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Particuology 2024年第5期88卷 210-217页

作者： Yuanting Wu xiaoying Wang Wenlong Zhong Shan zhang School of Material Science and Engineering Shaanxi University of Science and TechnologyXi'an 710021China

Heterogeneous photocatalysts exhibit high catalytic efficiency in the degradation of pollutants,but their stability and repeatability is not very good and requires high structural matching.Simply by nanosizing the pure Bi 2 WO6(BWO)photocatalyst without constructing a heterojunction,there is a significant improvement in its performance,with an enhancement effect of about 2.3 times(99.43%).The high photocatalytic degradation efficiency of the material can be attributed to the enhanced light absorption effect brought by the three-dimensional inverse-opal structure SiO 2(IS)and the abundant surface adsorbed oxygen generated after the formation of Si–O–W bonds.In addition,the introduction of IS greatly increases the surface area of nanostructured BWO,which accelerates the charge transfer process,while the adsorbed oxygen promotes the participation of·O2−in the photocatalytic reaction,thereby accelerating the consumption of photo-generated electrons and ultimately improving the separation of charge carriers.Furthermore,the matched photonic bandgap further improves the absorption and utilization of light of the material.In this work,we constructs Si–O–W bonds to obtain inverse-opal SiO2/Bi2 WO6 with uniformly growth of pure phase nano BWO,which provides a feasible strategy for the preparation of high-performance pure-phase photocatalysts.

关键词： Bi2WO6 SiO2 inverse-opal structure Photocatalysis Adsorbed oxygen

Ethanol changes Nestin-promoter induced neural stem cells to disturb newborn dendritic spine remodeling in the hippocampus of mice

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Neural Regeneration Research 2024年第2期19卷 416-424页

作者： Guixiang Wang Wenjia Wang Ye zhang xiaoying Gou Qingqing zhang Yanmiao Huang Kuo zhang Haotian zhang Jingyu Yang Yuting Li Wuya College of Innovation Shenyang Pharmaceutical UniversityShenyangLiaoning ProvinceChina Department of Pharmacology Shenyang Pharmaceutical UniversityShenyangLiaoning ProvinceChina

Adolescent binge drinking leads to long-lasting disorders of the adult central nervous system,particularly aberrant hippocampal neurogenesis.In this study,we applied in vivo fluorescent tracing using NestinCreERT2::Rosa26-tdTomato mice and analyzed the endogenous neurogenesis lineage progression of neural stem cells(NSCs)and dendritic spine formation of newborn neurons in the subgranular zone of the dentate gyrus.We found abnormal orientation of tamoxifen-induced tdTomato+(tdTom^(+))NSCs in adult mice 2 months after treatment with EtOH(5.0 g/kg,i.p.)for 7 consecutive days.EtOH markedly inhibited tdTom^(+)NSCs activation and hippocampal neurogenesis in mouse dentate gyrus from adolescence to adulthood.EtOH(100 mM)also significantly inhibited the proliferation to 39.2%and differentiation of primary NSCs in vitro.Adult mice exposed to EtOH also exhibited marked inhibitions in dendritic spine growth and newborn neuron maturation in the dentate gyrus,which was partially reversed by voluntary running or inhibition of the mammalian target of rapamycinenhancer of zeste homolog 2 pathway.In vivo tracing revealed that EtOH induced abnormal orientation of tdTom+NSCs and spatial misposition defects of newborn neurons,thus causing the disturbance of hippocampal neurogenesis and dendritic spine remodeling in mice.

关键词： adolescence adulthood ethanol dentate gyrus EZH2 in vivo tracing lineage progression mTOR neural stem cell newborn dendritic spine newborn neurons

Analysis of amino acid enantiomers in ambient aerosols:Effects and removal of coexistent aerosol matrix

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Journal of Environmental Sciences 2024年第3期137卷 732-740页

作者： Ying Li xiaoying Li Libin Wu Luhan Shi ShanWang Pingqing Fu Yingyi zhang Senchao Lai The Key Lab of Pollution Control and Ecosystem Restoration in Industry Clusters Ministry of EducationSchool of Environment and EnergySouth China University of TechnologyGuangzhou 510006China Institute of Surface-Earth System Science School of Earth System ScienceTianjin UniversityTianjin 300072China now at Hong Kong University of Science and Technology Hong Kong 00852China

Amino acids(AAs)including D-and L-enantiomers are a group of organic nitrogen species in ambient aerosol.Due to the low abundances of AAs(level of ng/m^(3))and the matrix effects by coexistent components,it is challenging to quantify AA enantiomers in ambient aerosols especially under pollution conditions.In this study,we present an optimized method for analyzing AA enantiomers in atmospheric aerosol samples including a pretreatment process and the detection by high performance liquid chromatography coupled to a fuorescence detector(HPLC-FLD).Matrix effects caused by coexistent chemicals on AA enantiomers analysis in ambient aerosol samples were investigated especially for those collected in pollution episodes.The results revealed that the determination of AA enantiomers is significantly affected by the coexistent organic carbon(as a proxy of organic matter)and water-soluble ion of NH_(4)^(+).To remove the matrix effects,we applied a pretreatment using the solid phase extraction column coupled with alkaline adjustment to sample extract.After pretreatment,18 AAs including 6 pairs of D-and L-enantiomers(i.e.,leucine,isoleucine,valine,alanine,serine,and aspartic acid)can be successfully separated and quantified in aerosol samples by HPLC-FLD.The recoveries are in the range of 67%-106%.This method was successfully applied to the urban aerosol samples from pollution and non-pollution periods for AA enantiomers determination.We suggest that the concentrations of D-AAs and the ratio of D-AA/L-AA are indicative of the contribution of bacterial sources and the infuence of biomass burning.

关键词： Amino acid enantiomers Atmospheric aerosol Organic carbon Ammonia Chiral ratio

Metabolite acetyl-L-carnitine participates in Bifidobacterium animalis F1-7 to ameliorate atherosclerotic inflammation by downregulating theTLR4/NF-κB pathway

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Food Science and Human Wellness 2024年第2期13卷 813-822页

作者： Xi Liang Zhe zhang xiaoying Tian Qingyu Cui Haiyan Lu Maozhen Zhao Tongjie Liu Huaxi Yi Pimin Gong Lanwei zhang Department of Nutrition and Food Hygiene School of public healthQingdao UniversityQingdao 266071China College of Food Science and Engineering Ocean University of ChinaQingdao 266003China

This study aimed to explore the effect of Bifidobacterium animalis F1-7 on the improvement of atherosclerotic inflammation.Arteriosclerosis model ApoE^(-/-)mice were orally administered with B.animalis F1-7 for 12 weeks.The probiotic intervention reduced the plaque areas in aorta and the accumulation of macrophages,and downregulated the expression of toll-like receptor 4(TLR4)/nuclear factorκB(NF-κB)pathway to reduce the levels of inflammatory factors.The widely-targeted metabolomics analysis showed that acetyl-L-carnitine(ALC)in the intestine of atherosclerotic mice was significantly increased after B.animalis F1-7 intervention.Correlation analysis proved that ALC was associated with atherosclerotic inflammatory response.By using oxidized low density lipoprotein induced macrophage foam cells,we further verified that ALC could reduce lipid accumulation and inflammatory response in foam cells by downregulating the TLR4/NF-κB pathway.Finally,our results revealed that B.animalis F1-7 upregulated the metabolite ALC to downregulate the inflammatory responses,leading to the reduction of plaque accumulation of atherosclerosis.

关键词： Bifidobacterium animalis F1-7 Atherosclerosis Inflammation Metabonomics Acetyl-L-carnitine

Neutrophil extracellular traps induced by interleukin 8 via CXCR1/2 promote the progression of gastric carcinoma through transcription factor IIB-related factor 1 and cyclin

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Genes & Diseases 2024年第2期11卷 575-578页

作者： Qianling Wang Yiyin zhang Wenxi Ding Cheng Feng Yuyan Wang Xiaoli Wei Ziting Qu Hui Wang xiaoying Liu Hua Wang Kangsheng Gu Department of Oncology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui 230022China School of Life Sciences Anhui Medical UniversityHefeiAnhui 230032China

Neutrophils constitute a significant portion of the immune cells present within the tumor microenvironment.Evidence generated by our group has confirmed neutrophils to be an adverse independent prognostic factor affecting the disease-free survival of gastric carcinoma(GC)patients.1 Neutrophil extracellular traps(NETs),protein-covered DNA webs that interact with tumor cells in the tumor microenvironment,were detected in GC tissues and found to clinically associated with disease progression in our previous study.2 NETosis could be mediated by a series of agonists,such as interleukin 8(IL-8).3 However,the mechanism of IL-8 in the progression of GC occurs via NETs remains unclear.In this study,we identified that IL-8-mediated NETosis can promote the proliferation,migration,and invasion of GC cells in vitro,which can be abrogated by NET degradation through deoxyribonucleaseI(DNase I)or IL-8 suppression through neutralizing antibodies.Disruption of NETs by DNase I or blockade of the IL-8-CXC chemokine receptor 2(CXCR2)axis could result in growth retardation in mouse models.We also confirmed that NETs may influence the biological behavior of GC cells by up-regulating the expression of transcription factor IB-related factor 1(BRF1)and cyclin p21/p27.

关键词： invasion gastric progression

The mechanisms of nucleotide actions in insulin resistance

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Journal of Genetics and Genomics 2022年第4期49卷 299-307页

作者： Kunpeng Liu Xiaogao Jin xiaoying zhang Hongkai Lian Jianping Ye Metabolic Disease Research Center Zhengzhou University Affiliated Zhengzhou Central HospitalZhengzhouHenan 450007China Cell-gene Therapy Translational Medicine Research Center The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510630China Center for Advanced Medicine College of MedicineZhengzhou UniversityZhengzhouHenan 450007China Department of Orthopedics Zhengzhou Central HospitalZhengzhouHenan 450000China

Insulin resistance contributes to metabolic disorders in obesity and type 2 diabetes.In mechanisms of insulin resistance,the roles of glucose,fatty acids,and amino acids have been extensively documented in literature.However,the activities of nucleotides remain to be reviewed comprehensively in the regulation of insulin sensitivity.Nucleotides are well known for their activities in biosynthesis of DNA and RNA as well as their signaling activities in the form of c AMP and c GAMP.Their activities in insulin resistance are dependent on the derivatives and corresponding receptors.ATP and NADH,derivatives of adenosine,inhibit insulin signaling inside cells by downregulation of activities of AMPK and SIRT1,respectively.ATP,ADP and AMP,the well-known energy carriers,regulate cellular responses to insulin outside cells through the purinergic receptors in cell surface.Current evidence suggests that ATP,NADH,c GAMP,and uridine are potential biomarkers of insulin resistance.However,GTP and c GMP are likely the markers of insulin sensitization.Here,studies crossing the biomedical fields are reviewed to characterize nucleotide activities in the regulation of insulin sensitivity.The knowledge brings new insights into the mechanisms of insulin resistance.

关键词： Insulin resistance Nucleotide Adenosine Guanosine Uridine AMPK Purinergic receptors

Mitigation of Optical Multipath Interference Algorithms in IM-DD Transmission System

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China Communications 2024年第4期21卷 1-9页

作者： Huo Jiahao Zhu Jin Zhu Zuqing zhang xiaoying Liu Shaonan Tao Jianlong Wei Huangfu School of Computer and Communication Engineering University of Science and Technology BeijingBeijing 100083China School of Information Science and Technology University of Science and Technology of ChinaHefei 230026China

This paper aimed to propose two algorithms,DA-M and RF-M,of reducing the impact of multipath interference(MPI)on intensity modulation direct detection(IM-DD)systems,particularly for four-level pulse amplitude modulation(PAM4)systems.DA-M reduced the fluctuation by averaging the signal in blocks,RF-M estimated MPI by subtracting the decision value of the corresponding block from the mean value of a signal block,and then generated interference-reduced samples by subtracting the interference signal from the product of the corresponding MPI estimate and then weighting factor.This paper firstly proposed to separate the signal before decision-making into multiple blocks,which significantly reduced the complexity of DA-M and RF-M.Simulation results showed that the MPI noise of 28 GBaud IMDD system under the linewidths of 1e5 Hz,1e6 Hz and 10e6 Hz can be effectively alleviated.

关键词： IM-DD multipath interference PAM4

Influences of the Fresh Air Volume on the Removal of Cough-Released Droplets in a Passenger Car of a High-Speed Train Using CFD

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Computer Modeling in Engineering & Sciences 2024年第3期138卷 2727-2748页

作者： Jun Xu Kai Bi Yibin Lu TiantianWang Hang zhang Zeyuan Zheng Fushan Shi Yaxin Zheng xiaoying Li Jingping Yang CRRC Changchun Railway Vehicles Co. Ltd.Changchun130062China Key Laboratory of Traffic Safety on Track Ministry of EducationSchool of Traffic&Transportation EngineeringCentral South UniversityChangsha410075China College of Mechanical and Vehicle Engineering Hunan UniversityChangsha410082China

The spread and removal of pollution sources,namely,cough-released droplets in three different areas(front,middle,and rear areas)of a fully-loaded passenger car in a high-speed train under different fresh air flow volume were studied using computational fluid dynamics(CFD)method.In addition,the structure of indoor flow fields was also analysed.The results show that the large eddies are more stable and flow faster in the air supply under Mode 2(fresh air volume:2200m3/h)compared to Mode 1(fresh air volume:1100m3/h).By analysing the spreading process of droplets sprayed at different locations in the passenger car and with different particle sizes,the removal trends for droplets are found to be similar under the two air supply modes.However,when increasing the fresh air flow volume,the droplets in the middle and front areas of the passenger car are removed faster.When the droplets had dispersed for 60s,Mode 2 exhibited a removal rate approximately 1%–3%higher than Mode 1 for small and medium-sized droplets with diameters of 10 and 50μm.While those in the rear area,the situation is reversed,with Mode 1 slightly surpassing Mode 2 by 1%–3%.For large droplets with a diameter of 100μm,both modes achieved a removal rate of over 96%in all three regions at the 60 s.The results can provide guidance for air supply modes of passenger cars of high-speed trains,thus suppressing the spread of virus-carrying droplets and reducing the risk of viral infection among passengers.

关键词： Cough-released pollutants CFD ventilation inside trains supply air volume

Asymmetric side-chain engineering of organic semiconductor for ultrasensitive gas sensing

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Chinese Chemical Letters 2024年第3期35卷 428-433页

作者： xiaoying Ma Xiaojuan Dai Lanyi Xiang Jiajun Chang Danfeng Zhi Haozhen Zhao Zhenjie Ni Ye Zou Xike Gao Fengjiao zhang School of Chemical Sciences University of Chinese Academy of SciencesBeijing 100049China Laboratory of Organic Solids Institute of ChemistryChinese Academy of SciencesBeijing 100190China Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China Binzhou Institute of Technology Binzhou 256606China

Molecular structure of organic semiconductor plays a critical role in determining the performance and functionality of organic electronic devices,by optimizing the electrical,optical and physicochemical properties.Substituted alkyl chains are fundamental units in tailering the solubility and assemblability,among which the asymmetric properties have been reported as key element for controlling the packing motifs and intrinsic charge transport.Here,we expanded the scope of molecular asymmetry dependent sensing features based on a new series of naphthalene diimides(NDI)-based derivatives substituted with a same branching alkyl chain but various linear-shaped alkyl chains(Cn-).A clear molecular stacking change,from head-to-head bilayer to head-to-tail monolayer packing model,is observed based on the features of anisotropic molecular interactions with the change in the chain length.Most importantly,a unique LUMO level shift of 0.17 eV is validated for NDI-PhC4,providing a record sensitivity up to 150%to 0.01 ppb ammonia,due to the desired molecular reactivity and device amplification properties.These results indicate that asymmetric side-chain engineering opens a route for breath healthcare.

关键词： Organic thin film transistor Asymmetric side chain Gas sensing Molecular stacking Energy level manipulating

Scutellarin alleviates complete freund’s adjuvant-induced rheumatoid arthritis in mice by regulating the Keap1/Nrf2/HO-1 pathway

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BIOCELL 2023年第6期47卷 1307-1316页

作者： JIAN LI QINGQING WANG xiaoying zhang Department of Pharmacy The First People’s Hospital of Xiaoshan DistrictXiaoshan Affiliated Hospital of Wenzhou Medical UniversityHangzhou311201China Department of Nursing Community Healthcare Center of Shushan StreetHangzhou311201China

Scutellarin(SCU)is a herbal flavonoid glucuronide with multiple pharmacological activities,including antioxidant,anti-inflammation,vascular relaxation,anti-platelet,and myocardial protection.However,the effect of SCU on complete Freund’s adjuvant(CFA)-induced rheumatoid arthritis(RA)had not been studied.In this study,we investigated the beneficial effects of SCU in the CFA-induced RA mice model and the anti-arthritic activity was evaluated by paw edema.Enzyme-linked immunosorbent assay(ELISA)was carried out to evaluate the plasma levels of immunoglobulin(Ig)G,IgE,tumor necrosis factor(TNF)-α,interleukin(IL)-1β,IL-6,receptor activator of nuclear factor-κB ligand(RANKL),and osteoprotegerin(OPG).Histological slides were prepared from the harvested paws of mice to determine the pathological changes in the joints.The proportions of T helper type 1(Th1)and T helper type 2(Th2)cells of CD4+T lymphocyte subsets were analyzed by flow cytometry.The expression of Kelch-like ECHassociated protein 1(Keap1),nuclear factor erythroid 2-related factor 2(Nrf2),and heme oxygenase-1(HO-1)was analyzed using real-time quantitative PCR(RT-qPCR)and western blotting assays.The present study demonstrated that SCU prevented CFA-induced RA,and inhibited the expression of inflammation factors,IgG,IgE,TNF-α,IL-1β,and IL-6.While SCU also reduced the RANKL level,it increased OPG expression in RA mice.The Th1/Th2 ratio was significantly lower in mice treated with SCU.Additionally,HO-1 expression was reduced while the expression of Keap1 and Nrf2 was elevated following SCU treatment.Results provide preliminary evidence to employ SCU in arthritis treatment which might be related to the regulation of Th1/Th2 balance and the Keap1/Nrf2/HO-1 pathway.

关键词： Scutellarin Rheumatoid arthritis Th1/Th2 balance Keap1/Nrf2/HO-1 pathway Immunosuppression