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Journal of Interventional Medicine 2023年第3期6卷 107-110页

作者： Hengyu Li Yu Zhou Xiaoxia Guo Qiwei Zhang xiaoyi ding Department of Interventional Radiology Ruijin HospitalShanghai Jiao Tong University School of MedicineNo.197Ruijin Er RoadShanghai200025China

Recently,interventional ablation techniques have gained prominence in tumor treatment guidelines and complement traditional approaches,such as surgery,chemotherapy,and *** ablation techniques,such as microwave,radiofrequency,and cryoablation,have been used;however,they have certain limitations,including the risk of damaging surrounding normal tissues and the heat sink effect caused by tumor blood flow.1 Irreversible electroporation(IRE),an ablation technology independent of thermal energy,is a promising alternative.2 Clinical studies have demonstrated IRE's efficacy in treating tumors,such as pancreatic and liver tumors.3 Recent research has shown that IRE can elicit specific anti-tumor immune responses in the body.5 IRE also plays a crucial role in eliminating residual tumor cells postoperatively and preventing tumor recurrence.

关键词： immunity chemotherapy irreversible

Bone marrow mesenchymal stem cells-derived exosomes for penetrating and targeted chemotherapy of pancreatic cancer

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Acta Pharmaceutica Sinica B 2020年第8期10卷 1563-1575页

作者： Yu Zhou Wenxi Zhou Xinli Chen Qingbing Wang Chao Li Qinjun Chen Yu Zhang Yifei Lu xiaoyi ding Chen Jiang Department of Interventional Radiology Ruijin HospitalShanghai Jiao Tong UniversitySchool of MedicineShanghai 200025China Key Laboratory of Smart Drug Delivery Ministry of EducationState Key Laboratory of Medical NeurobiologyDepartment of PharmaceuticsSchool of PharmacyFudan UniversityShanghai 200032China

Pancreatic ductal adenocarcinoma(PDAC) is one of the most intractable malignancy, with an only 6% 5-year relative survival rate. The dismal therapeutic effect is attributed to the chemotherapy resistance and unique pathophysiology with abundant inflammatory cytokines and abnormal hyperplasia of extracellular matrix(ECM). Based on the theory that bone marrow mesenchymal stem cells(BM-MSCs) can influence the tumorous microenvironment and malignant growth of PDAC, we employed exosomes(Exos) derived from BM-MSCs as PDAC-homing vehicles to surpass the restrictions of pathological ECM and increase the accumulation of therapeutics in tumor site. To overcome chemoresistance of PDAC, paclitaxel(PTX) and gemcitabine monophosphate(GEMP)-an intermediate product of gemcitabine metabolismd-were loaded in/on the purified Exos. In this work, the Exo delivery platform showed superiorities in homing and penetrating abilities, which were performed on tumor spheroids and PDAC orthotopic models. Meanwhile, the favorable anti-tumor efficacy in vivo and in vitro, plus relatively mild systemic toxicity, was found. Loading GEMP and PTX, benefitting from the naturally PDAC selectivity, the Exo platform we constructed performs combined functions on excellent penetrating, anti-matrix and overcoming chemoresistance(Scheme 1). Worth expectantly, the Exo platform may provide a prospective approach for targeted therapies of PDAC.

关键词： targeted metabolism chemotherapy

Experimental investigation of a novel micro gas turbine with flexible switching function for distributed power system

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Frontiers in Energy 2020年第4期14卷 790-800页

作者： Xiaojing LV Weilun ZENG xiaoyi ding Yiwu WENG Shilie WENG Research Center for Low Carbon Combustion and Engine System China-UK Low Carbon CollegeShanghai Jiao Tong UniversityShanghai 200240China Gas Turbine Research Institute School of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240China

Micro gas turbine(MGT)is widely used in small-scale distributed power systems because of its low emissions and fuel ***,the under-utilization of its exhaust heat and the low electric efficiency are the main bottlenecks that restrict its ***,the flexible switching between the power generated by the MGT and the power grid is also a key factor for keeping the secure operation of a distributed power ***,this paper conducted some experimental investigations of a 30 kW MGT to provide reference solutions for the above *** MGT is located at Shanghai Jiao Tong University(SJTU),which is designed by the Gas Turbine Research Institute of SJTU,and is manufactured by a turbo machinery factory in Chongqing,*** demonstration prototype is mainly composed of a single stage centrifugal compressor,a radial turbine,a combustor,a high-speed pennanent magnet generator,and a control *** results show that the MGT can achieve steady operation at a low rotational speed from 10000 r/min to 34000 r/min in the case of using oil lubricated bearings,which can greatly reduce the economic cost compared with the use of air *** the same time,the ignition success rate of combustion chamber(CC)reaches 98%at a low rotational speed,and a wide range of stable combustion area can be obtained,because of the novel design method of combustor by referencing the way applied in an axial flow *** MGT generating set can achieve functions,such as starting up,ignition,stable operation,loaded operation,grid-connection and *** system also can realize flexibly switching from the start motor mode to the generator mode,and from grid-connected mode to off^grid mode,because the innovative multi-state switching control system is *** above research work can make our state master independent intellectual property rights of micro gas turbine,rather than continue to be subject to the technological monopoly of the develop

关键词： gas turbine flexible switching system control system distributed power system emission test

Technological development of multi-energy complementary system based on solar PVs and MGT

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Frontiers in Energy 2018年第4期12卷 509-517页

作者： Xiaojing LV Yu WENG xiaoyi ding Shilie WENG Yiwu WENG Energy Research Institute School of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240China Shanghai Investment Consulting Corporation Shanghai 200003China

The complementary micro-energy network system consisting of solar photovoltaic power generation (solar PVs) and micro-gas turbine (MGT), which not only improves the absorption rate and reliability of photovoltaic power, but also has the advantages of low emission, high efficiency, and good fuel adaptability, has become one of the most promising distributed power systems in the field of micro grid. According to the development of current technology and the demand of actual work, this research described the domestic and foreign development of micro-energy network system based on solar PVs and MGT. Moreover, it analyzed the challenges and future development regarding the micro-energy network system in planning and design, energy utilization optimization and dispatching management, and system maintenance, respectively. Furthermore, it predicted the future development of the key technology of the multi-energy complementary system. These results will be beneficial for the progress of this field both in theory and practice.

关键词： renewable energy solar photovoltaic power generation micro gas turbine multi-energy complementary system micro-energy network

Identification of two novel mutations in the GALNT3 gene in a Chinese family with hyperphosphatemic familial tumoral calcinosis

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Bone Research 2016年第4期4卷 241-246页

作者： Lihao Sun Lin Zhao Lianiun Du Peipei Zhang Minjia Zhang Min Li Tingting Liu Lei Ye Bei Tao Hongyan Zhao Jianmin Liu xiaoyi ding Department of Endocrine and Metabolic Diseases Rui-jin Hospital Shanghai Jiao-Tong University School of Medicine 197 Rui-jin Er RoadShanghai 200025 China Department of Endocrinology and Metabolism Zhong-shan Hospital Fudan University Shanghai 200032 China Department of Radiology Rui-jin Hospital Shanghai Jiao-Tong University School of Medicine 197 Rui-jin Er Road Shanghai 200025 China

Hyperphosphatemic familial tumoral calcinosis(HFTC) is a rare, autosomal recessive genetic *** disease is characterized by the progressive calcification of soft tissues leading to symptoms of pressure and hyperphosphatemia but normal concentrations of serum calcium with or without an elevation of1,25-dihydroxyvitamin D3 *** is caused by loss-of-function mutations in the GALNT3, FGF23 or KL genes. Here, we identified two novel mutations in the GALNT3 gene in a Chinese family with *** of a novel genotype in HFTC provides clues for understanding the phenotype–genotype relationships in HFTC and may assist not only in the clinical diagnosis of HFTC but also in the interpretation of the genetic information used for prenatal diagnosis and genetic counseling.

关键词： FTC gene Figure

Irreversible electroporation treatment of pheochromocytoma at a complex site: A case report

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Journal of Interventional Medicine 2020年第2期3卷 101-105页

作者： Zhiyuan Wu Tingwei Su Fukang Sun Fujun Zhang Zhongmin Wang Wei Huang Qin Liu xiaoyi ding Department of Interventional Radiology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina

A 24-year-old man was seen 2 years prior for hematuria,hypertension(165/120 mmHg),and *** plasma normetanephrine(NMN)level was elevated(9812.4 pg/mL).Computed tomography(CT)showed bilateral adrenal tumors(Fig.1).Of the two tumors on the left adrenal gland,the lesion on the head aspect was relatively large,while that on the feet aspect(arrow)was relatively small and adjacent to the left renal *** was one lesion on the right adrenal *** emission tomography(PET)-CT showed increased radioactive tracer uptake in the regions of the bilateral adrenal tumors(Fig.2).The clinical diagnosis was pheochromocytoma.

关键词： adrenal diagnosis elevated

Balloon-occluded retrograde transvenous obliteration with lauromacrogol sclerosant foam for gastric varices

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Journal of Interventional Medicine 2022年第3期5卷 138-142页

作者： Zhiyang Wu Wei Wu Cheng Tao Qin Liu Wenchang Li Qinbing Wang Wei Huang Junwei Gu Xiaoyan Fei Zhongmin Wang xiaoyi ding Department of Interventional Radiology Rujin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China Department of Gastroenterology Rujin HospitalShanghai Jiao Tong Universiy School of MedicineShanghai200025China Department of Radiology University of Pttsburgh School of MedicinePittsburgh15213PennsylvaniaUSA Shanghai Clinical Research Center Member for Interventional Medicine China

Objectives:To evaluate the safety and efficacy of balloon-occluded retrograde transvenous obliteration(BRTO)using lauromacrogol sclerosant foam for gastric varices(GVs)with gastrorenal venous ***:Data of GV patients treated with BRTO using lauromacrogol sclerosant foam in 2016–2020 were retrospectively analyzed along with procedural success rate,complications,and follow-up ***:A total of 31 patients were treated with *** sclerosant foam was prepared by mixing iodinated oil,lauromacrogol,and air at a 1:2:3 *** BRTO procedure was successfully completed in 93.5%of *** patient was allergic to the lauromacrogol injection.A mild postoperative fever occurred in three *** patient experienced grand mal seizures after the *** was no significant difference in the median Child-Turcotte-Pugh scores before versus after *** GV resolution was observed in 93.1%of *** patient underwent endoscopic treatment for the development of high-risk esophageal *** patient underwent transjugular intrahepatic portosystemic shunt placement for the aggravation of ***:Lauromacrogol sclerosant foam is safe and effective in patients undergoing BRTO for GV.

关键词： Gastric varices Gastrorenal shunt Balloon-occluded retrograde transvenous obliteration Sclerotherapy

Shanghai expert consensus on totally implantable access ports 2019

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Journal of Interventional Medicine 2019年第4期2卷 141-145页

作者： xiaoyi ding Fang ding Yonggang Wang Liying Wang Jianfeng Wang Lichao Xu Wentao Li Jijin Yang Xiaoxi Meng Min Yuan Jun Chu Feng Ge Weihua Dong Mei Xue 无 Ruijin Hospital Affiliated with Shanghai Jiaotong University School of Medicine Shanghai200025China Sixth People's Hospital Affiliated with Shanghai Jiaotong University Shanghai200233China Fudan University Shanghai Cancer Center Department of OncologyShanghai Medical CollegeFudan UniversityShanghai200032China Shanghai First People's Hospital Shanghai Jiaotong UniversityShanghai200080China Changhai Hospital Affiliated with The Second Military Medical University Shanghai200433China Changzheng Hospital Affiliated with The Second Military Medical University Shanghai200003China Shanghai Public Health Clinical Center Affiliated with Fudan University Shanghai200083China Shanghai Children's Medical Center Affiliated with Shanghai Jiaotong University Shanghai200025China Zhongshan Hospital Affiliated with Fudan University Shanghai200032China Shanghai Cooperation Group on Central Venous Access Vascular Access Committee of the Solid Tumor Theranostics Committee Shanghai Anti-Cancer Association

Totally implantable access ports(TIAPs)are used for patients with poor peripheral vascular support requiring central venous *** recent years,TIAPs have been gradually accepted and promoted by patients,doctors,and nurses owing to their advantages of convenient carrying,a long maintenance period,low complications,and a high quality of life for ***,medical personnel that handle TIAP implantation and management in China are from different areas of healthcare,including surgery,internal medicine,radiology,nurse anesthesia,vascular access,etc.,and many only handle TIAP as a part of their ***,the operating procedures and steps for the diagnosis and treatment of complications of TIAP vary from person to person,resulting in different incidence and treatment methods for complications in the implantation and use of TIAP in different medical *** on this,we have updated the Shanghai expert consensus on TIAPs from 2015 and explored the diagnosis and treatment procedures of related complications while continuing to emphasize standardized implantation and maintenance.

关键词： Totally implantable access port Implantation Maintenance Standard Complication

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双边贸易、产品关联与中国产品内分工升级

经济地理 2022年第7期42卷 106-116页

作者：丁小义李佳欣浙江工业大学经济学院中国浙江杭州310023

文章基于产品空间视角,结合2001—2019年中国与130多个国家(地区)HS(1996)六分位双边贸易数据,创新引入区分出口目的地和进口来源地密度指标,考察中国与伙伴国(地区)双边产品内分工格局及产品空间结构关系,并采用两步系统GMM法实证检验... 详细信息

文章基于产品空间视角,结合2001—2019年中国与130多个国家(地区)HS(1996)六分位双边贸易数据,创新引入区分出口目的地和进口来源地密度指标,考察中国与伙伴国(地区)双边产品内分工格局及产品空间结构关系,并采用两步系统GMM法实证检验出口关联、进口关联对双边产品内分工深化和升级的影响。研究表明:①虽然2008年金融危机后全球价值链分工发展趋缓,但中国与各伙伴国间的产品内分工程度、产品空间关系仍呈上升趋势,其中“一带一路”沿线国家表现突出;②无论是对总产品内分工还是高端型产品内分工水平,出口关联发挥了积极促进作用,但进口关联不利于双边产品内分工深化与升级,稳健性检验也得到一致结论;③出口关联、进口关联的作用机制迥然不同,作用效应在2008年金融危机前后以及伴随伙伴国收入水平、贸易关系的不同存在差异性,其中“一带一路”沿线国家的出口关联与进口关联更为有效地促进了中国产品内分工深化与升级。

关键词：产品空间全球价值链双边出口关联双边进口关联高端型产品内分工 “一带一路”倡议金融危机

高、低端型产品内国际分工模式变迁及驱动因素分析

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数量经济技术经济研究 2018年第9期35卷 78-95页

作者：丁小义程惠芳浙江工业大学经贸管理学院

研究目标:探索高、低端型产品内分工的演变规律及其核心驱动因素。研究方法:基于45个国家(地区)1996~2016年的HS六位码数据构建指标测算分工水平,然后采用一步SYS-GMM进行实证检验。研究发现:当前的产品内分工体系呈四梯队型的"中心-外... 详细信息

研究目标:探索高、低端型产品内分工的演变规律及其核心驱动因素。研究方法:基于45个国家(地区)1996~2016年的HS六位码数据构建指标测算分工水平,然后采用一步SYS-GMM进行实证检验。研究发现:当前的产品内分工体系呈四梯队型的"中心-外围"格局,且各国的分工形态具有一定的延续性;分工模式的黏性使后期的各种驱动政策极易陷入乏力或失效的境地;相对而言,在"内力型"驱动要素中,人力资本投入对高端型产品内分工的提升作用最为显著;发达国家的OFDI对高端型产品内分工具有显著促进作用,但低端型分工为主国家的FDI、OFDI则反而加剧了"低端陷入"。研究创新:提出国别层面高、低端型产品内分工的测度方法,考察各影响因素对不同模式的作用差异。研究价值:为优化中国分工参与模式提供参考。

关键词：国际分工高端型低端型变迁轨迹驱动因素