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用于锂电池监测的声学和光学传感技术研究进展

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储能科学与技术 2024年第1期13卷 167-177页

作者：张怡葛筱渔李真黄云辉华中科技大学材料科学与工程学院湖北武汉430074

锂电池技术的快速发展使其成为了应用最广泛的电化学储能器件。然而电池性能提升的同时也带来了日益凸显的安全问题,需要开发先进的监测传感技术获取电池内部的物理、化学信息,以更好地理解电池的内在物理化学机制并评估电池状态。基于... 详细信息

锂电池技术的快速发展使其成为了应用最广泛的电化学储能器件。然而电池性能提升的同时也带来了日益凸显的安全问题,需要开发先进的监测传感技术获取电池内部的物理、化学信息,以更好地理解电池的内在物理化学机制并评估电池状态。基于此,本文首先介绍了电池无损监测技术的发展历史,并重点介绍了基于声学和光学的电池无损检测技术。声学传感技术只需在电池外部布设声学探头,即可获得其内部结构变化、产气等信息,是一种理想的无损监测方式。光学传感凭借其传感器体积小、耐腐蚀、抗电磁干扰等优势,可以植入到电池内部,获取电池全生命周期内部热学、力学、化学等多种传感信息。通过这些先进的传感技术,能够最大限度地评估和预测电池的健康状态、工况可靠性、剩余寿命和安全性。最后本文讨论了下一代智能电池开发应用面临的机遇与挑战。

关键词：电池监测光学传感声学传感锂离子电池

粤港澳大湾区体育产业集群与区域经济协同发展的实证研究

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吉林体育学院学报 2024年第1期40卷 10-17页

作者：盘劲呈葛小雨贵州财经大学新体育研究中心贵州贵阳550002 西北工业大学体育部陕西西安710072

体育产业集群能够促进区域经济高质量发展。本文构建了体育产业区域协同发展模型,剖析了粤港澳大湾区的体育产业与区域经济协同发展的过程,粤港澳体育产业呈现“三核一群”发展特征,在协同城市群经济、产业结构及区域合作方面作用显著... 详细信息

体育产业集群能够促进区域经济高质量发展。本文构建了体育产业区域协同发展模型,剖析了粤港澳大湾区的体育产业与区域经济协同发展的过程,粤港澳体育产业呈现“三核一群”发展特征,在协同城市群经济、产业结构及区域合作方面作用显著。分析发现:粤港澳大湾区经济带动了体育产业空间均衡发展,既拓展了城市体育新空间,也显现出与关联产业的协同创新效应;其协同发展过程受人文环境、工业化水平等因素影响。研究最后提出体育产业集群区域协同发展路径:加速城市群创新要素流动,积极培育国际体育产业集群、强化法治保障、深化关联性产业融合,进一步提升体育产业协同运行质量,畅通粤港澳大湾区体育产业国际大市场。

关键词：体育产业集群区域经济协同发展粤港澳大湾区

乡村全面振兴背景下青年返乡创业的发展现状与优化路径

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青年学报 2024年第4期 4-12页

作者：蔡文成葛晓瑜兰州大学马克思主义学院

在乡村振兴战略的政策支持和城乡融合发展的现实导向下,乡村青年群体逐渐形成返乡创业的热潮。青年返乡创业在个人层面能够彰显自我价值的实现和自我主体性的建构,提高个人生活水平,创造美好生活。同时,在社会层面能够激发乡村经济活力... 详细信息

在乡村振兴战略的政策支持和城乡融合发展的现实导向下,乡村青年群体逐渐形成返乡创业的热潮。青年返乡创业在个人层面能够彰显自我价值的实现和自我主体性的建构,提高个人生活水平,创造美好生活。同时,在社会层面能够激发乡村经济活力,加速乡村产业转型,创新三产融合发展模式,促进乡村经济发展,带动文明乡风构建,并着力以创业带动就业,解决乡村人口就业问题,增进乡村民生福祉,从而在实践中助力城乡融合进程,推动乡村全面振兴。

关键词：乡村振兴乡村全面振兴城乡融合青年返乡创业

Synchronous control for high-accuracy biaxial motion systems

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控制理论与应用（英文版） 2013年第2期11卷 294-298页

作者： Yong XIAO Yujun PANG xiaoyu ge Jingna SUN College of Information Engineering Shenyang University of Chemical Technology

This paper presents an efficient synchronization control scheme for a high-accuracy synchronous mo- tion system. In particular, an optimal PID controller for individual motion axis is first developed to guarantee satisfactory tracking performance according to traditional controller tuning strategy. Then, an additional synchronous controller is introduced to generate cross-coupling control action, so that synchronous position error across axes due to system manu- facturing tolerance or disturbance could be suppressed. Experimental results on a positioning system equipped with two permanent-magnet linear motors demonstrate that the synchronization performance with the proposed control scheme could be enhanced.

关键词： Synchronous motion Ripple force Permanent magnet linear motor

AWells-Riley/based COVID-19 infectiousrisk assessment model combining both short rangeandroom scale effects

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Building Simulation 2024年第1期17卷 93-111页

作者： Yinshuai Feng Yifan Fan xiaoyu Luo Jian ge College of Civil Engineering and Architecture Zhejiang UniversityHangzhouChina Center for Balance Architecture Zhejiang UniversityHangzhouChina International Research Center for Green Building and Low-Carbon City International CampusZhejiang UniversityHainingChina

There is growing evidence of the high transmission potential of COVID-19 through virus-laden *** aerosols are inhaled in various concentrations,an overall assessment of transmission risks at different indoor scales is ***,a comprehensive risk assessment method that evaluates the direct link between short-range and room-scale zones is stl *** this paper,a risk assessment model combining both short-range and room-scale effects is developed to obtain effective reproduction number in confined indoor environments,called Turbulent Jet Wells Riley(TJWR)*** with the viral load data and aerosol generation data of different human respiratory activities,the Monte Carlo simulation method is applied to calculate the quanta emission rate,which further provides the input parameters of the TJWR *** known outbreaks(Hangzhou banquet hall X,Guangzhou restaurant Y,and Hong Kong restaurant Z,China)are chosen to validate the TJWR *** show that the TJWR model is more efficient than the original Wells-Riley *** average relative error of the TJWR model ranges between 9%and 44%,while for the Wells-Riley model,it ranges between 57%and 78%.The TJWR model also proves that infection risk assessments using the well-mixed assumption can systematically underestimate the transmission risk for those close to the ***,there is a significant positive linear correlation between the total number of exposed individuals at the short-range and the effective reproduction *** newly developed TJWR model has great potential for rapid and real-time overall airborne transmission risk assessment in buildings and cities.

关键词： COVID-19 airborne transmission infection risk Wells-Riley model Monte Carlo simulation

AAV for gene Therapy in Ocular Diseases:Progress and Prospects

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Research 2024年第3期2023卷 651-670页

作者： xiaoyu He Yidian Fu Liang Ma Yizheng Yao Shengfang ge Zhi Yang Xianqun Fan Department of Ophthalmology Ninth People’s HospitalShanghai JiaoTong University School of MedicineShanghaiChina Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology ShanghaiChina Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience Soochow UniversityClinical Research Center of Neurological DiseaseThe Second Affiliated Hospital of Soochow UniversitySuzhouChina

Owing to the promising therapeutic effect and one-time treatment advantage, gene therapy may completely change the management of eye diseases, especially retinal diseases. Adeno-associated virus (AAV) is considered one of the most promising viral gene delivery tools because it can infect various types of tissues and is considered as a relatively safe gene delivery vector. The eye is one of the most popular organs for gene therapy, since its limited volume is suitable for small doses of AAV stably transduction. Recently, an increasing number of clinical trials of AAV-mediated gene therapy are underway. This review summarizes the biological functions of AAV and its application in the treatment of various ocular diseases, as well as the characteristics of different AAV delivery routes in clinical applications. Here, the latest research progresses in AAV-mediated gene editing and silencing strategies to modify that the genetic ocular diseases are systematically outlined, especially by base editing and prime editing. We discuss the progress of AAV in ocular optogenetic therapy. We also summarize the application of AAV-mediated gene therapy in animal models and the difficulties in its clinical transformation.

关键词： AAV organs treatment

Single‑cell sequencing reveals the reproductive variations between primiparous and multiparous Hu ewes

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Journal of Animal Science and Biotechnology 2024年第2期15卷 614-631页

作者： Ting ge Yifan Wen Bo Li xiaoyu Huang Shaohua Jiang Enping Zhang Key Laboratory of Animal genetics Breeding and Reproduction of Shaanxi ProvinceCollege of Animal Science and TechnologyNorthwest A&F UniversityYangling 712100China

Background In the modern sheep production systems,the reproductive performance of ewes determines the economic profitability of *** the genetic mechanisms underlying differences in the litter size is important for the selection and breeding of highly prolific *** sheep,a high-quality Chinese sheep breed,is known for its high fecundity and is often used as a model to study prolificacy *** the current study,animals were divided into two groups according to their delivery rates in three consecutive lambing seasons(namely,the high and low reproductive groups with≥3 lambs and one lamb per season,n=3,respectively).The ewes were slaughtered within 12 h of estrus,and unilateral ovarian tissues were collected and analyzed by 10×genomics single-cell RNA *** A total of 5 types of somatic cells were identified and corresponding expression profiles were mapped in the ovaries of each ***,the differences in the ovary somatic cell expression profiles between the high and low reproductive groups were mainly clustered in the granulosa ***,four granulosa cell subtypes were *** analysis revealed that the abundance of JPH1 expression and the reduction of LOC101112291 expression could lead to different evolutionary directions of the granulosa ***,the expression levels of FTH1 and FTL in mural granulosa cells of the highly reproductive group were significantly *** genes inhibit necroptosis and ferroptosis of mural granulosa cells,which helps prevent follicular *** This study provides insights into the molecular mechanisms underlying the high fecundity of Hu *** differences in gene expression profiles,particularly in the granulosa cells,suggest that these cells play a critical role in female *** findings also highlight the importance of genes such as JPH1,LOC101112291,FTH1,and FTL in regulating granulosa cell function and follicular development.

关键词： Granulosa cells Hu sheep Lambing number Ovarian somatic cells Single-cell RNA sequencing

Anti-lymphangiogenesis for boosting drug accumulation in tumors

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2161-2175页

作者： Chunling Wang Junchao Xu xiaoyu Cheng ge Sun Fenfen Li Guangjun Nie Yinlong Zhang CAS Key Laboratory for Biomedical Effects of Nanomaterials&Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China Sino-Danish College University of Chinese Academy of SciencesBeijing 100190China Sino-Danish Center for Education and Research Beijing 100190China Department of Bioengineering University of PennsylvaniaPhiladelphiaPA 19104USA School of Nanoscience and Engineering University of Chinese Academy of SciencesBeijing 100049China

The inadequate tumor accumulation of anti-cancer agents is a major shortcoming of current therapeutic drugs and remains an even more significant concern in the clinical prospects for *** strategies aiming at regulating the intratumoral permeability of therapeutic drugs have been explored in preclinical studies,with a primary focus on vascular regulation and stromal ***,these methods may trigger or facilitate tumor metastasis as a ***,there is an urgent need for innovative strategies that boost intratumoral drug accumulation without compromising treatment *** another important factor affecting drug tumor accumulation besides vasculature and stroma,the impact of tumor-associated lymphatic vessels(LVs)has not been widely *** the current research,we verified that anlotinib,a tyrosine kinase inhibitor with anti-lymphangiogenesis activity,and SAR131675,a selective VEGFR-3 inhibitor,effectively decreased the density of tumor lymphatic vessels in mouse cancer models,further enhancing drug accumulation in tumor *** combining anlotinib with therapeutic drugs,including doxorubicin(Dox),liposomal doxorubicin(Lip-Dox),and anti-PD-L1 antibody,we observed improved anti-tumor efficacy in comparison with monotherapy ***,this strategy significantly reduced tumor metastasis and elicited stronger anti-tumor immune *** work describes a new,clinically transferrable approach to augmenting intratumoral drug accumulation,which shows great potential to address the current,unsatisfactory efficacies of therapeutic drugs without introducing metastatic risk.

关键词： drugs angiogenesis metastasis

Fortifying Smart Grids: A Holistic Assessment Strategy against Cyber Attacks and Physical Threats for Intelligent Electronic Devices

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Computers, Materials & Continua 2024年第8期80卷 2579-2609页

作者： Yangrong Chen June Li Yu Xia Ruiwen Zhang Lingling Li xiaoyu Li Lin ge School of Computer Science Zhengzhou University of AeronauticsZhengzhou450046China Henan Xin’an Century Technology Co. Ltd.Henan Data Security Engineering Technology Research CenterZhengzhou450046China Key Laboratory of Aerospace Information Security and Trusted Computing Ministry of EducationSchool of Cyber Science and EngineeringWuhan UniversityWuhan430072China

Intelligent electronic devices(IEDs)are interconnected via communication networks and play pivotal roles in transmitting grid-related operational data and executing control *** the context of the heightened security challenges within smart grids,IEDs pose significant risks due to inherent hardware and software vulner-abilities,as well as the openness and vulnerability of communication *** grid security,distinct from traditional internet security,mainly relies on monitoring network security events at the platform layer,lacking an effective assessment mechanism for ***,we incorporate considerations for both cyber-attacks and physical faults,presenting security assessment indicators and methods specifically tailored for ***,we outline the security monitoring technology for IEDs,considering the necessary data sources for their security ***,we classify IEDs and establish a comprehensive security monitoring index system,incorporating factors such as running states,network traffic,and abnormal *** index system contains 18 indicators in 3 ***,we elucidate quantitative methods for various indicators and propose a hybrid security assessment method known as GRCW-hybrid,combining grey relational analysis(GRA),analytic hierarchy process(AHP),and entropy weight method(EWM).According to the proposed assessment method,the security risk level of IEDs can be graded into 6 levels,namely 0,1,2,3,4,and *** higher the level,the greater the security ***,we assess and simulate 15 scenarios in 3 categories,which are based on monitoring indicators and real-world situations encountered by *** results show that calculated security risk level based on the proposed assessment method are consistent with actual ***,the reasonableness and effectiveness of the proposed index system and assessment method are validated.

关键词： Smart grid intelligent electronic device security assessment abnormal behaviors network traffic running states