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The Basal Level Ethylene Response is Important to the Wall and Endomembrane Structure in the Hypocotyl Cells of Etiolated Arabidopsis Seedlings

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Journal of Integrative Plant Biology 2012年第7期54卷 434-455页

作者： Chan Xu xiaoyan gao Xiaobin Sun Chi-Kuang Wen National KeyLaboratory of Plant Molecular Genetics and National Center for Plant Gene Research(Shanghai) Institute of Plant Physiology and EcologyShanghai Institutes for Biological SciencesChinese Academy of Sciences300 Fenglin RdShanghai 200032China Shanghai Applied Protein Technology ShanghaiChina

The sub-cellular events that occur during the ethylene-modulated cell elongation were characterized by examining the ultra-structure of etiolated Arabidopsis seedling hypocotyl cells. Preventing the basal level ethylene response facilitated cell elongation, and the cells exhibited wall loosening and separation phenotype. Nearby the wall separation sites were frequently associated with an increase in the cortical rough endoplasmic reticulum （rER） membranes, the presence of paramural bodies, and the circular Golgi formation. The cortical rER proliferation and circular Golgi phenotype were reverted by the protein biosynthesis inhibitor cycloheximide. The cortical rER membranes were longer when the ethylene response was prevented and shortened with elevated ethylene responses. Proteomic changes between wild type and the ethylene-insensitive mutant ethylene insensitive2 （ein2） seedling hypocotyls indicated that distinct subsets of proteins involving endomembrane trafficking, remodeling, and wall modifications were differentially expressed. FM4-64 staining supported the proteomic changes, which indicated reduced endocytosis activity with alleviation of the ethylene response. The basal level ethylene response has an important role in endomembrane trafficking, biological materials transport and maintenance of the endomembrane organization. It is possible that endomembrane alterations may partly associate with the wall modifications, though the biological significance of the alterations should be addressed in future studies.

关键词： ER proliferation cell walls circular Golgi endomembrane trafficking ethylene.

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Rhubarb ameliorates cognitive dysfunction in a rat model of Alzheimer’s disease through regulation of the intestinal microbiome

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Journal of Traditional Chinese Medical Sciences 2019年第3期6卷 234-243页

作者： Huizhen Zhao Demin gao xiaoyan gao School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing102488China

Objective:To determine the mechanism whereby rhubarb(Rheum tanguticum MAXIM.Ex BALF.)may ameliorate cognitive dysfunction through regulation of the intestinal microbiome.Methods:We used a rat model of human microbiome-associated(HMA)-AD to characterize the therapeutic effect of rhubarb on cognitive dysfunction by assessing learning and spatial memory,tissue pathology,and neurotransmitter expression in brain tissue.Then,16S rRNA gene sequencing was used to analyze the intestinal microbial composition of the rats before and after rhubarb intervention,to determine whether changes in the intestinal microbiome might underpin the beneficial effect of rhubarb on cognitive dysfunction.Results:Morris water maze experiments showed that the learning and spatial memory of HMAAD rats were improved after rhubarb administration.Examination of brain sections showed that rhubarb had a protective effect on neurons in the brain tissue of HMA-AD rats.Brain tissue neurotransmitter analysis showed that rhubarb significantly reduces the 5-hydorxytryptamine concentration in the hippocampus of HMA-AD rats(P Z.0013).Furthermore,rhubarb affected the abundance of the Lachnospiraceae_NK4A136_group and Lactobacillus in the large intestine.Conclusion:This study suggests that rhubarb ameliorates cognitive dysfunction in rats with HMA-AD by regulating the abundance of beneficial bacteria,which likely affects the concentration of 5-hydorxytryptamine in the hippocampus.

关键词： Rhubarb Intestinal microbiome Alzheimer’s disease Cognitive function 5-hydroxytryptamine

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Corydalis Rhizoma as a model for herb-derived trace metabolites exploration:A cross-mapping strategy involving multiple doses and samples

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Journal of Pharmaceutical Analysis 2021年第3期11卷 308-319页

作者： Chanjuan Yu Fengyun Wang Xinyue Liu Jiayan Miao Siqi Tang Qin Jiang Xudong Tang xiaoyan gao School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing102488PR China Gastroenterology Department Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing100091PR China

Deciphering the metabolites of multiple components in herbal medicine has far-reaching significance for revealing pharmacodynamic ingredients.However,most chemical components of herbal medicine are secondary metabolites with low content whose in vivo metabolites are close to trace amounts,making it difficult to achieve comprehensive detection and identification.In this paper,an efficient strategy was proposed:herb-derived metabolites were predicted according to the structural characteristics and metabolic reactions of chemical constituents in Corydalis Rhizoma and chemical structure screening tables for metabolites were conducted.The fragmentation patterns were summarized from representative standards combining with specific cleavage behaviors to deduce structures of metabolites.Ion abundance plays an important role in compound identification,and high ion abundance can improve identification accuracy.The types of metabolites in different biological samples were very similar,but their ion abundance might be different.Therefore,for trace metabolites in biological samples,we used the following two methods to process:metabolites of high dose herbal extract were analyzed to characterize those of clinical dose herbal extracts in the same biological samples;cross-mapping of different biological samples was applied to identify trace metabolites based on the fact that a metabolite has different ion abundance in different biological samples.Compared with not using this strategy,44 more metabolites of clinical dose herbal extract were detected.This study improved the depth,breadth,and accuracy of current methods for herb-derived metabolites characterization.

关键词： Alkaloid Characteristic fragment Corydalis yanhusuo In vivo metabolism Metabolite

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Enhanced optical nonlinearity in a silicon–organic hybrid slot waveguide for all-optical signal processing

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Photonics Research 2022年第1期10卷 50-58页

作者： YONGHUA WANG SU HE xiaoyan gao PIAOPIAO YE LEI LEI WENCHAN DONG XINLIANG ZHANG PING XU College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhen 518060China School of Optical and Electronic Information Huazhong University of Science and TechnologyWuhan 430074China Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074China

Silicon photonic integrated devices used for nonlinear optical signal processing play a key role in ultrafast switching,computing,and modern optical communications.However,current devices suffer from limited operation speeds and low conversion efficiencies due to the intrinsically low nonlinear index of silicon.In this paper,we experimentally demonstrate enhanced optical nonlinearity in a silicon–organic hybrid slot waveguide consisting of an ultranarrow slot waveguide coated with a highly nonlinear organic material.The fabricated slot area is as narrow as 45 nm,which is,to the best of our knowledge,the narrowest slot width that has been experimentally reported in silicon slot waveguides.The nonlinear coefficient of the proposed device with a length of 3 mm is measured to be up to 1.43×10^(6) W^(-1)km^(-1).Based on the nanostructure design,the conversion efficiencies of degenerate four-wave mixing showed enhancements of more than 12 dB and 5 dB compared to those measured for an identical device without the organic material and a silicon strip waveguide,respectively.As a proof of concept,all-optical canonical logic units based on the prepared device with two inputs at 40 Gb/s are analyzed.The obtained logic results showed clear temporal waveforms and wide-open eye diagrams with error-free performance,illustrating that our device has great potential for use in high-speed all-optical signal processing and high-performance computing in the nodes and terminals of optical networks.

关键词： waveguide optical slot

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初中英语“自主学习”阅读课教学设计探讨

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英语教师 2024年第7期24卷 162-165页

作者：高晓燕浙江省杭州滨和中学浙江杭州310000

从自主学习的相关理论出发,通过学生在调查中反映的实际问题,结合教学经验,探究初中英语“自主学习”阅读课的教学设计路径。提出通过前任务、任务环、后任务、小结、作业等五个教学环节实施初中英语“自主学习”阅读课堂教学,唤起学生... 详细信息

从自主学习的相关理论出发,通过学生在调查中反映的实际问题,结合教学经验,探究初中英语“自主学习”阅读课的教学设计路径。提出通过前任务、任务环、后任务、小结、作业等五个教学环节实施初中英语“自主学习”阅读课堂教学,唤起学生的主体意识,挖掘他们的学习潜能,提升其学习效率。

关键词：自主学习阅读课初中英语

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补气凉血汤联合卡前列素氨丁三醇对宫缩乏力性产后出血的效果及对氧化应激的影响

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智慧健康 2024年第3期10卷 144-147页

作者：高晓艳常州市中医医院产科江苏常州213000

目的探讨补气凉血汤联合卡前列素氨丁三醇对宫缩乏力性产后出血的效果及对氧化应激的影响。方法纳入2022年1—12月本院收治的宫缩乏力性产后出血患者共90例,采用随机数字表法分为对照组(45例)和试验组(45例),分别给予卡前列素氨丁三... 详细信息

目的探讨补气凉血汤联合卡前列素氨丁三醇对宫缩乏力性产后出血的效果及对氧化应激的影响。方法纳入2022年1—12月本院收治的宫缩乏力性产后出血患者共90例,采用随机数字表法分为对照组(45例)和试验组(45例),分别给予卡前列素氨丁三醇治疗和补气凉血汤联合卡前列素氨丁三醇治疗;比较两组治疗总有效率、出血量、出血持续时间、产后出血相关并发症发生率、治疗前后超氧化物歧化酶、脂质过氧化物及谷胱甘肽过氧化物酶水平。结果试验组治疗总有效率显著高于对照组(P<0.05);试验组出血量和出血持续时间均显著少于对照组;试验组后期出血和产褥感染发生率显著低于对照组(P<0.05);两组治疗后超氧化物歧化酶显著高于治疗前(P<0.05);两组治疗后脂质过氧化物和谷胱甘肽过氧化物酶水平均显著低于治疗前(P<0.05);但试验组治疗后超氧化物歧化酶、脂质过氧化物及谷胱甘肽过氧化物酶水平均显著优于对照组(P<0.05)。结论补气凉血汤联合卡前列素氨丁三醇治疗宫缩乏力性产后出血可有效促进子宫收缩,控制出血量,缩短出血时间,降低产后出血相关并发症发生率,并有助于调节机体氧化应激水平。

关键词：补气凉血汤卡前列素氨丁三醇宫缩乏力性产后出血疗效氧化应激

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作战靴关键部位支撑防护材料应用研究

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皮革科学与工程 2024年第4期34卷 88-93页

作者：刘甜甜许文飞高晓琰中国人民武装警察部队研究院北京100012

从防穿刺性、防砸性、支撑稳定性三方面,系统梳理了历代作战靴支撑防护材料的应用发展情况,介绍了美军现役作战靴相应材料应用情况,通过对比不同材料性能及其国内外应用现状,基于我军设计理念,提出非金属防护材料尤其是高性能纤维材料... 详细信息

从防穿刺性、防砸性、支撑稳定性三方面,系统梳理了历代作战靴支撑防护材料的应用发展情况,介绍了美军现役作战靴相应材料应用情况,通过对比不同材料性能及其国内外应用现状,基于我军设计理念,提出非金属防护材料尤其是高性能纤维材料将成为应用趋势,并指出借鉴外军创新性理念,加强材料本身性能研究。

关键词：作战靴防护支撑高性能纤维材料美军作战靴发展趋势

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人工智能在儿童青少年焦虑和抑郁中应用的Scoping综述

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中国康复理论与实践 2024年第5期30卷 513-519页

作者：苏如峰钟晓珂高晓妍蒋长好首都体育学院体育人工智能研究院北京市100191 福建师范大学体育科学学院福建福州市350108 首都体育学院运动脑成像研究中心北京市100089

目的系统综述人工智能在儿童青少年焦虑和抑郁中的应用。方法检索2014年1月至2024年1月PubMed、Web of Science、中国知网和万方数据库中人工智能与儿童青少年焦虑和抑郁相关文献,进行Scoping综述。结果最终纳入10篇文献,来自美国、中... 详细信息

目的系统综述人工智能在儿童青少年焦虑和抑郁中的应用。方法检索2014年1月至2024年1月PubMed、Web of Science、中国知网和万方数据库中人工智能与儿童青少年焦虑和抑郁相关文献,进行Scoping综述。结果最终纳入10篇文献,来自美国、中国、澳大利亚和法国,主要来源于心理学、公共卫生、临床医学、神经科学、康复等领域的期刊,涉及6项横断面研究、3项纵向研究和1项访谈研究,包括10880例参与者,年龄3~18岁。数据类型主要包括问卷/量表、访谈数据和脑成像数据。从数据中提取与焦虑、抑郁相关的特征,使用人工智能技术建立模型,以识别或预测儿童青少年焦虑和抑郁。结论人工智能在识别或预测儿童和青少年焦虑和抑郁方面具有潜在的价值和应用前景。

关键词：儿童青少年人工智能焦虑抑郁 Scoping综述

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Non-Ischemic, Non-Hypoxic Myocardial Injury, and Long-Term Mortality in Patients with Coronavirus Disease 2019: A Retrospective Cohort Study

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Cardiology Discovery 2022年第2期2卷 77-82页

作者： Fajiu Li Xijie Zhu Ziyang Zhu Yinjian Yang Zhuang Tian Duolao Wang Shi Chen xiaoyan gao Yalin Xu Bo Zhang Wei Yu Min Liu Xiqi Xu Chenghong Li Shuyang Zhang Department of Pulmonary and Critical Care Medicine Affiliated Hospital of Jianghan UniversityWuhanHubei 430015China Department of Cardiology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Medical Science Research Center Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Clinical Sciences Liverpool School of Tropical MedicineLiverpoolMerseyside L35QAUnited Kingdom Department of Geriatrics Affiliated Hospital of Jianghan UniversityWuhanHubei 430015China Department of Cardiology Affiliated Hospital of Jianghan UniversityWuhanHubei 430015China.

Objective:Cardiac damage is commonly reported in patients with coronavirus disease 2019(COVID-19)but its prevalence and impact on the long-term survival of patients remain uncertain.This study aimed to explore the prevalence of myocardial injury and assess its prognostic value in patients with COVID-19.Methods:A single-center,retrospective cohort study was performed at the Affiliated Hospital of Jianghan University.Data from 766 patients with confirmed COVID-19 who were hospitalized from December 27,2019 to April 25,2020 were collected.Demographic,clinical,laboratory,electrocardiogram,treatment data and all-cause mortality during follow-up were collected and analyzed.Results:Of the 766 patients with moderate to critically ill COVID-19,86(11.2%)died after a mean follow-up of 72.8 days.Myocardial injury occurred in 94(12.3%)patients.The mortality rate was 64.9%(61/94)and 3.7%(25/672)in patients with and without myocardial injury,respectively.Cox regression showed that myocardial injury was an independent risk factor for mortality(hazard ratio:8.76,95%confidence interval:4.76–16.11,P<0.001).Of the 90 patients with myocardial injury with electrocardiogram results,sinus tachycardia was present in 29,bundle branch block in 26,low voltage in 10,and abnormal T-wave in 53.Conclusions:COVID-19 not only involves pneumonia but also cardiac damage.Myocardial injury is a common complication and an independent risk factor for mortality in COVID-19 patients.

关键词： Coronavirus COVID-19 Mortality Myocardial injury

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Design and Implementation of Peer-to-Peer Service Routing Algorithm

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Journal of Software Engineering and Applications 2015年第11期8卷 575-580页

作者： xiaoyan gao Department of Computer Science North China Institute of Science and Technology Beijing China

Due to the lack of QoS (quality of service) guarantee in current Peer-to-Peer services routing network, it is difficult to apply Peer-to-Peer network to business successfully. Therefore, a service guarantee routing model is proposed in this paper, and an ant colony algorithm is designed for this routing model. Finally, the experimental analysis of the Peer-to-Peer services routing algorithm is presented. The experimental result shows the effectiveness of the service routing algorithm.

关键词： Peer-to-Peer Services Routing Ant Colony Algorithm

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