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Insulin-like growth factor binding proteins 7 prevents dental pulp-derived mesenchymal stem cell senescence via metabolic downregulation of p21

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Science China(life Sciences) 2022年第11期65卷 2218-2232页

作者： xiaoyu li liang Feng Chunmei Zhang Jinsong Wang Songlin Wang Lei Hu Molecular Laboratory for Gene Therapy and Tooth Regeneration Beijing Key Laboratory of Tooth Regeneration and Function ReconstructionBeijing Laboratory of Oral HealthCapital Medical University School of StomatologyBeijing 100050China Immunology Research Center for Oral and Systemic Health Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Department of Biochemistry and Molecular Biology Capital Medical University School of Basic MedicineBeijing 100069China Laboratory for Oral and General Health Integration and Translation Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China Research Unit of Tooth Development and Regeneration Chinese Academy of Medical SciencesBeijing 100700China Department of Prosthodontics Capital Medical University School of StomatologyBeijing 100050China

Cellular senescence affects the efficacy of mesenchymal stem cells(MSCs)-mediated tissue regeneration.Insulin-like growth factor binding proteins-7(IGFBP7),as a member of the IGF family,is associated with osteogenic differentiation and the senescence of MSCs,but its exact function and mechanism remain unclear.We found IGFBP7 promoted the osteogenic differentiation and prevented the senescence of dental pulp-derived MSCs(DPSCs),as observed in the gain-of-function and lossof-function analyses,the senescence-associated marker p21 showed the most pronounced expression changes.We demonstrated that IGFBP7 activated the biological activity of SIRT1 deacetylase via metabolism,resulting in a deacetylation of H3K36ac and a decrease of the binding affinity of H3K36ac to p21 promoter,thereby reducing the transcription of p21,which ultimately prevents DPSCs senescence and promotes tissue regeneration.The activation of the mitochondrial electron transport chain(ETC)by Coenzyme Q10 could rescue the promotion of DPSC senescence induced by the knockdown of IGFBP7,whereas the inhibition of ETC by rotenone attenuated the prevention of DPSC senescence induced by IGFBP7 overexpression.In conclusion,our present results reveal a novel function of IGFBP7 in preventing DPSC senescence via the metabolism-induced deacetylation of H3K36ac and reduction of p21 transcription,suggesting that IGFBP7 is a potential target for promoting tissue regeneration in an aging environment.

关键词： dental pulp-derived mesenchymal stem cells insulin-like growth factor binding protein 7 senescence metabolism SIRT1 p21

Biallelic variants in RBM42 cause a multisystem disorder with neurological,facial,cardiac,and musculoskeletal involvement

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Protein & Cell 2024年第1期15卷 52-68页

作者： Yiyao Chen Bingxin Yang xiaoyu Merlin Zhang Songchang Chen Minhui Wang liya Hu Nina Pan Shuyuan li Weihui Shi Zhenhua Yang li Wang Yajing Tan Jian Wang Yanlin Wang Qinghe Xing Zhonghua Ma Jinsong li He-Feng Huang Jinglan Zhang Chenming Xu Institutes of Biomedical Sciences Fudan UniversityShanghai 200032China bstetrics and Gynecology Hospital Institute of Reproduction and DevelopmentFudan UniversityShanghai 200011China Intermational Peace Matermity and Child Health Hospital School of MedicineShanghai Jiao Tong UniversityShanghai 200030China Shanghai Key Laboratory of Embryo Original Diseases Shanghai 200030China State Key Laboratory of Cell Biology Shanghai Key Laboratory of Molecular AndrologyShanghai Institute of Biochemistry and Cell BiologyCAS Center for Excellence in Molecular Cell ScienceUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China State Key Laboratory of Rice Biology the Key Laboratory of Molecular Biology of Crop Pathogens and InsectsInstitute of BiotechnologyZhejiang UniversityHangzhou 310058China Verna and Marrs McLean Department of Biochemistry and Molecular Biology Baylor College of MedicineHoustonTX 77030USA Children's hospital of Fudan University Shanghai 201102China School of life Science and Technology Shanghai Tech UniversityShanghai 201210China School of life Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024ZhejiangChina Research Units of Embryo Original Diseases Chinese Academy of Medical Sciences(No.2019RU056)Shanghai 200011China

Here,we report a previously unrecognized syndromic neurodevelopmental disorder associated with biallelic loss-of-function variants in the RBM42 gene.The patient is a 2-year-old female with severe central nervous system(CNs)abnormalities,hypotonia,hearing loss,congenital heart defects,and dysmorphic facial features.Familial whole-exome sequencing(WEs)reveals that the patient has two compound heterozygous variants,c.304C>T(p.R102*)and c.1312G>A(p.A438T),in the RBM42 gene which encodes an integral component of splicing complex in the RNA-binding motif protein family.The p.A438T variant is in the RRM domain which impairs RBM42 pro-tein stability in vivo.Additionally,p.A438T disrupts the interaction of RBM42 with hnRNP K,which is the causa-tive gene for Au-Kline syndrome with overlapping disease characteristics seen in the index patient.The human R102*or A438T mutant protein failed to fully rescue the growth defects of RBM42 ortholog knockout△FgRbp1 in Fusarium while it was rescued by the wild-type(WT)human RBM42.A mouse model carying Rbm42 compound heterozygous variants,c.280C>T(p.Q94*)and c.1306_1308delinsACA(p.A436T),demonstrated gross fetal develop-mental defects and most of the double mutant animals died by E13.5.RNA-seq data confirmed that Rbm42 was involved in neurological and myocardial functions with an essential role in alternative splicing(As).Overall,we present clinical,genetic,and functional data to demonstrate that defects in RBM42 constitute the underlying etiology of a new neurodevelopmental disease which links the dysregulation of global AS to abnormal embryonic development.

关键词： RBM42 gene RNA-binding protein neurodevelopmental disorder Au-Kline syndrome alternative splicing

Nerves of Steel,Heart of Gold

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ChinAfrica 2024年第3期16卷 54-55页

作者： li xiaoyu 不详

The unwavering commitment of a Chinese neurosurgeon on African soil.Wang Xingwen,a 49-year-old neurosurgeon at the Xuanwu Hospital affiliated to Capital Medical University,is completing the final operation of the Year of the Rabbit.He must ensure his patient is in a stable post-operative state before he can purchase his train ticket to join his family in Shandong Province for the Lunar New Year.Due to his demanding career over the last 24 years,Wang has become accustomed to solitude during important festivities.

关键词： Rabbit surgeon custom

A Safari That Changed life

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ChinAfrica 2024年第2期16卷 48-49页

作者： li xiaoyu 不详

During his tour of Africa in March 2013,Chinese President Xi Jinping shared a heartwarming story about a Chinese couple at the Julius Nyerere International Convention Centre in Tanzania.The story exemplified the strong bond between the Chinese and African peoples,evoking a powerful emotional response and receiving warm applause from the African audience.

关键词： emotional warming story

A Clear Vision for Healthy Upbringing

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ChinAfrica 2024年第6期16卷 34-35页

作者： li xiaoyu 不详

China has made a remarkable progress in the overall improvement of children’s health.Infant mortality and under-five mortality rates in the country were down to 4.5 per 1,000 and 6.2 per 1,000 children,respectively,in 2023,a decrease of 16.7 percent and 17.3 percent from 2020,according to the 2024 Blue Book of Children,a report on the development of children in China recently published by the China National Children’s Centre.These figures are among the best in the middle-and higher-income countries.However,there is also a worrying trend related to the health of Chinese children and adolescents:an increase in myopia and obesity.More attention is now being paid to these issues,a task that requires solid cooperation between various stakeholders.

关键词： mortality bringing obesity

Granulomatosis with polyangiitis presented as multiple cutaneous abscesses after hysterectomy

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Chinese Medical Journal 2024年第6期137卷 755-756页

作者： Xiaoting Song Mengrui li Yinggai Song Ping Tu Hang li Yang Wang Rong Xu Min Chen Xiaojuan Yu Suxia Wang Fude Zhou Minghui Zhao Ruoyu li xiaoyu Jia Xiaowen Wang Department of Dermatology and Venereology Peking University First HospitalBeijing 100034China Beijing Key Laboratory of Molecular Diagnosis on Dermatoses Beijing 100034China National Clinical Research Center for Skin and Immune Diseases Beijing 100034China Renal Division Department of MedicinePeking University First HospitalBeijing 100034China Institute of Nephrology Peking UniversityBeijing 100034China Key Laboratory of Renal Disease Ministry of Health of ChinaBeijing 100034China Research Units of Diagnosis and Treatment of Immune-mediated Kidney Diseases Chinese Academy of Medical SciencesBeijing 100034China

To the Editor:A 62-year-old woman presented to the dermatology department with a 5-month history of multiple painless cutaneous abscesses and ulcers[Figure 1A],occurring 1 month after a transvaginal hysterectomy due to uterine prolapse.Her general condition was good before and after the surgery,with no abnormal physical signs apart from metroptosis.She reported no fever,night sweat,cough,or abdominal pain,but 10 kg weight-loss.She has no history of diabetes,autoimmune diseases,or chronic infectious diseases.There was no similar illness in her family.

关键词： hysterectomy pain surgery

Aerosol deposition technology and its applications in batteries

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Nano Materials Science 2024年第1期6卷 24-37页

作者： Xinyu Wang Ramon Alberto Paredes Camacho xiaoyu Xu Yumei Wang Yi Qiang Hans Kungl Ruediger-AEichel Yunfeng Zhang li Lu National University of Singapore(Chongqing)Research Institute Chongqing401123PR China National University of Singapore Singapore117576 Fundamental Electrochemistry(IEK-9) Institute of Energy and Climate ResearchForschungszentrum Jülich52425JülichGermany

Aerosol deposition(AD)method is a kind of additive manufacturing technology for fabricating dense films such as metals and ceramics at room temperature.It resolves the challenge of integrating ceramic films onto temperaturesensitive substrates,including metals,glasses,and polymers.It should be emphasized that the AD is a spray coating technology that uses powder without thermal assistance to generate films with high density.Compared to the traditional sputter-based approach,the AD shows several advantages in efficiency,convenience,better interfacial bonding and so on.Therefore,it opens some possibilities to the field of batteries,especially all-solidstate batteries(ASSBs)and draws much attention not only for research but also for large scale applications.The purpose of this work is to provide a critical review on the science and technology of AD as well as its applications in the field of batteries.The process,mechanism and effective parameters of AD,and recent developments in AD applications in the field of batteries will be systematically reviewed so that a trend for AD will be finally provided.

关键词： Aerosol deposition Room temperature impact consolidation Ceramic film All-solid-state battery Spray coating technology

Beneficial effects of lacquer seed oil on bromocriptine-induced postpartum hypogalactia in rats

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Food Science and Human Wellness 2024年

作者： Mengting li xiaoyu Song lin Shi Jie li Mayira·Ahat Yaojie liu Chen Hou Jianke li University Key Laboratory of Food Processing Byproducts for Advanced Development and High Value Utilization Shaanxi Normal University College of Food Engineering and Nutritional Science Shaanxi Normal University

The high incidence of postpartum hypogalactia hinders the healthy development of postpartum women and the next generation. Lacquer seed oil (LSO)， the oil extracted from the seeds of the lacquer tree， has been traditionally used as a dietary supplement for promoting postpartum lactation and recovery in some districts of China. However， its physiological effects have not been verified， and the mechanism and active components of LSO have not been analyzed. Thus， we applied LSO to bromocriptine-induced postpartum hypogalactia rats. The results showed that LSO supplement effectively improves bromocriptine-induced postpartum hypogalactia. LSO also increased prolactin levels reduced by bromocriptine， promoted JAK2/STAT5 and PI3K/AKT pathways and several gene expression levels of milk synthesis in mammary gland. Moreover， metabolomic and network pharmacological analysis further revealed that JAK2/STAT5， PI3K/AKT， and estrogen signaling pathway are the potential main regulatory sites for the beneficial effects of LSO on postpartum hypogalactia， and that quercetin， kaempferol， arachidonic acid， epicatechin， and β-sitosterol are the top 5 main active ingredients of LSO. Our results suggested that LSO has great potential in the application of the improvement of postpartum hypogalactia.

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The Mulan Of Africa

ChinAfrica 2024年第7期16卷 50-51页

作者： li xiaoyu 不详

A Beninese actress pursues her film dream in China to build bridges between the two cultures Rawdoth Alazi Soumaila,a young actress and model from Benin,has recently been cast in a leading role on the Chinese small sc... 详细信息

关键词： bridges film dream