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菌食性甲虫几何形态学分析

韶关学院学报 2024年第3期45卷 60-65页

作者：张应明李盼盼佟一杰李晓璇何镜琳谭海蓉白明广东车八岭国家级自然保护区管理局广东韶关512500 中国科学院动物研究所动物进化与系统学重点实验室北京100101

菌食性甲虫与真菌之间的相互作用紧密且复杂,菌食性甲虫的形态演化是否受到真菌和环境因素的影响尚不可知.为此,选取12科菌食性甲虫并将其按栖息地的基质环境分为两类:a类栖息地的基质为森林生态系统落叶层腐殖质,b类栖息地的基质为经... 详细信息

菌食性甲虫与真菌之间的相互作用紧密且复杂,菌食性甲虫的形态演化是否受到真菌和环境因素的影响尚不可知.为此,选取12科菌食性甲虫并将其按栖息地的基质环境分为两类:a类栖息地的基质为森林生态系统落叶层腐殖质,b类栖息地的基质为经真菌菌丝体分解的林木;通过几何形态学手段对两类菌食性甲虫形态进行比较,探究菌食性甲虫形态多样性与生活习性之间的关系.研究发现,a类菌食性甲虫整体形态偏圆且纵向隆起;b类菌食性甲虫整体多扁平偏椭圆.因此,菌食性甲虫前胸背板和鞘翅形态上的多样性在一定程度上反映了菌食性甲虫对生存环境的适应性.

关键词：菌食性甲虫几何形态学前胸背板鞘翅

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非饱和黏性土水-力耦合弹塑性组合双面模型

岩石力学与工程学报 2023年第S1期42卷 3654-3662页

作者：李潇旋李涛黄河勘测规划设计研究院有限公司河南郑州450003 黄河勘测规划设计研究院有限公司博士后科研工作站河南郑州450003 北京交通大学土木建筑工程学院北京100044

非饱和黏性土在外荷载作用下呈现出复杂的水-力耦合特性。为描述水-力耦合对非饱和土应力-应变特性的影响,基于弹塑性理论,采用提出的循环塑性硬化法则,考虑(p’-q-s)空间内的任意应力路径变化,建立能够描述非饱和黏性土水-力耦合特性... 详细信息

非饱和黏性土在外荷载作用下呈现出复杂的水-力耦合特性。为描述水-力耦合对非饱和土应力-应变特性的影响,基于弹塑性理论,采用提出的循环塑性硬化法则,考虑(p’-q-s)空间内的任意应力路径变化,建立能够描述非饱和黏性土水-力耦合特性的弹塑性组合双面模型。该模型通过平均骨架应力和修正吸力反映应力和吸力的耦合作用,采用2组加载面和边界面组合,分别描述加载、干湿过程中水-力耦合引起的塑性屈服,实现非饱和黏性土水-力特性的全耦合分析和求解。与非饱和黏性土的常规静力三轴剪切试验结果的比较表明,所建模型能较好地模拟非饱和黏性土水-力耦合下的应力-应变特性。

关键词：土力学非饱和土基质吸力水-力耦合硬化法则弹塑性双面模型

Polygonisation of railway wheels:a critical review

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Railway Engineering Science 2020年第4期28卷 317-345页

作者： Gongquan Tao Zefeng Wen Xuesong Jin xiaoxuan Yang State Key Laboratory of Traction Power Southwest Jiaotong UniversityChengdu 610031China

Polygonisation is a com.on nonuniform.wear phenom.non occurring in railway vehicle wheels and has a severe im.act on the vehicle–track system.ride com.ort,and lineside *** paper first sum.arizes periodic defects of the wheels,including wheel polygonisation and wheel corrugation,occurring in railways ***,the effects of wheel polygonisation on the wheel–rail interaction,noise and vibration,and fatigue failure of the vehicle and track com.onents are *** on the different causes,the form.tion m.chanism. of periodic wheel defects are classified into three categories:(1)initial defects of wheels,(2)natural vibration of the vehicle–track system.and(3)therm.elastic *** addition,the sim.lation m.thods of wheel polygonisation evolution and counterm.asures to m.tigate wheel polygonisation are *** is given to the characteristics,effects,causes,and solutions of wheel polygonisation in m.tro vehicles,locom.tives,and highspeed trains in ***,the guidance is provided on further understanding the form.tion m.chanism.,m.nitoring technology,and m.intenance criterion of wheel polygonisation.

关键词： Railway vehicle Wheel polygonisation Wear m.chanism Wheel-rail interaction

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“缠达”新考

音乐研究 2023年第3期 46-55页

作者：闫晓璇山西师范大学戏剧与影视学院

“缠达”是中国古代说唱技艺“唱赚”的一种曲式类型。自王国维《宋元戏曲考》始,学界对于“缠达”的考证便有许多争议。“缠达”非关“转踏”,可以根据《说文解字》“达”“迭”互通之说法,将“缠达”释为“缠迭”,“迭”即迭奏之意。... 详细信息

“缠达”是中国古代说唱技艺“唱赚”的一种曲式类型。自王国维《宋元戏曲考》始,学界对于“缠达”的考证便有许多争议。“缠达”非关“转踏”,可以根据《说文解字》“达”“迭”互通之说法,将“缠达”释为“缠迭”,“迭”即迭奏之意。“缠达”的本质形态是将两支曲子(或称“两腔”)反复迭奏构成的套式结构。如果变换“两腔”中的一个曲调则成为“间花体”;如果将“两腔”独立出来,则成为“子母调”。在“缠达”的发展过程中,“缠迭”的本质形态被继承和延续,并以“子母调”的形式灵活地存在于套曲之中。

关键词：缠达缠令唱赚转踏子母调间花体

丙戊酸镁缓释片治疗躁狂发作的药品临床综合评价

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中国医院用药评价与分析 2024年第8期24卷 973-977页

作者：李晓曦邢晓璇冯英楠庄伟王之舟王可张蔷张兰董宪喆首都医科大学宣武医院药学部国家老年疾病临床医学研究中心北京100053 首都医科大学药学院北京100069

目的:对丙戊酸镁缓释片治疗躁狂发作的临床综合价值进行评价,为临床合理用药和相关用药决策提供证据支持。方法:系统检索Pubm.d、the Cochrane Library、中国知网、万方数据库等中英文数据库(检索时限均为建库至2023年7月11日),筛选丙... 详细信息

目的:对丙戊酸镁缓释片治疗躁狂发作的临床综合价值进行评价,为临床合理用药和相关用药决策提供证据支持。方法:系统检索Pubm.d、the Cochrane Library、中国知网、万方数据库等中英文数据库(检索时限均为建库至2023年7月11日),筛选丙戊酸镁缓释片治疗躁狂发作的随机对照试验(研究组为丙戊酸镁缓释片或在其基础上联合常规抗躁狂药物治疗,对照组为常规抗躁狂药物治疗)。采用文献研究的方法,基于当前可获得的证据,围绕丙戊酸镁缓释片治疗躁狂发作的有效性、安全性、经济性、创新性、适宜性和可及性6个维度,开展临床综合评价。结果:共纳入20篇随机对照试验研究进行m.ta分析。有效性方面,丙戊酸镁缓释片改善躁狂症状的总有效率与喹硫平、碳酸锂等一线药物相似(OR=1.19,95%CI=0.94~1.49,P=0.14);安全性方面,使用丙戊酸镁缓释片的患者出现头晕头痛、乏力等不良反应的发生率(OR=0.57,95%CI=0.37~0.89,P=0.01)及严重程度(m.=-1.23,95%CI=-1.70~-0.75,P<0.000 01)均低于对照药物;经济学方面,最小成本分析结果显示,丙戊酸镁缓释片治疗躁狂发作的经济性优于喹硫平;创新性方面,丙戊酸镁缓释片由我国湖南省湘中制药有限公司生产,其可通过多途径提高脑内抑制性递质的含量,是目前全球唯一的丙戊酸镁制剂,该药制备工艺及外观均获得专利保护;适宜性方面,丙戊酸镁具有良好的技术特点适宜性,使用方便且便于存储;可及性方面,丙戊酸镁缓释片已被纳入国家医保目录,覆盖范围广,且可负担性较高。结论:丙戊酸镁缓释片作为我国自主生产研发的药物,在有效性、安全性和经济性方面具有显著优势,药品作用机制具有创新性,适宜性、可获得性及可负担性均较好。

关键词：丙戊酸镁缓释片躁狂发作药品临床综合评价

Optim.zed photocatalytic regeneration of adsorption-photocatalysis bifunctional com.osite saturated with m.thyl Orange

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Journal of Environm.ntal Sciences 2020年第8期32卷 40-51页

作者： Yi Shang Xing Li Yanling Yang Nan Wang xiaoxuan Zhuang Zhiwei Zhou College of Architecture and Civil engineering Beijing University of TechnologyBeijing 100124China

Photo-responsive adsorption-photocatalysis nanocom.osites are generally used in water and wastewater decontam.nation;however,the prolonged adsorption capacity of com.osites and the role of adsorption in concom.tant photocatalysis are typically *** com.osites can be regenerated under light irradiation as their adsorption capacity ***,a novel adsorption-photocatalysis bifunctional nanocom.osite,Bi-doped TiO2 supported on powdered activated carbon(Bi2O3/TiO2/PAC),was prepared using the solim.regnation-hydrotherm.l ***2O3/TiO2/PAC with a secondary calcination tem.erature of 700℃under a nitrogen atm.sphere was selected for m.xim.m.adsorption capacity on m.thyl Orange(m.).The com.osite displayed an excellent adsorption capacity and was easily separated and *** results dem.nstrate that 71.2%photocatalytic regeneration efficiency could be attained under visible light irradiation for 1 hr at an intensity of 750 W/m.2 and pH *** of the as-prepared Bi2O3/TiO2/PAC nanocom.osite(700℃)indicates that it possesses a highly specific surface area and great optical properties,showing bifunctional adsorption-photocatalysis *** p-n heterojunction of the com.osite played a dom.nant role in the photocatalytic regeneration process,and effective degradation of m. could be achieved along with com.osite regeneration.

关键词： Photocatalytic regeneration Nanocom.osite Powdered activated carbon Adsorption Photocatalysis

科罗索酸抑制NLRP3炎症小体活性在糖尿病肾病中的保护作用

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生物加工过程 2024年第4期22卷 412-418页

作者：鲍晓文韦景熏王小轩李佳琪任朝兴司马昕瑜陈佳怡马博南京工业大学药学院江苏南京211800

探讨科罗索酸(CA)对糖尿病肾病(DN)的治疗作用及其机制。采用高脂饲料结合链脲佐菌素(STZ)构建DN小鼠的病理模型。并将小鼠随机分为空白组、模型组和CA低、中和高剂量组。CA治疗8周后,测定各组小鼠24 h排尿量,采用试剂盒检测血尿素氮(B... 详细信息

探讨科罗索酸(CA)对糖尿病肾病(DN)的治疗作用及其机制。采用高脂饲料结合链脲佐菌素(STZ)构建DN小鼠的病理模型。并将小鼠随机分为空白组、模型组和CA低、中和高剂量组。CA治疗8周后,测定各组小鼠24 h排尿量,采用试剂盒检测血尿素氮(BUN)、血糖浓度、糖化血清蛋白(GSP),并计算肾脏指数。以HE和PAS染色方法评价CA对糖尿病(Dm.诱导小鼠肾损伤的保护作用;同时采用免疫组化法检测肾组织中胶原蛋白Ⅳ(collagenⅣ)、纤连蛋白(fibronectin)和NLRP3炎症小体的表达和分布,实时荧光定量聚合酶链反应(Real tim. PCR)检测肾脏组织中collagenⅣ、fibronectin、白介素18(IL 18)以及白介素1β(IL 1β)的m.RNA表达。结果表明:与空白组相比,模型组血糖浓度、GSP浓度、24 h排尿量、BUN浓度及肾脏指数明显升高。给予CA治疗8周后,可以显著地降低DN小鼠的血糖浓度、GSP浓度、24 h排尿量、BUN浓度及肾脏指数。同时,CA组还可明显改善DN小鼠肾脏的病理变化,降低肾脏组织中collagenⅣ和fibronectin蛋白及其m.RNA的表达。此外,CA可以通过调控NOD样受体蛋白3(NLRP3)炎症小体活性抑制DN小鼠肾脏组织IL 18和IL 1β水平,以减轻炎症损伤。CA可以明显恢复DN小鼠肾功能,有效缓解肾脏的组织损伤和纤维化病变,并通过调控NLRP3炎症小体活性抑制DN小鼠肾脏组织IL 18和IL 1β水平,发挥抗DN的作用。

关键词：科罗索酸糖尿病肾病 NLRP3 纤维化细胞外基质沉积

Extending Lifespan of Alzheim.r's m.de Nem.tode CL4176 Using a Novel Bifunctional Peptide with Inhibition ofβ-Am.loid Aggregation and Anti-oxidation

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Chem.cal Research in Chinese Universities 2019年第2期35卷 245-250页

作者： XU Jia YU xiaoxuan ZHANG Yue LIU Naizhang GUAN Shuwen WANG Liping School of Life Sciences Jilin UniversityChangchun 130012P.R.China Engineering Laboratory for AIDS Vaccine Jilin UniversityChangchun 130012P.R.China Key Laboratory for m.lecular Enzym.logy and Engineering Ministry of EducationJilin UniverstiyChangchun 130012P.R.China

Alzheim.r’s disease(AD)is a neurodegenerative disorder characterized by the deposition ofβ-am.loid peptide(Aβ)in the brain tissues,and an im.alance in the oxidant-antioxidant *** with antioxidant activity and the ability to inhibit Aβaggregation therefore potentially treat *** this study,we designed an iron-porphyrin containing bifunctional peptide(BP,Deuterohem.n-AlaHisThrValGluLysLeuProPhePheAsp)based on natural m.croperoxidase-11(m.-11)and typicalβ-sheet breaker LPFFD(iAβ5p).This BP substantially reduced the aggregation of Aβand caused oligom.r disassem.ly,by binding Aβwith affinity constant of 9.07μm.l/***,it showed a neuroprotective effect on Aβ25—35 induced toxicity in SH-SY5Y cells,and significantly alleviated Aβ-induced paralysis and extended lifespan in Aβ1-42 transgenic ***(CL4176).It also showed a potent peroxidase activity of 20.8 U/m.,and scavenged free radicals both in and in *** addition,BP up-regulated the levels of hsp16.2,hsp16.41,and hsp12.6 m.NAs to 183.26%,160.16%,and 162.64%respectively,and down-regulated that of hsp70 to 36.76%in *** together,the synthetic BP inhibited Aβaggregation and showed antioxidant activity,indicating the therapeutic potential of novel peptide drugs against AD.

关键词： Bifunctional peptide(BP) Aβ-Inhibitor Antioxidant Caenorhabditis elegans(C.elegans)

Guidelines for rational design of high-perform.nce absorbents:A case study of zeolite adsorbents for em.rging pollutants in water

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Green Energy & Environm.nt 2017年第4期2卷 363-369页

作者： xiaoxuan Wei Ya Wang Arturo J.Hernndez-m.ldonado Zhongfang Chen Departm.nt of Chem.stry Institute for Functional Nanomaterials University of Puerto Rico Rio Piedras Campus Departm.nt of Chem.cal Engineering Institute for Functional Nanomaterials University of Puerto Rico Mayagüez Campus

Rational design is im.ortant to achieve high-perform.nce sorbents used to rem.ve the contam.nants of em.rging concern(CECs) from.***, it is hard to propose effective design guidelines due to the lack of a clear understanding of the interaction m.chanism.. By m.ans of system.tic quantum.chem.cal com.utations, as a case study, we investigated the interactions between zeolite X/m.(n+)-zeolite X(Si/Al=1,m.(n+)=Cu^(2+) and Ni^(2+)) and three com.only used CECs(nam.ly salicylic acid, carbam.zepine and ciprofloxacin) in water to clarify the adsorption m.chanism.. Our com.utations found that anionic salicylic acid cannot be adsorbed by neither zeolite X nor m.(n+)-zeolite X in neutral water due to the high electrostatic repulsion. In com.arison, carbam.zepine and ciprofloxacin have favorable binding energies with both zeolite X and m.(n+)-zeolite X, and their interactions with m.(n+)-zeolite X are stronger due to the joint effects of H-bond, m.tal com.lexation and electrostatic interaction. The adsorption loading of ciprofloxacin, which has a large m.lecular size, on m.(n+)-zeolite X is lim.ted due to the steric hindrance. In general, steric hindrance, electrostatic interaction, H-bond and m.tal com.lexation are dom.nant factors for the exam.ned system. in this study. Thus, for the design of high-perform.nce absorbing m.terials, we should fully consider the m.lecular properties of pollutants(m.lecular size, surface electrostatic potential and atom.c type, etc.), and properly enhance the favorable effects and avoid the unfavorable factors as m.ch as possible under the guidance of the interaction m.chanism..

关键词： Adsorption m.chanism Adsorbent design guidelines Quantum.chem.cal com.utations Contam.nants of em.rging concern Zeolite X