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Epilepsy: Quality of life and assessment scale evaluation

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Neural Regeneration Research 2008年第1期3卷 83-88页

作者： Fayun Hu xiaoyi zou Department of Neurology West China Hospital Sichuan University Chengdu 610041 Sichuan Province China

BACKGROUND： Quality of life （QOL） is an important topic in current international research of epilepsy. In countries other than China, QOL in epilepsy has been well studied, and many assessment scales or QOL of epilepsy have been developed and used in the clinical practice. In China, concern for QOL of epilepsy patients is very recent, and QOL assessment scales, which correspond to China＇s basic conditions, are still needed. OBJECTIVE： This review aimed to analyze the primary influencing factors and assessment scales of QOL in epilepsy, to investigate the topics of current and future research for QOL of epilepsy patients, and to highlight the importance of QOL for epilepsy patients, according to China＇s basic conditions. RETRIEVAL STRATEGY： Using the terms ＂quality of life in epilepsy＂, we computer-retrieved from the PubMed （http：//***/PubMed） database human studies published between January 1998 and April 2007 in the English language. A total of 745 manuscripts were searched, of which 243 were review papers. At the same time, we computer-searched the China National Knowledge Infrastructure with the terms ＂epilepsy and quality and life＂ in the Chinese language for studies published between 2002 and 2007. Altogether, 181 Chinese literatures were retrieved, 32 of which were from high-impact journals. LITERATURE EVALUATION： The retrieved manuscripts were initially selected, but 50 were kept for further analysis. The selected manuscripts were as follows： 31 Chinese and/or English studies addressed the influencing factors of QOL for epilepsy patients, as well as assessment scales for QOL in different populations of epilepsy patients, of which 5 were review articles and the remaining 26 were clinical studies; and 19 Chinese and/or English literatures were rejected, because they were not in accordance with the inclusive criteria. DATA SYNTHESIS： QOL for epilepsy patients is an emerging field. At present, ＂the Liverpool group model for determining QOL in peo

关键词： epilepsy quality of life China.

Levetiracetam induces tyrosine kinase receptor B expression in SH-SY5Y cells

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Neural Regeneration Research 2011年第14期6卷 1082-1085页

作者： Danrong Lei Shengfu Li xiaoyi zou Department of Neurology West China Hospital Sichuan University Chengdu 610041 Sichuan Province China Laboratory of Transplantation Immunity Sichuan University Chengdu 610041 Sichuan Province China

Tyrosine kinase receptor B （TrkB） plays an important role in long-term potentiation and memory *** present study used all-trans retinoic acid to induce TrkB expression in SH-SY5Y cells,and observed the effects of levetiracetam （LEV） on TrkB *** exposure to 10,50,and 100 μg/mL LEV,the number of TrkB-positive cells,and average absorbance value were *** demonstrated that LEV can induce TrkB expression in SH-SY5Y cells.

关键词： levetiracetam tyrosine kinase receptor B brain-derived neurotrophic factor cognition SH-SY5Y cells neural regeneration

Dopaminergic system abnormalities Etiopathogenesis of dystonia

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Neural Regeneration Research 2008年第3期3卷 301-304页

作者： Shuhui Wu Huifang Shang xiaoyi zou Department of Neurology West China Hospital Sichuan University Chengdu 610041 Sichuan Province China

BACKGROUND： Much research has focused on the close relationship between etiopathogenesis of dystonia and abnormalities of the dopaminergic system. Nevertheless, details of the mechanism are still not clear. OBJECTIVE： To review studies from the past few years about pathogenesis and molecular interactions involved in the relationship between dystonia and abnormalities of the dopaminergic system. RETRIEVAL STRATEGY： Using the key words ＂dystonia＂ and ＂dopamine＂, PubMed database and SCI databases were searched from January 1990 to December 2005 for relevant English publications. A total of 73 articles were searched and, initially, all articles were selected. Inclusive criteria： studies based on pathogenesis and molecular interactions involved in the relationship between dystonia and abnormalities of the dopaminergic system. Exclusive criteria： duplicated studies. A total of 19 articles were extracted after preliminary screening. LITERATURE EVALUATION： The data sources were the PubMed and SCI databases. The types of articles chosen were reviews and original articles. DATA SYNTHESIS： Metabolism and function of dopamine in the central nervous system： the chemical constitution of dopamine is a single benzene ring. The encephalic regions of dopamine synthesis and their fiber projections comprise four nervous system pathways. One of these pathways is the substantia nigra-striatum dopamine pathway, which is a side-loop of the basal ganglia circuitry that participates in movement control and plays a main role in the adjustment of extracorticospinal tract movement. Dopamine can lead to the facilitation of movement. Dystonia and abnormalities of the dopaminergic system： different modes of dopamine abnormality exist in various forms of dystonia. Abnormalities of the dopaminergic system in several primary dystonias： at present, fifteen gene loci of primary dystonia have been reported （DYT1-DYT15）. The relationship between abnormalities of the dopaminergic system and the etiopathog

关键词： dystonia dopamine review

Research on the Relationship Between Reading Anxiety and Reading Strategy in English Reading:A Quantitative Study in Chengdu University

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Sociology Study 2022年第3期12卷 110-117页

作者： Weiqiao Kong xiaoyi zou Chengdu University ChengduSichuanChina

According to a large number of studies since the 1970s,learners’emotional state is one of the important factors affecting learning effect of foreign language *** addition,reading is an important input and practice method in English learning,especially when it comes to language learning.102 students majoring in English at the Faculty of Foreign Languages of Chengdu University were investigated by using two scales,FLRAS and ERSS,based on the Individual Learner Differences and Affective filter *** study uses the social science statistical tool SPSSPRO to process and analyze all the data,aiming to explore the degree of English reading anxiety and the relationship between reading anxiety and reading strategies in English reading.

关键词： English reading anxiety English reading strategies correlation

An ischemic area-targeting,peroxynitrite-responsive,biomimetic carbon monoxide nanogenerator for preventing myocardial ischemia-reperfusion injury

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Bioactive Materials 2023年第10期28卷 480-494页

作者： Jinyan Zhang Liwei Liu Zhen Dong Xicun Lu Wenxuan Hong Jin Liu xiaoyi zou Jinfeng Gao Hao Jiang Xiaolei Sun Kai Hu Youjun Yang Junbo Ge Xiao Luo Aijun Sun Department of Cardiology Zhongshan HospitalFudan UniversityChina Shanghai Institute of Cardiovascular Diseases ShanghaiChina Institutes of Biomedical Sciences Fudan UniversityShanghaiChina NHC Key Laboratory of Viral Heart Diseases ShanghaiChina Key Laboratory of Viral Heart Diseases Chinese Academy of Medical SciencesChina State Key Laboratory of Bioreactor Engineering Shanghai Key Laboratory of Chemical BiologySchool of PharmacyEast China University of Science and TechnologyShanghai200237China Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development School of Chemistry and Molecular EngineeringEast China Normal UniversityShanghaiChina

Myocardial ischemia-reperfusion (MI/R) injury is common in patients who undergo revascularization therapy for myocardial infarction, often leading to cardiac dysfunction. Carbon monoxide (CO) has emerged as a therapeutic molecule due to its beneficial properties such as anti-inflammatory, anti-apoptotic, and mitochondrial biogenesis-promoting properties. However, its clinical application is limited due to uncontrolled release, potential toxicity, and poor targeting efficiency. To address these limitations, a peroxynitrite (ONOO􀀀 )-triggered CO donor (PCOD585) is utilized to generate a poly (lactic-co-glycolic acid) (PLGA)-based, biomimetic CO nanogenerator (M/PCOD@PLGA) that is coated with the macrophage membrane, which could target to the ischemic area and neutralize proinflammatory cytokines. In the ischemic area, local produced ONOO􀀀 triggers the continuous release of CO from M/PCOD@PLGA, which efficiently ameliorates MI/R injury by clearing harmful ONOO􀀀 , attenuating the inflammatory response, inhibiting cardiomyocyte apoptosis, and promoting mitochondrial biogenesis. This study provides a novel insight into the safe therapeutic use of CO for MI/R injury by utilizing a novel CO donor combined with biomimetic technology. The M/PCOD@PLGA nanogenerator offers targeted delivery of CO to the ischemic area, minimizing potential toxicity and enhancing therapeutic efficacy.

关键词： Ischemia-reperfusion injury Macrophage membrane Mitochondria Inflammation Peroxynitrite

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自贸试验区制度创新的高端要素流入效应

国际商务（对外经济贸易大学学报） 2024年第3期 20-38页

作者：戴翔邹小奕南京审计大学统计与数据科学学院江苏南京211815

形成和集聚高端要素是夯实经济高质量发展基石的关键。本文在创新性地测度制度创新水平的基础上,基于双向固定效应模型,采用29个自贸片区及其对应的17个地级市数据,实证检验了自贸试验区制度创新对高端要素流入的影响。检验结果表明:自... 详细信息

形成和集聚高端要素是夯实经济高质量发展基石的关键。本文在创新性地测度制度创新水平的基础上,基于双向固定效应模型,采用29个自贸片区及其对应的17个地级市数据,实证检验了自贸试验区制度创新对高端要素流入的影响。检验结果表明:自贸试验区制度创新主要通过知识产权保护、贸易便利化和产业优化升级等机制,促进高端要素流入,其中教育水平在此过程中起调节作用。实证研究还发现,自贸试验区制度创新促进高端要素流入的现实效应,因城市区位、设立批次、城市规模而有所差异。本文的研究结论为进一步推进自贸试验区制度创新,实现高端要素流入,从而夯实经济高质量发展提供经验证据。

关键词：自贸试验区高端要素制度创新

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新型椭圆固定阀塔板的流体力学性能

石油炼制与化工 2023年第9期54卷 51-61页

作者：邹小艺赵培孙浩华东理工大学化工学院上海200237

在现有固定阀塔板的基础上进行结构改进,开发一种新型抗堵塞塔板——椭圆固定阀塔板。采用空气-水为试验体系,在直径1200 mm的冷模塔内对椭圆固定阀塔板的流体力学性能进行试验研究,通过改变结构参数和操作参数测定了塔板压降、雾沫夹... 详细信息

在现有固定阀塔板的基础上进行结构改进,开发一种新型抗堵塞塔板——椭圆固定阀塔板。采用空气-水为试验体系,在直径1200 mm的冷模塔内对椭圆固定阀塔板的流体力学性能进行试验研究,通过改变结构参数和操作参数测定了塔板压降、雾沫夹带及漏液率。结果表明:椭圆固定阀塔板的雾沫夹带率和漏液率较低,压降较高。从整体上相较筛孔塔板有明显改观,气相负荷性能表现更好,综合性能更优异。同时为了优化塔板结构设计,对椭圆固定阀塔板两相流场进行了计算流体力学(CFD)分析,进一步提升了塔板性能,拓宽椭圆固定阀塔板在石化领域的应用前景。

关键词：固定阀塔板筛孔塔板流体力学性能数值模拟

从金国楠《金筑山歌》看民国前期贵阳的社会生活

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兴义民族师范学院学报 2023年第2期 33-39,90页

作者：邹潇逸贵州师范大学历史与政治学院贵州贵阳550001

竹枝词具有较高的文献与史料价值,是观察民众社会生活的重要材料。金国楠《金筑山歌》以竹枝词的形式,记录了民国前期(1912-1931)贵阳的城市社会生活,其中记载了许多下层民众的日常生活活动,是研究民国前期贵阳城市社会生活史不可多得... 详细信息

竹枝词具有较高的文献与史料价值,是观察民众社会生活的重要材料。金国楠《金筑山歌》以竹枝词的形式,记录了民国前期(1912-1931)贵阳的城市社会生活,其中记载了许多下层民众的日常生活活动,是研究民国前期贵阳城市社会生活史不可多得的一手资料。自道光《贵阳府志》后至民国时期,贵阳没有官修地方志,有关民国前期史料记载较少。通过对《金筑山歌》史料价值的剖析,弥补了民国时期贵阳无方志记载的缺陷。

关键词：竹枝词贵阳民国前期城市社会生活史

基于儿童赋权理念的博物馆学习研究——以圣地亚哥儿童探索博物馆为例

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科学教育与博物馆 2023年第4期9卷 18-24页

作者：邹晓熠吉林大学考古学院

对圣地亚哥儿童探索博物馆如何运用儿童赋权理念设计博物馆学习体验进行研究,在此基础上提炼儿童赋权应用于儿童博物馆的原则、理念和方式,使儿童观众能够在开放包容的博物馆环境中享有平等的参与权、表达权、分享权与创造权,达到社会... 详细信息

对圣地亚哥儿童探索博物馆如何运用儿童赋权理念设计博物馆学习体验进行研究,在此基础上提炼儿童赋权应用于儿童博物馆的原则、理念和方式,使儿童观众能够在开放包容的博物馆环境中享有平等的参与权、表达权、分享权与创造权,达到社会层面的儿童活动保障和个体发展和谐统一,为同行寻找儿童赋权理念并将其融入儿童博物馆学习提供参考。

关键词：儿童赋权儿童博物馆博物馆学习