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粪菌移植抑制NF-κB/NLRP3改善大鼠脓毒症相关脑病

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中华急诊医学杂志 2024年第6期33卷 792-799页

作者：袁晓宇赵红睿王国华徐峰苏州大学附属第一医院急诊医学科苏州215006 南通大学附属医院急诊医学科南通226006 南通大学急诊教研室南通226004 南通大学特种医学研究院南通226019

目的探索粪菌移植(fecal microbiota transplantation,FMT)通过调节肠道菌群对SAE大鼠的神经保护作用。方法30只SD大鼠分为假手术、SAE、SAE+FMT、SAE+FMT+NF-κB激动剂,SAE+FMT+NLRP3激动剂组。通过16S rRNA测序、神经行为学评分、水... 详细信息

目的探索粪菌移植(fecal microbiota transplantation,FMT)通过调节肠道菌群对SAE大鼠的神经保护作用。方法30只SD大鼠分为假手术、SAE、SAE+FMT、SAE+FMT+NF-κB激动剂,SAE+FMT+NLRP3激动剂组。通过16S rRNA测序、神经行为学评分、水迷宫测试、尼氏染色、定量逆转录聚合酶链反应和蛋白质免疫印迹试验等分析大鼠肠道菌群,神经功能及炎症反应改变。采用SPSS软件对组间多样本行单因素方差分析,进一步两两比较采用Tukey检验。结果①与假手术组相比,SAE大鼠α多样性降低(P<0.01),而FMT治疗后的SAE大鼠的α多样性升高(P<0.05),SAE组有益菌Bacteroidete,Clostridiales相比假手术组减少,FMT后增加。②与假手术组相比,SAE大鼠mNSS降低(P<0.01),学习记忆能力降低(P<0.01),海马CA1区神经元数量减少(P<0.01),而FMT治疗后的SAE大鼠的mNSS评分提高(P<0.01),学习记忆能力增加(P<0.05),神经元数量增加(P<0.05)。③与假手术组相比,SAE组大鼠肝肾功能指标、炎症相关因子、血脑屏障蛋白、NLRP3通路蛋白、NF-κB通路蛋白表达增加(P<0.05),FMT降低以上指标(P<0.05),④NF-κB和NLRP3激动剂干预后抵消了FMT的作用(P<0.05)。结论FMT通过调节肠道菌群并抑制脑内NF-κB/NLRP3信号通路。这为SAE的治疗提供了新的见解,同时强调了在临床治疗中考虑肠道微生物的重要性。

关键词：粪菌移植肠道菌群微生物 NF-κB/NLRP3 脓毒症相关脑病炎症神经保护脑肠轴

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我国未成年人社区矫正制度:反思与重构

南京航空航天大学学报（社会科学版） 2024年第1期26卷 71-81页

作者：彭文华袁小玉上海政法学院刑事司法学院

未成年人社区矫正从本质上讲是国家纠正、治理未成年人犯罪的重要体系之一,其落脚点是未成年人的身心健康发展,是“最有利于未成年人”这一原则的重要实践面向。目前,我国的未成年人社区矫正概念过于狭隘,不利于帮助未成年人改过自新和... 详细信息

未成年人社区矫正从本质上讲是国家纠正、治理未成年人犯罪的重要体系之一,其落脚点是未成年人的身心健康发展,是“最有利于未成年人”这一原则的重要实践面向。目前,我国的未成年人社区矫正概念过于狭隘,不利于帮助未成年人改过自新和重新融入社会。关于未成年人社区矫正制度的构建,应在“最有利于未成年人原则”的基础上,扩充未成年人社区矫正的内涵,将严重不良行为的矫正与未成年人附条件不起诉制度纳入未成年人社区矫正,并寻求“基于证据”的矫正有效性。

关键词：未成年人社区矫正最有利于未成年人原则

医学学术期刊的短视频传播现状及其优化策略研究

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出版与印刷 2024年第3期 36-44页

作者：袁潇雨舒安琴杨秀重庆大学新闻学院重庆大学附属肿瘤医院

分析医学学术期刊短视频传播的现状和问题并提出优化策略,为医学学术期刊把握短视频发展趋势、扩大期刊影响力提供借鉴。文章以《中文核心期刊要目总览(2020年版)》记录的32种医学学术期刊为研究对象,对其在微信视频号、西瓜视频、抖音... 详细信息

分析医学学术期刊短视频传播的现状和问题并提出优化策略,为医学学术期刊把握短视频发展趋势、扩大期刊影响力提供借鉴。文章以《中文核心期刊要目总览(2020年版)》记录的32种医学学术期刊为研究对象,对其在微信视频号、西瓜视频、抖音、B站四大主要短视频平台内容传播的基本情况进行调研,发现医学学术期刊短视频传播存在的主要问题有:未能体现期刊品牌的定位、未根据不同平台的用户特点进行分众化传播、作品形式单一、整合传播力度不足。提出医学学术期刊应明确短视频内容定位、实施分众化传播策略、创新短视频内容的表现形式、进行内容的协同发布和整合传播,从而不断提升医学学术期刊短视频内容的传播能力以及自身的品牌影响力。

关键词：短视频医学学术期刊分众化传播整合传播

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Intelligently assembly of W_(18)O_(49)nanorod clusters with directionally generated oxygen vacancies and excellent electrochemical properties

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Nano Research 2022年第4期15卷 3575-3586页

作者： Dan Zhou Xiaojiao Guo Yixiang Chen xiaoyu yuan Jinku Liu Key Laboratory for Advanced Materials School of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai 200237China

Mixed-valence metallic compounds are a class of functional materials with peculiar electrochemical *** the correlation between defects and corrosion resistance of mixed-valence metallic compounds is a novel and interesting *** an intelligently designed synergistic process of reduction and directed assembly,not only the directional generation of oxygen vacancies along the normal direction of the(010)crystal plane was achieved,but also the W_(18)O_(49)mixed-valence metal oxide(MVMO)with a single crystalline phase and an assembled ordered three-dimensional cluster structure of nanorods was *** attractive effects of oriented oxygen vacancies in W_(18)O_(49)MVMO were ***,the oxygen vacancy channels realized the directional concentrated transport of oxygen atoms to form dense oxide passivation ***,the directional concentrated oxygen vacancies as active centers effectively solved the problem of difficult photoelectron leap and separation of pure-phase semiconductors,realizing photogenerated cathodic ***,the high-energy vacancies endowed the material with antibacterial function,which contributed to the stable existence of the anti-corrosion *** resistance value of W_(18)O_(49)MVMO as an anti-corrosion functional material was increased to more than 4.00 times that of the original metal protection *** experimental results obtained in this research were of great reference value for revealing the intrinsic mechanism of correlation between oxygen defect orientation of MVMOs and electrochemistry.

关键词： oxygen vacancy directional generated W_(18)O_(49) mixed-valence metal oxide electrochemical properties

A Multi-strategy Improved Snake Optimizer Assisted with Population Crowding Analysis for Engineering Design Problems

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Journal of Bionic Engineering 2024年第3期21卷 1567-1591页

作者： Lei Peng Zhuoming yuan Guangming Dai Maocai Wang Jian Li Zhiming Song xiaoyu Chen School of Computer Science China University of GeosciencesWuhan430074China Hubei Key Laboratory of Intelligent Geo-Information Processing China University of GeosciencesWuhan430074China China Astronautics Standards Institute Beijing100071China

Snake Optimizer(SO)is a novel Meta-heuristic Algorithm(MA)inspired by the mating behaviour of snakes,which has achieved success in global numerical optimization problems and practical engineering ***,it also has certain drawbacks for the exploration stage and the egg hatch process,resulting in slow convergence speed and inferior solution *** address the above issues,a novel multi-strategy improved SO(MISO)with the assistance of population crowding analysis is proposed in this *** the algorithm,a novel multi-strategy operator is designed for the exploration stage,which not only focuses on using the information of better performing individuals to improve the quality of solution,but also focuses on maintaining population *** boost the efficiency of the egg hatch process,the multi-strategy egg hatch process is proposed to regenerate individuals according to the results of the population crowding *** addition,a local search method is employed to further enhance the convergence speed and the local search *** is first compared with three sets of algorithms in the CEC2020 benchmark functions,including SO with its two recently discussed variants,ten advanced MAs,and six powerful CEC competition *** performance of MISO is then verified on five practical engineering design *** experimental results show that MISO provides a promising performance for the above optimization cases in terms of convergence speed and solution quality.

关键词： Snake optimizer Multi-strategy Population crowding analysis Engineering design problem

The Fabrication and Detection Performance of High Sensitivity Au-Ag Alloy Nanostar/Paper Flexible Surface Enhanced Raman Spectroscopy Sensors

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Journal of Wuhan University of Technology(Materials Science) 2024年第2期39卷 436-443页

作者：邓芷盈 WANG Tianyi CAO Shiyi ZHAO yuan HAN xiaoyu 张继红谢俊 State Key Laboratory of Silicate Materials for Architectures Department of Materials Science and Engineering Wuhan University of TechnologyWuhan 430070China Hainan Institute of Wuhan University of Technology Sanya 572000China International School of Materials Science and Engineering Wuhan University of TechnologyWuhan 430070China Hepu Research Center for Silicate Materials Industry Technology Beihai 536100China

Au-Ag alloy nanostars based flexible paper surface enhanced Raman spectroscopy sensors were fabricated through simple nanostar coating on regular office paper,and the surface enhanced Raman spectroscopy detection performances were investigated using crystal violet dye ***-Ag nanostars with sharp tips were synthesized via metal ions reduction *** electron microscope images,X-Ray diffraction pattern and energy dispersive spectroscopy elemental mapping confirmed the nanostar geometry and Au/Ag components of the ***-Vis-NIR absorption spectrum shows wide local surface plasmon resonance induced optical *** addition,finite-difference time-domain simulation shows much stronger electromagnetic field from nanostars than from sphere *** effect of coating layer on Raman signal intensities was discussed,and optimized 5-layer coating with best Raman signal was *** Au-Ag nanostatrs homogeneously distribute on paper fiber *** detection limit is 10-10 M,and the relationship between analyte concentrations and Raman signal intensities shows well linear,for potential quantitative *** calculated enhancement factor is 4.795×10^(6).The flexible paper surface enhanced Raman spectroscopy sensors could be applied for trace chemical and biology molecule detection.

关键词： surface-enhanced raman gold-silver alloy nanostars paper-based SERS sensor flexibility

基于TransU-Net网络的高分辨率遥感影像水体提取

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计算机应用文摘 2024年第10期40卷 45-47页

作者：韩久春袁啸宇杜海峰张玉明邱征安徽建工交通航务集团有限公司合肥230011 合肥工业大学土木与水利工程学院合肥230009

在高分辨率遥感影像水体提取任务中,基础UNet网络提取精度较低,在规则水体的边缘提取上不够清晰,且对于细小水体提取不够完全。对此,文章提出了一种基于TransU-Net网络模型的水体提取方法。其中,TransU-Net网络模型能够完整有效地对水... 详细信息

在高分辨率遥感影像水体提取任务中,基础UNet网络提取精度较低,在规则水体的边缘提取上不够清晰,且对于细小水体提取不够完全。对此,文章提出了一种基于TransU-Net网络模型的水体提取方法。其中,TransU-Net网络模型能够完整有效地对水体边缘和局部特征进行提取。实验结果表明,该方法优于基础UNet方法,提取精度相较基础UNet提高了3.63%,能够有效完成高分辨率遥感影像水体提取任务。

关键词：高分辨率遥感影像深度学习水体提取 TransU-Net网络

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重庆两场森林火灾蔓延特征的数值模拟

气象科技 2024年第2期52卷 205-217页

作者：王宇虹陈仲榆杨晓丹赵鲁强袁晓玉梁莉中国气象局公共气象服务中心北京100081

为了深入认识同时段内发生的两场森林火灾蔓延特征以及大气、地形等对不同林火行为的影响,进而为多起林火扑灭火工作提供科学支撑,选取2022年8月17日发生在涪陵两场森林火灾,利用高分辨率地理信息、植被数据和气象数据对两场林火行为进... 详细信息

为了深入认识同时段内发生的两场森林火灾蔓延特征以及大气、地形等对不同林火行为的影响,进而为多起林火扑灭火工作提供科学支撑,选取2022年8月17日发生在涪陵两场森林火灾,利用高分辨率地理信息、植被数据和气象数据对两场林火行为进行分析研究,同时运用林火大气耦合WRF-Fire(Weather Research and Forecasting Model with Fire Module)模式进行数值模拟。研究发现:①受深厚高压控制,两场林火是在持续高温、干燥背景下发生的,气象干旱等级达到重旱,火险气象等级高。②模式模拟风向风速变化与实况较为一致,基本体现出火场风向和风速突变,表明WRF-Fire模式可以较准确地再现火场蔓延情况。③基于林火蔓延特征时间和空间变化可将大梁山林火发展分为6个阶段、北山坪林火分为4个阶段,造成直线距离相隔4.4 km两个火场蔓延发展程度不同的原因在于地形差异造成的局地风场差异。

关键词：重庆林火大气耦合模式林火蔓延特征数值模拟

Nickel-Catalyzed Regioselective Hydrosilylation of Conjugated Dienes

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Chinese Journal of Chemistry 2024年第1期42卷 13-19,I0004页

作者： xiaoyu Wu Wei Liu Liqun Yang Yue Wang Tianwen Liu Yao yuan Yan Lu Zhaoguo Zhang Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs School of Chemistry and Chemical EngineeringShanghai JiaoTong University800 Dongchuan RoadShanghai 200240China Joseph Black Building The University of EdinburghDavid Brewster RoadEdinburghEH9 3FJUK

With the increasing demand for homoallylic silanes and allylic silanes,the highly efficient and regioselective hydrosilylations of conjugated dienes are urgently ***,we developed a Ni-catalyzed regiodivergent hydrosilylation of aromatic conjugated dienes by adjusting the temperature and *** low temperature(-30℃),an eternal-ligand-free system(Ni/t-BuOk)can efficiently facilitate the 3,4-anti-Markovnikov hydrosilylation to provide homoallylic silanes via electrophilic activation process;under room temperature(25℃),a ligand-controlled system(Ni/t-BuOk/PPh3)can eventuate the 3,4-Markovnikov hydrosilylation to produce allylic silanes via Chalk-Harrod *** systems are compatible with various conjugated dienes and primary silanes in excellent yields andregioselectivities.

关键词： Nickel-catalyzed Regioselective hydrosilylation Conjugated dienes Electrophilic activation Homoallylic silanes