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Variational Reconstruction and Simulation Experiments of Sea Surface Wind Field for Ocean Data Buoy

Journal of Ocean University of China 2024年第3期23卷 577-582页

作者： li Yunzhou HUANG Sixun YAN Shen SUN Xuejin QI Suiping WANG Zhongqiu TANG xiaoyu College of Meteorology and Oceanography National University of Defense TechnologyChangsha 410073China Institute of Oceanographic Instrumentation Qilu University of Technology(Shandong Academy of Sciences)Qingdao 266061China State Key Laboratory of Industrial Control Technology College of Control Science and EngineeringZhejiang UniversityHangzhou 310027China Laoshan Laboratory Qingdao 266237China

The sea surface wind field is an important physical parameter in oceanography and meteorology.With the continuous refinement of numerical weather prediction,air-sea interface materials,energy exchange,and other studies,three-dimensional(3D)wind field distribution at local locations on the sea surface must be measured accurately.The current in-situ observation of sea surface wind parameters is mainly achieved through the installation of wind sensors on ocean data buoys.However,the results obtained from this single-point measurement method cannot reflect wind field distribution in a vertical direction above the sea surface.Thus,the present paper proposes a theoretical framework for the optimal inversion of the 3D wind field structure variation in the area where the buoy is located.The variation analysis method is first used to reconstruct the wind field distribution at different heights of the buoy,after which theoretical analysis verification and numerical simulation experiments are conducted.The results indicate that the use of variational methods to reconstruct 3D wind fields is significantly effective in eliminating disturbance errors in observations,which also verifies the correctness of the theoretical analysis of this method.The findings of this article can provide a reference for the layout optimization design of wind measuring instruments in buoy observation systems and also provide theoretical guidance for the design of new observation buoys in the future.

关键词： moored buoy three-dimensional wind field distribution variational analysis wind field reconstruction

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Effects of physical properties of supercritical water on coarse graining of particle cluster

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Particuology 2023年第11期82卷 166-178页

作者： xiaoyu li Huibo Wang Yi li Hui Jin State Key Laboratory of Multiphase Flow in Power Engineering Xi'an Jiaotong UniversityXi'an710049China

The coarse graining of particle cluster is of great significance to the study of a fluidized bed. The effects of variations in the physical properties of supercritical water on the coarse graining of particle cluster are investigated in this work. The drag coefficient distributions of the particle cluster are not influenced by the physical properties. However, the physical properties have effects on the values of drag coefficient. The effects of physical properties are weaker in the case of large particle concentrations. Furthermore, the physical properties lead to that the effect of particle cluster wake on the drag of downstream particles being significantly different from that of constant property flow. The variation trend of drag of coarse graining particle is consistent with that of isolated particle. The physical properties lead to significant differences in the values of drag. In this paper, the dominance of the effects of physical properties in a variety of cases is confirmed. Finally, a physical properties effect model is developed accordingly.

关键词： Supercritical water Variations in physical properties Fluidized bed Coarse grain method Particle drag

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Genome editing of PAR2 through targeted delivery of CRISPR-Cas9 system for alleviating acute lung inflammation via ERK/NLRP3/IL-1β and NO/iNOS signalling

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1441-1456页

作者： Xin Zhuo Yue Wu Xiujuan Fu Jianbin li Yuxin Xiang xiaoyu liang Canquan Mao Yuhong Jiang Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs School of Life Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031China

Excessive and uncontrollable inflammatory responses in alveoli can dramatically exacerbate pulmonary disease progressions through vigorous cytokine releases,immune cell infiltration and protease-driven tissue damages.It is an urgent need to explore potential drug strategies for mitigating lung inflammation.Protease-activated receptor 2(PAR2)as a vital molecular target principally participates in various inflammatory diseases via intracellular signal transduction.However,it has been rarely reported about the role of PAR2 in lung inflammation.This study applied CRISPR-Cas9 system encoding Cas9 and sg RNA(p Cas9-PAR2)for PAR2 knockout and fabricated an anionic human serum albuminbased nanoparticles to deliver p Cas9-PAR2 with superior inflammation-targeting efficiency and stability(TAP/p Cas9-PAR2).TAP/p Cas9-PAR2 robustly facilitated p Cas9-PAR2 to enter and transfect inflammatory cells,eliciting precise gene editing of PAR2 in vitro and in vivo.Importantly,PAR2 deficiency by TAP/p Cas9-PAR2 effectively and safely promoted macrophage polarization,suppressed proinflammatory cytokine releases and alleviated acute lung inflammation,uncovering a novel value of PAR2.It also revealed that PAR2-mediated pulmonary inflammation prevented by TAP/p Cas9-PAR2was mainly dependent on ERK-mediated NLRP3/IL-1β and NO/i NOS signalling.Therefore,this work indicated PAR2 as a novel target for lung inflammation and provided a potential nanodrug strategy for PAR2 deficiency in treating inflammatory diseases.

关键词： Protease-activated receptor 2(PAR2) CRISPR-Cas9 Gene editing Inflammation Acute lung inflammation NLRP3 Nanoparticles Drug delivery

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Unlocking single-atom catalysts via amorphous substrates

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Nano Research 2024年第5期17卷 3533-3546页

作者： Bohua Sun Mingyuan Xu Xiaoxia li Baohong Zhang Rui Hao xiaoyu Fan Binbin Jia Dingshun She School of Engineering and Technology China University of Geosciences(Beijing)Beijing 100083China Zhengzhou Institute China University of Geosciences(Beijing)Zhengzhou 451283China College of Materials and Chemical Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion MaterialsChina Three Gorges UniversityYichang 443002China School of Chemistry Beihang UniversityBeijing 100191China Chinese Academy of Sciences(CAS)Key Laboratory of Nanosystem and Hierarchy Fabrication CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China National Engineering Research Center of Nonferrous Metals Materials and Products for New EnergyChina GRINM Group Co.Ltd.Beijing 100088China

Single-atom catalysts(SACs)reveal great potential for application in catalysis due to their fully exposed active sites.In general,single atoms(SAs)and the coordination substrates need to have strong interactions or charge transfer to ensure the atomic dispersion,which requires the selection of a suitable substrate to stabilize the target atoms.Recent studies have demonstrated that amorphous materials with abundant defects and coordinatively unsaturated sites can be used as substrates for more efficient capturing SAs,further enhancing the catalytic performance.In this review,we discuss recent research progress of SAs loaded on amorphous substrates for enhanced catalytic activity.Firstly,we summarize the commonly used amorphous substrates for stabilizing SAs.Subsequently,we present several advanced applications of amorphous SACs in the field of catalysis,including electrocatalysis and photocatalysis.And then,we also clarify the synergistic mechanism between SAs and amorphous substrate on catalytic process.Finally,we summarize the challenges with our personal views and provide a critical outlook on how amorphous SACs continue to evolve.

关键词： single-atoms amorphous substrate synthetic strategy catalysis

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Remote sensing of quality traits in cereal and arable production systems:A review

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The Crop Journal 2024年第1期12卷 45-57页

作者： Zhenhai li Chengzhi Fan Yu Zhao Xiuliang Jin Raffaele Casa Wenjiang Huang xiaoyu Song Gerald Blasch Guijun Yang James Taylor Zhenhong li College of Geodesy and Geomatics Shandong University of Science and TechnologyQingdao 266590ShandongChina Key Laboratory of Quantitative Remote Sensing in Ministry of Agriculture and Rural Affairs Information Technology Research CenterBeijing Academy of Agriculture and Forestry SciencesBeijing 100097China Institute of Crop Sciences Chinese Academy of Agricultural Sciences/Key Laboratory of Crop Physiology and EcologyMinistry of Agriculture and Rural AffairsBeijing 100081China DAFNE Universitàdella TusciaVia San Camillo de Lellis01100 ViterboItaly Key Laboratory of Digital Earth Science Aerospace Information Research InstituteChinese Academy of SciencesBeijing 100094China International Maize and Wheat Improvement Center(CIMMYT) PO Box 5689Addis AbabaEthiopia ITAP Univ.MontpellierINRAEInstitut AgroMontpellier 34000France College of Geological Engineering and Geomatics Chang’an UniversityXi’an 710054ShaanxiChina

Cereal is an essential source of calories and protein for the global population.Accurately predicting cereal quality before harvest is highly desirable in order to optimise management for farmers,grading harvest and categorised storage for enterprises,future trading prices,and policy planning.The use of remote sensing data with extensive spatial coverage demonstrates some potential in predicting crop quality traits.Many studies have also proposed models and methods for predicting such traits based on multiplatform remote sensing data.In this paper,the key quality traits that are of interest to producers and consumers are introduced.The literature related to grain quality prediction was analyzed in detail,and a review was conducted on remote sensing platforms,commonly used methods,potential gaps,and future trends in crop quality prediction.This review recommends new research directions that go beyond the traditional methods and discusses grain quality retrieval and the associated challenges from the perspective of remote sensing data.

关键词： Remote sensing Quality traits Grain protein Cereal

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The Effect of Moisture in Different Altitude Layers on the Eastward Propagation of MJO

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Journal of Meteorological Research 2024年第3期38卷 437-452页

作者： xiaoyu ZHU Zhong ZHONG Yimin ZHU Yunying li Yijia HU Yao HA College of Meteorology and Oceanography National University of Defense Technology Key Laboratory for Virtual Geographic Environment School of Geography Science Nanjing Normal University Jiangsu Collaborative Innovation Center for Climate Change School of Atmospheric Sciences Nanjing University

In this study, driven by ERA5 reanalysis data, the Weather Research and Forecasting(WRF) version 4.0 was used to investigate the eastward propagation of the Madden–Julian oscillation(MJO) in the tropical atmosphere during December–February(DJF) of 2007/2008. The experiment with 11 cumulus parameterization schemes respectively shows that the Grell 3D scheme is one of several worse ones in describing MJO activities. In addition, still by use of the Grell 3D scheme, four nudging assimilation experiments for water vapor in all model vertical layers(Ndg＿all),lower layers(Ndg＿low), middle layers(Ndg＿mid), and upper layers(Ndg＿upp) were conducted. It is found that when the water vapor in the model approaches to the observed value, the model performance for MJO activities is improved greatly. Among the four nudging simulations, Ndg＿all certainly performs best. Although Ndg＿mid is important for the MJO-filtered profiles related to moisture, Ndg＿low and Ndg＿upp exhibit superiority to Ndg＿mid in simulating MJO eastward propagation. Ndg＿low has advantages when MJO features are represented by zonal wind at850 hPa and precipitation because the lower-level MJO-filtered moisture is conducive to the existence of lower-level condensational heating to the east of the MJO convective center. Ndg＿upp performs better when describing the MJO eastward propagation features by outgoing longwave radiation(OLR) since it can capture the moisture and cloud top temperature of deep convection associated with MJO, as well as front Walker cell. These results suggest that the lower-level moisture is more important in regulating the MJO eastward propagation, and the observed maximum MJO-filtered moisture in the middle troposphere might be a phenomenon accompanying the MJO deep convection,but not a factor controlling its eastward propagation.

关键词： Madden–Julian oscillation (MJO) nudging technique Weather Research and Forecasting (WRF) model vertical moisture structure

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Pomegranate juice combined with inulin promote their mutual metabolic transformation by gut microbiota and prevent HFD-induced metabolic disorder in rats

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Food Science and Human Wellness 2024年

作者： xiaoyu Song Zhuoting Luo Mengting li Jianke li Chen Hou College of Food Engineering and Nutritional Science Shaanxi Normal University University Key Laboratory of Food Processing Byproducts for Advanced Development and High Value Utilization Shaanxi Normal University

High-fat diet (HFD) promotes the imbalance of gut microbiota， contributing to the development of metabolic disorders. Pomegranate juice (PJ) and inulin， as dietary polyphenol and dietary fiber respectively， have been reported to ameliorate diet-induced gut microbiota dysbiosis and metabolic disorders. However， the combined effect of PJ and inulin on HFD-induced metabolic disorders has not been elucidated. In current study， we found that the combination of PJ and inulin prevent HFD-induced obesity， dyslipidemia， and gut microbiota dysbiosis. Moreover， the fecal levels of short-chain fatty acids (SCFAs) produced by inulin were increased after inulin combined with PJ. The levels of pomegranate polyphenol metabolites produced by PJ were also increased after PJ combined with inulin， especially pharmacokinetic analysis showed that the presence of inulin enhance the absorption level of urolithin A. Fecal metabolomic analysis found that PJ combined with inulin alter the metabolic status compared with PJ. It was also showed that the levels of SCFAs and pomegranate polyphenol metabolites among groups were correlated with gut microbiota and metabolic disorders indicators. Our results suggested that PJ combined with inulin prevent HFD-induced metabolic disorders， which may be attributed to the promotion of mutual metabolic transformation and absorption of PJ and inulin by gut microbiota.

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Pomegranate peel polyphenols improves diet-induced obesity and promotes adipose browning development through gut microbiota in mice

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Food Science and Human Wellness 2024年

作者： Zhuoting Luo xiaoyu Song Mengting li Jianke li Chen Hou University Key Laboratory of Food Processing Byproducts for Advanced Development and High Value Utilization Shaanxi Normal University College of Food Engineering and Nutritional Science Shaanxi Normal University

Gut microbiota regulate the activation of adipose browning， which promote energy dissipation and combat diet-induced obesity. Pomegranate peel polyphenols (PPPs) have been shown to reduce obesity， regulate lipid metabolism in adipose tissue， and modulate the composition of gut microbiota in animal fed high-fat diet (HFD). However， the role of gut microbiota in the improvement of obesity by PPPs has not been elucidated. In current study， we applied antibiotics to inhibit gut microbiota in mice fed HFD and treated with PPPs. The results showed that the inhibition of gut microbiota impair the effect of PPPs on reducing obesity and promoting adipose browning， and change the fecal metabolomic profiles in respond to PPPs. Moreover， the inhibition of gut microbiota supressed the promotive effects of PPPs on the levels of Akkermansia and microbiota-related metabolites， such as urolithin A， short-chain fatty acids (SCFAs)， and bile acids (BAs)， which were associated with activating adipose browning. Therefore， our results suggested that the presence of gut microbiota is essential for PPPs to ameliorate HFD-induced obesity. The related bacteria or metabolites generated by the interaction between PPPs and microbiota promote adipose browning and facilitate the beneficial effects of PPPs.

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Bioinspired Multifunctional Self-Sensing Actuated Gradient Hydrogel for Soft-Hard Robot Remote Interaction

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Nano-Micro Letters 2024年第4期16卷 139-152页

作者： He liu Haoxiang Chu Hailiang Yuan Deliang li Weisi Deng Zhiwei Fu Ruonan liu Yiying liu Yixuan Han Yanpeng Wang Yue Zhao xiaoyu Cui Ye Tian College of Medicine and Biological Information Engineering Northeastern UniversityShenyang 110169People’s Republic of China Foshan Graduate School of Innovation Northeastern UniversityFoshan 528300People’s Republic of China

The development of bioinspired gradient hydrogels with self-sensing actuated capabilities for remote interaction with soft-hard robots remains a challenging endeavor. Here, we propose a novel multifunctional self-sensing actuated gradient hydrogel that combines ultrafast actuation and high sensitivity for remote interaction with robotic hand. The gradient network structure, achieved through a wettability difference method involving the rapid precipitation of MoO_(2) nanosheets, introduces hydrophilic disparities between two sides within hydrogel. This distinctive approach bestows the hydrogel with ultrafast thermo-responsive actuation(21° s^(-1)) and enhanced photothermal efficiency(increase by 3.7 ℃ s^(-1) under 808 nm near-infrared). Moreover, the local cross-linking of sodium alginate with Ca^(2+) endows the hydrogel with programmable deformability and information display capabilities. Additionally, the hydrogel exhibits high sensitivity(gauge factor 3.94 within a wide strain range of 600%), fast response times(140 ms) and good cycling stability. Leveraging these exceptional properties, we incorporate the hydrogel into various soft actuators, including soft gripper, artificial iris, and bioinspired jellyfish, as well as wearable electronics capable of precise human motion and physiological signal detection. Furthermore, through the synergistic combination of remarkable actuation and sensitivity, we realize a self-sensing touch bioinspired tongue. Notably, by employing quantitative analysis of actuation-sensing, we realize remote interaction between soft-hard robot via the Internet of Things. The multifunctional self-sensing actuated gradient hydrogel presented in this study provides a new insight for advanced somatosensory materials, self-feedback intelligent soft robots and human–machine interactions.

关键词： Self-sensing Gradient structure Bioinspired actuator Hydrogel sensor Remote interaction

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Global characterization of OsPIP aquaporins reveals that the H_(2)O_(2)transporter OsPIP2;6 increases resistance to rice blast

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The Crop Journal 2024年第1期12卷 102-109页

作者： Gousi li Jingluan Han Chen Yi Hao Luo Yuzhu Wang Fengpin Wang xiaoyu Wang Letian Chen Yaling Zhang State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources College of Life SciencesSouth China Agricultural UniversityGuangzhou 510642GuangdongChina Guangdong Laboratory for lingnan Modern Agriculture Guangzhou 510642GuangdongChina National Key Laboratory of Plant Molecular Genetics Shanghai Center for Plant Stress BiologyCAS Center for Excellence in Molecular Plant SciencesShanghai Institute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200032China

Plasma membrane intrinsic proteins(PIPs)are conserved plant aquaporins that transport small molecules across the plasma membrane to trigger instant stress responses and maintain cellular homeostasis under biotic and abiotic stress.To elucidate their roles in plant immunity to pathogen attack,we characterized the expression patterns,subcellular localizations,and H_(2)O_(2)-transport ability of 11 OsPIPs in rice(Oryza sativa),and identified OsPIP2;6 as necessary for rice disease resistance.OsPIP2;6 resides on the plasma membrane and facilitates cytoplasmic import of the immune signaling molecule H_(2)O_(2).Knockout of OsPIP2;6 increases rice susceptibility to Magnaporthe oryzae,indicating a positive function in plant immunity.OsPIP2;6 interacts with OsPIP2;2,which has been reported to increase rice resistance to pathogens via H_(2)O_(2)transport.Our findings suggest that OsPIP2;6 cooperates with OsPIP2;2 as a defense signal transporter complex during plant–pathogen interaction.

关键词： Aquaporin Plant immunity Rice blast H_(2)O_(2)transport

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