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青年女性自发冠状动脉夹层导致急性心肌梗死1例并文献复习

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临床荟萃 2023年第2期38卷 162-165页

作者：王家琦王文静刘立天张飞飞党懿齐晓勇河北北方学院研究生院河北张家口075000 河北省人民医院心血管内科河北石家庄050000

目的探讨自发性冠状动脉夹层的临床特点,以期提高对该病的诊治与认识。方法回顾性分析1例青年女性自发性冠状动脉夹层导致急性心肌梗死患者的临床资料,并以“自发性冠状动脉夹层”、“急性心肌梗死”以及“青年女性”等关键词,通过检索... 详细信息

目的探讨自发性冠状动脉夹层的临床特点,以期提高对该病的诊治与认识。方法回顾性分析1例青年女性自发性冠状动脉夹层导致急性心肌梗死患者的临床资料,并以“自发性冠状动脉夹层”、“急性心肌梗死”以及“青年女性”等关键词,通过检索中国知网、PubMed及万方数据库,筛选公开发表的相关中英文文献,以分析自发性冠状动脉夹层的临床特点。结果本例为青年女性,35岁,因间断胸痛就诊,心电图检查提示I、aVL及V2-V5导联ST段抬高,肌钙蛋白T升高(>2000 ng/L),冠状动脉造影结果示左主干(LM)自开口可见夹层,延伸至左前降支(LAD)远段及回旋支(LCX)中段,管腔全程受压,近段血管部分不能显影,经血管内超声(intravenous ultrasound,IVUS)指导下行经皮冠状动脉介入(percutaneous coronary intervention,PCI)治疗,随访1个月并复查冠状动脉造影(coronary angiography,CAG)患者治疗效果良好。结论自发性冠状动脉夹层是导致急性冠脉综合征的罕见病因,其疾病特点及治疗方法与冠状动脉粥样硬化不同,诊断具有挑战性,临床易误诊误治,因此对于年轻急性冠状动脉综合征(acute coronary syndrome,ACS)患者需要考虑自发性冠状动脉夹层可能。

关键词：动脉瘤,夹层青年女性心肌梗死

Nanographene oxide labeling with (188)~Re

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Nuclear Science and Techniques 2011年第2期22卷 99-104页

作者： ZHANG xiaoyong LI Jing ZHU Ying qi Yujin ZHU Zhiyong LI Wenxin HUANG qing Laboratory of Physical Biology Shanghai Institute of Applied Physics Chinese Academy of Sciences Shanghai 201800 China Graduate School of Chinese Academy of Sciences Beijing 100049 China

Nanographene oxide (NGO) is currently being explored for various biomedical ***,little information is known about its biological behaviors in vitro and in *** further studying its pharmacokinetics and related biological behaviors in living systems,an effective and convenient tracing method is particularly *** this work,NGO was labeled with radionuclide 188Re (188Re-NGO).To obtain high labeling yield and purity,a number of labeling conditions,including concentration of SnCl2 and ascorbic acid,reaction time and temperature,and pH were optimized,and stability of the 188Re-NGO in vitro and in vivo was *** results showed that NGO could be effectively labeled with high *** purified 188Re-NGO showed high stability in vitro and in vivo.A pretest of NGO biodistribution with single photon emission computed tomography showed that the 188Re-NGO was rapidly taken by organs such as lungs,liver,and *** biodistribution of 188Re-NGO differs significantly from the free radionuclide,indicating that the labeling procedure is highly suitable for investigating its biological behavior in living systems.

关键词：氧化物标签非政府组织铼计算机断层扫描生物学行为放射性核素生物医学应用

急性ST段抬高型心肌梗死患者经皮冠状动脉介入术后无复流的研究进展

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国际心血管病杂志 2022年第1期49卷 32-35页

作者：郑士航张飞飞高曼王禹丹李英肖党懿齐晓勇河北北方学院研究生院张家口075000 河北省人民医院心内科石家庄050051 河北医科大学研究生院石家庄050017

约1/3的急性ST段抬高型心肌梗死患者接受直接经皮冠状动脉介入术后出现无复流。无复流的常用诊断方法是冠状动脉造影,治疗和预防策略主要包括降低血栓负荷、改善微循环功能、减轻缺血再灌注损伤及诱导受损心肌再生。该文介绍急性ST段抬... 详细信息

约1/3的急性ST段抬高型心肌梗死患者接受直接经皮冠状动脉介入术后出现无复流。无复流的常用诊断方法是冠状动脉造影,治疗和预防策略主要包括降低血栓负荷、改善微循环功能、减轻缺血再灌注损伤及诱导受损心肌再生。该文介绍急性ST段抬高型心肌梗死患者经皮冠状动脉介入术后无复流的治疗进展。

关键词：急性ST段抬高型心肌梗死无复流缓血流经皮冠脉介入术

光学相干断层成像指导治疗变异型心绞痛1例并文献复习

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临床荟萃 2023年第10期38卷 917-921页

作者：王家琦谢悦陶高曼宋学莲张飞飞党懿齐晓勇河北北方学院研究生院河北张家口075000 河北省人民医院心血管内科河北石家庄050051

目的探讨变异型心绞痛的临床特点,以期提高对该病的诊疗与认识。方法回顾性分析1例由光学相干断层成像指导治疗的变异型心绞痛患者临床资料,并以“变异型心绞痛”以及“光学相干断层成像”等关键词,通过检索中国知网、PubMed及万方数据... 详细信息

目的探讨变异型心绞痛的临床特点,以期提高对该病的诊疗与认识。方法回顾性分析1例由光学相干断层成像指导治疗的变异型心绞痛患者临床资料,并以“变异型心绞痛”以及“光学相干断层成像”等关键词,通过检索中国知网、PubMed及万方数据库,筛选公开发表的中英文文献,以分析变异型心绞痛的临床特点。结果本例患者老年男性,因间断胸闷2年余,加重10余天就诊,发作时心电图检查提示Ⅱ、Ⅲ、aVF导联ST段抬高,其余导联ST段显著压低,症状缓解后ST段回落,于光学相关断层成像指导下行冠状动脉造影结果示右冠状动脉近中段狭窄20%~30%,中段第二转折狭窄70%,远段可见支架影,右冠状动脉行麦角新碱激发试验,可见弥漫痉挛,给予硝酸甘油及硝普钠后痉挛解除,考虑患者胸闷症状反复发作,药物控制欠佳,且术中冠脉痉挛明显,遂给予右冠状动脉支架置入,经治疗患者胸闷症状未再发作,治疗效果良好。结论变异型心绞痛疾病特点及治疗方法与冠状动脉粥样硬化不同,临床易误诊误治,因此提高对其的警惕性及认识,及早行腔内影像学检查及激发试验可明确诊断,有助于选择合适的治疗方案并改善患者预后。

关键词：光学相干断层成像变异型心绞痛冠状动脉介入治疗

修正休克指数对急性ST段抬高型心肌梗死患者PCI后发生院内主要不良心血管事件的预测价值研究

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实用心脑肺血管病杂志 2022年第5期30卷 35-39页

作者：王家琦吴路路张飞飞杨亚崇李英肖党懿齐晓勇河北北方学院研究生院河北省张家口市075000 河北省人民医院心血管内科河北省石家庄市050051

目的探讨修正休克指数(MSI)对急性ST段抬高型心肌梗死(STEMI)患者PCI后发生院内主要不良心血管事件(MACE)的预测价值。方法选取2017年1月至2020年6月就诊于河北省人民医院心血管内科并接受直接PCI的急性STEMI患者1137例为研究对象。根... 详细信息

目的探讨修正休克指数(MSI)对急性ST段抬高型心肌梗死(STEMI)患者PCI后发生院内主要不良心血管事件(MACE)的预测价值。方法选取2017年1月至2020年6月就诊于河北省人民医院心血管内科并接受直接PCI的急性STEMI患者1137例为研究对象。根据急性STEMI患者PCI后是否发生院内MACE将其分为MACE组(n=115)和非MACE组(n=1022)。统计患者临床资料,采用多因素Logistic回归分析探讨急性STEMI患者PCI后发生院内MACE的独立影响因素,绘制ROC曲线以分析MSI对急性STEMI患者PCI后发生院内MACE的预测价值。结果多因素Logistic回归分析结果显示,年龄〔OR=1.033,95%CI(1.010,1.057)〕、收缩压〔OR=0.983,95%CI(0.967,0.999)〕、舒张压〔OR=1.030,95%CI(1.004,1.057)〕、MSI〔OR=26.410,95%CI(6.908,100.963)〕、心肌肌钙蛋白T(cTnT)〔OR=1.004,95%CI(1.004,1.005)〕、左心室射血分数(LVEF)〔OR=0.969,95%CI(0.943,0.995)〕是急性STEMI患者PCI后发生院内MACE的独立影响因素(P<0.05)。ROC曲线分析结果显示,MSI预测急性STEMI患者PCI后发生院内MACE的曲线下面积为0.736〔95%CI(0.692,0.781)〕,最佳截断值为0.728,灵敏度、特异度分别为90.4%、46.1%,约登指数为0.365。结论高龄及收缩压降低、舒张压升高、MSI升高、cTnT升高、LVEF降低是急性STEMI患者PCI后发生院内MACE的独立危险因素,MSI对急性STEMI患者PCI后发生院内MACE具有一定的预测价值,可用于评估患者早期预后。

关键词： ST段抬高型心肌梗死经皮冠状动脉介入治疗修正休克指数主要不良心血管事件

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双腔起搏器植入术后发生心房颤动的相关临床分析

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中国循证心血管医学杂志 2024年第7期16卷 798-800页

作者：王帆杨倩张飞飞李鑫柠宋学莲齐晓勇李英肖党懿河北省人民医院心血管内科石家庄市050000

目的探讨双腔起搏器植入术后发生心房颤动的相关影响因素。方法回顾性分析2016年1月至2018年12月于河北省人民医院行永久性双腔心脏起搏器植入,并已完成规律随访1年的429例病例的临床资料和随访资料,其中130例患者存在心房颤动发作(心... 详细信息

目的探讨双腔起搏器植入术后发生心房颤动的相关影响因素。方法回顾性分析2016年1月至2018年12月于河北省人民医院行永久性双腔心脏起搏器植入,并已完成规律随访1年的429例病例的临床资料和随访资料,其中130例患者存在心房颤动发作(心房颤动组),299例患者无心房颤动发作(对照组),收集患者基本临床资料、术前心脏超声参数、术前及随访期间内长期服用药物,并读取随访时程控仪内存储信息,记录心房高频事件持续时间及心房心室起搏比例。结果心房颤动组患者年龄较对照组大[(76.92±8.68)岁vs.(64.62±10.01)岁,P=0.004],男性占比较高(56.92%vs.45.48%,P=0.029),伴有冠状动脉粥样硬化性心脏病(冠心病)、高血压患者较多,左心房内径较对照组大[(40.45±9.13)mm vs.(38.22±7.95)mm,P=0.045],心房起搏比例、心房电极阻抗高于对照组(P<0.05),进一步Logistic回归分析发现年龄(OR=1.011,95%CI:1.134~1.216)、男性(OR=1.572,95%CI:1.031~2.396)及心房起搏比例较高(OR=1.021,95%CI:1.011~1.032)与心房颤动的发生有关(P<0.05)。结论年龄、男性及心房起搏比例高是双腔起搏器植入术后发生心房颤动的危险因素。

关键词：心房颤动双腔起搏器临床分析

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A 3D Investigation of Geological Structure and Its Relationship to Mineralization in the Nanling-Xuancheng Ore District,Middle-Lower Yangtze River Metallogenic Belt,China

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Journal of Earth Science 2022年第3期33卷 664-680页

作者： Sanming Lu Xueyi Lan Lili Zhao Zanzan Zhang xiaoyong Yang Zhuang Zhao Dong Guo Xiaochun Xu Yongsheng Wang Jianshe Li Huasheng qi Public Geological Survey Management Center of Anhui Province Hefei 230091China Geological Exploration Technology Institute of Anhui Province Hefei 230031China School of Resources and Environmental Engineering Hefei University of TechnologyHefei 230009China CAS Center for Excellence in Comparative Planetology University of Science and Technology of ChinaHefei 230026China

The Nanling-Xuancheng ore region of Anhui Province is located in the Middle-Lower Yangtze River metallogenic *** exploration and research have been carried out in this newly defined ore district,although the Chating large porphyry Cu-Au deposit and a few middle-sized skarntype Cu polymetallic deposits have been *** this study,we carried out high-resolution seismic reflection,magnetotelluric,gravity,and magnetic investigations,and constructed the 3 D geological structure of the uppermost crust in a depth range of 0-5 km using a comprehensive inversion of the new data constrained by previous deep-drilling *** hence proposed some new insights to understand the mineralization processes of this district.A system of alternating ridges and valleys is suggested as the major structure pattern,composed of“two-layer structure”of the basins and“three-layer structure”of ***,a conjugated fault system and its distribution features are revealed in our models,including the Jiangnan fault,Zhouwang fault,and Kunshan thrust *** Jiangnan and Kunshan faults are suggested to have controlled the diagenesis and *** deep concealed plutons located in Chating and Magushan are found,forming the Mesozoic diorite-felsic *** intrusions are believed to be the causes of hydrothermal deposits such as the Chating deposit and the Magushan deposit.

关键词： geophysical exploration 3D structure metallogenic mechanism Nanling-Xuancheng ore region Middle-Lower Yangtze River metallogenic belt ore deposits

Cross-boundary transport and source apportionment for PM_(2.5) in a typical industrial city in the Hebei Province,China:A modeling study

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Journal of Environmental Sciences 2022年第5期34卷 465-473页

作者： xiaoyong Liu Xiaole Pan Jie Li Xi Chen Hang Liu Yu Tian Yuting Zhang Shandong Lei Weijie Yao qi Liao Yele Sun Zifa Wang Hong He State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Center for Excellence in Regional Atmospheric Environment Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China Research Center for Eco-Environmental Sciences Chinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China College of Earth Sciences University of Chinese Academy of SciencesBeijing 100049China

Cross-boundary transport of air pollution is a difficult issue in pollution control for the North China *** this study,an industrial district(Shahe City)with a large glass manufactur-ing sector was investigated to clarify the relative contribution of fine particulate matter(PM_(2.5))to the city's high levels of *** Nest Air Quality Prediction Model System(NAQPMS),paired with Weather Research and Forecasting(WRF),was adopted and applied with a spatial resolution of 5 *** the study period,the mean mass concentrations of PM_(2.5),SO_(2),and NO_(2)were observed to be 132.0,76.1,and 55.5μg/m^(3),*** model reproduced the variations in pollutant concentrations in Shahe at an acceptable *** simulation of online source-tagging revealed that pollutants emitted within a 50-km radius of downtown Shahe contributed 63.4%of the city's total PM_(2.5)*** contribu-tion increased to 73.9±21.2%when unfavorable meteorological conditions(high relative hu-midity,weak wind,and low planetary boundary layer height)were present;such conditions are more frequently associated with severe pollution(PM_(2.5)≥250μg/m^(3)).The contribution from Shahe was 52.3±21.6%.The source apportionment results showed that industry(47%),transportation(10%),power(17%),and residential(26%)sectors were the most important sources of PM_(2.5)in *** glass factories(where chimney stack heights were normally<70 m)in Shahe contributed 32.1%of the total PM_(2.5)concentration in *** an in-crease in PM_(2.5)concentration,the emissions from glass factories accumulated vertically and narrowed *** times when pollution levels were severe,the horizontally influ-enced area mainly covered ***,sensitivity tests indicated that reducing emissions by 20%,40%,and 60% could lead to a decrease in themass concentration of PM_(2.5) of of 12.0%,23.8%,and 35.5%,respectively.

关键词： Industrial cities PM_(2.5) Pollution transport Source apportionment

Design, synthesis, molecular modeling, and biological evaluation of acrylamide derivatives as potent inhibitors of human dihydroorotate dehydrogenase for the treatment of rheumatoid arthritis

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Acta Pharmaceutica Sinica B 2021年第3期11卷 795-809页

作者： Fanxun Zeng Shiliang Li Guantian Yang Yating Luo Tiantian qi Yingfan Liang Tingyuan Yang Letian Zhang Rui Wang Lili Zhu Honglin Li xiaoyong Xu Shanghai Key Laboratory of Chemical Biology School of PharmacyEast China University of Science&TechnologyShanghai 200237China Shanghai Key Laboratory of New Drug Design State Key Laboratory of Bioreactor EngineeringSchool of PharmacyEast China University of Science&TechnologyShanghai 200237China

Human dihydroorotate dehydrogenase(DHODH) is a viable target for the development of therapeutics to treat cancer and immunological diseases, such as rheumatoid arthritis(RA), psoriasis and multiple sclerosis(MS). Herein, a series of acrylamide-based novel DHODH inhibitors as potential RA treatment agents were designed and synthesized. 2-Acrylamidobenzoic acid analog 11 was identified as the lead compound for structureeactivity relationship(SAR) studies. The replacement of the phenyl group with naphthyl moieties improved inhibitory activity significantly to double-digit nanomolar *** structure optimization revealed that an acrylamide with small hydrophobic groups(Me, Cl or Br)at the 2-position was preferred. Moreover, adding a fluoro atom at the 5-position of the benzoic acid enhanced the potency. The optimization efforts led to potent compounds 42 and 53-55 with IC50 values of 41, 44, 32, and 42 nmol/L, respectively. The most potent compound 54 also displayed favorable pharmacokinetic(PK) profiles and encouraging in vivo anti-arthritic effects in a dose-dependent manner.

关键词： DHODH De novo pyrimidine biosynthesis DHODH inhibitors Acrylamide derivatives Rheumatoid arthritis