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Incorporating redox-sensitive nanogels into bioabsorbable nanofibrous membrane to acquire ROS-balance capacity for skin regeneration

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Bioactive Materials 2021年第10期6卷 3461-3472页

作者： Shihao Zhang Yamin li Xiaofeng Qiu Anqi Jiao Wei luo Xiajie lin Xiaohui Zhang Zeren Zhang Jiachan Hong Peihao Cai Yuhong Zhang Yan wu Jie Gao Changsheng liu yulin li The Key Laboratory for Ultrafine Materials of Ministry of Education State Key Laboratory of Bioreactor EngineeringEngineering Research Center for Biomedical Materials of Ministry of EducationSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai200237China Institute of Translational Medicine Shanghai UniversityShanghai200444China Heilongjiang Key Laboratory of Anti-fibrosis Biotherapy Mudanjiang Medical UniversityMudanjiang157011China Shanghai Jiaotong University Affiliated Sixth People’s Hospital Shanghai200233China Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional MoleculesCollege of Chemistry and Chemical EngineeringHubei UniversityWuhan430062China

Facing the high incidence of skin diseases,it is urgent to develop functional materials with high bioactivity for wound healing,where reactive oxygen species(ROS)play an important role in the wound healing process mainly via adjustment of immune response and *** this study,we developed a kind of bioabsorbable materials with ROS-mediation capacity for skin disease ***,redox-sensitive poly(N-isopropylacrylamide-acrylic acid)(PNA)nanogels were synthesized by radical emulsion polymerization method using a disulfide molecule as *** resulting nanogels were then incorporated into the nanofibrous membrane of poly(L-lactic acid)(PLLA)via airbrushing approach to offer bioabsorbable membrane with redox-sensitive ROS-balance *** vitro biological evaluation indicated that the PNA-contained bioabsorbable membrane improved cell adhesion and proliferation compared to the native PLLA *** vivo study using mouse wound skin model demonstrated that PNA-doped nanofibrous membranes could promote the wound healing process,where the disulfide bonds in them were able to adjust the ROS level in the wound skin for mediation of redox potential to achieve higher wound healing efficacy.

关键词： Polylactide Nanofibrous membrane Redox sensitivity ROS-Balance capacity Skin regeneration

Methylesterification of cell-wall pectin controls the diurnal flower-opening times in rice

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Molecular Plant 2022年第6期15卷 956-972页

作者： Mumei Wang Xiaopei Zhu Guoqing Peng Minglong liu Shuqing Zhang Minghao Chen Shitang liao xiaoying Wei Peng Xu Xiyu Tan Fangping li Zhichuan li li Deng Ziliang luo liya Zhu Shuai Zhao Dagang Jiang Jing li Zhenlan liu Xianrong Xie Shaokui Wang Aimin wu Chuxiong Zhuang Hai Zhou Guangdong Laboratory for lingnan Modern Agriculture State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresourcesCollege of Life SciencesSouth China Agricultural UniversityGuangzhou 510642China Guangdong Laboratory for lingnan Modern Agriculture State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresourcesCollege of AgricultureSouth China Agricultural UniversityGuangzhou 510642China Agronomy Department University of FloridaGainesvilleFL 32610USA State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources College of Life Science and TechnologyGuangxi UniversityNanning 530004China State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources College of Forestry and Landscape ArchitectureSouth China Agricultural UniversityGuangzhou 510642China

Flowers are the core reproductive organ of plants, and flowering is essential for cross-pollination. Diurnal flower-opening time is thus a key trait influencing reproductive isolation, hybrid breeding, and thermostability in plants. However, the molecular mechanisms controlling this trait remain unknown. Here, we report that rice Diurnal Flower Opening Time 1 (DFOT1) modulates pectin methylesterase (PME) activity to regulate pectin methylesterification levels of the lodicule cell walls, which affect lodicule swelling to control diurnal flower-opening time. DFOT1 is specifically expressed in the lodicules, and its expression gradually increases with the approach to flowering but decreases with flowering. Importantly, a knockout of DFOT1 showed earlier diurnal flower opening. We demonstrate that DFOT1 interacts directly with multiple PMEs to promote their activity. Knockout of PME40 also resulted in early diurnal flower opening, whereas overexpression of PME42 delayed diurnal flower opening. Lower PME activity was observed to be associated with higher levels of pectin methylesterification and the softening of cell walls in lodicules, which contribute to the absorption of water by lodicules and cause them to swell, thus promoting early diurnal flower opening. Higher PME activity had the opposite effect. Collectively, our work uncovers a molecular mechanism underlying the regulation of diurnal flower-opening time in rice, which would help reduce the costs of hybrid breeding and improve the heat tolerance of flowering plants by avoiding higher temperatures at anthesis.

关键词： rice hybrid breeding flowering diurnal flower-opening times cell wall pectin methylesterase

左旋多巴对形觉剥夺性弱视鼠VEP及视网膜内多巴胺含量的影响

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眼科研究 2009年第7期27卷 549-553页

作者：吴小影刘德林罗瑜琳刘双珍中南大学湘雅医院眼科长沙410008

目的观察不同剂量左旋多巴对形觉剥夺性弱视大鼠视觉诱发电位(VEP)及视网膜内多巴胺质量分数的影响,探讨其治疗弱视的可能机制。方法30只14日龄SD大鼠建立单眼形觉剥夺性弱视鼠模型,按随机数字表法随机分为弱视对照组、小剂量给药组、... 详细信息

目的观察不同剂量左旋多巴对形觉剥夺性弱视大鼠视觉诱发电位(VEP)及视网膜内多巴胺质量分数的影响,探讨其治疗弱视的可能机制。方法30只14日龄SD大鼠建立单眼形觉剥夺性弱视鼠模型,按随机数字表法随机分为弱视对照组、小剂量给药组、大剂量给药组,每组10只,分别给予8%淀粉溶液及20mg/kg、80mg/kg左旋多巴灌胃,于给药前(45日龄)和给药后(75日龄)测量闪光视觉诱发电位(F-VEP),并于75日龄时检测各组大鼠视网膜内多巴胺的质量分数。结果给药前剥夺眼P1波潜伏期较未剥夺眼明显延长,差异有统计学意义(P0.05);剥夺眼视网膜内多巴胺的质量分数较未剥夺眼低(P0.05)。结论左旋多巴能显著提高形觉剥夺性弱视鼠弱视模型眼的视网膜内多巴胺质量分数,改善弱视眼视觉传导功能,并由此影响视觉系统发育可塑性敏感期。

关键词：左旋多巴形觉剥夺性弱视视觉诱发电位多巴胺视网膜

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偏置式垂直转子微小型泵内的黏性流动

清华大学学报（自然科学版） 2007年第5期47卷 682-685页

作者：李金伟刘树红罗先武吴玉林清华大学热能工程系北京100084

为研究垂直转子微小型泵的内部黏性流动,根据偏置于两平板间的转子两端剪切力不平衡的原理,设计了一种偏置式垂直转子微小型泵,并利用粒子成像测速(PIV)技术对泵体内部的黏性流动进行了可视化量测。根据N-S方程对微小型泵的内部粘性流... 详细信息

为研究垂直转子微小型泵的内部黏性流动,根据偏置于两平板间的转子两端剪切力不平衡的原理,设计了一种偏置式垂直转子微小型泵,并利用粒子成像测速(PIV)技术对泵体内部的黏性流动进行了可视化量测。根据N-S方程对微小型泵的内部粘性流动进行了数值模拟计算。用这2种方法均得到了泵体内部的流线分布、泵体出口端面的平均速度和体积流量与Reynolds数的关系曲线。比较和分析结果表明:当Reynolds数小于100时,泵体出口端面的平均速度、体积流量与Reynolds数基本成正比关系;随着Reynolds数的减小,流体的黏性作用相对增大,垂直转子微小型泵可对流体进行更加有效的输送。

关键词：微小型泵粒子成像测速(PIV)技术可视化数值模拟

AMPK-SIRT1通路介导的热量限制对成年单眼剥夺弱视小鼠视皮层可塑性的再激活作用

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中华实验眼科杂志 2018年第5期36卷 330-336页

作者：涂艳琼罗瑜琳刘政海吴小影中南大学湘雅医院眼科长沙410008 湖南省儿童医院眼科长沙410007 南华大学应用解剖与生殖医学研究所衡阳421001

目的探讨热量限制对成年单眼剥夺（MD）弱视小鼠视皮层可塑性的调节作用及对弱视治疗的促进作用,并探讨其可能的分子机制.方法采用随机数字表法将50只清洁级健康新生昆明小鼠随机分为正常对照组（n=14）、MD＋自由进食组（n=18）和MD... 详细信息

目的探讨热量限制对成年单眼剥夺（MD）弱视小鼠视皮层可塑性的调节作用及对弱视治疗的促进作用,并探讨其可能的分子机制.方法采用随机数字表法将50只清洁级健康新生昆明小鼠随机分为正常对照组（n=14）、MD＋自由进食组（n=18）和MD＋热量限制组（n=18）.选取MD＋自由进食组和MD＋热量限制组小鼠建立MD弱视模型,分别以自由进食和热量限制的方式进行饲养.检测各组小鼠视敏度和闪光视觉诱发电位（F-VEP）,透射电子显微镜下观察视皮层神经元突触超微结构,Western blot法检测视皮层中磷酸化腺苷酸激活蛋白激酶α（p-AMPKα）、沉默信息调节因子1（SIRT1）蛋白的表达. 结果从第1周开始,MD＋热量限制组小鼠体质量增加的百分比明显低于MD＋自由进食组.与MD＋自由进食组比较,MD＋热量限制组小鼠视敏度明显恢复,F-VEP示P100波潜伏期缩短、振幅增加,差异均有统计学意义（均P＜0.05）.与正常对照组相比,MD＋自由进食组小鼠视皮层神经元突触间隙明显增宽,差异有统计学意义（P＜0.05）;MD＋热量限制组视皮层神经元突触间隙明显窄于MD＋自由进食组,差异有统计学意义（P＜0.05）.MD＋自由进食组视皮层神经元突触后致密物厚度明显薄于正常对照组和MD＋热量限制组,差异均有统计学意义（均P＜0.05）.Western blot检测结果显示,正常对照组、MD＋热量限制组和MD＋自由进食组p-AMPKα蛋白表达水平分别为0.89±0.03、0.94±0.02和0.74±0.02,SIRT1蛋白的表达水平分别为0.97±0.11、0.95±0.14和0.58±0.13,差异均有统计学意义（F=14.57,P=0.00;F=23.91,P=0.00）,其中MD＋热量限制组较MD＋自由进食组小鼠视皮层中p-AMPKα及SIRT1蛋白的表达显著升高,差异均有统计学意义（均P＜0.05）. 结论热量限制能重塑成年MD小鼠视皮层神经元突触的超微结构,重新激活视皮层结构可塑性,改善其视觉功能,其机制可能与激活AMPK-SIRT1通路有关.

关键词：热量限制成年小鼠单眼剥夺视皮层可塑性

热量限制对成年弱视小鼠初级视皮质突触可塑性的调控作用

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中华眼视光学与视觉科学杂志 2019年第1期21卷 47-52页

作者：吴小影罗瑜琳刘政海涂艳琼中南大学湘雅医院眼科长沙410008 湖南省儿童医院眼科长沙410007 南华大学医学院临床应用解剖与生殖研究所衡阳421001

目的:探讨热量限制(CR)对成年单眼形觉剥夺(MD)弱视小鼠视皮质突触可塑性的调控作用及可能的分子机制。方法:实验研究。将54只新生健康昆明小鼠按随机数字表法分为正常组、MD+自由进食(AL)组、MD+CR组,每组18只。小鼠21日龄时构建MD模型... 详细信息

目的:探讨热量限制(CR)对成年单眼形觉剥夺(MD)弱视小鼠视皮质突触可塑性的调控作用及可能的分子机制。方法:实验研究。将54只新生健康昆明小鼠按随机数字表法分为正常组、MD+自由进食(AL)组、MD+CR组,每组18只。小鼠21日龄时构建MD模型,35日龄时去除剥夺因素,63日龄时通过行为学检测视敏度及电生理检测视功能;免疫组织化学及WesternBlot法检测视皮质组织中可塑性相关蛋白突触后致密蛋白95(PSD95)、突触素(SYP)、生长相关蛋白43(GAP-43)等的表达;RT-PCR检测胰岛素样生长因子1(IGF-1)的表达。采用重复测量双因素方差分析比较各组数据差异。结果:最终正常组、MD+AL组、MD+CR组分别有14、18、18只小鼠完成研究。从第1周开始,MD+CR组小鼠体质量百分比的增加明显低于MD+AL组(P<0.05)。MD+AL组小鼠视敏度明显低于正常组和MD+CR组小鼠的视敏度(P<0.05)。MD+AL组小鼠PSD95、GAP-43、SYP的表达均明显低于正常组和MD+CR组小鼠(P<0.05)。MD+AL组小鼠视皮质中IGF-1mRNA水平较正常组和MD+CR组显著降低(P<0.05)。结论:CR能改善成年MD弱视小鼠视觉功能,增加视皮质中可塑性相关蛋白的表达,重新激活视皮质可塑性,其机制可能与其调节IGF-1的表达有关。

关键词：热量限制形觉剥夺弱视视功能小鼠

丰富环境对成年弱视小鼠视觉功能及突触可塑性的影响

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中华实验眼科杂志 2019年第7期37卷 508-513页

作者：罗瑜琳陶利娟刘政海罗诗诗高明吴小影涂艳琼湖南省儿童医院眼科长沙410007 南华大学应用解剖与生殖医学研究所衡阳421001 中南大学湘雅医院眼科长沙410008

目的探讨丰富环境(EE)在调控成年单眼剥夺(MD)弱视小鼠视觉功能恢复过程中的作用及可能的机制。方法采用随机数字表法将72只健康新生昆明小鼠分为正常对照组、MD组、MD+EE组和MD+氟西汀组。除正常对照组外,其余各组小鼠于出生后21d缝合... 详细信息

目的探讨丰富环境(EE)在调控成年单眼剥夺(MD)弱视小鼠视觉功能恢复过程中的作用及可能的机制。方法采用随机数字表法将72只健康新生昆明小鼠分为正常对照组、MD组、MD+EE组和MD+氟西汀组。除正常对照组外,其余各组小鼠于出生后21d缝合右侧眼睑建立MD弱视模型,根据分组分别在标准环境和EE中饲养4周。检测各组小鼠视敏度和闪光视觉诱发电位(F-VEP)。采用免疫组织化学检测各组小鼠视皮层中树突棘修剪相关标记物微管相关蛋白2(MAP2)的表达变化。Westernblot法检测各组小鼠视皮层中MAP2、突触囊泡素(SYP)和突触后致密蛋白95(PSD-95)的表达。结果各组小鼠剥夺眼视敏度总体比较,差异有统计学意义(F=114.632,P<0.001)。MD组小鼠剥夺眼视敏度明显低于正常对照组,差异有统计学意义(t=15.480,P<0.001);MD+EE组和MD+氟西汀组小鼠剥夺眼视敏度明显高于MD组,差异有统计学意义(t=15.071,P<0.001;t=14.841,P<0.001)。各组小鼠F-VEPP2波潜伏期及振幅总体比较,差异有统计学意义(F=36.510、F=34.140,均P=0.000)。与正常对照组比较,MD组小鼠剥夺眼闪光视觉诱发电位P2波潜伏期延长,振幅降低,差异有统计学意义(t=10.220,P=0.000;t=10.090,P=0.000);与MD组比较,MD+EE组小鼠剥夺眼闪光视觉诱发电位P2波潜伏期缩短,振幅增加,差异有统计学意义(t=7.051,P=0.003;t=5.030,P=0.000)。免疫组织化学染色结果显示,与正常对照组比较,MD组小鼠剥夺眼对侧视皮层神经元MAP2表达明显减少,棕褐色神经元突起难以分辨。MD+EE组和MD+氟西汀组视皮层区域可见明显棕褐色神经元突起,但MAP2表达强度弱于正常对照组。各组视皮层中MAP2蛋白相对表达总体比较,差异有统计学意义(F=18.142,P=0.000)。MD组小鼠视皮质MAP2相对表达量明显低于正常对照组,差异有统计学意义(t=3.056,P<0.01);MD+EE组和MD+氟西汀组小鼠视皮质MAP2蛋白相对表达较MD组显著增加,差异有统计学意义(t=2.541,P=0.031;t=2.157,P=0.017)。各组SYP及PSD-95蛋白表达量总体比较,差异有统计学意义(F=12.871、25.060,均P=0.000)。与正常对照组比较,MD组小鼠剥夺眼对侧视皮层中SYP和PSD-95的相对表达量明显下调,差异有统计学意义(t=6.054,P=0.000;t=8.631,P=0.000);MD+EE组小鼠剥夺眼对侧视皮层中SYP和PSD-95蛋白相对表达明显高于MD组,差异有统计学意义(t=2.088,P=0.046;t=3.766,P=0.002);MD+氟西汀组小鼠剥夺眼对侧视皮层中SYP和PSD-95蛋白相对表达明显高于MD组,差异有统计学意义(t=2.520,P=0.018;t=4.730,P=0.000)。结论EE可通过上调成年MD弱视小鼠视皮层中MAP2的表达促进视觉功能恢复,可能与MAP2促进突触相关蛋白PSD-95及SYP的表达,重塑神经可塑性有关。

关键词：丰富环境单眼剥夺弱视视皮层可塑性

Safety and efficacy of thalidomide in patients with transfusiondependentβ-thalassemia:a randomized clinical trial

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Signal Transduction and Targeted Therapy 2021年第12期6卷 3723-3729页

作者： Jiang-Ming Chen Wei-Jian Zhu Jie liu Gui-Zhen Wang Xiao-Qin Chen Yun Tan Wei-Wei Xu li-Wei Qu Jin-Yan li Huan-Ju Yang Lan Huang Ning Cai Wei-Da Wang Ken Huang Jian-Quan Xu Guo-Hui li Sheng He Tian-Ying luo Yi Huang Song-Hua liu Wen-Qiang wu Qi-Yang Lu Mei-Guang Zhou Shu-Ying Chen Rong-Lan li Mei-ling Hu Ying Huang Jin-Hua Wei Jun-Min li Sai-Juan Chen Guang-Biao Zhou Department of Hematology Wuzhou Gongren HospitalWuzhou 543001 GuangxiChina Department of Hematology Zhuhai People’s Hospital(Zhuhai Hospital Affiliated with Jinan University)Zhuhai 541000 GuangdongChina State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Reproductive Medicine The First Affiliated Hospital of Hebei North UniversityZhangjiakou 075000 HebeiChina State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineMedical Oncology DepartmentSun Yat-Sen University Cancer CenterGuangzhou 510060 GuangdongChina State Key Laboratory of Medical Genomics Shanghai Institute of HematologyNational Research Center for Translational MedicineRuijin Hospital Affiliated with Shanghai Jiao Tong University School of MedicineShanghai 200025China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of Sciences&University of Chinese Academy of SciencesBeijing 100101China Department of Pediatrics Affiliated Hospital of Youjiang Medical University for NationalitiesBaise City 533000 GuangxiChina Department of Hematology Yulin Guinan HospitalYulin 537005 GuangxiChina Department of neurology Wuzhou Gongren HospitalWuzhou 543001 GuangxiChina Guangxi Key Laboratory of Basic Research on Birth Defects Prevention and Treatment Guangxi Zhuang Autonomous Region Women and Children Health Care HospitalNanning 530000 GuangxiChina Department of Hematology Guigang People’s HospitalGuigang 537100 GuangxiChina Department of Hematology Hospital of Traditional Chinese Medicine of Wuzhou CityWuzhou 543002 GuangxiChina Department of Hematology Wuzhou Red Cross HospitalWuzhou 543002 GuangxiChina Department of Hematology Hechi People’s HospitalHechi City 547000 GuangxiChina

Thalidomide inducesγ-globin expression in erythroid progenitor cells,but its efficacy on patients with transfusion-dependentβ-thalassemia(TDT)remains *** this phase 2,multi-center,randomized,double-blind clinical trial,we aimed to determine the safety and efficacy of thalidomide in TDT patients.A hundred patients of 14 years or older were randomly assigned to receive placebo or thalidomide for 12 weeks,followed by an extension phase of at least 36 *** primary endpoint was the change of hemoglobin(Hb)level in the *** secondary endpoints included the red blood cell(RBC)units transfused and adverse *** the placebo-controlled period,Hb concentrations in patients treated with thalidomide achieved a median elevation of 14.0(range,2.5 to 37.5)g/L,whereas Hb in patients treated with placebo did not significantly *** the 12 weeks,the mean RBC transfusion volume for patients treated with thalidomide and placebo was 5.4±5.0 U and 10.3±6.4 U,respectively(Plidomide than *** the extension phase,treatment with thalidomide for 24 weeks resulted in a sustainable increase in Hb concentrations which reached 104.9±19.0 g/L,without blood *** increase in Hb concentration and reduction in RBC transfusions were associated with nonβ0/β0 and HBS1L-MYB(rs9399137 C/T,C/C;rs4895441 A/G,G/G)*** results demonstrated that thalidomide is effective in patients with TDT.

关键词： transfusion patients thalidomide

Determination of Double Beta Decay Half-life of 136Xe with the PandaX-4T Natural Xenon Detector

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Research 2023年第2期2022卷 33-41页

作者： lin Si Zhaokan Cheng Abdusalam Abdukerim Zihao Bo Wei Chen Xun Chen Yunhua Chen Chen Cheng Yunshan Cheng Xiangyi Cui Yingjie Fan Deqing Fang Changbo Fu Mengting Fu lisheng Geng Karl Giboni linhui Gu Xuyuan Guo Ke Han Changda He Jinrong He Di Huang Yanlin Huang Zhou Huang Ruquan Hou Xiangdong Ji Yonglin Ju Chenxiang li Jiafu li Mingchuan li Shu li Shuaijie li Qing lin Jianglai liu xiaoying Lu lingyin luo Yunyang luo Wenbo Ma Yugang Ma Yujun Mao Yue Meng Nasir Shaheed Xiaofeng Shang Xuyang Ning Ningchun Qi Zhicheng Qian Xiangxiang Ren Changsong Shang Guofang Shen Wenliang Sun Andi Tan Yi Tao Anqing Wang Meng Wang Qiuhong Wang Shaobo Wang Siguang Wang Wei Wang Xiuli Wang Zhou Wang Yuehuan Wei Mengmeng wu Weihao wu Jingkai Xia Mengjiao Xiao Xiang Xiao Pengwei Xie Binbin Yan Xiyu Yan Yong Yang Chunxu Yu Jumin Yuan Ying Yuan Zhe Yuan Dan Zhang Minzhen Zhang Peng Zhang Shibo Zhang Shu Zhang Tao Zhang li Zhao Qibin Zheng Jifang Zhou Ning Zhou Xiaopeng Zhou Yong Zhou IMOE Key Laboratory for Particle Astrophysics and Cosmology Shanghai Key Laboratory for Particle Physics and Cosmology School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Sino-French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China Sichuan Research Institute Shanghai Jiao Tong UniversityChengdu 610213China Yalong River Hydropower Development Company Ltd.288 Shuanglin RoadChengdu 610051China School of Physics Sun Yat-sen UniversityGuangzhou 510275China Research Center for Particle Science and Technology Institute of Frontier and Interdisciplinary ScienceShandong UniversityQingdao266237 ShandongChina Key Laboratory of Particle Physics and Particle Irradiation of Ministry of Education Shandong UniversityQingdao266237 ShandongChina Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghai 200240China School of Physics Nankai UniversityTianjin 300071China Key Laboratory NuclearPyics and Ionampplication(MOE)Instituteof ModenPysics Fun Universty Shanghai 200433China School of Physics Peking UniversityBeijing 100871China Schol of Physics Beihang UniversityBejing 100191China International Research Center for Nuclei and Particles in the Cosmos Beijing key Laboratory of Advanced Nuclear Materials and Physics Beihang UniversityBeijing 100191China School of Medical Instrument and Food Engineering University of Shanghai for Science and TechnologyShanghai200093China Department of Physics University of MarylandCollge ParkMaryland 20742USA School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China State Key Laboratoryof Particle Detetion and Electronics University of Scienceand Technology of ChinaHefei230026China Department of Modern Physics University of Science and Technology of ChinaHefei230026China SJTU ParisElite Instute of Technology Shanghai Jiao Tong UniversityShanghai 200240China

Precise measurement of two-neutrino double beta decay(DBD)half-life is an important step for the searches of Majorana neutrinos with neutrinoless double beta *** report the measurement of DBD half-life of 136xe using the Pandax-4T dual-phase Time Projection Chamber(TPC)with 3.7-tonne natural xenon and the first 94.9-day physics data release.

关键词： decay double Determination