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中国胸心血管外科临床杂志 2024年第3期31卷 421-427页

作者：李帆郭元婷周小宇梁振兴郑州大学第一附属医院麻醉与围术期医学部郑州450052 郑州大学第一附属医院心脏大血管外三科郑州450052 上海交通大学附属胸科医院心外科上海200030

目的研究心脏康复计划在全身麻醉下小切口冠状动脉旁路移植术患者早期康复中的作用。方法回顾性纳入2015年1月—2020年1月于郑州大学第一附属医院接受全身麻醉下小切口冠状动脉旁路移植术患者,按是否接受康复计划分为康复计划组和对照... 详细信息

目的研究心脏康复计划在全身麻醉下小切口冠状动脉旁路移植术患者早期康复中的作用。方法回顾性纳入2015年1月—2020年1月于郑州大学第一附属医院接受全身麻醉下小切口冠状动脉旁路移植术患者,按是否接受康复计划分为康复计划组和对照组。按照最近邻匹配法进行1∶1倾向性评分匹配,分析匹配后两组患者在康复计划开始6个月、12个月后的临床数据。主要观察指标为心肺功能测试的摄氧峰值(peak oxygen intake,VO_(2) peak)和随访期(20个月)三级医院心血管专科就诊患者数。结果共纳入600例患者,其中康复计划组200例,男137例、女63例,年龄61.00(56.00,65.00)岁;对照组400例,男285例、女115例,年龄60.00(56.00,65.00)岁。匹配后,两组各纳入患者176例,两组患者基线资料差异均无统计学意义(P>0.05)。心脏康复计划6个月及12个月后,康复计划组与对照组相比,VO_(2) peak差异有统计学意义[6个月:1.96(1.59,2.38)L/min vs.1.72(1.38,2.12)L/min,P<0.001;12个月:2.40(2.21,2.63)L/min vs.2.12(1.83,2.45)L/min,P<0.001]。随访期内两组患者三级医院心血管专科就诊率差异有统计学意义(P=0.004)。结论心脏康复计划对全身麻醉下小切口冠状动脉旁路移植术早期康复有积极作用,可改善患者运动能力。

关键词：心脏康复小切口冠状动脉旁路移植术加速康复

Phosphorylation of Atg31 is required for autophagy

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Protein & Cell 2015年第4期6卷 288-296页

作者： Wenzhi Feng tong Wu xiaoyu Dan Yuling Chen Lin Li She Chen Di Miao Haiteng Deng Xinqi Gong Li Yu PTN Program College of Life Science Peking University Beijing 100871 China State Key Laboratory of Biomembrane and Membrane Biotechnology Tsinghua University-Peking University Joint Center for Life Sciences School of Life Sciences Tsinghua University Beijing 100084 China Center for Biomedical Analysis Tsinghua University Beijing 100084 China National Institute of Biological Sciences Beijing 102206 China Institute for Mathematical-Sciences Renmin-University of China Beijing 100872 China

Autophagy is an evolutionarily conserved cellular pro- cess which degrades intracellular contents. The Atg17- Atg31-Atg29 complex plays a key role in autophagy in- duction by various stimuli. In yeast, autophagy occurs with autophagosome formation at a special site near the vacuole named the pre-autophagosomal structure （PAS）. The Atg17-Atg31-Atg29 complex forms a scaffold for PAS organization, and recruits other autophagy-re- lated （Atg） proteins to the PAS. Here, we show that Atg31 is a phosphorylated protein. The phosphorylation sites on Atg31 were identified by mass spectrometry. Analy- sis of mutants in which the phosphorylated amino acids were replaced by alanine, either individually or in var- ious combinations, identified S174 as the functional phosphorylation site. An S174A mutant showed a simi- lar degree of autophagy impairment as an Atg31 deletion mutant. S174 phosphorylation is required for autophagy induced by various autophagy stimuli such as nitrogen starvation and rapamycin treatment. Mass spectrometry analysis showed that S174 is phosphorylated constitu- tively, and expression of a phosphorylation-mimic mu- tant （S174D） in the Atg31 deletion strain restores autophagy. In the S174A mutant, Atg9-positive vesicles accumulate at the PAS. Thus, S174 phosphorylation is required for formation of autophagosomes, possibly by facilitating the recycling of Atg9 from the PAS. Our data demonstrate the role of phosphorylation of Atg31 in autophagy.

关键词： autophagy Atg31 phosphorylation,autophagosome pre-autophagosomal structure (PAS)

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数字孪生钱塘江“四预”应用建设实践

水利信息化 2024年第5期 1-7,15页

作者：毛肖钰许志良吕昊阳林彬彬童安涛陈刚浙江省钱塘江流域中心浙江杭州310020 中国电建集团华东勘测设计研究院有限公司浙江杭州311122

为解决钱塘江流域治理面临的防洪能力不足、数据整合与利用不充分等问题,提升流域治理的协同性与系统性,利用富春江电站以上预报调度一体化等专业模型,以及工程安全智能感知、潮汐河口动床洪水演进、防洪预报调度一体化等关键技术,通过... 详细信息

为解决钱塘江流域治理面临的防洪能力不足、数据整合与利用不充分等问题,提升流域治理的协同性与系统性,利用富春江电站以上预报调度一体化等专业模型,以及工程安全智能感知、潮汐河口动床洪水演进、防洪预报调度一体化等关键技术,通过打造“天空地”一体化流域感知网和多源数据融合数据底板,构建流域防洪预报、预警、预演、预案“四预”功能多跨场景应用,聚焦汛情态势分析及未来趋势预报,实现对流域雨情、水情、工情、灾情的实时监控与精准管理。研究成果在钱塘江流域防洪和杭州亚运会保障方面取得一定成效,可为全国数字孪生流域建设提供借鉴和参考。

关键词：数字孪生 “四预” 流域防洪钱塘江流域

Structural origin of magnetic softening in a Fe-based amorphous alloy upon annealing

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Journal of Materials Science & Technology 2022年第1期96卷 233-240页

作者： Xing tong Yan Zhang Yaocen Wang xiaoyu Liang Kai Zhang Fan Zhang Yuanfei Cai Haibo Ke Gang Wang Jun Shen Akihiro Makino Weihua Wang Songshan Lake Materials Laboratory Dongguan 523808China Ningbo Institute of Materials Technology and Engineering Chinese Academy of ScienceNingbo 315201China New Industry Creation Hatchery Center(NICHe) Tohoku UniversitySendai 980-8577Japan Institute for Materials Research Tohoku UniversitySendai 980-8577Japan School of Physical Science and Technology Northwestern Polytechnical UniversityXi’an 710072China Institute of Multidisciplinary Research for Advanced Materials Tohoku UniversitySendai 980-8577Japan Center for High Pressure Science and Technology Advanced Research(HPSTAR) Shanghai 201203China Advanced Institute for Materials Research Tohoku UniversitySendai 980-8577Japan Laboratory for Microstructures Institute of MaterialsShanghai UniversityShanghai 200444China College of Mechatronics and Control Engineering Shenzhen UniversityShenzhen 518060China Institute of Physics Chinese Academy of SciencesBeijing 100190China College of Materials Science and Engineering Tongji UniversityShanghai 201804China

The underlying structural origin of magnetic properties is still elusive in Fe-based amorphous *** this study,distinctive soft magnetic properties were developed in Fe_(76)Si_(9)B_(10)P_(5)amorphous ribbons through systematic design of annealing *** with synchrotron radiation,high-resolution transmission electron microscopy and first principle ab initio molecular dynamic simulation,it is found that the atomic structural evolution both in short range order and medium range order is responsible for the magnetic softness at proper annealing *** short range,formation of separated and densely coordinated Fe-metalloid clusters is instigated to adapt energy minimization,resulting in strengthening of ferromagnetic exchange interaction *** medium range,a homogeneous exchangecoupling from the uniformly strong and weak ferromagnetic regions is generated,which significantly weakens magnetic heterogeneity and leads to the excellent magnetic *** findings may provide an effective/promising pathway to modulate the magnetic properties for Fe-based amorphous alloys,and give a comprehensive and quantitative understanding of the structure-properties relationship in amorphous materials.

关键词： Amorphous alloy Soft magnetic properties Synchrotron radiation Atomic structure

未来气候变化下白花龙在我国的潜在适生区预测

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浙江林业科技 2024年第5期44卷 1-8页

作者：童丽丽程瑶许晓岗王洪超田露蒋孝禹金陵科技学院园艺园林学院江苏南京210038 南京林业大学生命科学学院南方现代林业协同创新中心江苏南京210037

白花龙Styrax faberi为安息香科Styracaceae安息香属Styrax灌木,现今对白花龙的研究仅集中于繁殖技术、叶片成分及系统演化等方面,而对其地理分布及未来变化趋势的研究报道甚少。本文研究未来气候变化情景下白花龙的潜在适生区可为其野... 详细信息

白花龙Styrax faberi为安息香科Styracaceae安息香属Styrax灌木,现今对白花龙的研究仅集中于繁殖技术、叶片成分及系统演化等方面,而对其地理分布及未来变化趋势的研究报道甚少。本文研究未来气候变化情景下白花龙的潜在适生区可为其野生资源保护及引种提供理论依据。基于本研究组白花龙的标本采集地,以及通过百度地图(https://***)、生物多样性信息网络(https://***)、国家标本平台(http://***/)、中国植物志(http://***/)、中国数字植物标本馆(https://***)等获得的地理信息数据,共得到235条可靠的现代分布记录和多重环境变量,通过MaxEnt、ArcGIS并以刀切法、标准差椭圆计算、多元相似度面和最不相似变量等方法,预测在当前(1970—2000年)和未来(2041—2060年)气候变化情景(SSP126和SSP585)下白花龙在中国的潜在分布。结果表明:当前白花龙的高、中度适生区主要集中在我国江西、广东、广西和福建的大部分地区;在2050年气候变化情景下,适宜区面积均将大幅减少,缩减的区域以轻度适宜区为主,预示白花龙在未来的气候环境下,物种的扩张潜力下降,分布中心有向西北高纬度地区迁移的趋势;降水量和温度是制约白花龙分布的主要因素,其中最冷季节降水量(贡献率56.6%)是影响白花龙未来分布的主导因子。

关键词：白花龙气候变化最大熵模型潜在分布区主导因子

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铁铬铝骤冷过程最小膜态沸腾温度实验研究

核动力工程 2024年第4期45卷 267-273页

作者：王泽锋邓坚邱志方陈曦王啸宇陈建达熊进标中国核动力研究设计院核反应堆系统设计技术重点实验室成都610213 上海交通大学机械与动力工程学院上海200240

铁铬铝(FeCrAl)作为事故容错燃料(ATF)包壳的主要候选材料,能够抑制反应堆在严重事故下产氢释能的风险,提高反应堆的事故耐受能力。本文基于可视化方法研究了FeCrAl和Zr-4在骤冷过程中的沸腾传热行为。通过一维导热反问题求解计算FeCrA... 详细信息

铁铬铝(FeCrAl)作为事故容错燃料(ATF)包壳的主要候选材料,能够抑制反应堆在严重事故下产氢释能的风险,提高反应堆的事故耐受能力。本文基于可视化方法研究了FeCrAl和Zr-4在骤冷过程中的沸腾传热行为。通过一维导热反问题求解计算FeCrAl的表面热流密度和温度,分析了表面氧化、固体热物性对铁铬铝骤冷行为的影响。研究结果表明随着过冷度的增大,骤冷时间减小,最小膜态沸腾温度增大;随着固体热物性(ρcp)w的增大,骤冷时间增大,最小膜态沸腾温度减小。由于铁铬铝优异的高温抗氧化性,其骤冷过程的沸腾传热行为受表面氧化的影响可忽略不计。

关键词：事故容错燃料(ATF) 固体热物性骤冷行为最小膜态沸腾温度

Fluid-structure interaction simulation of pathological mitral valve dynamics in a coupled mitral valve-left ventricle model

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智慧医学(英文) 2023年第2期3卷 104-114页

作者： Li Cai tong Zhao Yongheng Wang xiaoyu Luo Hao Gao NPU-UoG International Cooperative Lab for Computation and Application in Cardiology School of Mathematics and StatisticsNorthwestern Polytechnical UniversityXi’anShaanxi 710129China Xi’an Key Laboratory of Scientific Computation and Applied Statistics Xi’anShaanxi 710129China School of Mathematics and Statistics University of GlasgowGlasgowG128QQUnited Kingdom

Background Understanding the interaction between the mitral valve(MV)and the left ventricle(LV)is very important in assessing cardiac pump function,especially when the MV is *** dysfunction is a major medical problem owing to the essential role of the MV in cardiac pump *** modelling can provide new approaches to gain insight into the functions of the MV and *** In this study,a previously developed LV-MV model was used to study cardiac dynamics of MV leaflets under normal and pathological conditions,including hypertrophic cardiomyopathy(HOCM)and calcification of the *** coupled LV-MV model was implemented using a hybrid immersed boundary/finite element method to enable assessment of MV haemodynamic *** parameters of the HOCM and calcified valves were inversely determined from published experimental *** LV compensation mechanism was further studied in the case of the calcified *** Our results showed that MV dynamics and LV pump function could be greatly affected by MV *** example,the HOCM case showed bulged MV leaflets at the systole owing to low stiffness,and the calcified MV was associated with impaired diastolic filling and much-reduced stroke *** further demonstrated that either increasing the LV filling pressure or increasing myocardial contractility could enable a calcified valve to achieve near-normal pump *** The modelling approach developed in this study may deepen our understanding of the interactions between the MV and the LV and help in risk stratification of heart valve disease and in silico treatment planning by exploring intrinsic compensation mechanisms.

关键词： Mitral valve Left ventricle Valve disease Hybrid immersed boundary/finite element method Calcification Hypertrophic cardiomyopathy

Optical Micro/Nano Fibers Enabled Smart Textiles for Human-Machine Interface

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Advanced Fiber Materials 2022年第5期4卷 1108-1117页

作者： Shuqi Ma xiaoyu Wang Pan Li Ni Yao Jianliang Xiao Haitao Liu Zhang Zhang Longteng Yu Guangming Tao Xiong Li Limin tong Lei Zhang Research Center for Intelligent Sensing Zhejiang LabHangzhou 310000People’s Republic of China Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074People’s Republic of China State Key Laboratory of Modern Optical Instrumentation College of Optical Science and EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China Tencent Robotics X Lab Tencent Technology(Shenzhen)Co.Ltd.Shenzhen 518054People’s Republic of China

Wearable human-machine interface(HMI)is an advanced technology that has a wide range of applications from robotics to augmented/virtual reality(AR/VR).In this study,an optically driven wearable human-interactive smart textile is proposed by integrating a polydimethylsiloxane(PDMS)patch embedded with optical micro/nanofibers(MNF)array with a piece of *** by the highly sensitive pressure dependent bending loss of MNF,the smart textile shows high sensitivity(65.5 kPa^(−1))and fast response(25 ms)for touch *** from the warp and weft structure of the textile,the optical smart textile can feel slight finger slip along the ***,machine learning is utilized to classify the touch manners,achieving a recognition accuracy as high as 98.1%.As a proof-of-concept,a remote-control robotic hand and a smart interactive doll are demonstrated based on the optical smart *** optical smart textile represents an ideal HMI for AR/VR and robotics applications.

关键词： Smart textiles Human-machine interfaces Optical micro/nano fiber tactile sensor Augmented/virtual reality Robotics

Effects of dietary supplementation of Artemisia argyi aqueous extract on antioxidant indexes of small intestine in broilers

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Animal Nutrition 2016年第3期2卷 198-203页

作者： Fei Zhao Binlin Shi Dengsheng Sun Hongyan Chen Manman tong Pengfei Zhang xiaoyu Guo Sumei Yan College of Animal Science Inner Mongolia Agricultural University

The present study was conducted to investigate the effect of Artemisia argyi aqueous extract(AAE) on antioxidant indexes in the small intestine. A total of 192 Arbor Acre broiler chickens(one-day-old) were randomly divided into 4 treatments with 6 replicates of 8 chickens. These 4 diets were formulated by adding 0, 500,1,000 and 2,000 mg/kg AAE to the basal diet. The results showed as follows: 1) compared with the control, the total antioxidant capacity(T-AOC) in ileum for the 2,000 mg/kg treatment group was significantly increased at 21 days of age(P < 0.05); the T-AOC levels in jejunum and ileum were significantly increased in broilers supplemented with 500 mg/kg AAE at 42 days of age(P < 0.05), and the T-AOC levels in jejunum and ileum were significantly improved in 1,000 mg/kg treatment group(P < 0.01), 2) At 21 days of age, supplementation of 500 mg/kg AAE significantly increased the catalase(CAT) activity of small intestine, and the glutathione peroxidase(GSH-Px) activity of jejunum was improved(P < 0.01), meanwhile, the GSH-Px activity of duodenum and the total superoxide dismutase(T-SOD) activity of duodenum and jejunum were significantly higher than those of the control group(P < 0.05); supplementation of 1,000 mg/kg AAE significantly increased the CAT activity of duodenum and ileum and the GSH-Px activity of duodenum and jejunum(P < 0.05), and the ileum GSH-Px activity was significantly increased(P < 0.01); supplementation of 2,000 mg/kg AAE significantly increased the CAT activity of duodenum and ileum(P < 0.05). At 42 days of age, supplementation of 500 mg/kg AAE significantly increased the GSH-Px activity of ileum and the T-SOD activity of duodenum(P < 0.05),meanwhile, the T-SOD activity of jejunum was significantly increased(P < 0.01); supplementation of1,000 mg/kg AAE significantly increased the CAT activity of jejunum and the T-SOD activity of ileum(P < 0.01), and the GSH-Px activity of jejunum was significantly increased(P < 0.05); supplementation o

关键词： Artemisia argyi extract Broiler Small intestine Antioxidant index