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Echinatin inhibits tumor growth and synergizes with chemotherapeutic agents against human bladder cancer cells by activating p38 and suppressing wnt/β-catenin pathways

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Genes & Diseases 2024年第2期11卷 1050-1065页

作者： xiaoxuan w.ng Lijuan Luo Jingtao Xu Qiuping Lu Haichao Xia Yanran Huang Lulu Zhang Liping Xie Habu Jiwa Shiqiong Liang Xiaoji Luo Jinyong Luo Key Laboratory of Diagnostic Medicine Designated By the Chinese Ministry of Education School of Laboratory MedicineChongqing Medical UniversityChongqing 400016China Department of Orthopedics The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400042China

Bladder cancer (BC) is one of the most common malignant tumors in the urinary *** to the poor prognosis and high mortality rate of the disease,it is urgent to develop new drugs with high efficacy and low toxicity to treat *** (Ecn) is a bioactive natural flavonoid oflicorice that has attracted special attention for its promising anti-tumor ***,we explored the inhibitory effects of Echinatin on BC cells and probed the possible molecular *** found that Ecnin vitro inhibited the proliferation,migration,and invasion,arrested the cell cycle at the G2/M phase,and promoted apoptosis in BC ***,Ecn had no notable cytotoxicity towards human normal *** subsequently confirmed that Ecn restrained xenograft tumor growth and metastasis of BC cells in vivo .Mechanistically,Ecn activated the p38 signaling pathway but inactivated the wnt/β-catenin signaling pathway,while over-expression of β-catenin and the p38 inhibitor both attenuated the inhibitory effects of Ecn on BC ***,Ecn combined with cisplatin (DDP) or gemcitabine (Gem) had synergistic inhibitory effects on BC *** summary,our results validate that Ecn inhibits the tumor growth of human BC cells via p38 and wnt/β-catenin signaling *** meaningfully,our results suggest a potential strategy to enhance DDP- or Gem-induced inhibitory effects on BC cells by combining with Ecn.

关键词： Bladder cancer Combination chemotherapy Echinatin p38 wnt/β-catenin

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Efficacy and safety of anlotinib combined with the STUPP regimen in patients with newly diagnosed glioblastoma: a multicenter, single-arm, phase Ⅱ trial

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Cancer Biology & Medicine 2024年第5期21卷 433-444页

作者： Shuzhen Lai Peijing Li Xiaohui Liu Guihong Liu Tieming Xie Xing Zhang xiaoxuan w.ng Jing Huang Yiqiang Tang Zhigang Liu Guoping Shen Chaoming Li Fangxiao Lu Lei w.ng Fagui Jiang Caixing Sun Yuanyuan Chen Ming Chen Department of Radiation Oncology The Second Affiliated Hospital of Soochow UniversitySuzhou 215000China Department of Radiation Oncology Yuebei People’s Hospital Affiliated to the Medical College of Shantou UniversityShaoguan 512026China Chinese Academy of SciencesHangzhou 310022China Department of Radiation Oncology The Second Clinical Medical College of Zhejiang Chinese Medical UniversityHangzhou 311403China Department of Radiation Oncology The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221004China Chinese Academy of SciencesHangzhou 310022China State Key Laboratory of Translational Medicine and Innovative Drug Development Jiangsu Simcere Diagnostics Co.LtdNanjing 210000China Department of Radiation Oncology The Affiliated Huai’an First People’s Hospital of Nanjing Medical UniversityHuai’an 223399China Department of Radiation Oncology Jiangxi Cancer Hospital of Nanchang UniversityNanchang 330029China Department of Radiotherapy Dongguan Institute of Clinical Cancer ResearchDongguan Key Laboratory of Precision Diagnosis and Treatment for TumorsAffiliated Dongguan HospitalSouthern Medical UniversityDongguan 523059China The Cancer Center The Fifth Affiliated Hospital of Sun Yat-Sen UniversityZhuhai 519000China Department of Radiation Oncology The First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510080China Department of Oncology Maoming People’s HospitalMaoming 525000China Department of Radiation Oncology Kecheng District People’s HospitalQuzhou 324003China Chinese Academy of SciencesHangzhou 310022China Department of Radiation Oncology State Key Laboratory of Oncology in South ChinaSun Yat-sen University Cancer CenterGuangzhou 510060China United Laboratory of Frontier Radiotherapy Technology of Sun Yat-sen University&Chinese Academy of Sciences Ion Medical Technology Co. LtdGuangzhou 510060China

Objective:Glioblastomas are highly vascularized malignant *** determined the efficacy and safety of the anti-angiogenic multi-kinase inhibitor,anlotinib,for a newly diagnosed ***:This multicenter,single-arm trial(NCT04119674)enrolled 33 treatment-naïve patients with histologically proven glioblastomas between March 2019 and November *** underwent treatment with the standard STUPP regimen[fractionated focal irradiation in daily fractions of 1.8-2 Gy given 5 d/w×6 w(total=54-60 Gy)]or radiotherapy plus continuous daily temozolomide(TMZ)(75 mg/m^(2)of body surface area/d,7 d/w from the first to the last day of radiotherapy),followed by 6 cycles of adjuvant TMZ(150-200 mg/m^(2)×5 d during each 28-d cycle)plus anlotinib(8 mg/d on d 1-14 of each 3-w cycle for 2 cycles during concomitant chemoradiotherapy,8 maximal cycles as adjuvant therapy,followed by maintenance at 8 mg/*** primary endpoint was progression-free survival(PFS).Secondary endpoints included overall survival(OS)and adverse events(AEs).Results:Thirty-three patients received the planned *** median PFS was 10.9 months(95%CI,9.9-18.7 months)and the 12-month PFS rate was 48.5%.The median OS was 17.4 months(95%CI,14.5-21.1 months)and the 12-month OS rate was 81.8%.The most common AEs included hypertriglyceridemia[58%(n=19)],hypoalbuminemia[46%(n=15)],and hypercholesterolemia[46%(n=15)]during concurrent chemoradiotherapy and leukopenia[73%(n=24)],hypertriglyceridemia[67%(n=22)],and neutropenia[52%(n=17)]during adjuvant *** patients discontinued treatment due to ***1(HR,5.6;95%CI,1.3-23.7;P=0.021)and RP1L1 alterations(HR,11.1;95%CI,2.2-57.2;P=0.004)were associated with a significantly shorter ***:Anlotinib plus the STUPP regimen has promising anti-tumor activity against glioblastoma and manageable ***1 and RP1L1 alterations might be novel predictive biomarkers of the response to anlotinib.

关键词： Glioblastoma anti-angiogenesis multi-kinase inhibitor anlotinib temozolomide progression-free survival

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脑脊液胆碱乙酰转移酶及胆碱酯酶与老年患者术后谵妄的关系

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中国临床研究 2024年第4期37卷 510-513页

作者：刘晨李肖璇毕燕琳林旭王彬齐峰山东大学齐鲁医院麻醉科山东济南250012 青岛市妇女儿童医院麻醉科山东青岛266000 青岛市市立医院麻醉科山东青岛266000

目的检测老年患者脑脊液胆碱乙酰转移酶(ChAT)及胆碱酯酶(ChE)浓度,探讨其与术后谵妄(POD)的关系。方法纳入2018年9月至2019年8月于青岛市市立医院行全膝/全髋关节置换术的患者183例。全部患者实施全膝或全髋关节置换术,采用腰硬联合... 详细信息

目的检测老年患者脑脊液胆碱乙酰转移酶(ChAT)及胆碱酯酶(ChE)浓度,探讨其与术后谵妄(POD)的关系。方法纳入2018年9月至2019年8月于青岛市市立医院行全膝/全髋关节置换术的患者183例。全部患者实施全膝或全髋关节置换术,采用腰硬联合麻醉,在蛛网膜下腔穿刺完毕之后,提取脑脊液2 mL。使用酶联免疫吸附试验法检测脑脊液ChAT、ChE、肿瘤坏死因子-α(TNF-α)和白细胞介素6(IL-6)的浓度;使用分光光度法检测脑脊液ChAT、ChE的活性。手术后采用意识模糊评估法(CAM)评定POD的发生情况。结果术后72 h内183例患者,未发生POD 157例(非POD组),发生POD 26例(POD组),发生率为14.21%。与非POD组相比,POD组术前脑脊液ChE浓度[(31.99±2.78)vs(40.89±4.19) ng/mL,t=13.915,Png/mL,t=12.920,P<0.01]、TNF-α [(17.19±1.32)vs(12.29±1.64) pg/mL,t=14.467,P<0.01]、IL-6 [(33.98±5.02)vs(16.98±3.41) pg/mL,t=16.643,P<0.01]浓度明显升高。与非POD组相比,POD组术前脑脊液ChE活性明显降低[(4.28±0.52)vs(5.25±0.26) u/mL,t=9.321,P<0.01],ChAT活性明显升高[(0.36±0.05)vs(0.27±0.03) u/mL,t=8.916,P<0.01]。结论脑脊液中的ChAT高活性、ChE低活性与老年患者POD的发生有关,其中胆碱能的退化与其发生密切相关。

关键词：脑脊液胆碱酯酶胆碱乙酰转移酶术后谵妄老年关节置换术

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Optical characteristics of Ce,Eu:YAG single crystal grown by Czochralski method

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Journal of Rare Earths 2019年第2期37卷 145-150页

作者： Jingfeng Zhang Guorui Gu xiaoxuan Di weidong Xiang Xiaojuan Liang College of Material Science and Engineering Tongji University College of Chemistry and Materials Engineering Wenzhou University

Eu-doped Ce:YAG single crystal(SC) was fabricated by the Czochralski method. The crystal structure,optical and photoelectric property of the constructed w-LED was investigated. The XRD and HRTEM results show that YAG crystal structure has little change when Eu^(3+), Ce^(3+) are doped. Absorption spectra and photoluminescence spectra show that the Ce,Eu:YAG single crystal can effectively absorb the 460 nm blue light to form a broadband emission center at 530 nm, decay curves of the crystal show that the energy transfer between Ce^(3+) and Eu^(3+) is highly suppressed. Compared with commercial Ce:YAG phosphor, Ce,Eu:YAG exhibits better thermal stability.

关键词： Ce,Eu:YAG Thermal stability Photoelectric parameter Rare earths

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Minimal-invasive enhancement of auditory perception by terahertz wave modulation

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Nano Research 2022年第6期15卷 5235-5244页

作者： xiaoxuan Tan Kaijie wu Shuang Liu Yifang Yuan Chao Chang wei Xiong Innovation Laboratory of Terahertz Biophysics National Innovation Institute of Defense TechnologyBeijing 100071China School of Life Science Tsinghua UniversityBeijing 100071China School of Physics Peking UniversityBeijing 100071China

Hearing impairment is a common disease affecting a substantial proportion of the global ***,the most effective clinical treatment for patients with sensorineural deafness is to implant an artificial electronic ***,the improvements to hearing perception are variable and limited among healthy ***,cochlear implants have disadvantages,such as crosstalk derived from the currents that spread into non-target tissue between the ***,in this work,we describe terahertz wave modulation,a new and minimally invasive technology that can enhance hearing perception in animals by reversible modulation of currents in cochlear hair *** single-cell electrophysiology,guinea pig audiometry,and molecular dynamics simulations,we show that THM can reversibly increase mechano-electrical transducer currents(~50%higher)and voltage-gated K^(+)currents in cochlear hair cells through collective resonance of–C=O *** addition,measurement of auditory brainstem response(ABR)in guinea pigs treated with THM indicated a~10 dB increase in hearing *** study thus reports a new method of highly spatially selective hearing enhancement without introducing any exogeneous gene,which has potential applications for treatment of hearing disorders as well as several other areas of neuroscience.

关键词： terahertz wave neuromodulation hearing enhancement potassium channels cochlea

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Optimized photocatalytic regeneration of adsorption-photocatalysis bifunctional composite saturated with Methyl Orange

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Journal of Environmental Sciences 2020年第8期32卷 40-51页

作者： Yi Shang Xing Li Yanling Yang Nan w.ng xiaoxuan Zhuang Zhiwei Zhou College of Architecture and Civil engineering Beijing University of TechnologyBeijing 100124China

Photo-responsive adsorption-photocatalysis nanocomposites are generally used in water and wastewater decontamination;however,the prolonged adsorption capacity of composites and the role of adsorption in concomitant photocatalysis are typically *** composites can be regenerated under light irradiation as their adsorption capacity ***,a novel adsorption-photocatalysis bifunctional nanocomposite,Bi-doped TiO2 supported on powdered activated carbon(Bi2O3/TiO2/PAC),was prepared using the solimpregnation-hydrothermal ***2O3/TiO2/PAC with a secondary calcination temperature of 700℃under a nitrogen atmosphere was selected for maximum adsorption capacity on Methyl Orange(MO).The composite displayed an excellent adsorption capacity and was easily separated and *** results demonstrate that 71.2%photocatalytic regeneration efficiency could be attained under visible light irradiation for 1 hr at an intensity of 750 w/m^2 and pH *** of the as-prepared Bi2O3/TiO2/PAC nanocomposite(700℃)indicates that it possesses a highly specific surface area and great optical properties,show.ng bifunctional adsorption-photocatalysis *** p-n heterojunction of the composite played a dominant role in the photocatalytic regeneration process,and effective degradation of MO could be achieved along with composite regeneration.

关键词： Photocatalytic regeneration Nanocomposite Powdered activated carbon Adsorption Photocatalysis

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动物双歧杆菌和罗伊氏乳杆菌对肥胖小鼠体脂分布和血脂的影响

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现代食品科技 2024年第1期40卷 34-46页

作者：朱梅珍郑晗盈郭东北陈小旋潘莉莉李红卫厦门大学公共卫生学院福建厦门361100

利用肥胖小鼠模型探讨动物双歧杆菌CP-9(Bifidobacterium animalisCP-9,CP-9)和罗伊氏乳杆菌ADR-1(Limosilactobacillus reuteri ADR-1,ADR-1)对体质量、体脂分布和血脂的影响。高脂饲料喂养的肥胖小鼠随机分为高脂饮食对照组(High-fat Diet,HFD)、CP-9组、ADR-1组,正常饮食组(Normal Diet,ND)普通饲料喂养,每组12只,连续灌胃10 w。测量小鼠体质量、体成分,观察体脂肪分布、肝组织病理变化,检测血液生化指标,测定肝脏组织脂肪酸合成酶(Fattty Acid Synthase,FAS)和过氧化物酶体增殖物激活受体γ(Peroxisome Proliferator-activated Receptor-γ,PPARγ)基因的蛋白表达。干预结束时,与HFD相比,CP-9和ADR-1组小鼠体质量(-18.82%,-18.82%vs HFD)、腹腔和皮下脂肪、血清低密度脂蛋白胆固醇(Low-density Lipoprotein Cholesterol,LDL-C)、甘油三酯(Triglyceride,TG)、谷丙转氨酶(AlanineAminotransferase,ALT)显著降低(P<0.05)。CP-9、ADR-1组肝脂肪变性及肝损伤较HFD组明显改善,且肝脏FAS基因的蛋白表达减少(-53.22%,-53.22%vs HFD),PPARγ基因的蛋白表达增加(571.43%,714.29%vs HFD)。综上,CP-9和ADR-1干预可有效减轻肥胖小鼠体质量、腹腔和皮下脂肪,改善肝脂肪变性及肝损伤,可能是通过调节肝脏FAS和PPARγ基因的蛋白表达降低TG、LDL-C从而改善脂肪代谢异常。

关键词：动物双歧杆菌罗伊氏乳杆菌减重脂肪分布血脂

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Bacterial diacetyl suppresses abiotic stress-induced senescence in Arabidopsis

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Journal of Integrative Plant Biology 2022年第6期64卷 1135-1139页

作者： Sunil K.Singh Yazhou Sun Yu Yang Ziwei Zuo xiaoxuan wu Chuyang Shao Li Peng Paul w.Paré Huiming Zhang Shanghai Center for Plant Stress Biology Center for Excellence in Molecular Plant Sciencesthe Chinese Academy of SciencesShanghai 201602China University of Chinese Academy of Sciences Beijing 100049China Department of Chemistry and Biochemistry Texas Tech UniversityLubbock 79409TexasUSA

Premature plant senescence induced by abiotic stresses is a major cause of agricultural losses worldwide. Tools for suppressing stress-induced plant senescence are limited. Here, we report that diacetyl, a natural compound emitted by the plantbeneficial bacterium Bacillus amyloliquefaciens,suppresses abscisic acid-mediated foliar senescence in Arabidopsis thaliana under various abiotic stress conditions. Our results establish diacetyl as an effective protector against stressinduced plant senescence and reveal a molecular mechanism for bacteria-enhanced plant stress resistance.

关键词： ABA diacetyl microbial volatile leaf senescence

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Developing the QSPR model for predicting the storage lipid/water distribution coefficient of organic compounds

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Frontiers of Environmental Science & Engineering 2021年第2期15卷 87-94页

作者： Miao Li Jian Li Yuchen Lu Cenyang Han xiaoxuan wei Guangcai Ma Haiying Yu College of Geography and Environmental Sciences Zhejiang Normal UniversityJinhua 321004China

The distribution of organic compounds in stored lipids affects their migration,transformation,bioaccumulation,and toxicity in *** storage lipid/water distribution coefficient(log K_(lip/w))of organic chemicals,which quantitatively determines such distribution,has become a key parameter to assist their ecological security and health *** to the impossibility to measure K_(lip/w)values for a huge amount of chemicals,it is necessary to develop predictive *** this work,a quantitative structure-property relationship(QSPR)model for estimating log K_(lip/w)values of small organic compounds was constructed based on 305 experimental log K_(lip/w)*** chemical descriptors and n-octanol/water partitioning coefficient were employed to characterize the intermolecular interactions that dominate log K_(lip/w)*** hydrophobic and electrostatic interactions and molecular size have been found to play important roles in governing the distribution of chemicals between lipids and aqueous *** regression(R2=0.959)and validation(Q2=0.960)results indicate good fitting performance and robustness of the developed model.A comparison with the predictive performance of other commercial software further proves the higher accuracy and stronger predictive ability of the developed K_(lip/w)predictive ***,it can be used to predict the K_(lip/w)values of cycloalkanes,long-chain alkanes,halides(with fluorine,chlorine,and bromine as substituents),esters(without phosphate groups),alcohols(without methoxy groups),and aromatic compounds.

关键词： Storage lipid/water distribution coefficient log Klip/w Organic compounds QSPR Quantum chemical descriptors

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Trimetallic synergistic optimization of 0D NiCoFe-P QDs anchoring on 2D porous carbon for efficient electrocatalysis and high-energy supercapacitor

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Journal of Energy Chemistry 2022年第11期31卷 149-158,I0006页

作者： Ruiqi Liu Xue-Rong Shi Yi wen xiaoxuan Shao Chen Su Jing Hu Shusheng Xu School of Materials Engineering Shanghai University of Engineering ScienceShanghai 201620China School of Advanced Materials and Nanotechnology Xidian UniversityXi’an 710071ShaanxiChina School of Materials Science and Engineering Suzhou University of Science and TechnologySuzhou 215009JiangsuChina

Developing multi-functional and low-cost noble-metal-free catalysts such as transition metal phosphides(TMPs)to replace noble-metal is of practical significance for energy conversion and ***,the low-durability and the agglomeration phenomenon during the electrochemical process limit their practical ***,using metal–organic frameworks(MOFs)as the precursor and a combined strategy of gradient temperature calcination and thermal phosphorization,a 0D/2D heterostructure of NiCoFe-P quantum dots(QDs)anchored on porous carbon was successfully developed as highly efficient electrode materials for overall water splitting and *** to this distinctive 0D/2D heterostructure and the synergistic effect of multi-metallic TMPs,the NiCoFe-P/C exhibits excellent electrocatalytic activity and durability of HER(87 mV at 10 mA cm^(-2))and OER(257 mV at 100 mA cm^(-2))in the KOH *** NiCoFe-P/C is used as the two electrodes of electrolyzed water,only 1.55 V can drive the current density to 10 m A cm^(-2).At the same time,our NiCoFe-P/C possessed extraordinary property for charge *** particular,an ultra-high energy density of 100.8 wh kg^(-1) was achieved at a power density of 900.0 w kg^(-1) for our assembled hybrid supercapacitor device NiCoFe-P/C(2:1)//activated carbon(AC).This work may open a potential way for the design of 0D/2D hybrid multifunctional nanomaterials based on TMPs QDs.

关键词： Metal-organic frameworks Transition metal phosphide quantum dots 0D/2D heterostructure Overall water splitting Supercapacitor First-principle calculations

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