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A fractional-N frequency divider for multi-standard wireless transceiver fabricated in 0.18μm CMOS process

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Journal of Semiconductors 2017年第12期38卷 73-80页

作者： Jiafeng Wangt Xiangning Fan xiaoyang shi Zhigong Wang Nanjing Research Institute of Electronics Technology Nanjing 210000China

With the rapid evolution of wireless communication technology, integrating various communication modes in a mobile terminal has become the popular trend. Because of this, multi-standard wireless technology is one of the hot spots in current research. This paper presents a wideband fractional-N frequency divider of the multi-standard wireless transceiver for many applications. High-speed divider-by-2 with traditional source- coupled-logic is designed for very wide band usage. Phase switching technique and a chain of divider-by-2/3 are applied to the programmable frequency divider with 0.5 step. The phase noise of the whole frequency synthesizer will be decreased by the narrower step of programmable frequency divider. A-E modulator is achieved by an improved MASH 1-1-1 structure. This structure has excellent performance in many ways, such as noise, spur and input dynamic range. Fabricated in TSMC 0.18/tin CMOS process, the fractional-N frequency divider occupies a chip area of 1130 × 510μm^2 and it can correctly divide within the frequency range of 0.8-9 GHz. With 1.8 V supply voltage, its division ratio ranges from 62.5 to 254 and the total current consumption is 29 mA.

关键词： multi-standard frequency synthesizer fractional-N frequency divider phase switching △-∑ modulat-or

Experimental Investigation of the Operating Characteristics of a Pulsating Heat Pipe with Ultra-Pure Water and Micro Encapsulated Phase Change Material Suspension

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Journal of Thermal Science 2024年第2期33卷 457-468页

作者： shi Weixiu SU xiaoyang CHEN Hongdi PAN Lisheng Beijing Engineering Research Center of Sustainable Energy and Buildings Beijing University of Civil Engineering and ArchitectureBeijing100044China School of Environment and Energy Engineering Beijing University of Civil Engineering and ArchitectureBeijing100044China State Key Laboratory of High Temperature Gas Dynamics Institute of MechanicsChinese Academy of SciencesBeijing100190China

The specific heat capacity of working fluid is an important influence factor on heat transfer characteristic of the pulsating heat pipe(PHP).Due to the relatively large specific heat capacity of micro encapsulated phase change material(MEPCM) suspension,a heat transfer performance experimental facility of the PHP was established.The heat transfer characteristic with MEPCM suspension of different mass concentrations(0.5% and 1.0%) and ultra-pure water were compared experimentally.It was found that when the PHP uses MEPCM suspension as its working fluid,operating stability is impoverished under lower heating power and the operating stability is better under higher heating power.At the inclination angle of 90°,the temperature at heating side decreases compared to ultra-pure water and the temperature at heating side decreases with the raising of MEPCM suspension mass concentration.The heat transfer characteristic of the PHP is positively correlated with the inclination angle and the 90° is optimum.The unfavorable effect of the inclination angle decreases with heating power increasing.When the inclination angle is 90°,the PHP with MEPCM suspension at 1.0% of mass concentration has the lowest thermal transfer resistance and followed by ultra-pure water and MEPCM suspension at 0.5% of mass concentration has the highest thermal transfer resistance.When the inclination angles are 60° and30°,the effect of gravity on the flow direction is reduced to 86.6% and 50% of that on the inclination angle of 90°,respectively,and the promoting effect of gravity on the working fluid is further weakened as the inclination angle further decreases.Due to the high viscosity of MEPCM suspension,the PHP with ultra-pure water has the lowest heat transfer resistance.When the inclination angles is 60°,the thermal resistance with MEPCM suspension at0.5% of the mass concentration is lower than that at 1.0% at the heating power below 230 W.The thermal resistance of MEPCM suspension tends to be similar for heating power of 230-250 W.At the heating

关键词： pulsating heat pipe(PHP) micro encapsulated phase change material(MEPCM) heat transfer characteristic inclination angle

2型糖尿病患者血糖目标范围内时间与代谢相关脂肪性肝病及肝纤维化的相关性研究

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中华内分泌代谢杂志 2024年第3期40卷 198-203页

作者：王丹钰刘凯坤邓欣如史晓阳杨俊朋徐娜陈耀楠袁慧娟河南省人民医院(郑州大学人民医院)内分泌科郑州450003 河南省人民医院(郑州大学人民医院)老年医学科郑州450003

目的探讨2型糖尿病患者血糖目标范围内时间(time in range,TIR)与代谢相关脂肪性肝病(metabolic associated fatty liver disease,MAFLD)及进展期肝纤维化的相关性。方法本研究为回顾性研究,选取2019年10月至2022年4月河南省人民医院内... 详细信息

目的探讨2型糖尿病患者血糖目标范围内时间(time in range,TIR)与代谢相关脂肪性肝病(metabolic associated fatty liver disease,MAFLD)及进展期肝纤维化的相关性。方法本研究为回顾性研究,选取2019年10月至2022年4月河南省人民医院内分泌科494例2型糖尿病患者作为研究对象,TIR来自持续血糖监测数据,腹部超声诊断脂肪肝,瞬时弹性成像技术的肝脏硬度值评估肝纤维化。采用Pearson相关性分析及多元线性回归分析评估TIR与肝脏硬度值的相关性,采用logistic回归分析评估TIR与MAFLD及进展期肝纤维化患病风险的相关性。结果Pearson相关性分析显示,TIR与肝脏硬度值呈负相关(r=-0.86,P<0.001),稳态模型评估的胰岛素抵抗指数(HOMA-IR)与肝脏硬度值呈正相关(r=0.48,P<0.001);调整混杂因素后,多元线性回归分析显示,TIR负向预测肝脏硬度值(β=-0.75,P<0.001),HOMA-IR正向预测肝脏硬度值(β=0.21,P=0.025);调整混杂因素后,logistic回归分析显示,与TIR Q4患者相比,TIR Q1患者MAFLD(OR=1.96,95%CI 1.07~3.62,P=0.027)及进展期肝纤维化(OR=3.82,95%CI 1.17~12.50,P=0.027)患病风险增加,HOMA-IR是MAFLD(OR=1.22,95%CI 1.04~1.43,P=0.005)及进展期肝纤维化(OR=1.26,95%CI 1.03~1.54,P=0.025)的独立危险因素。结论2型糖尿病患者中,低水平TIR、胰岛素抵抗是MAFLD及进展期肝纤维化的独立危险因素,TIR对MAFLD及进展期肝纤维化发生有显著的预测价值。

关键词：目标范围内时间代谢相关脂肪性肝病进展期肝纤维化

孕早期血清25-羟维生素D_(3)水平与胰岛素抵抗及妊娠糖尿病的相关性

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河南医学研究 2024年第8期33卷 1426-1429页

作者：杜小婉吕英华杨俊朋史晓阳郑州大学第一附属医院国际医学部河南郑州450000 河南省人民医院内分泌科河南郑州450000

目的探讨孕早期血清25-羟维生素D_(3)[25-(OH)D_(3)]水平与胰岛素抵抗和妊娠糖尿病(GDM)的关系。方法回顾性分析2022年1—12月在河南省人民医院体检的560例孕早期(孕5~12周)女性临床病历资料,根据孕24~28+6周的口服葡萄糖耐量试验检测... 详细信息

目的探讨孕早期血清25-羟维生素D_(3)[25-(OH)D_(3)]水平与胰岛素抵抗和妊娠糖尿病(GDM)的关系。方法回顾性分析2022年1—12月在河南省人民医院体检的560例孕早期(孕5~12周)女性临床病历资料,根据孕24~28+6周的口服葡萄糖耐量试验检测结果将患者分为GDM组和对照组。统计孕早期维生素D营养状态与GDM发生率,比较GDM组和对照组孕妇血清25-(OH)D_(3)水平、稳态模型的胰岛素抵抗指数(HOMA-IR),采用Pearson相关性分析孕早期血清25-(OH)D_(3)水平与HOMA-IR的相关性,采用logistic回归分析孕早期血清25-(OH)D_(3)水平及HOMA-IR与GDM的关系。结果纳入的560例孕妇中GDM发生率为7.86%,其中孕早期维生素D缺乏者,GDM发生率达到81.82%,孕早期不同维生素D营养状态的孕妇GDM发生率比较,差异有统计学意义(P<0.05)。GDM组孕妇血清25-(OH)D_(3)水平低于对照组,HOMA-IR高于对照组,差异均有统计学意义(P<0.05)。Pearson相关性分析结果显示,孕早期血清25-(OH)D_(3)水平与HOMA-IR呈负相关(r=-0.674,P<0.05);logistic回归分析结果显示,孕早期血清25-(OH)D_(3)水平低下和HOMA-IR升高是GDM发生的独立危险因素(P<0.05)。结论孕早期血清25-(OH)D_(3)水平与HOMA-IR呈负相关,是GDM发生的独立危险因素。孕早期维生素D缺乏在一定程度上可增加妊娠期妇女GDM发生风险,妊娠期应适当补充维生素D制剂,以降低GDM发生风险。

关键词：孕早期 25-羟维生素D_(3) 胰岛素抵抗妊娠糖尿病相关性

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Potential Secretory Transporters and Biosynthetic Precursors of Biological Nitrification Inhibitor 1,9-Decanediol in Rice as Revealed by Transcriptome and Metabolome Analyses

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Rice science 2024年第1期31卷 87-102页

作者： DI Dongwei MA Mingkun ZHANG xiaoyang LU Yufang Herbert J.KRONZUCKER shi Weiming State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China School of Food Science and Engineering Foshan UniversityFoshan 528000China School of BioSciences The University of MelbourneParkvilleVIC 3010Australia University of Chinese Academy of Sciences Beijing 100049China

Biological nitrification inhibitors(BNIs)are released from plant roots and inhibit the nitrification activity of microorganisms in soils,reducing NO_(3)^(‒)leaching and N2O emissions,and increasing nitrogenuse efficiency(NUE).Several recent studies have focused on the identification of new BNIs,yet little is known about the genetic loci that govern their biosynthesis and secretion.We applied a combined transcriptomic and metabolomic analysis to investigate possible biosynthetic pathways and transporters involved in the biosynthesis and release of BNI 1,9-decanediol(1,9-D),which was previously identified in rice root exudates.Our results linked four fatty acids,icosapentaenoic acid,linoleate,norlinolenic acid,and polyhydroxy-α,ω-divarboxylic acid,with 1,9-D biosynthesis and three transporter families,namely the ATP-binding cassette protein family,the multidrug and toxic compound extrusion family,and the major facilitator superfamily,with 1,9-D release from roots into the soil medium.Our finding provided candidates for further work on the genes implicated in the biosynthesis and secretion of 1,9-D and pinpoint genetic loci for crop breeding to improve NUE by enhancing 1,9-D secretion,with the potential to reduce NO_(3)^(‒)leaching and N2O emissions from agricultural soils.

关键词： 1,9-decanediol biological nitrification inhibitor metabolomic analysis nitrogen-use efficiency transcriptomic analysis

基于体医融合思想的成年人科学健身素养评价量表的编制及信效度检验

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中华全科医学 2024年第4期22卷 685-689页

作者：赵佳丽刘鑫羽陈志华石潇洋高尚尚郭建军王彦河北大学护理学院河北保定071000 保定市莲池区退役军人事务局河北保定072750 河北大学体育教学部河北保定071000 天津中医药大学护理学院天津300193 首都体育学院北京100091

目的基于体医融合思想编制成年人科学健身素养评价量表,并对所编制量表进行信、效度检验,为评价成年人科学健身素养提供测评工具。方法以课题组前期构建的体医融合背景下成年人科学健身素养指标体系为基础,将三级指标转化为量表的具体条... 详细信息

目的基于体医融合思想编制成年人科学健身素养评价量表,并对所编制量表进行信、效度检验,为评价成年人科学健身素养提供测评工具。方法以课题组前期构建的体医融合背景下成年人科学健身素养指标体系为基础,将三级指标转化为量表的具体条目,通过专家咨询评价量表内容效度和小样本预实验进行量表的语言调试;采用便利抽样法选取18~59岁成年人进行问卷调查,将回收的581份有效问卷分为2个部分,其中300份样本用于条目筛选,281份样本用于信效度检验。结果经专家评定、条目筛选,最终确定了基于体医融合思想的成年人科学健身素养评价量表包含科学健身知识、科学健身态度、科学健身行为与技能3个维度,共53个条目。内容效度指数S-CVI/Ave为0.981,I-CVI为0.833~1.000;通过探索性因子分析,提取3个公因子,累积方差贡献率为52.26%;通过验证性因子分析,提示模型与数据拟合良好(χ^(2)/df=2.054,RMSEA=0.061,SRMR=0.049,IFI=0.882,TLI=0.876,CFI=0.881),支持三因子模型;总量表Cronbach'sα系数为0.964,2周后总量表的重测信度为0.871。结论本研究中编制的基于体医融合思想的成年人科学健身素养评价量表具有良好的信度和效度,可用于评价成年人科学健身素养水平。

关键词：科学健身素养体医融合成年人量表信效度

Wheat kinase TaSnRK2.4 forms a functional module with phosphatase TaPP2C01 and transcription factor TaABF2 to regulate drought response

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The Crop Journal 2024年第2期12卷 384-400页

作者： Yanyang Zhang xiaoyang Hou Tianjiao Li Ziyi Wang Jiaqi Zhang Chunlin Zhang Xianchang Liu Xinxin shi Wanrong Duan Kai Xiao State Key Laboratory of North China Crop Improvement and Regulation Baoding 071001HebeiChina College of Agronomy Hebei Agricultural UniversityBaoding 071001HebeiChina

SNF1-related protein kinase 2(SnRK2)family members are essential components of the plant abscisic acid(ABA)signaling pathway initiated by osmotic stress and triggering a drought stress response.This study characterized the molecular properties of TaSnRK2.4 and its function in mediating adaptation to drought in Triticum aestivum.Transcripts of TaSnRK2.4 were upregulated upon drought and ABA signaling and associated with drought-and ABA-responsive cis-elements ABRE and DRE,and MYB and MYC binding sites in the promoter as indicated by reporter GUS protein staining and activity driven by truncations of the promoter.Yeast two-hybrid,BiFC,and Co-IP assays indicated that TaSnRK2.4 protein interacts with TaPP2C01 and an ABF transcription factor(TF)TaABF2.The results suggested that TaSnRK2.4 forms a functional TaPP2C01-TaSnRK2.4-TaABF2 module with its upstream and downstream partners.Transgene analysis revealed that TaSnRK2.4 and TaABF2 positively regulate drought tolerance whereas TaPP2C01 acts negatively by modulating stomatal movement,osmotic adjustment,reactive oxygen species(ROS)homeostasis,and root morphology.Expression analysis,yeast one-hybrid,and transcriptional activation assays indicated that several osmotic stress-responsive genes,including TaSLAC1-4,TaP5CS3,TaSOD5,TaCAT1,and TaPIN4,are regulated by TaABF2.Transgene analysis verified their functions in positively regulating stomatal movement(TaSLAC1-4),proline accumulation(TaP5CS3),SOD activity(TaSOD5),CAT activity(TaCAT1),and root morphology(TaPIN4).There were high correlations between plant biomass and yield with module transcripts in a wheat variety panel cultivated under drought conditions in the field.Our findings provide insights into understanding plant drought response underlying the SnRK2 signaling pathway in common wheat.

关键词： Triticum aestivum SnRK2.4 kinase Gene expression Protein interaction Transgene analysis Transcriptional activation

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口腔微生物与食管疾病关系的研究进展

临床误诊误治 2024年第4期37卷 96-100页

作者：李晓芳曹旭师晓阳李玉婵王津郭嘉璇吕一豪王慧洁石家庄市中医院内镜室石家庄050051

口腔微生物与人类疾病的相关性是近年来的研究热点。口腔微生物除了与口腔疾病具有密切关系外,还与消化道其他器官疾病密切相关,其中食管疾病很少受到关注。本文旨在总结当前口腔微生物组与食管疾病之间关联的证据,这些证据表明与胃食... 详细信息

口腔微生物与人类疾病的相关性是近年来的研究热点。口腔微生物除了与口腔疾病具有密切关系外,还与消化道其他器官疾病密切相关,其中食管疾病很少受到关注。本文旨在总结当前口腔微生物组与食管疾病之间关联的证据,这些证据表明与胃食管反流病、巴雷特食管、食管鳞状细胞癌和食管腺癌相关的口腔微生物组具有独有的特征,这种从较高革兰阳性菌比例到革兰阴性菌更占优势的转变被认为与食管疾病的发生发展有关。口腔微生物组改变与食管疾病的关联机制可能是由于革兰阴性菌脂多糖的表达,特别是福赛斯坦纳菌和牙龈卟啉单胞菌参与食管癌发展的信号通路。识别口腔微生物组的改变将会促进临床对食管疾病病因、发病机制和进展的理解,促进新诊断方法出现,并为制订个性化治疗方案奠定基础。

关键词：口腔微生物组胃食管反流病巴雷特食管食管鳞状细胞癌食管腺癌革兰阳性菌革兰阴性菌综述

长短效胰高糖素样肽-1受体激动剂序贯联合钠-葡萄糖共转运蛋白2抑制剂优化治疗合并心血管疾病高风险的长病程2型糖尿病患者1例

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中华糖尿病杂志 2022年第11期14卷 1314-1317页

作者：史晓阳阚全娥袁慧娟河南省人民医院内分泌代谢病科郑州450003

回顾性分析1例在河南省人民医院内分泌代谢病科住院合并心血管疾病(CVD)高风险的长病程2型糖尿病(T2DM)患者在给予胰岛素强化治疗后,先后应用利拉鲁肽和司美格鲁肽序贯治疗的诊疗过程并进行文献复习。患者为60岁女性,体型肥胖,合并高血... 详细信息

回顾性分析1例在河南省人民医院内分泌代谢病科住院合并心血管疾病(CVD)高风险的长病程2型糖尿病(T2DM)患者在给予胰岛素强化治疗后,先后应用利拉鲁肽和司美格鲁肽序贯治疗的诊疗过程并进行文献复习。患者为60岁女性,体型肥胖,合并高血压、血脂异常,既往T2DM病史15年,长期应用胰岛素降糖治疗,评估胰岛功能及CVD风险后,出院时调整治疗方案为利拉鲁肽(1.2 mg/d),联合二甲双胍0.5 g(3次/d)、卡格列净100 mg(1次/d)。随访期间将利拉鲁肽调整为司美格鲁肽0.5 mg(1次/周),观察3个月后,患者血糖平稳,体重达标,依从性良好。对于存在CVD高危因素或有动脉粥样硬化性心血管疾病的T2DM患者,长效胰高糖素样肽-1受体激动剂(GLP-1RA)司美格鲁肽可联合其他降糖药物,简化用药、平稳降糖,同时实现CVD获益。

关键词：糖尿病,2型心血管疾病胰高糖素样肽-1受体激动剂