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Return and reformation after a century-from 1918 to 2009 H1N1

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Protein & Cell 2010年第5期1卷 425-426页

作者： xiaoxue zhang 不详

Undoubtedly,H1N1 has been a keyword for the past year of *** swine influenza virus is the first pandemic of the 21st century(announced by the World Health Organization(WHO)on June 11th,2009)and took around 18,000 lives by April,2010(http://***/csr/don/2010_04_23a/en/***).Despite of the well-acknowledged high mutation rate for pandemic influenza viruses,the Wilson group at the Scripps Research Institute(Xu et al.,2010),the Stevens group at Centers for Disease Control and Prevention(Yang et al.2010),and the Gao group at the Institute of Microbiology,Chinese Academy of Sciences(in the current issue of Protein&Cell)independently discovered that the 1918 and 2009 pandemic influenza viruses share fantastic similarities in regards to the structure of hemagglutinin(HA),which is the major influenza virus surface envelope *** addition,the Gao group also reported the changes of N-glycosylation sites in the HA protein and proposed another underlying evolutionary hint.

关键词： H1N1 evolutionary spite

From synthetic genome to creation of life

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Protein & Cell 2010年第6期1卷 501-502页

作者： xiaoxue zhang

Understanding the world and then changing the world is an everlasting mission of the human *** is an important component and one of the most sophisticated elements on the *** recent decades,the rapid development of molecular biology,genetics and the related biotechnology and bioengineering kept bringing surprises to scientists worldwide,including the cloning of Dolly(Wilmut et al.,1997)(followed by cloning of a variety of animals),the completion of Human Genome Project(Cheung et al.,2001;Lander et al.,2001;Venter et al.,2001)(followed by the reports of complete genome from other species and by the spread of personalized genome sequencing service),and the induction of pluripotent stem cells(Takahashi and Yamanaka,2006)(followed by the production of viable iPS mice(Zhao et al.,2009)).Recently,another breakthrough was brought by John Craig Venter and his team,who achieved the first synthetic life—Mycoplasma that only contains synthetic genome(Gibson et al.,2010).

关键词： synthetic life breakthrough

Game-theoretic multi-agent motion planning in a mixed environment

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Control Theory and Technology 2024年第3期22卷 379-393页

作者： xiaoxue zhang Lihua Xie School of Electrical and Electronic Engineering Nanyang Technological UniversitySingapore City 639798Singapore

The motion planning problem for multi-agent systems becomes particularly challenging when humans or human-controlled robots are present in a mixed *** address this challenge,this paper presents an interaction-aware motion planning approach based on game theory in a receding-horizon manner Leveraging the framework provided by dynamic potential games for handling the interactions among agents,this approach formulates the multi-agent motion planning problem as a differential potential game,highlighting the effectiveness of constrained potential games in facilitating interactive motion planning among ***,online learning techniques are incorporated to dynamically learn the unknown preferences and models of humans or human-controlled robots through the analysis of observed *** evaluate the effectiveness of the proposed approach,numerical simulations are conducted,demonstrating its capability to generate interactive trajectories for all agents,including humans and human-controlled agents,operating within the mixed *** simulation results illustrate the effectiveness of the proposed approach in handling the complexities of multi-agent motion planning in real-world scenarios.

关键词： Motion planning Differential potential game Multi-agent systems Constrained potential game

EphB2:a signature of colorectal cancer stem cells to predict relapse

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Protein & Cell 2011年第5期2卷 347-348页

作者： xiaoxue zhang 不详

Colorectal cancer is one of the most commonly diagnosed cancers and is the second leading cause of death from ***,the conventional treatment in clinics is surgery combined with chemotherapy or radiation *** new drugs have been developed,relapse and metastasis occur in nearly half of colorectal cancer *** most other types of cancer,the recurrence rate of colorectal cancer is negatively correlated with the disease stage at diagnosis.

关键词： drugs chemotherapy metastasis death

Protein targets for structure-based antiMycobacterium tuberculosis drug discovery

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Protein & Cell 2010年第5期1卷 435-442页

作者： Zhiyong Lou xiaoxue zhang Laboratory of Structural Biology Tsinghua UniversityBeijing 100084China Higher Education Press Beijing 100029China

Mycobacterium tuberculosis,which belongs to the genus Mycobacterium,is the pathogenic agent for most tuberculosis(TB).As TB remains one of the most rampant infectious diseases,causing morbidity and death with emergence of multi-drug-resistant and extensively-drugresistant forms,it is urgent to identify new drugs with novel targets to ensure future therapeutic *** this regards,the structural genomics of *** provides important information to identify potential targets,perform biochemical assays,determine crystal structures in complex with potential inhibitor(s),reveal the key sites/residues for biological activity,and thus validate drug targets and discover novel *** this review,we will discuss the recent progress on novel targets for structure-based *** drug discovery.

关键词： Mycobacterium tuberculosis crystal structure drug discovery target

Improved Subsynchronous Oscillation Parameter Identification with Synchrophasor Based on Matrix Pencil Method in Power Systems

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Journal of Modern Power Systems and Clean Energy 2024年第1期12卷 22-33页

作者： xiaoxue zhang Fang zhang Wenzhong Gao Jinghan He the School of Electrical Engineering Beijing Jiaotong UniversityBeijing 100044China the Department of Electrical and Computer Engineering University of DenverDenverUSA

The subsynchronous oscillations(SSOs)related to renewable generation seriously affect the stability and safety of the power *** realize the dynamic monitoring of SSOs by utilizing the high computational efficiency and noise-resilient features of the matrix pencil method(MPM),this paper propos es an improved MPM-based parameter identification with syn *** MPM is enhanced by the angular frequency fitting equations based on the characteristic polynomial coeffi cients of the matrix pencil to ensure the accuracy of the identi fied parameters,since the existing eigenvalue solution of the MPM ignores the angular frequency conjugation constraints of the two fundamental modes and two oscillation ***,the identification and recovery of bad data are proposed by uti lizing the difference in temporal continuity of the synchropha sors before and after noise *** proposed parameter identification is verified with synthetic,simulated,and actual measured phase measurement unit(PMU)*** with the existing MPM,the improved MPM achieves better accuracy for parameter identification of each component in SSOs,better real-time performance,and significantly reduces the effect of bad data.

关键词： Subsynchronous oscillations(SSOs) synchrophasor parameter identification matrix pencil method bad data

From the first human gene-editing to the birth of three-parent baby

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Science China(Life Sciences) 2016年第12期59卷 1341-1342页

作者： xiaoxue zhang Si Wang Higher Education Press Beijing 100029China National Laboratory of Biomacromolecules CAS Center for Excellence in Biomacromolecules Institute of BiophysicsChinese Academy of SciencesBeijing 100101China

Gene Editing refers to the process of making targeted modi- fications to the genome, such as the deletion, insertion or replacement of targeted DNA sequences （Pan et al., 2011）. Gene editing technologies fundamentally improve our ap- proaches to biological basic research, gene therapy, genetic improvement, etc. In the field of stem cells, gene editing can be used to modulate cell fate, such as generation of in- duced pluripotent stem cells （iPSCs）（Ding et al., 2015）, cellular differentiation and transdifferentiation （zhang et al., 2014）. In gene therapy, gene editing can be used to con＇ect disease mutations in patient-derived cells, which holds great promise to cure related diseases in the future （Liu et al., 2012; Liu et al., 2014）.

关键词： gene DNA

Hepatitis A virus exhibits a structure unique among picornaviruses

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Protein & Cell 2015年第2期6卷 79-80页

作者： Ling Zhu xiaoxue zhang National Laboratory of Macromolecules Institute of Biophysics Chinese Academy of Science Beijing 100101 China Division of Structural Biology University of Oxford The Henry Wellcome Building for Genomic Medicine Headington Oxford UK Higher Education Press Beijing 100029 China

Hepatitis A, which is a major global health problem （Nainan et al., 2006）, is caused by hepatitis A virus （HAV）. Approxi- mately 1.4 cases of hepatitis A have been reported annually. HAV belongs to the family of Picomaviridae and genus He- patovirus, which is a sole member of this family. HAV has radically different properties from those of other picomavi- ruses. First, HAV is extremely resistant to degradation caused by environmental conditions.

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Functionality evaluation of system of systems architecture based on extended influence diagrams

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Journal of Systems Engineering and Electronics 2018年第3期29卷 510-518页

作者： zhang Mengmeng CHEN Honghui zhang xiaoxue LUO Aimin LIU Junxian Science and Technology on Information Systems Engineering Laboratory National University of Defense TechnologyChangsha 410072China

System of systems architecture（SoSA） has received increasing emphasis by scholars since Zachman ignited its flame in 1987. Given its complexity and abstractness, it is critical to validate and evaluate SoSA to ensure requirements have been *** qualities are discussed in the literature of SoSA evaluation, while research on functionality is scarce. In order to assess SoSA functionality, an extended influence diagram（EID） is developed in this paper. Meanwhile, a simulation method is proposed to elicit the conditional probabilities in EID through designing and executing SoSA. An illustrative anti-missile architecture case is introduced for EID development, architecture design, and simulation.

关键词： system of systems architecture(SoSA) functionality evaluation extended influence diagram(EID) anti-missile architecture simulation