检索结果-南通市图书馆

中国注册会计师 2002年第9期 28-31页

作者：罗孝银四川省注册会计师协会

● 造就一批优秀的中国注册会计师● 实现会计师事务所规模经营● 拓宽我国会计服务业务边界● 严格事务所内部管理和质量控制●

关键词：中国注册会计师行业发展战略会计师队伍建设会计师事务所规模经营内部管理会计服务业务

Crystal structures of Babesia microti Lactate Dehydrogenase BmLDH reveal a critical role for Arg99 in catalysis

在线全文

学校读者我要写书评

暂无评论

Crystal structures of Babesia microti Lactate Dehydrogenase ...

超声引导侧卧位注射利凡诺联合米索前列醇在未成年中期妊娠引产中的运用

中国畜牧兽医学会兽医寄生虫学分会第一届青年科学家学术论...

作者： Long Yu Zhou Shen Qin Liu Xueyan Zhan xiaoyin luo Xiaomeng An Yali Sun Muxiac Li Sen Wang Zheng Nie Yangsiqi Ao Yangnan Zhao Guiqing Peng Choukri Ben Mamoun Lan He Junlong Zhao State Key Laboratory of Agricultural Microbiology College of Veterinary MedicineHuazhong Agricultural University Department of Internal Medicine Section of Infectious DiseasesYale School of Medicine

The tick and transfusion-transmitted human pathogen Babesia microti infects host erythrocytes to cause the pathological symptoms associated with human babesiosis,an emerging disease with worldwide distribution and potentially fatal clinical *** currently recommended for the treatment of babesiosis are associated with a high failure rate and significant adverse events,highlighting the urgent need for more effective and safer babesiosis *** other apicomplexan parasites,*** lacks a canonical lactate dehydrogenase but instead expresses a unique enzyme,BmLDH,acquired through evolution by horizontal transfer from a mammalian *** we report the crystal structures of BmLDH in apo state and ternary complex (enzyme-NADH-oxamate) solved at 2.79 and 1.89 *** of these structures revealed that upon binding to the coenzyme and substrate,the active pocket of BmLDH undergoes a major conformational change from an opened and disordered to a closed and stabilized *** assays using wild type and mutant *** and human LDHs identified Arg99 as a critical residue for the catalytic activity of BmLDH but not its human ***,mutation of Arg99 to Ala had no impact on the overall structure and affinity of BmLDH to NADH,but dramatically altered the closure of the enzyme’s active *** these structural and biochemical data highlight significant differences between *** and human LDH enzymes and suggest that BmLDH could be a suitable target for the development of selective anti-babesial inhibitors.

关键词： lactate dehydrogenase crystal structure growth inhibitor catalytic mechanism babesiosis

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

临床医药实践 2018年第9期27卷 675-678页

作者：张蕾龙千里姬芝栩罗小英田程淮台江县妇幼保健计划生育服务中心贵州台江556300 台江县人民医院贵州台江556300 台江县民族医院贵州台江556300

目的:探讨中期妊娠行超声定位引导羊膜腔穿刺,转侧卧位注入乳酸依沙吖啶注射液(利凡诺),联合阴道后穹窿放置米索前列醇引产的临床运用效果。方法:选取2010年1月—2016年6月18岁以下孕13~20周待引产的意外妊娠患者110例,按随机数字法分... 详细信息

目的:探讨中期妊娠行超声定位引导羊膜腔穿刺,转侧卧位注入乳酸依沙吖啶注射液(利凡诺),联合阴道后穹窿放置米索前列醇引产的临床运用效果。方法:选取2010年1月—2016年6月18岁以下孕13~20周待引产的意外妊娠患者110例,按随机数字法分为观察组和对照组,每组55例。观察组超声引导定位,仰卧位羊膜腔穿刺后改成侧卧位,羊水自然流出或轻松抽吸出羊水后注入利凡诺50 mg,注射后立即将米索前列醇200μg置于阴道后穹窿。对照组常规仰卧羊膜腔穿刺注射利凡诺100 mg。统计两组羊膜腔穿刺成功率、终止妊娠时间、出血量、残留物等。结果:观察组55例均一次穿刺并于48 h内引产成功,无一例出现需处理的并发症。对照组一次穿刺成功率仅56.36%。观察组终止妊娠时间、出血量、残留物等与对照组比较,差异均有统计学意义(P<0.01)。结论:超声引导定位羊膜腔穿刺后转侧卧位注射利凡诺,减少了重复穿刺引发的感染和出血,引产穿刺成功率高。联合阴道后穹窿放置米索前列醇,能促进宫颈成熟软化,明显缩短产程,减轻产妇疼痛,避免宫颈撕裂及大出血的可能。

关键词：超声引导羊膜腔穿刺体位改变中期妊娠利凡诺米索前列醇引产

Genetic Analysis and Fine Mapping of a Novel Semidominant Dwarfing Gene LB4D in Rice

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Plant Biology 2011年第4期53卷 312-323页

作者： Fei Liang Xiaoyun Xin Zejun Hu Jiandi Xu Gang Wei xiaoyin Qian Jinshui Yang Haohua He Xiaojin luo State Key Laboratory of Genetic Engineering Instituteof Genetics School of Life Sciences Fudan University Shanghai 200433 China Key Laboratory of Crop Physiology Ecology and Genetic Breeding Ministry of Education Jiangxi Agricultural University Nanchang 330045 China Institute of Rice Research Shandong Academy of Agricultural Sciences Jining 272100 China

A dwarf mutant,designated LB4D,was obtained among the progeny of backcrosses to a wild rice introgression *** analysis of LB4D indicated that the dwarf phenotype was controlled by a single semidominant dwarfing gene,which was named *** mutants were categorized as dn-type dwarf mutants according to the pattern of internode *** addition,gibberellin（GA） response tests showed that LB4D plants were neither deficient nor insensitive to *** study found that tiller formation by LB4D plants was decreased by 40%compared with the wild type,in contrast to other dominant dwarf mutants that have been identified,indicating that a different dwarfing mechanism might be involved in the LB4D dominant *** reduction of plant height in F1 plants ranged from 27.9%to 38.1%in different genetic backgrounds,showing that LB4D exerted a stronger dominant dwarfing effect. Using large F2 and F3 populations derived from a cross between heterozygous LB4D and the japonica cultivar Nipponbare,the LB4D gene was localized to a 46 kb region between the markers Indel 4 and Indel G on the short arm of chromosome 11,and four predicted genes were identified as candidates in the target region.

关键词： Dwarfism Dwarfs Mutants Viverridae Genetics Genes Reduction Gibberellic acid Plants Planting

Biomaterials and tissue engineering in traumatic brain injury:novel perspectives on promoting neural regeneration

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第10期19卷 2157-2174页

作者： Shihong Zhu xiaoyin Liu Xiyue Lu Qiang Liao Huiyang luo Yuan Tian Xu Cheng Yaxin Jiang Guangdi Liu Jing Chen Department of Neurosurgery West China HospitalWest China Medical SchoolSichuan UniversityChengduSichuan ProvinceChina National Engineering Research Center for Biomaterials College of Biomedical EngineeringSichuan UniversityChengduSichuan ProvinceChina Department of Anesthesiology West China HospitalWest China Medical SchoolSichuan UniversityChengduSichuan ProvinceChina Department of Pharmacy West China HospitalWest China Medical SchoolSichuan UniversityChengduSichuan ProvinceChina Out-patient Department West China HospitalWest China Medical SchoolSichuan UniversityChengduSichuan ProvinceChina Department of Respiratory and Critical Care Medicine West China HospitalWest China Medical SchoolSichuan UniversityChengduSichuan ProvinceChina

Traumatic brain injury is a serious medical condition that can be attributed to falls, motor vehicle accidents, sports injuries and acts of violence, causing a series of neural injuries and neuropsychiatric symptoms. However, limited accessibility to the injury sites, complicated histological and anatomical structure, intricate cellular and extracellular milieu, lack of regenerative capacity in the native cells, vast variety of damage routes, and the insufficient time available for treatment have restricted the widespread application of several therapeutic methods in cases of central nervous system injury. Tissue engineering and regenerative medicine have emerged as innovative approaches in the field of nerve regeneration. By combining biomaterials, stem cells, and growth factors, these approaches have provided a platform for developing effective treatments for neural injuries, which can offer the potential to restore neural function, improve patient outcomes, and reduce the need for drugs and invasive surgical procedures. Biomaterials have shown advantages in promoting neural development, inhibiting glial scar formation, and providing a suitable biomimetic neural microenvironment, which makes their application promising in the field of neural regeneration. For instance, bioactive scaffolds loaded with stem cells can provide a biocompatible and biodegradable milieu. Furthermore, stem cells-derived exosomes combine the advantages of stem cells, avoid the risk of immune rejection, cooperate with biomaterials to enhance their biological functions, and exert stable functions, thereby inducing angiogenesis and neural regeneration in patients with traumatic brain injury and promoting the recovery of brain function. Unfortunately, biomaterials have shown positive effects in the laboratory, but when similar materials are used in clinical studies of human central nervous system regeneration, their efficacy is unsatisfactory. Here, we review the characteristics and properties

关键词： bioactive materials biomaterials exosomes neural regeneration scaffolds stem cells tissue engineering traumatic brain injury

Acceleration-Level Inverse-Free G2 Scheme for Inverse Kinematics Path Tracking of Robot Manipulators 36

在线全文

学校读者我要写书评

暂无评论

Acceleration-Level Inverse-Free G2 Scheme for Inverse Kinema...

茶文化展示新模式探索——以中国茶叶博物馆“嘉木苑”为例

第36届中国控制会议

作者： Jiawei luo Jun Zhang Zhiyong Xie xiaoyin Zhang Lin Xiao Xiao Su Pingxiang University Jiangxi Vocational College of Industry and Engineering College of Information Science and Engineering Jishou University

ISBN: (纸本)9781538629185

The mature analysis formula has been well used in the robotic forward kinematics for redundant manipulators,but the inverse-kinematics（IK） question is *** methods have been adopted to resolve the complicated inverse-kinematics problem;for example,the previous pseudo-inverse based（PIB） method that have to calculate the computationally expensive inverse（specifically,pseudo-inverse） of Jacobian ***,this method brings a lot of defects and *** that,to drastically avoid the Jacobian inversion and also to obtain the accurate solution of the time-varying IK problem for redundant robot manipulators,it is necessary to indagate other inverse-kinematics schemes through applying the related dynamic *** on many previously excellent researches,the dynamic methods used in this paper consist of gradient dynamics（GD）.By using GD kinematic method twice,a scheme called G2 is studied for solving the redundancy question of robot manipulators in an inverse-free *** a representative application of GD method,the G2 scheme,which is exploited at the acceleration level instead of the velocity ***,we conduct the end-effector path-tracking simulations performed on planar robot manipulators of different links to substantiate the effectiveness and accuracy of the proposed inverse-free G2 *** results illustrate the physical reahzability of the proposed novel solution for handling the time-varying IK problem of the redundant robot manipulator（s） in an inverse-free manner.

关键词： Inverse Kinematics Question Gradient Dynamics Inverse-Free G2 Scheme Redundant Manipulators PathTracking

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

茶叶 2007年第4期33卷 248-250页

作者：姚晓燕王建荣罗晓莹王宏黄灏赵东陆建良梁月荣中国茶叶博物馆杭州310013 浙江大学茶学系杭州310029

传统的茶文化展示通常以实物和图版相结合,通过一定的茶文化发展脉络来展现。本文介绍了一种称为"嘉木苑"的形式,则延伸了茶文化的内涵,为陈列展览注入了新的活力,拓宽了博物馆的陈列方式。

关键词：嘉木苑陈列方式开放性以人为本

Broadband high-efficiency polymerized liquid crystal metasurfaces with spin-multiplexed functionalities in the visible

在线全文

学校读者我要写书评

暂无评论

Photonics Research 2022年第6期10卷 1380-1393页

作者： XINJIAN LU xiaoyin LI YINGHUI GUO MINGBO PU JIANGYU WANG YAXIN ZHANG XIONG LI XIAOLIANG MA XIANGANG luo State Key Laboratory of Optical Technologies on Nano-Fabrication and Micro-Engineering Institute of Optics and ElectronicsChinese Academy of SciencesChengdu 610209China School of Optoelectronics University of Chinese Academy of SciencesBeijing 100049China Vector Light Field Research Center Institute of Optics and ElectronicsChinese Academy of SciencesChengdu 610209China School of Optoelectronic Science and Engineering University of Electronic Science and Technology of ChinaChengdu 610054China

Traditional optical components are usually designed for a single functionality and narrow operation band,leading to the limited practical *** date,it is still quite challenging to efficiently achieve multifunctional performances within broadband operating bandwidth via a single planar optical ***,a broadband high-efficiency polarization-multiplexing method based on a geometric phase polymerized liquid crystal metasurface is proposed to yield the polarization-switchable functionalities in the *** proofs of the concept,two broadband high-efficiency polymerized liquid crystal metalenses are designed to obtain the spin-controlled behavior from diffraction-limited focusing to sub-diffraction focusing or focusing vortex *** experimental results within a broadband range indicate the stable and excellent optical performance of the planar liquid crystal *** addition,low-cost polymerized liquid crystal metasurfaces possess unique superiority in large-scale patterning due to the straightforward processing technique rather than the point-by-point nanopatterning method with high cost and low *** high-efficiency liquid crystal metasurfaces also have unrivalled advantages benefiting from the characteristic with low waveguide *** proposed strategy paves the way toward multifunctional and high-integrity optical systems,showing great potential in mobile devices,optical imaging,robotics,chiral materials,and optical interconnections.

关键词： polarization interconnection waveguide

氧化应激对牛肉肉色及其稳定性的影响研究进展

在线全文

学校读者我要写书评

暂无评论

食品科学 2023年第7期44卷 260-266页

作者：齐婷婷张一敏杨啸吟罗欣毛衍伟山东农业大学食品科学与工程学院山东泰安271018

肉色作为衡量肉品质的关键指标一直是肉品产业关注的焦点。刚屠宰的牛胴体由于缺氧、缺血产生了大量活性氧,活性氧积累造成胴体氧化应激,进一步促进肌红蛋白的氧化,对肉色产生不利影响。但目前关于氧化应激对肉色及肉色稳定性的影响鲜... 详细信息

肉色作为衡量肉品质的关键指标一直是肉品产业关注的焦点。刚屠宰的牛胴体由于缺氧、缺血产生了大量活性氧,活性氧积累造成胴体氧化应激,进一步促进肌红蛋白的氧化,对肉色产生不利影响。但目前关于氧化应激对肉色及肉色稳定性的影响鲜有系统、深入总结。本文综述氧化应激通过调控脂质氧化、蛋白质氧化和降解以及线粒体的功能等途径对肉色及其稳定性的影响,以期为通过控制宰后氧化应激来保持牛肉良好的肉色提供理论依据。

关键词：氧化应激肉色肌红蛋白氧化

同方期刊数据库

峨眉武术在全球法语国家(Francophonie)的传播路径及策略研究

在线全文

学校读者我要写书评

暂无评论

四川体育科学 2024年第5期43卷 8-12,76页

作者：罗炬胡晓银成都体育学院外国语学院四川成都610041 成都体育学院新闻传播学院四川成都610041

采用文献研究、访谈法和案例分析等方法,对全球法语国家地区的峨眉武术发展及传播现状进行梳理,并对法语国家组织(OIF)创办的法语国家联盟运动会剖析解读,尝试申报该运动会的表演展示项目,利用该平台在法语世界的影响力扩大传播空间,拓... 详细信息

采用文献研究、访谈法和案例分析等方法,对全球法语国家地区的峨眉武术发展及传播现状进行梳理,并对法语国家组织(OIF)创办的法语国家联盟运动会剖析解读,尝试申报该运动会的表演展示项目,利用该平台在法语世界的影响力扩大传播空间,拓宽峨眉武术的国际传播渠道,改善在法语国家传播中所遇困境,旨在探讨峨眉武术在法语国家的传播策略和路径。突出问题:(1)核心文化欠缺,指导方案缺失;(2)人才资源短缺,翻译资料匮乏;(3)传统渠道受众面低,数字网络化滞后。结论建议:(1)突出峨眉武术文化内涵,加速标准化建设进程;(2)加快多语种材料翻译,细化国际人才培养;(3)新旧渠道融合互补,打造多维度宣传模式。

关键词：峨眉武术法语国家非洲传播策略

维普期刊数据库博看期刊