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Tubulin detyrosination promotes human trophoblast syncytium formation

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Journal of Molecular Cell Biology 2019年第11期11卷 967-978页

作者： Rui Wang Ruoxuan Yu Cheng Zhu Hai-Yan Lin xiaoyin lu Hongmei Wang State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Department of Experimental Radiation Oncology the University of Texas MD Anderson Cancer CenterHoustonTXUSA University of Chinese Academy of Sciences BeijingChina

Human trophoblast syncytialization is one of the most important yet least understood events during placental *** this study,we found that detyrosinated a-tubulin(detyr-a-tub),which is negatively regulated by tubulin tyrosine Ugase(TTL),was elevated during human placental cytotrophoblast ***,relatively high expression of TTL protein was observed in first-trimester human placental cytotrophoblast cells,but fusing trophoblast cells exhibited much lower levels of T T L Notably,fusion of preeclamptic cytotrophoblast cells was compromised but could be partially rescued by knockdown of TTL ***,chronic downregulation of TTL in trophoblast cells resulted in significantly elevated expression of *** of detyr-a-tub thus contributed to the cell surface localization of the fusogenic protein Syncytin-2 and the gap junction protein Connexin 43(Cx43),which in turn promoted successful fusion between trophoblast *** together,the results suggest that tubulin detyrosination plays an essential role in human trophoblast fusogenic protein aggregation and *** tubulin detyrosination leads to defects in syncytialization and potentially to the onset of preeclampsia.

关键词： TTL detyrosination syncytialization preeclampsia placenta syncytin

失眠患者数字化失眠认知行为治疗选择倾向的影响因素分析

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中华精神科杂志 2024年第9期57卷 579-585页

作者：周娱菁雷彬斌魏婷卢晓茵危咏陈秋强周名清张继辉广州医科大学附属脑科医院睡眠与节律医学中心广州510370 南方医科大学附属广东省人民医院(广东省医学科学院)广东省心血管病研究所、广东省精神卫生中心广州510000 南方医科大学第二临床医学院广州510515

目的初步探索影响失眠患者对数字化失眠认知行为治疗(electronically-delivered cognitive behavioral therapy for insomnia,e-CBTI)选择的因素,为e-CBTI在临床推广提供实证证据。方法于2022年11月至2023年7月,采用方便抽样法在全国38家公立医院门诊及其附近社区收集样本,共纳入18~65岁失眠患者756例。根据患者是否选择e-CBTI治疗进行分组,其中605例患者(605/756,80.0%)选择e-CBTI治疗(e-CBTI组),151例患者(151/756,20.0%)未选择参与e-CBTI治疗(对照组)。通过结构化临床访谈,根据睡眠模式及障碍诊断访谈以及DSM-5中相关诊断标准,对2组失眠患者的失眠相关症状、精神障碍、其他睡眠障碍及自杀自伤进行他评,组间差异比较采用t检验或卡方检验,并采用Logistic回归分析确定e-CBTI选择的影响因素。结果与对照组相比,e-CBTI组女性比例(χ^(2)=4.29)以及文化水平较高(χ^(2)=5.76),而居住在乡镇(χ^(2)=6.87)比例较低(均P<0.05)。与对照组相比,e-CBTI组日间症状的比例较高,包括注意力或记忆力下降(χ^(2)=16.42)、功能受损或表现下降(χ^(2)=6.75)、情绪变化(χ^(2)=4.71)以及积极性、精力或动力不足(χ^(2)=4.77,均P<0.05)。e-CBTI组较对照组睡眠时相延迟倾向(χ^(2)=6.61)、广泛性焦虑障碍(χ^(2)=6.22)、自杀意念(χ^(2)=10.45)和非自杀性自伤(χ^(2)=5.19)比例较高,差异均有统计学意义(均P<0.05)。多因素Logistic回归分析显示,居住地类型(OR=0.53,95%CI=0.29~0.95)、文化程度(OR=2.42,95%CI=1.34~4.37)、注意力或记忆力(OR=1.95,95%CI=1.11~3.42)及功能受损或表现受损(OR=1.80,95%CI=1.15~2.82)以及自杀意念(OR=3.12,95%CI=1.29~7.58)影响e-CBTI的选择,失眠的夜间症状,包括入睡困难、睡眠维持困难和过度早醒与e-CBTI选择倾向未见相关。结论失眠的日间症状和自杀意念是促使失眠患者选择e-CBTI的重要因素。

关键词：睡眠障碍失眠认知行为治疗数字化日间症状昼夜节律自杀

Variations in mesenchymal-epithelial transition-related transcription factors during reprogramming of somatic cells from different germ layers into iPSCs

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Journal of Genetics and Genomics 2016年第10期43卷 609-612页

作者： xiaoyin lu Yukai Wang Long Yan Libin Wang Wei Li Hongmei Wang State Key Laboratory of Stem Cell and Reproductive Biology Institute of Zoology Chinese Academy of Sciences University of Chinese Academy of Sciences

Introducing a combination of transcription factors such as Oct4,Sox2,Klf4 and c-Myc（OSKM）enables reprogramming which converts somatic cells into induced pluripotent stem cells（i PSCs）（Takahashi and Yamanaka,2006）.i PSCs play an important role in clinical and regenerative medicine because they can be utilized to model a specific disease or differentiate into functional cells for *** the efficiency of induction and improving the qualities of iPSCs are constant themes in this field.

关键词： PSCs Variations in mesenchymal-epithelial transition-related transcription factors during reprogramming of somatic cells from different germ layers into iPSCs

Biomaterials and tissue engineering in traumatic brain injury:novel perspectives on promoting neural regeneration

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Neural Regeneration Research 2024年第10期19卷 2157-2174页

作者： Shihong Zhu xiaoyin Liu Xiyue lu Qiang Liao Huiyang luo Yuan Tian Xu Cheng Yaxin Jiang Guangdi Liu Jing Chen Department of Neurosurgery West China HospitalWest China Medical SchoolSichuan UniversityChengduSichuan ProvinceChina National Engineering Research Center for Biomaterials College of Biomedical EngineeringSichuan UniversityChengduSichuan ProvinceChina Department of Anesthesiology West China HospitalWest China Medical SchoolSichuan UniversityChengduSichuan ProvinceChina Department of Pharmacy West China HospitalWest China Medical SchoolSichuan UniversityChengduSichuan ProvinceChina Out-patient Department West China HospitalWest China Medical SchoolSichuan UniversityChengduSichuan ProvinceChina Department of Respiratory and Critical Care Medicine West China HospitalWest China Medical SchoolSichuan UniversityChengduSichuan ProvinceChina

Traumatic brain injury is a serious medical condition that can be attributed to falls, motor vehicle accidents, sports injuries and acts of violence, causing a series of neural injuries and neuropsychiatric symptoms. However, limited accessibility to the injury sites, complicated histological and anatomical structure, intricate cellular and extracellular milieu, lack of regenerative capacity in the native cells, vast variety of damage routes, and the insufficient time available for treatment have restricted the widespread application of several therapeutic methods in cases of central nervous system injury. Tissue engineering and regenerative medicine have emerged as innovative approaches in the field of nerve regeneration. By combining biomaterials, stem cells, and growth factors, these approaches have provided a platform for developing effective treatments for neural injuries, which can offer the potential to restore neural function, improve patient outcomes, and reduce the need for drugs and invasive surgical procedures. Biomaterials have shown advantages in promoting neural development, inhibiting glial scar formation, and providing a suitable biomimetic neural microenvironment, which makes their application promising in the field of neural regeneration. For instance, bioactive scaffolds loaded with stem cells can provide a biocompatible and biodegradable milieu. Furthermore, stem cells-derived exosomes combine the advantages of stem cells, avoid the risk of immune rejection, cooperate with biomaterials to enhance their biological functions, and exert stable functions, thereby inducing angiogenesis and neural regeneration in patients with traumatic brain injury and promoting the recovery of brain function. Unfortunately, biomaterials have shown positive effects in the laboratory, but when similar materials are used in clinical studies of human central nervous system regeneration, their efficacy is unsatisfactory. Here, we review the characteristics and properties

关键词： bioactive materials biomaterials exosomes neural regeneration scaffolds stem cells tissue engineering traumatic brain injury

Research progress in the off-target effects of Bacille Calmette-Guérin vaccine

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中华医学杂志(英文版) 2024年第17期137卷 2065-2074页

作者： Wu Yanfei Zhang xiaoyin Zhou Li lu Jiayu Zhu Fengcai Li Jingxin School of Public Health Southeast University Nanjing Jiangsu China Center for Global Health School of Public Health Nanjing Medical University Nanjing Jiangsu China IB Course Center of High School Affiliated to Shanghai Jiaotong University Shanghai China NHC Key Laboratory of Enteric Pathogenic Microbiology Jiangsu Provincial Center for Disease Control and Prevention Nanjing Jiangsu China Institute of Global Public Health and Emergency Pharmacy China Pharmaceutical University Nanjing Jiangsu China

Bacille Calmette-Guérin (BCG) vaccine is designed to provide protection against tuberculosis (TB). However, numerous epidemiological, clinical, and immunological studies have shown that BCG vaccination affects neonatal and infant mortality, which may be related to the reduction of TB-unrelated infections and diseases by BCG vaccine. We aimed to discuss the off-target effects of BCG vaccine on un-TB infections and diseases, as well as the potential mechanism and influencing factors. Literature was retrieved mainly from PubMed using medical subject headings "BCG, variations, and non-specific, heterologous or off-target". Studies have showed that BCG vaccination can prevent various heterologous infections, including respiratory tract infections, leprosy, and malaria, treat viral infections including human papillomavirus and herpes simplex virus infection as immunotherapy, and improve the immune responses as vaccine adjuvant. Besides, BCG vaccine can reduce the recurrence rate of non-muscle-invasive bladder cancer, and may provide protection against autoimmune diseases. These off-target effects of BCG vaccine are thought to be achieved by modulating heterologous lymphocyte responses or inducing trained immunity, which were found to be sex-differentiated and affected by the BCG vaccine strains, sequence or time of vaccination.

关键词： BCG vaccine Off-target effects of vaccines Infections Non-muscle-invasive bladder cancer Autoimmune diseases Trained immunity

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高速摄影仪成像噪声去除方法研究

仪器仪表学报 2023年第2期44卷 211-220页

作者：陈怀安卢小银单奕萌阚艳金一中国科学技术大学工程科学学院合肥230026 合肥中科君达视界技术股份有限公司合肥230051 国营芜湖机械厂芜湖241000

高速摄影仪在超高帧率下(>10000 FPS)易产生噪声,该噪声分布复杂,难以获取与有噪图像完全对应的清晰图像。针对该问题,提出一种基于非理想配对图像的卷积去噪网络训练方法。首先利用高速和低速摄影仪拍摄相同场景图像,获得有噪图像及与... 详细信息

高速摄影仪在超高帧率下(>10000 FPS)易产生噪声,该噪声分布复杂,难以获取与有噪图像完全对应的清晰图像。针对该问题,提出一种基于非理想配对图像的卷积去噪网络训练方法。首先利用高速和低速摄影仪拍摄相同场景图像,获得有噪图像及与其对应的非理想配对清晰图像;然后,建立基于卷积神经网络的深度去噪模型,结合亮度一致化和图像对齐方法,实现非理想配对图像的监督学习,从而去除成像噪声;最后,引入模型量化技术将模型参数和激活值由32位浮点数量化为8位定点数,降低模型大小、内存需求和运行时间。实验结果表明,提出的去噪方法可有效去除高速摄影仪成像噪声,相比于其他方法,去噪图像峰值信噪比提高1.96 dB,结构相似性提高1.95%;通过模型量化,模型大小降低4倍,内存需求降低45.62%,运行时间降低37.5%。

关键词：高速摄影图像去噪非理想配对卷积神经网络模型量化

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风淬急冷对高钛矿渣结构的影响研究

材料导报 2024年第17期38卷 144-150页

作者：徐梓馨李军卢忠远李晓英徐陈西南科技大学材料与化学学院四川绵阳621010 西南科技大学环境友好能源材料国家重点实验室四川绵阳621010

本工作制得了风淬急冷高钛矿渣,研究了风淬急冷对其结构的影响,并将其与自然冷却和水淬急冷高钛矿渣进行对比。结果表明:自然冷却高钛矿渣中结晶矿物较多,Q_(0)、Q_(1)、Q_(2)和Q_(3)硅酸盐结构共存,Ti以四配位和六配位为主;水淬急冷高... 详细信息

本工作制得了风淬急冷高钛矿渣,研究了风淬急冷对其结构的影响,并将其与自然冷却和水淬急冷高钛矿渣进行对比。结果表明:自然冷却高钛矿渣中结晶矿物较多,Q_(0)、Q_(1)、Q_(2)和Q_(3)硅酸盐结构共存,Ti以四配位和六配位为主;水淬急冷高钛矿渣中结晶矿物的种类及含量降低,硅酸盐结构以Q_(0)、Q_(1)和Q_(2)为主,Ti^(4+)以[TiO_(5)]的形式进入到玻璃网络中;风淬急冷高钛矿渣为连续玻璃相,硅酸盐结构以Q_(0)和Q_(2)为主,粗颗粒中Ti以五配位为主,随其粒径减小,四配位和六配位Ti阴离子团出现。Ti的配位数整体升高并进入玻璃体结构中与硅铝酸盐连接形成玻璃网络骨架,增强了玻璃网络聚合度,提高了风淬高钛矿渣的化学稳定性。

关键词：高钛矿渣风淬急冷硅酸盐结构

对比观察芬太尼与地佐辛对老年乳腺癌术后患者镇痛效果、应激反应、炎症因子及细胞免疫的影响

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老年医学与保健 2020年第5期26卷 776-779,794页

作者：刘康郭海峰陆小寅费敏东部战区空军医院麻醉科江苏南京210001 南京应天骨科医院骨科江苏南京211106 上海市中西医结合医院风湿科上海200083

目的比较芬太尼与地佐辛对老年乳腺癌患者术后镇痛效果、应激反应、炎症因子及细胞免疫的影响。方法选取2018年12月-2019年12月于东部战区空军医院麻醉科行乳腺癌根治术的120例老年患者,按随机盲法设为试验组(n=60)和对照组(n=60),试验... 详细信息

目的比较芬太尼与地佐辛对老年乳腺癌患者术后镇痛效果、应激反应、炎症因子及细胞免疫的影响。方法选取2018年12月-2019年12月于东部战区空军医院麻醉科行乳腺癌根治术的120例老年患者,按随机盲法设为试验组(n=60)和对照组(n=60),试验组给予地佐辛治疗,对照组给予芬太尼治疗。观察并比较2组术后各时间点视觉模拟评分(VAS)、应激反应、炎症因子及免疫细胞水平。结果试验组患者术后4 h、12 h、24 h、48 h VAS评分低于对照组(P<0.05)。试验组患者术后12 h、24 h血浆醛固酮、皮质醇、肾素、血管紧张素II低于对照组(P<0.05)。2组患者在T1、T2时NK细胞和T细胞亚群水平较T0时均降低(P<0.05)。试验组患者在T1、T2时NK细胞、T淋巴细胞亚群指标以及白介素(IL)-2水平高于对照组(P<0.05),在T2时,试验组患者IL-10水平低于对照组(P<0.05)。结论老年乳腺癌患者根治术后应用地佐辛可有效缓解疼痛,减轻应激反应,调节炎症因子和免疫细胞的水平,促进免疫功能的恢复。

关键词：老年地佐辛芬太尼乳腺癌根治术炎症因子细胞免疫

基于PCA和Fisher判别分析的锋电位在线分类算法

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北京生物医学工程 2013年第2期32卷 122-126,133页

作者：卢小银梁振周保琢周逸峰中国科学技术大学电子科学技术系合肥230027 安徽医科大学生命科学学院合肥230032 中国科学技术大学生命科学学院合肥230027

目的大脑神经元胞外单细胞动作电位(即锋电位)的检测与分类,是研究神经系统处理信息机制的关键。常用方法是实验完成后对记录到的数据进行离线检测与分类,然而当需要在短时完成大量数据的处理或无线传输时,则需实现锋电位的在线检测与... 详细信息

目的大脑神经元胞外单细胞动作电位(即锋电位)的检测与分类,是研究神经系统处理信息机制的关键。常用方法是实验完成后对记录到的数据进行离线检测与分类,然而当需要在短时完成大量数据的处理或无线传输时,则需实现锋电位的在线检测与分类。方法为实现在线分类,本文在利用主成分分析法(principal component analysis,PCA)和K均值分类法对一定量数据进行预分类的基础上,提出使用PCA结合Fisher判别分析的方法,并与基于距离的模板匹配法、BP神经网络分类法进行了分类效果和算法复杂度的比较。结果仿真结果表明,该方法相对于其它两种方法在分类效果和算法复杂度上都具有一定的优势。结论此方法是实现锋电位在线分类的不错选择。

关键词：锋电位在线分类主成分分析 Fisher判别分析模板匹配神经网络