Crop Diseases Sichuan Agricultural UniversityChengdu 611130SichuanChina

Micro RNAs(mi RNAs)act as regulators of plant development and multiple stress *** we demonstrate that the rice mi R171 b-SCL6-IIs module regulates the balance between blast resistance,grain yield,and *** R171 b-overexpressing rice plants(OX171 b)displayed increased rice blast resistance accompanied with enhanced defense responses and late heading,whereas blocking mi R171 b expression in rice(MIM171)led to greater susceptibility to blast disease,associated with compromised defense responses and early *** overexpressing or silencing of mi R171 b significantly affected plant height and number of filled seeds per panicle(seed-setting rate),resulting in decreased grain *** R171 b targets SCL6-IIa,SCL6-IIb,and SCL6-IIc,whose expression was suppressed in OX171 b but increased in *** of SCL6-IIa,SCL6-IIb,and SCL6-IIc all displayed phenotypes like that of OX171 b,including markedly increased blast disease resistance,slightly decreased grain yield,and delayed *** of mi R171 b increased gradually in leaves during the vegetative stage but decreased gradually in panicles during the reproductive stage,whereas SCL6-IIs displayed the reverse expression ***,these results suggest that the expression of mi R171 b was time-and space-dependent during the rice growth period and regulated the balance between rice blast disease resistance,grain yield,and flowering via SCL6-IIs,and that appropriate accumulation of mi R171 b is essential for rice development.

关键词： miR171b SCL6-IIs Blast disease resistance Yield trait Flowering