检索结果-南通市图书馆

Elevated CO_(2) increases soil redox potential by promoting root radial oxygen loss in paddy field

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第2期136卷 11-20页

作者： Jie li Han Zhang Wenyi Xie Cheng liu xiaoyu liu Xuhui Zhang lianqing li Genxing Pan Institute of Resource Ecosystem and Environment of AgricultureNanjing Agricultural UniversityNanjing 210095China College of Agriculture Nanjing Agricultural UniversityNanjing 210095China

Soil redox potential(Eh)plays an important role in the biogeochemical cycling of soil nutrients.Whereas its effect soil process and nutrients'availability under elevated atmospheric CO_(2) concentration and warming has seldom been investigated.Thus,in this study,a field experiment was used to elucidate the effect of elevated CO_(2) concentration and warming on soil Eh,redox-sensitive elements and root radial oxygen loss(ROL).We hypothesized elevated CO_(2) and warming could alter soil Eh by promoting or inhibiting ROL.We found that soil Eh in the rhizosphere was significantly higher than that of non-rhizosphere.Elevated CO_(2) enhanced soil Eh by 11.5%,which corresponded to a significant decrease in soil Fe^(2+)and Mn^(2+)concentration.Under elevated CO_(2),the concentration of Fe^(2+)and Mn^(2+)decreased by 14.7%and 13.7%,respectively.We also found that elevated CO_(2) altered rice root aerenchyma structure and promoted rice root ROL.Under elevated CO_(2),rice root ROL increased by 79.5%and 112.2%for Yangdao 6 and Changyou 5,respectively.Warming had no effect on soil Eh and rice root ROL.While warming increased the concentration of Mn^(2+)and SO_(4)^(2-)by 4.9%and 19.3%,respectively.There was a significant interaction between elevated CO_(2) and warming on Fe^(2+)and Mn^(2+).Under elevated CO_(2),warming had no effect on the concentration of Fe^(2+)but decreased Mn^(2+)concentration significantly.Our study demonstrated that elevated atmospheric CO_(2) in the future could increase soil Eh by promoting rice root ROL,which will alter some soil nutrients'availability,such as Fe^(2+)and Mn^(2+).

关键词： Atmospheric CO_(2)enrichment Global warming Soil redox potential FACE Rice root aerenchyma

Anti-lymphangiogenesis for boosting drug accumulation in tumors

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第5期9卷 2161-2175页

作者： Chunling Wang Junchao Xu xiaoyu Cheng Ge Sun Fenfen li Guangjun Nie Yinlong Zhang CAS Key Laboratory for Biomedical Effects of Nanomaterials&Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China Sino-Danish College University of Chinese Academy of SciencesBeijing 100190China Sino-Danish Center for Education and Research Beijing 100190China Department of Bioengineering University of PennsylvaniaPhiladelphiaPA 19104USA School of Nanoscience and Engineering University of Chinese Academy of SciencesBeijing 100049China

The inadequate tumor accumulation of anti-cancer agents is a major shortcoming of current therapeutic drugs and remains an even more significant concern in the clinical prospects for nanomedicines.Various strategies aiming at regulating the intratumoral permeability of therapeutic drugs have been explored in preclinical studies,with a primary focus on vascular regulation and stromal reduction.However,these methods may trigger or facilitate tumor metastasis as a tradeoff.Therefore,there is an urgent need for innovative strategies that boost intratumoral drug accumulation without compromising treatment outcomes.As another important factor affecting drug tumor accumulation besides vasculature and stroma,the impact of tumor-associated lymphatic vessels(LVs)has not been widely considered.In the current research,we verified that anlotinib,a tyrosine kinase inhibitor with anti-lymphangiogenesis activity,and SAR131675,a selective VEGFR-3 inhibitor,effectively decreased the density of tumor lymphatic vessels in mouse cancer models,further enhancing drug accumulation in tumor tissue.By combining anlotinib with therapeutic drugs,including doxorubicin(Dox),liposomal doxorubicin(lip-Dox),and anti-PD-L1 antibody,we observed improved anti-tumor efficacy in comparison with monotherapy regimens.Meanwhile,this strategy significantly reduced tumor metastasis and elicited stronger anti-tumor immune responses.Our work describes a new,clinically transferrable approach to augmenting intratumoral drug accumulation,which shows great potential to address the current,unsatisfactory efficacies of therapeutic drugs without introducing metastatic risk.

关键词： drugs angiogenesis metastasis

Fundamental Understanding of Hydrogen Evolution Reaction on Zinc Anode Surface:A First‑Principles Study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro Letters 2024年第6期16卷 180-191页

作者： xiaoyu liu Yiming Guo Fanghua Ning Yuyu liu Siqi Shi Qian li Jiujun Zhang Shigang Lu Jin Yi Institute for Sustainable Energy&Department of Chemistry Shanghai UniversityShanghai 200444People’s Republic of China School of Materials Science and Engineering Shanghai UniversityShanghai 200444People’s Republic of China College of Materials Science and Engineering National Engineering Research Center for Magnesium AlloysChongqing UniversityChongqing 400044People’s Republic of China

Hydrogen evolution reaction(HER)has become a key factor affecting the cycling stability of aqueous Zn-ion batteries,while the corresponding fundamental issues involving HER are still unclear.Herein,the reaction mechanisms of HER on various crystalline surfaces have been investigated by first-principle calculations based on density functional theory.It is found that the Volmer step is the ratelimiting step of HER on the Zn(002)and(100)surfaces,while,the reaction rates of HER on the Zn(101),(102)and(103)surfaces are determined by the Tafel step.Moreover,the correlation between HER activity and the generalized coordination number(CN)of Zn at the surfaces has been revealed.The relatively weaker HER activity on Zn(002)surface can be attributed to the higher CN of surface Zn atom.The atomically uneven Zn(002)surface shows significantly higher HER activity than the flat Zn(002)surface as the CN of the surface Zn atom is lowered.The CN of surface Zn atom is proposed as a key descriptor of HER activity.Tuning the CN of surface Zn atom would be a vital strategy to inhibit HER on the Zn anode surface based on the presented theoretical studies.Furthermore,this work provides a theoretical basis for the in-depth understanding of HER on the Zn surface.

关键词： Aqueous Zn-ion battery Zn anode Hydrogen evolution reaction Coordination number First-principles calculation

Mechanism of PARP inhibitor resistance and potential overcoming strategies

在线全文

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第1期11卷 306-320页

作者： xiaoyu Fu Ping li Qi Zhou Ruyuan He Guannan Wang Shiya Zhu Amir Bagheri Gary Kupfer Huadong Pei Juanjuan li Department of Oncology Georgetown Lombardi Comprehensive Cancer CenterGeorgetown University Medical CenterWashingtonDC 20057USA Department of Breast and Thyroid Surgery Renmin Hospital of Wuhan UniversityWuhanHubei 430060China Cancer Center Renmin Hospital of Wuhan UniversityWuhanHubei 430060China Department of Thoracic Surgery Renmin Hospital of Wuhan UniversityWuhanHubei 430060China

PARP inhibitors(PARPi)are a kind of cancer therapy that targets poly(ADP-ribose)polymerase.PARPi is the first clinically approved drug to exert synthetic lethality by obstruct-ing the DNA single-strand break repair process.Despite the significant therapeutic effect in pa-tients with homologous recombination(HR)repair deficiency,innate and acquired resistance to PARPi is a main challenge in the clinic.In this review,we mainly discussed the underlying mechanisms of PARPi resistance and summarized the promising solutions to overcome PARPi resistance,aiming at extending PARPi application and improving patient outcomes.

关键词： Drug resistance Homologous recombination PARP PARP inhibitor Poly(ADP-ribose)polymerase

Adverse effects of exposure to fine particles and ultrafine particles in the environment on different organs of organisms

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第1期135卷 449-473页

作者： Jianwei Zhang Zhao Chen Dan Shan Yang Wu Yue Zhao Chen li Yue Shu xiaoyu linghu Baiqi Wang Department of Occupational and Environmental Health School of Public HealthTianjin Medical UniversityTianjin 300070China Department of Medical Tianjin Stomatological HospitalSchool of MedicineNankai UniversityTianjin 300041China Tianjin Key Laboratory of Environment Nutrition and Public HealthTianjin 300070China National Demonstration Center for Experimental Preventive Medicine Education(Tianjin Medical University) Tianjin 300070China

Particulate pollution is a global risk factor that seriously threatens human health.Fine particles(FPs)and ultrafine particles(UFPs)have small particle diameters and large specific surface areas,which can easily adsorb metals,microorganisms and other pollutants.FPs and UFPs can enter the human body in multiple ways and can be easily and quickly absorbed by the cells,tissues and organs.In the body,the particles can induce oxidative stress,inflammatory response and apoptosis,furthermore causing great adverse effects.Epidemiological studies mainly take the population as the research object to study the distribution of diseases and health conditions in a specific population and to focus on the identification of influencing factors.However,the mechanism by which a substance harms the health of organisms is mainly demonstrated through toxicological studies.Combining epidemiological studies with toxicological studies will provide a more systematic and comprehensive understanding of the impact of PM on the health of organisms.In this review,the sources,compositions,and morphologies of FPs and UFPs are briefly introduced in the first part.The effects and action mechanisms of exposure to FPs and UFPs on the heart,lungs,brain,liver,spleen,kidneys,pancreas,gastrointestinal tract,joints and reproductive system are systematically summarized.In addition,challenges are further pointed out at the end of the paper.This work provides useful theoretical guidance and a strong experimental foundation for investigating and preventing the adverse effects of FPs and UFPs on human health.

关键词： Fine particles Ultrafine particles Organs Adverse effect

Aerosol-radiation interaction and its variation in North China within 2015–2019 period under continuous PM_(2.5)improvements

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第2期136卷 81-94页

作者： Zhe Lv Xiaoqi Wang Wei Wei Huahua Bai xiaoyu liu Guohao li Shuiyuan Cheng Department of Environmental Science and Engineering Beijing University of TechnologyBeijing 100124China Key Laboratory of Beijing on Regional Air Pollution Control Beijing 100124China Beijing Municipal Research Institute of Eco-Environmental Protection Beijing 100037China Beijing Key Laboratory of Urban Atmospheric Volatile Organic Compounds Pollution Control and Application Beijing 100037China

A study was conducted on aerosol-radiation interactions over six cities in this region within the 2015–2019 period.WRF-Chem simulations on 2017 showed that based on the six-city average,the aerosol load(PM_(2.5)concentrations)of 121.9,49.6,43.3,and 66.3μg/m^(3)in January,April,July,and October,mainly lowered the level of downward shortwave radiation by 38.9,24.0,59.1,and 24.4 W/m~2and reduced the boundary layer height by 79.9,40.8,87.4,and 31.0 m,via scattering and absorbing solar radiation.The sensitivity of meteorological changes to identical aerosol loads varied in the order July>January>October and April.Then,the cooling and stabilizing effects of aerosols further led to increases in PM_(2.5),by23.0,3.4,4.6,and 7.3μg/m^(3)respectively in the four months.The sensitivity of the effect of aerosols on PM_(2.5)was greatest in January rather than in July,contrary to the effect on meteorology.Moreover,a negative linear relation was observed between daily BLH reductions and aerosol loads in fall and winter,and between PM_(2.5)increases and aerosol loads in all seasons.With the PM_(2.5)pollution improvements in this region,the aerosol radiative forcing was effectively reduced.This should result in daily BLH increases of 10–24 m in fall and winter,and the estimates in Beijing agreed well with the corresponding results based on AMDAR data.Additionally,the reduction in aerosol radiation effects brought about daily PM_(2.5)decreases of 1.6-2.8μg/m^(3),accounting for 7.0%–17.7%in PM_(2.5)improvements.

关键词： Radiative forcing Aerosol PM_(2.5) Boundary layer height(BLH) North China

Current status and future development of aortic stent fenestration-assisted techniques

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2024年第6期137卷 752-754页

作者： Gezheng Chen xiaoyu Qi Wanying Wu Dongsheng Fu li Qin Chao Yang Department of Vascular Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Department of Vascular Surgery Nanjing Drum Tower HospitalAffiliate Hospital of Nanjing University Medical SchoolNanjingJiangsu 210008China

To the Editor:In 1996,Parodi et al^([1])introduced the technique of fenestrated endovascular aneurysm repair(f-EVAR)for treatment of pararenal abdominal aortic aneurysms.They use physician modified stent grafts(PMSGs)for fenestration,which allows for stent grafts to gain sufficient proximal sealing zones and maintain the blood perfusion of visceral arteries.^([2])Stent grafts used in the f-EVAR technique developed from PMSGs to Company Modified Devices(CMDs)and off-the-shelf devices.^([3])To improve the precision of PMSGs and shorten the time of stent graft modification,various techniques that assist in the process of fenestration have been researched and developed,including 3-dimensional(3D)printing technique,the Mixed Reality(MR)technique,and the 3D parametric surface planar topological guide plate.This article describes the current status and future development of these techniques.

关键词： aortic perfusion arteries

Reconstructing cell lineage trees with genomic barcoding:approaches and applications

在线全文

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2024年第1期51卷 35-47页

作者： Zizhang li Wenjing Yang Peng Wu Yuyan Shan xiaoyu Zhang Feng Chen Junnan Yang Jian-Rong Yang Advanced Medical Technology Center The First Affiliated HospitalZhongshan School of MedicineSun Yat-sen UniversityGuangzhouGuangdong 510080China Department of Genetics and Biomedical Informatics Zhongshan School of MedicineSun Yat-sen UniversityGuangzhouGuangdong 510080China Key Laboratory of Tropical Disease Control Ministry of EducationSun Yat-sen UniversityGuangzhouGuangdong 510080China

In multicellular organisms,developmental history of cell divisions and functional annotation of terminal cells can be organized into a cell lineage tree(CLT).The reconstruction of the CLT has long been a major goal in developmental biology and other related fields.Recent technological advancements,especially those in editable genomic barcodes and single-cell high-throughput sequencing,have sparked a new wave of experimental methods for reconstructing CLTs.Here we review the existing experimental approaches to the reconstruction of CLT,which are broadly categorized as either image-based or DNA barcode-based methods.In addition,we present a summary of the related literature based on the biological insight pro-vided by the obtained CLTs.Moreover,we discuss the challenges that will arise as more and better CLT data become available in the near future.Genomic barcoding-based CLT reconstructions and analyses,due to their wide applicability and high scalability,offer the potential for novel biological discoveries,especially those related to general and systemic properties of the developmental process.

关键词： Cell lineage tree Developmental regulation Biotechnology Computational biology

Uncertainty quantification of inverse analysis for geomaterials using probabilistic programming

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Rock Mechanics and Geotechnical Engineering 2024年第3期16卷 895-908页

作者： Hongbo Zhao Shaojun li xiaoyu Zang Xinyi liu lin Zhang Jiaolong Ren School of Civil Engineering and Geomatics Shandong University of TechnologyZibo255000China State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China

Uncertainty is an essentially challenging for safe construction and long-term stability of geotechnical engineering.The inverse analysis is commonly utilized to determine the physico-mechanical parameters.However,conventional inverse analysis cannot deal with uncertainty in geotechnical and geological systems.In this study,a framework was developed to evaluate and quantify uncertainty in inverse analysis based on the reduced-order model(ROM)and probabilistic programming.The ROM was utilized to capture the mechanical and deformation properties of surrounding rock mass in geomechanical problems.Probabilistic programming was employed to evaluate uncertainty during construction in geotechnical engineering.A circular tunnel was then used to illustrate the proposed framework using analytical and numerical solution.The results show that the geomechanical parameters and associated uncertainty can be properly obtained and the proposed framework can capture the mechanical behaviors under uncertainty.Then,a slope case was employed to demonstrate the performance of the developed framework.The results prove that the proposed framework provides a scientific,feasible,and effective tool to characterize the properties and physical mechanism of geomaterials under uncertainty in geotechnical engineering problems.

关键词： Geological engineering Geotechnical engineering Inverse analysis Uncertainty quantification Probabilistic programming