检索结果-南通市图书馆

Efficacy of exercise rehabilitation for managing patients with Alzheimer's disease

Neural Regeneration Research 2024年第10期19卷 2175-2188页

作者： Dan Li Jinning Jia Haibo Zeng xiaoyan zhong Hui Chen Chenju Yi Department of Pathology The First Affiliated Hospital of Gannan Medical UniversityGanzhouJiangxi ProvinceChina Department of Pathology Huichang County People’s HospitalGanzhouJiangxi ProvinceChina School of Life Sciences Faculty of ScienceUniversity of Technology SydneyUltimoNSWAustralia Research Center The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhenGuangdong ProvinceChina Shenzhen Key Laboratory of Chinese Medicine Active Substance Screening and Translational Research ShenzhenGuangdong ProvinceChina Guangdong Provincial Key Laboratory of Brain Function and Disease GuangzhouGuangdong ProvinceChina

Alzheimer's disease(AD) is a progressive and degenerative neurological disease characterized by the deterioration of cognitive functions. While a definitive cure and optimal medication to impede disease progression are currently unavailable, a plethora of studies have highlighted the potential advantages of exercise rehabilitation for managing this condition. Those studies show that exercise rehabilitation can enhance cognitive function and improve the quality of life for individuals affected by AD. Therefore, exercise rehabilitation has been regarded as one of the most important strategies for managing patients with AD. Herein, we provide a comprehensive analysis of the currently available findings on exercise rehabilitation in patients with AD, with a focus on the exercise types which have shown efficacy when implemented alone or combined with other treatment methods, as well as the potential mechanisms underlying these positive effects. Specifically, we explain how exercise may improve the brain microenvironment and neuronal plasticity. In conclusion, exercise is a cost-effective intervention to enhance cognitive performance and improve quality of life in patients with mild to moderate cognitive dysfunction. Therefore, it can potentially become both a physical activity and a tailored intervention. This review may aid the development of more effective and individualized treatment strategies to address the challenges imposed by this debilitating disease, especially in low-and middle-income countries.

关键词： Alzheimer's disease cerebrovascular function cognitive function epigenetic regulation exercise hippocampal neurogenesis mitochondria neuroinflammation neuronal plasticity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Mixed Integer Robust Programming Model for Multimodal Fresh Agricultural Products Terminal Distribution Network Design

引用

工程与科学中的计算机建模(英文) 2024年第1期138卷 719-738页

作者： Feng Yang zhong Wu xiaoyan Teng Business School University of Shanghai for Science and TechnologyShanghai200093China School of Management Shanghai University of International Business and EconomicsShanghai201620China

The low efficiency and high cost of fresh agricultural product terminal distribution directly restrict the operation of the entire supply network.To reduce costs and optimize the distribution network,we construct a mixed integer programmingmodel that comprehensively considers tominimize fixed,transportation,fresh-keeping,time,carbon emissions,and performance incentive costs.We analyzed the performance of traditional rider distribution and robot distribution modes in detail.In addition,the uncertainty of the actual market demand poses a huge threat to the stability of the terminal distribution network.In order to resist uncertain interference,we further extend the model to a robust counterpart form.The results of the simulation show that the instability of random parameters will lead to an increase in the cost.Compared with the traditional rider distribution mode,the robot distribution mode can save 12.7%on logistics costs,and the distribution efficiency is higher.Our research can provide support for the design of planning schemes for transportation enterprise managers.

关键词： Fresh agricultural product terminal distribution network rider delivery robot delivery uncertainty

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ultrasmall iron-quercetin metal natural product nanocomplex with antioxidant and macrophage regulation in rheumatoid arthritis

引用

Acta Pharmaceutica Sinica B 2023年第4期13卷 1726-1739页

作者： Zhihui Han Xiang Gao Yuanjie Wang Shuning Cheng xiaoyan zhong Yong Xu Xiaozhong Zhou Zengli Zhang Zhuang Liu Liang Cheng Institute of Functional Nano&Soft Materials(FUNSOM) Collaborative Innovation Center of Suzhou Nano Science and TechnologySoochow UniversitySuzhou 215123China Department of Orthopedics The Second Affiliated Hospital of Soochow UniversitySuzhou 215004China Department of Environmental Health School of Public HealthSoochow UniversitySuzhou 215123China School of Materials and Energy Guangdong University of TechnologyGuangzhou 510006China

Oxidative stress,due to the disruption of the balance between reactive oxygen species(ROS)generation and the antioxidant defense system,plays an important role in the pathogenesis of rheumatoid arthritis(RA).Excessive ROS leads to the loss of biological molecules and cellular functions,release of many inflammatory mediators,stimulate the polarization of macrophages,and aggravate the inflammatory response,thus promoting osteoclasts and bone damage.Therefore,foreign antioxidants would effectively treat RA.Herein,ultrasmall iron-quercetin natural coordination nanoparticles(Fe-Qur NCNs)with excellent anti-inflammatory and antioxidant properties were constructed to effectively treat RA.Fe-Qur NCNs obtained by simple mixing retain the inherent ability to remove ROS of quercetin and have a better water-solubility and biocompatibility.In vitro experiments showed that Fe-Qur NCNs could effectively remove excess ROS,avoid cell apoptosis,and inhibit the polarization of inflammatory macrophages by reducing the activation of the nuclear factor-κ-gene binding(NF-κB)pathways.In vivo experiments showed that the swollen joints of mice with rheumatoid arthritis treated with Fe-Qur NCNs significantly improved,with Fe-Qur NCNs largely reducing inflammatory cell infiltration,increasing antiinflammatory macrophage phenotypes,and thus inhibiting osteoclasts,which led to bone erosion.This study demonstrated that the new metal-natural coordination nanoparticles could be an effective therapeutic agent for the prevention of RA and other diseases associated with oxidative stress.

关键词： Metal-natural coordination nanoparticles ROS scavenge Macrophage polarization Rheumatoid arthritis Antioxidant Inflammation Nanomedicine Apoptosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Titanium carbide nanosheets with defect structure for photothermal-enhanced sonodynamic therapy

引用

Bioactive Materials 2022年第2期7卷 409-419页

作者： Guangqiang Li xiaoyan zhong Xianwen Wang Fei Gong Huali Lei Yangkai Zhou Chengfei Li Zhidong Xiao Guoxi Ren Liang Zhang Zhiqiang Dong Zhuang Liu Liang Cheng College of Science State Key Laboratory of Agricultural MicrobiologyHuazhong Agricultural UniversityWuhan430070China Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow UniversitySuzhou215123China Department of Toxicology School of Public HealthMedical College of Soochow UniversitySuzhou215123China State Key Laboratory of Functional Materials for Informatics Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai200050China College of Biomedicine and Health College of Life Science and TechnologyHuazhong Agricultural UniversityWuhanHubei430070China

Sonodynamic therapy(SDT)has attracted widespread interest in biomedicine,owing to its novel and noninvasive therapeutic method triggered by ultrasound(US).Herein,the Ti_(3)C_(2) MXene nanosheets(Ti_(3)C_(2) NSs)are developed as good sonosensitizers via a two-step method of chemical exfoliation and high-temperature treatment.With the high-temperature treatment,the oxygen defect of Ti_(3)C_(2) MXene nanosheets(H-Ti_(3)C_(2) NSs)is greatly increased.Therefore,the electron(e^(-))and hole(h^(+))generated by US can be separated faster due to the improved degree of oxidation,and then the recombination of e^(-)-h^(+)can be prevented with the abundant oxygen defect under US irradiation,which induced the sonodynamic efficiency greatly to improve around 3.7-fold compared with Ti_(3)C_(2) NSs without high-temperature treatment.After PEGylation,the H-Ti_(3)C_(2)-PEG NSs show good stability and biocompatibility.In vitro studies exhibit that the inherent property of mild photothermal effect can promote the endocytosis of H-Ti_(3)C_(2)-PEG NSs,which can improve the SDT efficacy.In vivo studies further display that the increased blood supply by the mild photothermal effect can significantly relieve hypoxia in the tumor microenvironment,showing photothermal therapy(PTT)enhanced SDT.Most importantly,the H-Ti_(3)C_(2)-PEG NSs can be biodegraded and excreted out of the body,showing no significant long-term toxicity.Our work develops the defective H-Ti_(3)C_(2) NSs as high-efficiency and safe sonosensitizers for photothermal-enhanced SDT of cancer,extending the biomedical application of MXene-based nanoplatforms.

关键词： Ti_(3)C_(2)MXenes Oxygen defect Sonosensitizers Sonodynamic therapy Biosafety

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

新时代全民阅读文旅融合新模式的创新探索与实践——以“走读广西”品牌建设为例

引用

新世纪图书馆 2024年第2期 17-24页

作者：秦小燕陈赢钟晖广西壮族自治区图书馆广西南宁530022 广西壮族自治区图书馆办公室广西南宁530022 广西壮族自治区图书馆阅读推广部广西南宁530022

在文旅融合发展、全民阅读深入推进的新形势下,作为现代公共文化服务体系重要环节和全民阅读核心阵地的公共图书馆,如何主动适应和高质量地融入“文旅融合”的时代潮流,成为一个全新的现实课题。2020年起,广西创新思路举措、大胆实践探... 详细信息

在文旅融合发展、全民阅读深入推进的新形势下,作为现代公共文化服务体系重要环节和全民阅读核心阵地的公共图书馆,如何主动适应和高质量地融入“文旅融合”的时代潮流,成为一个全新的现实课题。2020年起,广西创新思路举措、大胆实践探索,率先在全国提出并实践“走读”系列活动,成功打造“走读广西”公共服务融合品牌,总结出全民阅读文旅融合的广西经验。

关键词：文旅融合全民阅读公共图书馆走读广西

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

TAR DNA-Binding Protein 43 is Cleaved by the Protease 3C of Enterovirus A71

引用

Virologica Sinica 2021年第1期36卷 95-103页

作者： Xiaoman Wo Yuan Yuan Yong Xu Yang Chen Yao Wang Shuoxuan Zhao Lexun Lin xiaoyan zhong Yan Wang Zhaohua zhong Wenran Zhao Department of Cell Biology Harbin Medical UniversityHarbin 150081China Department of Microbiology Harbin Medical UniversityHarbin 150081China

Enterovirus A71(EV-A71)is one of the etiological pathogens leading to hand,foot,and mouth disease(HFMD),which can cause severe neurological complications.The neuropathogenesis of EV-A71 infection is not well understood.The mislocalization and aggregation of TAR DNA-binding protein 43(TDP-43)is the pathological hallmark of amyotrophic lateral sclerosis(ALS).However,whether TDP-43 was impacted by EV-A71 infection is unknown.This study demonstrated that TDP-43 was cleaved during EV-A71 infection.The cleavage of TDP-43 requires EV-A71 replication rather than the activated caspases due to viral infection.TDP-43 is cleaved by viral protease 3 C between the residues 331 Q and332 S,while mutated TDP-43(Q331 A)was not cleaved.In addition,mutated 3 C which lacks the protease activity failed to induce TDP-43 cleavage.We also found that TDP-43 was translocated from the nucleus to the cytoplasm,and the mislocalization of TDP-43 was induced by viral protease 2 A rather than 3 C.Taken together,we demonstrated that TDP-43 was cleaved by viral protease and translocated to the cytoplasm during EV-A71 infection,implicating the possible involvement of TDP-43 in the pathogenesis of EV-A71 infection.

关键词： Enterovirus A71(EV-A71) TAR DNA-binding protein 43(TDP-43) 3C protease 2A protease

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

母源因子在哺乳动物卵母细胞向胚胎转变中的作用

引用

中国细胞生物学学报 2024年第4期46卷 612-627页

作者：钟欧孙小燕霍然南京医科大学生殖医学与子代健康全国重点实验室南京211166 苏州市立医院苏州215008

卵母细胞在形成过程中合成和储存了大量由母源效应基因(maternal effect genes,MEGs)编码的母源因子(maternalfactors),它们在卵母细胞和早期胚胎发育过程的多个环节(包括母源mRNAs的合成与积累、细胞器的有序排列、表观遗传重编程、受... 详细信息

卵母细胞在形成过程中合成和储存了大量由母源效应基因(maternal effect genes,MEGs)编码的母源因子(maternalfactors),它们在卵母细胞和早期胚胎发育过程的多个环节(包括母源mRNAs的合成与积累、细胞器的有序排列、表观遗传重编程、受精后卵子的激活、合子基因组激活的启动以及母源转录物的清除等)中起到关键作用。该综述按照卵母细胞成熟至受精后早期胚胎发育的时间线,详细阐述了母源因子对哺乳动物卵母细胞和早期胚胎发育关键进程的影响,同时描述了母源因子的表达调控和定位。研究发现,MEGs的变异与一系列不良生殖结局有关。在人类中,这些变异可能导致不孕症、胎儿结构性发育缺陷和出生子代患有多位点印记障碍的风险增加。深入研究母源因子及其调控机制有助于更好地理解卵母细胞和早期胚胎发育的生理过程,提高不孕症诊断和治疗的精确性,并为预防相关疾病提供新的策略。

关键词：母源效应基因母源因子卵母细胞胚胎母体到合子的转变

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Stress Granule Formation is One of the Early Antiviral Mechanisms for Host Cells Against Coxsackievirus B Infection

引用

Virologica Sinica 2018年第4期33卷 314-322页

作者： Xia Zhai Shuo Wu Lexun Lin Tianying Wang xiaoyan zhong Yang Chen Weizhen Xu Lei Tong Yan Wang Wenran Zhao Zhaohua zhong Department of Microbiology Harbin Medical University Harbin 150081 China Department of Cell Biology Harbin Medical University Harbin 150081 China

Stress granules(SGs) are intracellular granules formed when cellular translation is blocked and have been reported to be involved in a variety of viral infections. Our previous studies revealed that SGs are involved in the coxsackievirus B(CVB)infection process, but the role of SGs in CVB infection has not been fully explored. In this study, we found that CVB type 3(CVB3) could induce SG formation in the early phase of infection. Results showed that levels of CVB3 RNA and protein were significantly inhibited during the early stage of CVB3 infection by the elevated formation of SGs, while viral RNA and protein synthesis were significantly promoted when SG formation was blocked. Our findings suggest that SG formation is one of the early antiviral mechanisms for host cells against CVB infection.

关键词：感染过程抗病毒主人机制压力蛋白质合成粒形壁板

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

超声评估妊娠糖尿病患者顺产后肛提肌裂孔形态改变

引用

中国介入影像与治疗学 2024年第1期21卷 33-37页

作者：钟小燕郝晓英万小梅钟清莲自贡市妇幼保健院超声医学科四川自贡643000

目的采用超声检查评估妊娠糖尿病(GDM)患者顺产后肛提肌裂孔形态改变。方法前瞻性纳入302名孕早期(6~8周)孕妇,分别于孕早期、产后12周、6个月及1年以超声测量静息态(静息期)、缩肛状态(收缩期)及瓦尔萨尔瓦动作(张力期)下盆底肌裂孔指... 详细信息

目的采用超声检查评估妊娠糖尿病(GDM)患者顺产后肛提肌裂孔形态改变。方法前瞻性纳入302名孕早期(6~8周)孕妇,分别于孕早期、产后12周、6个月及1年以超声测量静息态(静息期)、缩肛状态(收缩期)及瓦尔萨尔瓦动作(张力期)下盆底肌裂孔指标。于孕28周测量血糖据以诊断GDM并将纳入孕妇分为GDM组及非GDM组;比较GDM组与非GDM组间超声指标及产后盆底肌张力分级,采用Spearman相关性分析评价GDM组盆底肌张力分级与肛提肌裂孔指标的相关性。结果共纳入153名受试者,包括51例GDM及102名非GDM。2组产后12周不同状态下肛提肌裂孔横径(LH-TD)、肛提肌裂孔前后径(LH-APD)、肛提肌裂孔面积(LHA)均高于孕早期(P均<0.05)。产后6个月及1年,GDM组收缩期LH-APD、LHA及张力期LH-TD、LH-APD、LHA均高于孕早期(P均<0.05),非GDM组张力期LH-APD、LHA均高于孕早期(P均<0.05)。产后1年GDM组收缩期LH-APD、LHA及张力期LH-TD、LHA均高于非GDM组(P均<0.05),盆底肌张力Ⅱ~Ⅲ级比例高于、而Ⅳ~Ⅴ级比例低于非GDM组(P<0.05)。产后1年GDM组盆底肌张力分级与静息期、收缩期、张力期LH-TD、LH-APD、LHA均呈负相关(P均<0.05)。结论GDM患者顺产后肛提肌裂孔形态变化较大,需早期开展康复训练。

关键词：糖尿病,妊娠肛提肌裂孔超声检查

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

人工智能在儿童青少年焦虑和抑郁中应用的Scoping综述

引用

中国康复理论与实践 2024年第5期30卷 513-519页

作者：苏如峰钟晓珂高晓妍蒋长好首都体育学院体育人工智能研究院北京市100191 福建师范大学体育科学学院福建福州市350108 首都体育学院运动脑成像研究中心北京市100089

目的系统综述人工智能在儿童青少年焦虑和抑郁中的应用。方法检索2014年1月至2024年1月PubMed、Web of Science、中国知网和万方数据库中人工智能与儿童青少年焦虑和抑郁相关文献,进行Scoping综述。结果最终纳入10篇文献,来自美国、中... 详细信息

目的系统综述人工智能在儿童青少年焦虑和抑郁中的应用。方法检索2014年1月至2024年1月PubMed、Web of Science、中国知网和万方数据库中人工智能与儿童青少年焦虑和抑郁相关文献,进行Scoping综述。结果最终纳入10篇文献,来自美国、中国、澳大利亚和法国,主要来源于心理学、公共卫生、临床医学、神经科学、康复等领域的期刊,涉及6项横断面研究、3项纵向研究和1项访谈研究,包括10880例参与者,年龄3~18岁。数据类型主要包括问卷/量表、访谈数据和脑成像数据。从数据中提取与焦虑、抑郁相关的特征,使用人工智能技术建立模型,以识别或预测儿童青少年焦虑和抑郁。结论人工智能在识别或预测儿童和青少年焦虑和抑郁方面具有潜在的价值和应用前景。

关键词：儿童青少年人工智能焦虑抑郁 Scoping综述

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：