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Journal of Integrative Plant Biology 2007年第9期49卷 1327-1333页

作者： Yanmei Li Yantao Jia Zhongkai Zhang xiaoying Chen Hongping He Rongxiang Fang Xiaojiang Hao State Key Laboratory of Photochemistry and Plant Resources in West China Kunming Institute of Botany the Chinese Academy of Sciences Kunming 650204 China State Key Laboratory of Plant Genomics Institute of Microbiology the Chinese Academy of Sciences Beijing 100080 China Laboratory of Plant Virology Yunnan Academy of Agricultural Sciences Kunming 650223 China The Graduate School of the Chinese Academy of Sciences Beijing 100049 China

A new ribosome-inactivating protein （RIP） with a molecular weight of 31 kDa induced by Cinchonaglycoside C （1） designated CIP31, was isolated from tobacco leaves. Analysis of this protein sequence indicated that it belongs to the RIP family and it was distinct from the other plant RIPs reported previously at its N-terminal amino acid sequence. CIP31 can directly impair synthesis of coat protein （CP） of tobacco mosaic virus （TMV）, which resulted in inhibition of TMV long distance movement and multiplication in tobacco plants at concentrations of ng/mL. Furthermore, no toxicity was shown to the growth and fertility of the plants. CIP31 was synthesized only in the presence of Cinchonaglycoside C （1） and was independent of the salicylic acid （SA） signal pathway. We provided evidence for the SA-independent biological induction of resistance.

关键词： antiviral protein Cinchonaglycoside C (1) coat protein medical plant ribosome inactivating protein salicylic acid tobacco mosaic virus.

慢性盆腔炎中医病因病机及辨证论治的研究进展

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长春中医药大学学报 2024年第6期40卷 700-703页

作者：言娜雷磊刘慧婷范孝盈湖南中医药大学长沙410208 湖南中医药高等专科学校附属第一医院/湖南省直中医医院妇科长沙412000 湖南中医药大学中西医结合学院妇产科教研室长沙410208 益阳市中医医院湖南益阳413000

慢性盆腔炎是女性患者的盆腔部位结缔组织、盆腔腹膜等处的炎症性疾病,具有病程长、症状明显、疼痛程度剧烈、治疗难度大等特点。中医认为,本病属于“妇人腹痛”“癥瘕”“带下病”范畴,发病过程中受到寒、湿、热、虚、瘀等多种因素的... 详细信息

慢性盆腔炎是女性患者的盆腔部位结缔组织、盆腔腹膜等处的炎症性疾病,具有病程长、症状明显、疼痛程度剧烈、治疗难度大等特点。中医认为,本病属于“妇人腹痛”“癥瘕”“带下病”范畴,发病过程中受到寒、湿、热、虚、瘀等多种因素的相互作用,具体病机分型为湿热瘀结、血瘀气滞、寒湿凝滞、气虚血瘀症等,根据相应症型给予针对性的中医治疗。现从慢性盆腔炎中医病机和辨证论治两个方面对当前的研究进行综述分析。

关键词：慢性盆腔炎中医病机辨证论治中医治疗

多学科团队在肝癌患者全程营养管理中的应用研究进展

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中外医学研究 2024年第11期22卷 164-167页

作者：吴光柳尹如娇杨雪梅周小英昆明医科大学第二附属医院云南昆明650101

肝癌患者易发生营养不良,且营养不良贯穿疾病的整个病程,多学科医疗团队共同合作的全程营养管理对肝癌患者来说十分重要。本文从肝癌患者全程营养管理中多学科团队的构成和应用现状两方面进行综述,包括肝癌患者全程营养管理多学科团队... 详细信息

肝癌患者易发生营养不良,且营养不良贯穿疾病的整个病程,多学科医疗团队共同合作的全程营养管理对肝癌患者来说十分重要。本文从肝癌患者全程营养管理中多学科团队的构成和应用现状两方面进行综述,包括肝癌患者全程营养管理多学科团队组成、多学科团队在肝癌患者的营养筛查和营养评定、个性化营养支持治疗及营养随访管理中的应用现状。本文可为制定适宜我国肿瘤患者营养管理多学科团队运作模式提供借鉴,建议未来将患者的参与纳入多学科团队中,同时为患者提供出院和家庭营养支持的延伸管理,进一步提高患者的临床疗效,实现高效、优质、长期、全周期的营养管理。

关键词：多学科团队肝癌全程营养管理综述

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自主跑轮运动对小鼠抑郁症与单胺神经递质及HPA轴的影响

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黑龙江科学 2024年第6期15卷 85-87,92页

作者：张静陈永芳黄晓燕杨笑莹南宁师范大学体育与健康学院南宁530100 国家体育总局运动医学研究所北京100061

为探究自主跑轮运动对小鼠抑郁症与单胺神经递质及下丘脑-垂体-肾上腺轴(HPA)的影响,选取40只C57BL/6J小鼠,随机分成对照组(10只)与抑郁症组(30只)。抑郁症组小鼠采用长期社会击败应激(CSDS)方法建立抑郁症模型,将建模成功的小鼠随机分... 详细信息

为探究自主跑轮运动对小鼠抑郁症与单胺神经递质及下丘脑-垂体-肾上腺轴(HPA)的影响,选取40只C57BL/6J小鼠,随机分成对照组(10只)与抑郁症组(30只)。抑郁症组小鼠采用长期社会击败应激(CSDS)方法建立抑郁症模型,将建模成功的小鼠随机分成抑郁症组(10只)与抑郁症运动组(10只)。抑郁症运动组进行为期3周的自主跑轮运动后,通过旷场及悬尾测小鼠的焦虑样及抑郁样行为,高效液相色谱法测单胺神经递质的变化,酶联免疫吸附测定法测HPA轴的变化。结果表明,与抑郁症组相比,抑郁症运动组旷场中间区域时间百分比显著增加(P<0.05),悬尾不动时间显著减少(P<0.05);海马单胺神经递质中的5-羟色胺(5-HT)、去甲肾上腺素(NE)、多巴胺(DA)含量显著增加(P<0.05);血浆中的HPA轴的促肾上腺皮质激素释放激素(CRH)、促肾上腺皮质激素(ACTH)及皮质醇(CORT)含量显著下降(P<0.05)。说明自主跑轮运动对于抑郁症小鼠的焦虑及抑郁有改善作用,其作用机制可能与调节单胺神经递质水平及HPA轴功能有关。

关键词：自主跑轮运动长期社会击败应激抑郁症单胺神经递质 HPA轴

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间冷循环燃气轮机低压工作线及影响因素分析

燃气轮机技术 2024年第1期37卷 8-15页

作者：吕二立高珊于淼罗美千子郝晓莹中国航发沈阳发动机研究所沈阳110015

为详细掌握间冷循环燃气轮机的工作特性及实际运行过程中低压工作线的变动,考虑空气系统引气、压气机出口漏气对流量连续的影响,引入压气机与涡轮及相邻涡轮间的流量比例系数,理论推导间冷循环燃气轮机低压工作线方程,得到影响低压工作... 详细信息

为详细掌握间冷循环燃气轮机的工作特性及实际运行过程中低压工作线的变动,考虑空气系统引气、压气机出口漏气对流量连续的影响,引入压气机与涡轮及相邻涡轮间的流量比例系数,理论推导间冷循环燃气轮机低压工作线方程,得到影响低压工作线的典型因素。开展间冷循环燃气轮机低压工作线在典型影响因素下的变动机理分析,不同于高压工作线变动分析采用等换算转速条件,低压工作线变动分析采用等高压转子增压比条件更为合理。依据间冷循环燃气轮机长期运行后典型影响因素的变化,获得间冷循环燃气轮机低压工作线的具体变动结果,即高压压气机效率降低、高压涡轮效率降低、高压涡轮导向器面积增加、间冷器性能衰减及二次水温度升高等会导致低压工作线升高,低压压气机效率降低、低压涡轮效率降低、低压涡轮导向器面积增加、低压出口漏气量增加及大气温度增加等会导致低压工作线降低。

关键词：间冷循环燃气轮机低压工作线影响因素高压转子增压比大气温度二次水温度

SNHG10低表达与卵巢癌预后和耐药的相关性研究

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广西医科大学学报 2024年第2期41卷 193-203页

作者：施丽州陈小英于玥蔡美婷刘夏尹富强广西医科大学生命科学研究院南宁530021 广西医科大学转化医学研究中心“长寿与老年相关疾病”教育部重点实验室、神经科学研究所“广西脑科学研究”重点实验室南宁530021

目的:探讨长链非编码小核仁RNA宿主基因10(SNHG10)与卵巢癌细胞增殖、耐药及预后的关系。方法:通过开放大数据(库)筛选88例正常卵巢组织和426例卵巢癌组织中差异表达SNHGs,分析其与卵巢癌患者预后的相关性,并通过受试者工作特征(ROC)曲... 详细信息

目的:探讨长链非编码小核仁RNA宿主基因10(SNHG10)与卵巢癌细胞增殖、耐药及预后的关系。方法:通过开放大数据(库)筛选88例正常卵巢组织和426例卵巢癌组织中差异表达SNHGs,分析其与卵巢癌患者预后的相关性,并通过受试者工作特征(ROC)曲线评估SNHGs预警卵巢癌紫杉醇和铂类药物耐药的价值。采用实时荧光定量PCR(RT-qPCR)检测SNHG10在卵巢癌紫杉醇/卡铂耐药细胞(SKOV3-R/SKOV3-CBP)及其亲本细胞(SKOV3)中的相对表达水平。通过慢病毒感染在卵巢癌亲本细胞SKOV3中构建过表达SNHG10的细胞株,分为对照组(S-eGFP组)和过表达组(S-SNHG10组)。采用CCK-8、平板克隆形成实验评估细胞增殖能力;通过Cell Titer-Glo发光活细胞检测法评估细胞对紫杉醇的敏感性。结果:SNHG10在卵巢癌组织显著低表达(P0.6,P<0.05)。与S-eGFP组相比,S-SNHG10组细胞的增殖能力下降,对紫杉醇的敏感性增强(P<0.001)。结论:过表达SNHG10显著抑制卵巢癌细胞增殖并提高卵巢癌细胞对紫杉醇的敏感性。

关键词：小核仁RNA宿主基因10 卵巢癌预后耐药

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多元复合声疗法在耳鸣治疗中的应用进展

医学综述 2024年第17期30卷 2123-2126,2132页

作者：潘庆春李蓓米雪芹宋小影刘海川北医学院附属医院耳鼻咽喉头颈外科四川南充637000 川北医学院运动医学与康复学院四川南充637000

目前耳鸣已成为一个全球性问题,其被认为是一种与耳蜗、听神经、大脑听觉区域、大脑非听觉区域相关的独特病理变化。耳鸣的治疗方法很多,但由于病因复杂、机制不明,目前尚无统一的治疗标准。多元复合声疗法(MIST)可针对耳鸣患者的耳鸣... 详细信息

目前耳鸣已成为一个全球性问题,其被认为是一种与耳蜗、听神经、大脑听觉区域、大脑非听觉区域相关的独特病理变化。耳鸣的治疗方法很多,但由于病因复杂、机制不明,目前尚无统一的治疗标准。多元复合声疗法(MIST)可针对耳鸣患者的耳鸣频率和响度进行精细化匹配,并定制个性化声学处方,以达到减轻、消除耳鸣的目的。目前已有多位学者采用MIST对耳鸣患者进行短期及长期治疗,且认为MIST对耳鸣的治疗有效,但是其在耳鸣治疗方面是否优于其他方法尚需进一步研究。

关键词：耳鸣多元复合声疗法耳鸣残疾量表残余抑制试验

Effects of salinity and alkalinity on fatty acids, free amino acids and related substance anabolic metabolism of Nile tilapia

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Aquaculture and Fisheries 2022年第4期7卷 389-395页

作者： Yamei Cheng Jinliang Zhao Christian Larbi Ayisi xiaoying Cao Key Laboratory of Freshwater Fishery Germplasm Resources Ministry of Agriculture and Rural AffairsShanghai Ocean UniversityShanghai201306China Shanghai Collaborative Innovation for Aquatic Animal Genetics and Breeding Shanghai Ocean UniversityShanghai201306China Center for Research on Environmental Ecology and Fish Nutrition of the Ministry of Agriculture and Rural Affairs Shanghai Ocean UniversityShanghai201306China Department of Fisheries and Aquatic Resources Management Faculty of Natural Resources and EnvironmentUniversity for Development StudiesTamaleGhana

A 56-day experiment was conducted to investigate the effects of ambient salinity and alkalinity on fatty acids,free amino acids and related anabolic metabolisms of Nile *** fatty acid and free amino acid contents in the muscle of tilapia cultured in saline water(SW),alkaline water(AW),saline-alkaline water(SAW)and fresh water(FW)conditions were analyzed and *** mRNA levels and enzymatic activities of fatty acyl desaturase(FADS2),elongation of very long-chain fatty acids(ELOVL5),Δ1-pyrroline-5-carboxylate synthase(P5CS),ornithine-δ-aminotransferase(δ-OAT),and proline dehydrogenase(PDH)were also *** contents of saturated and monounsaturated fatty acids were significantly higher in the AW and SAW groups than those in the SW group,and those of eicosapentaenoic acid(EPA)and docosahexaenoic acid(DHA)were the highest in the SAW *** contents of flavor amino acids in the SAW and AW groups were significantly higher than that in the SW group,and that of proline in the SW,AW,and SAW groups was 3.58-,4.11-,and 4.15-times higher than that in the FW *** mRNA levels and enzyme activities of FADS 2,ELOVL5,PDH and P5CS were found to differ among the different *** results suggested that ambient salinity and alkalinity could effectively improve flesh quality of tilapia by regulating lipid and proline metabolism pathways.

关键词： Nile tilapia Nutritional value Flavor Metabolism Salinity Alkalinity

Effect modifications of BMI transition and trajectory in the associations of adverse childhood experiences with new-onset dementia and its subtypes in older US adults

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General Psychiatry 2023年第4期36卷 312-320页

作者： Ziyang Ren Binbin Su Yushan Du Tianjing Zhou xiaoying Zheng Jufen Liu Institute of Reproductive and Child Health/National Health Commission Key Laboratory of Reproductive Health Peking UniversityBeijingChina Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijingChina School of Population Medicine and Public Health Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina APEC Health Science Academy(HeSAY) Peking UniversityBeijingChin

Background Adverse childhood experiences(ACEs)and dementia are associated and comorbid with ***,according to emerging research,the role of obesity in the association between ACEs and dementia seems *** This analysis aimed to explore the associations between ACEs and different dementia subtypes and the effect modification of long-term body mass index(BMI).Methods Data were obtained from the US Health and Retirement *** ACEs were categorised as 0,1 and 2 or ***-cause dementia,Alzheimer’s disease(AD)and other dementias were defined by self-reported or proxy-reported physician *** proportional hazards regression was used to explore the associations of ACEs with new-onset all-cause dementia,AD and other dementias from 2010 to *** modification of BMI in 2010 and BMI transition and trajectory(fitted by group-based trajectory modelling)from 2004 to 2010 were *** 15282 participants with a mean age of 67.0 years(58.0–75.0)were included in the 2010 data *** interactions of ACEs with baseline BMI,BMI transition and BMI trajectory in their associations with new-onset all-cause dementia and AD were observed(all plong-term abnormally elevated BMI but not with long-term normal or decreasing *** weight management throughout life could prevent dementia among those with childhood adversity.

关键词： elevated maintain transition

Five‑year outcomes of EVO implantable collamer lens implantation for the correction of high myopia and super high myopia

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Eye and Vision 2021年第1期8卷 404-411页

作者： Xun Chen Xuanqi Wang Yilin Xu Mingrui Cheng Tian Han LingLing Niu xiaoying Wang Xingtao Zhou Fudan University Eye Ear Nose and Throat Hospital No.19 BaoQing RoadXuHui DistrictShanghai 200031China National Health Commission Key Lab of Myopia(Fudan University) ShanghaiChina Shanghai Research Center of Ophthalmology and Optometry ShanghaiChina

Background:To evaluate the long-term safety,efficacy,predictability,and stability of implantable collamer lens with a central hole(EVO ICL)implantation for correcting high myopia(HM)and super high myopia(SHM).Methods:This prospective study evaluated 83 eyes of 46 patients who were divided into groups based on their spherical equivalent refractive error(SE):HM group(−12 D≤SE<−6 D)and SHM group(SE<−12 D).They were followed up for 5 years after ICL implantation;assessments of uncorrected distance visual acuity(UDVA),corrected distance visual acuity(CDVA),manifest refractive error,axial length,intraocular pressure,corneal endothelial cell density,and vault were conducted,and a questionnaire was ***:At 5 years postoperatively,the safety indices of the HM and SHM groups were 1.03±0.10 and 1.32±0.39,and the efficacy indices were 0.83±0.25 and 0.86±0.32,*** the HM group,60.47%and 79.07%of the eyes were within±0.50 D and±1.00 D of the attempted correction,while it was achieved for 22.50%and 47.50%of the eyes in the SHM group,*** SE of the HM group decreased from−9.72±1.41 D preoperatively to 0.04±0.39 D 1 month postoperatively and−0.67±0.57 D 5 years postoperatively,while in the SHM group,it decreased from−15.78±3.06 D preoperatively to−0.69±0.97 D 1 month postoperatively and−1.74±1.19 D 5 years ***:EVO ICL implantation is safe,effective,and predictable for correcting HM and *** improved more after surgery for SHM,but the growth of axial length still needs attention.

关键词： Posterior chamber phakic intraocular lens implantation High myopia Super high myopia EVO ICL