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Dynamic extending nonlinear H_∞ control and its application to hydraulic turbine governor

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Science China(Technological Sciences) 2007年第5期50卷 618-635页

作者： MEI ShengWei GUI xiaoyang SHEN Chen lu Qiang State Key Laboratory of Power System Department of Electrical Engineering Tsinghua University Beijing 100084 China State Key Laboratory of Power System Department of Electrical Engineering Tsinghua University Beijing 100084 China State Key Laboratory of Power System Department of Electrical Engineering Tsinghua University Beijing 100084 China State Key Laboratory of Power System Department of Electrical Engineering Tsinghua University Beijing 100084 China

There exists a large class of nonlinear systems with uncertainties, such as hydrau- lic turbine governors, whose robust control problem is hard to solve by means of the existing robust control approaches. For this class of systems, this work pre- sents a dynamic extending H∞ controller via both differential geometry and H∞ the- ory. Furthermore, based on differential game theory, it has been verified that the proposed control strategy has robustness in the sense that the disturbance can be attenuated effectively because the L2-gain from the disturbance input to the regu- lation output signal could be reduced to any given level. Thirdly, a robust control strategy for hydraulic turbine governor is designed according to the proposed ex- tending H∞ control method, and has been developed into a real control equipment. Finally the field experiments are carried out which show clearly that the developed control equipment can enhance transient stability of power systems more effec- tively than the conventional controller.

关键词： dynamic extending H∞ control, nonlinear system, robust control, hydraulic turbine governor

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针刺联合尼莫地平治疗缺血性脑卒中的效果

世界复合医学 2024年第3期10卷 128-131页

作者：张琴卢晓阳李世魁金昌市中心医院神经内外科甘肃金昌737100

目的探究针刺联合尼莫地平治疗缺血性脑卒中的效果。方法便利选取2022年9月—2023年11月金昌市中心医院收治的72例缺血性脑卒中患者为研究对象,利用双色球分组法分为常规组(红球)和研究组(白球),各36例。常规组予以基本治疗方案,研究组... 详细信息

目的探究针刺联合尼莫地平治疗缺血性脑卒中的效果。方法便利选取2022年9月—2023年11月金昌市中心医院收治的72例缺血性脑卒中患者为研究对象,利用双色球分组法分为常规组(红球)和研究组(白球),各36例。常规组予以基本治疗方案,研究组在常规组基础上予以针刺治疗,比较两组治疗有效率、治疗前后脑血管动力学参数、治疗前后美国国立卫生研究院卒中量表(National Institutes of Health Stroke Scale,NIHSS)评分和中医证候积分。结果研究组的治疗有效率、治疗后脑血管动力学参数均优于常规组,差异有统计学意义(P均<0.05)。研究组治疗后NIHSS评分和中医证候积分分别为(4.55±1.30)分、(9.58±3.13)分,均低于常规组,差异有统计学意义(t=10.996、11.809,P均<0.05)。结论针刺联合尼莫地平治疗可有效减轻缺血性脑卒中患者的症状,改善脑血管动力,促进神经功能恢复,安全性较高。

关键词：缺血性脑卒中尼莫地平针刺效果

静脉注射头孢菌素类药物患者过敏反应发生率及其影响因素的多中心临床研究

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浙江大学学报（医学版） 2024年第5期53卷 615-622页

作者：阳平戴单单李晴宇詹海潮李旭梅芦小燕何敏陈娜姜赛平卢晓阳浙江大学医学院附属第一医院临床药学科浙江杭州310003 浙江省药物评价与临床研究重点实验室浙江杭州310003 浙江省中药临床评价与转化研究重点实验室浙江杭州310003 宁波大学第一附属医院药学部浙江宁波315000 浙江大学医学院附属杭州市第一人民医院药学部浙江杭州310006 金华市中心医院药学部浙江金华321000 嘉兴市第二医院药学部浙江嘉兴314001 宁波市第二医院药学部浙江宁波315010 杭州市萧山区第一人民医院临床药学科浙江杭州311200

目的:分析头孢菌素类药物过敏反应的发生率及其影响因素。方法:横断面调研2021年4月1日至6月30日浙江省29家医疗机构所有接受静脉注射头孢菌素类药物的患者,统计头孢菌素类药物过敏反应的发生率,采用泊松回归模型分析头孢菌素类药物诱... 详细信息

目的:分析头孢菌素类药物过敏反应的发生率及其影响因素。方法:横断面调研2021年4月1日至6月30日浙江省29家医疗机构所有接受静脉注射头孢菌素类药物的患者,统计头孢菌素类药物过敏反应的发生率,采用泊松回归模型分析头孢菌素类药物诱导过敏反应发生的相关影响因素。结果:研究共纳入56155例患者,头孢菌素类药物过敏反应总发生率为1.67‰,过敏反应发生率最高的是头孢唑肟(4.27‰),其次是头孢曲松(3.49‰)和头孢噻肟(2.40‰)。与皮试阴性组比较,非皮试组患者过敏反应发生率无明显增加(分别为1.75‰与1.63‰,RR=1.07,95%CI:0.70~1.63,P>0.05)。泊松回归分析结果显示,体重指数低于18.5 kg/m^(2)(RR=2.43,95%CI:1.23~4.82,P<0.05)、其他β-内酰胺类药物过敏史(RR=33.88,95%CI:1.47~781.12,P<0.05)会增加头孢菌素类药物过敏反应的发生率,且与头孢呋辛比较,头孢曲松(RR=3.08,95%CI:1.70~5.59,P<0.01)、头孢他啶(RR=1.89,95%CI:1.03~3.47,P<0.05)和头孢唑肟(RR=3.74,95%CI:1.64~8.50,P<0.01)过敏反应发生的风险增加。结论:头孢菌素类药物过敏反应与低体重指数和β-内酰胺类药物过敏史有关,头孢菌素类药物的常规皮试筛查并不能减少过敏反应发生。

关键词：头孢菌素皮试过敏反应体重指数 β-内酰胺类药物

Insights into the catalytic mechanism of a type I sulfide quinone oxidoreductase(SQR)from Acidithiobacillus caldus

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Systems Microbiology and Biomanufacturing 2023年第3期3卷 414-426页

作者： xiaoyang lu Linghui Zhao Yanjun Tong Hailin Yang Shoushuai Feng Key Laboratory of Industrial Biotechnology Ministry of EducationSchool of BiotechnologyJiangnan UniversityWuxiChina State Key Laboratory of Food Science and Technology Jiangnan UniversityWuxiChina School of Food Science and Technology Jiangnan University1800 Lihu RoadWuxiChina

Acidithiobacillus caldus,a typical sulfur oxidizer,derives the majority of its energy from sulfur *** the essential enzyme for sulfide oxidation catalysis is sulfide quinone oxidoreductase(SQR),an ancient ***,the catalytic mechanism of SQR generated from *** was investigated(SQR^(Ac)).According to phylogenetic study,SQR^(Ac)(ACAty RS11315)is closely related to SQR(BAD99305)of Acidithiobacillus ferrooxidans NASF-1 and is classified as a type I Sqr ***^(Ac)heterologously produced in Escherichia coli exhibits the distinctive absorption peaks(375,450 nm)of the flavoproteins family of proteins in its absorption *** site-directed mutagenesis,the function of conserved cysteines in the catalytic pathway was *** on the sulfide quinone redox reactions in vitro of SQR^(Ac)and variations,Cys160 and Cys356 have been identified as enzyme-active *** of another cysteine present in all type I SQRs(Cys128)decreased enzyme activity by 56%,indicating that this residue plays an important but non-essential role in enzyme *** addition,the binding affinities of SQR^(Ac),the visualization of its 3D structure,and the interaction between receptors and ligands were ***,a suitable sulfide quinone redox catalytic mechanism for *** was proposed.

关键词： Sulfide quinone oxidoreductase Sulfur metabolism Quinone redox Acidithiobacillus caldus Enzyme kinetics

Pressure of Newtonian Fluid Flow through Curved Pipes and Elbows

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Journal of Thermal Science 2013年第4期22卷 372-376页

作者： Hao Zhang Xinxin Zhang Haosen Sun Mingjiu Chen xiaoyang lu Yuancheng Wang Xueting Liu Key Laboratory of Renewable Energy Utilization Technologies in Buildings Ministry of Education Shandong Key Laboratory of Renewable Energy Utilization Technologies in Buildings Shandong Jianzhu University School of Thermal Energy Engineering Shandong Jianzhu University Department of Thermal Engineering University of Science and Technology Beijing Shandong Jianzhu University Archives Institute of Engineering Mechanics Shandong Jianzhu University

Under conditions of high temperature and high pressure, the non-uniformity of pressure loads has intensified the stress concentration which impacts the safety of curved pipes and elbows. This paper focuses on the pressure distribution and flow characteristic in a curved 90° bend pipe with circular cross-sections, which are widely used in industrial applications. These flow and pressure characteristics in curved bend pipes have been researched by employing numerical simulation and theoretical analysis. Based on the dimensionless analysis method a formula for the pressure of Newtonian fluid flow through the elbow pipes is deduced. Also the pressure distributions of several elbows with different curvature ratio R/D are obtained by numerical methods. The influence of these non-dimensional parameters such as non-dimensional curvature ratio, Reynolds number and non-dimensional axial angle a and circumferential angle fl on the pressure distribution in elbow pipes is discussed in detail. A number of important results have been achieved. This paper provides theoretical and numerical methods to understand the mechanical property of fluid flow in elbow pipes, to analyze the stress and to design the wall thickness of elbow pipes.

关键词： Newtonian fluid Dimensional analysis Pressure formula Numerical study

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利用GAT的光伏阵列故障诊断方法

福州大学学报（自然科学版） 2024年第5期52卷 505-512页

作者：董浪灿卢箫扬林培杰程树英陈志聪吴丽君福州大学物理与信息工程学院微纳器件与太阳能电池研究所福建福州350108

提出一种基于图注意力网络(graph attention network,GAT)的光伏阵列故障诊断模型,以解决光伏阵列中因故障导致的发电效率降低、正常运行受阻等问题.通过离散小波变换和滑窗算法截取故障后稳态时序信号并将其分割成子区间,将子区间视为... 详细信息

提出一种基于图注意力网络(graph attention network,GAT)的光伏阵列故障诊断模型,以解决光伏阵列中因故障导致的发电效率降低、正常运行受阻等问题.通过离散小波变换和滑窗算法截取故障后稳态时序信号并将其分割成子区间,将子区间视为图节点.使用K邻近构图法将故障后稳态电压、电流数据转变成图结构,构建节点级GAT模型.通过多头注意力机制自动提取电压、电流图结构的故障特征.通过实验室光伏阵列获取实验数据集,对所提模型进行测试.结果表明,本模型能准确诊断光伏阵列的不同故障状态,平均准确率达到99.790%,效果优于所对比的其他网络模型.

关键词：光伏阵列故障诊断图结构图神经网络注意力机制

The Memory-Bounded Speedup Model and Its Impacts in Computing

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Journal of Computer Science & Technology 2023年第1期38卷 64-79页

作者：孙贤和鲁潇阳 Department of Computer Science Illinois Institute of TechnologyChicago 60616U.S.A.

With the surge of big data applications and the worsening of the memory-wall problem,the memory system,instead of the computing unit,becomes the commonly recognized major concern of ***,this“memorycentric”common understanding has a humble *** than three decades ago,the memory-bounded speedup model is the first model recognizing memory as the bound of computing and provided a general bound of speedup and a computing-memory trade-off *** memory-bounded model was well received even by *** was immediately introduced in several advanced computer architecture and parallel computing textbooks in the 1990’s as a must-know for scalable *** include *** Hwang’s book“Scalable Parallel Computing”in which he introduced the memory-bounded speedup model as the Sun-Ni’s Law,parallel with the Amdahl’s Law and the Gustafson’s *** the years,the impacts of this model have grown far beyond parallel processing and into the fundamental of *** this article,we revisit the memory-bounded speedup model and discuss its progress and impacts in depth to make a unique contribution to this special issue,to stimulate new solutions for big data applications,and to promote data-centric thinking and rethinking.

关键词： memory-bounded speedup scalable computing memory-wall performance modeling and optimization data-centric design

基于R语言软件挖掘姚魁武教授辨治高血压组方用药规律研究

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四川中医 2024年第8期42卷 17-22页

作者：逯晓阳姚魁武刘思琛孙迪徐思雨段锦龙中国中医科学院广安门医院北京100053 中国中医科学院眼科医院北京100000

目的:基于R语言软件分析首都中青年名中医、中国中医科学院博士研究生导师姚魁武教授辨治高血压组方用药规律。方法:筛选姚魁武教授2021年1月~2023年10月门诊治疗高血压病的病案,检索并收集主诊断为高血压患者的临床病历资料及中医处方... 详细信息

目的:基于R语言软件分析首都中青年名中医、中国中医科学院博士研究生导师姚魁武教授辨治高血压组方用药规律。方法:筛选姚魁武教授2021年1月~2023年10月门诊治疗高血压病的病案,检索并收集主诊断为高血压患者的临床病历资料及中医处方信息,通过EXCEl 2019软件构建高血压患者门诊病历数据库,归纳分析患者年龄性别、中医证型、中药性味归经、药物关联规则、高频药物相关性及聚类分析。结果:共筛选出324位患者病历信息,年龄以40~70岁频数最多;涵盖中医证型16种,频数前五的中医证型为肝阳上亢证、痰瘀互结证、肝肾阴虚证、肝郁脾虚证、气滞血瘀证;使用中药139味,使用频数前10的中药为葛根、天麻、川芎、白芍、茯苓、桂枝、丹参、白术、珍珠母、杜仲,四气以寒、温、平为主,五味以甘、苦、辛居多,归经则集中在肝、心、脾、肺、肾、胃经;使用频数≥60的中药共有33味;设置支持度≥15%,置信度≥90%,得到关联规则33个;相关性分析获得较强关联的药物12组;聚类分析共得到9类。结论:姚魁武教授临床治疗高血压病以“和合思想”为主,用药重在调肝脾、合阴阳,随证配伍兼顾补虚、清热、活血化瘀、祛浊化痰等法,为临床治疗高血压病提供新的思路与指导。

关键词：高血压用药规律姚魁武 R语言数据挖掘

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《抗菌药物临床应用管理标准》制订与解析

医药导报 2024年第8期43卷 1222-1225页

作者：陈璋璋甄健存吕迁洲姜玲卢晓阳张志清陈英李晓宇复旦大学附属中山医院药剂科上海200032 首都医科大学附属北京积水潭医院药学部北京100035 中国医院协会药事专业委员会北京100035 中国科学技术大学附属第一医院(安徽省立医院)药学部合肥230031 浙江大学医学院附属第一医院药学部杭州310003 河北医科大学第二医院药学部石家庄050000 广西壮族自治区人民医院药学部南宁530016

抗菌药物临床应用管理是医疗机构药事管理和药学服务的重要组成部分。该标准以抗菌药物在医疗机构的生命全周期为主线,以国家政策法规为依据,以科学性、通用性、指导性和可操作性为编写原则,通过梳理问题、征集意见、专家论证审议而形成... 详细信息

抗菌药物临床应用管理是医疗机构药事管理和药学服务的重要组成部分。该标准以抗菌药物在医疗机构的生命全周期为主线,以国家政策法规为依据,以科学性、通用性、指导性和可操作性为编写原则,通过梳理问题、征集意见、专家论证审议而形成,是国内外首部对抗菌药物临床应用管理进行规范的团体标准。该文通过对该标准制订过程中的团队组成、问题梳理和编制流程以及标准各要素进行介绍与解析,为广大使用该标准的同行提供参考。

关键词：抗菌药物细菌耐药性合理用药治疗药物监测