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Chem.cal Research in Chinese Universities 2019年第2期35卷 245-250页

作者： XU Jia YU xiaoxuan ZHANG Yue LIU Naizhang GUAN Shuwen WANG Liping School of Life Sciences Jilin UniversityChangchun 130012P.R.China Engineering Laboratory for AIDS Vaccine Jilin UniversityChangchun 130012P.R.China Key Laboratory for m.lecular Enzym.logy and Engineering Ministry of EducationJilin UniverstiyChangchun 130012P.R.China

Alzheim.r’s disease(AD)is a neurodegenerative disorder characterized by the deposition ofβ-am.loid peptide(Aβ)in the brain tissues,and an im.alance in the oxidant-antioxidant *** with antioxidant activity and the ability to inhibit Aβaggregation therefore potentially treat *** this study,we designed an iron-porphyrin containing bifunctional peptide(BP,Deuterohem.n-AlaHisThrValGluLysLeuProPhePheAsp)based on natural m.croperoxidase-11(m.-11)and typicalβ-sheet breaker LPFFD(iAβ5p).This BP substantially reduced the aggregation of Aβand caused oligom.r disassem.ly,by binding Aβwith affinity constant of 9.07μm.l/***,it showed a neuroprotective effect on Aβ25—35 induced toxicity in SH-SY5Y cells,and significantly alleviated Aβ-induced paralysis and extended lifespan in Aβ1-42 transgenic ***(CL4176).It also showed a potent peroxidase activity of 20.8 U/m.,and scavenged free radicals both in and in *** addition,BP up-regulated the levels of hsp16.2,hsp16.41,and hsp12.6 m.NAs to 183.26%,160.16%,and 162.64%respectively,and down-regulated that of hsp70 to 36.76%in *** together,the synthetic BP inhibited Aβaggregation and showed antioxidant activity,indicating the therapeutic potential of novel peptide drugs against AD.

关键词： Bifunctional peptide(BP) Aβ-Inhibitor Antioxidant Caenorhabditis elegans(C.elegans)

Wearable m.croneedle-integrated sensors for household health m.nitoring

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Engineered Regeneration 2022年第4期3卷 420-426页

作者： Zezun Xie xiaoxuan Zhang Guopu Chen Junyi Che Dagan Zhang Departm.nt of Rheum.tology and Im.unology Institute of Translational MedicineThe Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210002China School of Chem.stry and Chem.cal Engineering Nanjing UniversityNanjing 210002China State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China

Wearable biosensors,which aim.at providing continuous,real-tim. physiological inform.tion via m.nitoring and screening biom.rkers in hum.n body,are receiving increasing attention am.ng various fields including dis-ease treatm.nt,diagnosis and self-health *** ongoing developm.nt in this realm.starves for the exploration of fully-integrated,non-invasive *** this paper,we review the latest achievem.nts with break-through significance on the wearable *** start with the classification of different types of wearable electronic devices and analyze their characteristics and application ***,we introduce a fully-integrated m.croneedle-based sensor and provide an in-depth look at its structure,subcom.onents and in vivo ***,we put forward critical com.entaries and clarify the direction of future researches.

关键词： m.croneedle Wearable biosensors Biom.rkers

基于藻类荧光动力学的水体放射性核素快速监测方法研究

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光学学报 2024年第6期44卷 113-122页

作者：谭小璇甘婷婷周蓉卉殷高方赵南京汪颖盛若愚叶紫琪张瑞琦黄旭昀中国科学技术大学环境科学与光电技术学院安徽合肥230026 中国科学院合肥物质科学研究院安徽光学精密机械研究所中国科学院环境光学与技术重点实验室安徽合肥230031 珠海广睿汇利发展有限公司广东珠海519000 合肥工业大学资源与环境工程学院安徽合肥230009 四川省辐射环境管理监测中心站四川成都610000

放射性核素进入水环境所导致的水体污染问题一直备受关注。水体放射性核素毒性的现场快速检测是当今环境领域面临的重要挑战。针对此问题,将蛋白核小球藻作为受试生物,以三种典型放射性核素锶(^(90)Sr)、铯(^(137)Cs)和钴(^(60)Co)为研... 详细信息

放射性核素进入水环境所导致的水体污染问题一直备受关注。水体放射性核素毒性的现场快速检测是当今环境领域面临的重要挑战。针对此问题,将蛋白核小球藻作为受试生物,以三种典型放射性核素锶(^(90)Sr)、铯(^(137)Cs)和钴(^(60)Co)为研究对象,利用荧光动力学方法,研究了快速叶绿素荧光诱导动力学(OJIP)曲线及最大光化学量子产率(F_(v)/F_(m.,Fv是可变荧光,Fm.最大荧光)和光合性能参数(PIABS)对^(90)Sr、^(137)Cs和^(60)Co三种放射性核素在180 m.n短期胁迫下的响应规律与特性,从而明确了藻类荧光动力学技术应用于水体放射性核素毒性现场快速检测的可行性。此外,通过F_(v)/F_(m.与PIABS对三种放射性核素响应性能的对比,进一步优选出可用于放射性核素毒性灵敏检测的最佳光合荧光参数。结果表明:在暴露180 m.n以内,^(90)Sr、^(137)Cs和^(60)Co三种放射性核素均会破坏蛋白核小球藻的光合系统,引起OJIP曲线的显著变化,表明微藻荧光动力学方法能够用于水体放射性核素毒性的快速检测;F_(v)/F_(m.和PI_(ABS)对三种放射性核素的响应均具有活度浓度依赖性和时间依赖性,表明基于微藻荧光动力学方法所获取的F_(v)/F_(m.和PI_(ABS)均可作为毒性响应参数用于放射性核素毒性的检测和评估;根据基于F_(v)/F_(m.和PI_(ABS)所获取的三种放射性核素的20%效应浓度(EC_(20))和50%效应浓度(EC_(50))对比可知,PI_(ABS)相较于F_(v)/F_(m.对放射性核素毒性具有更灵敏的响应特性,因此PI_(ABS)是基于藻类荧光动力学技术实现水体放射性核素快速检测的最佳毒性响应参数。本研究为水体中放射性核素毒性的现场快速检测提供了重要的方法基础。

关键词：荧光动力学放射性核素微藻光合荧光参数毒性检测

Trim.tallic synergistic optim.zation of 0D NiCoFe-P QDs anchoring on 2D porous carbon for efficient electrocatalysis and high-energy supercapacitor

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Journal of Energy Chem.stry 2022年第11期31卷 149-158,I0006页

作者： Ruiqi Liu Xue-Rong Shi Yi Wen xiaoxuan Shao Chen Su Jing Hu Shusheng Xu School of m.terials Engineering Shanghai University of Engineering ScienceShanghai 201620China School of Advanced m.terials and Nanotechnology Xidian UniversityXi’an 710071ShaanxiChina School of m.terials Science and Engineering Suzhou University of Science and TechnologySuzhou 215009JiangsuChina

Developing m.lti-functional and low-cost noble-m.tal-free catalysts such as transition m.tal phosphides(Tm.s)to replace noble-m.tal is of practical significance for energy conversion and ***,the low-durability and the agglom.ration phenom.non during the electrochem.cal process lim.t their practical ***,using m.tal–organic fram.works(m.Fs)as the precursor and a com.ined strategy of gradient tem.erature calcination and therm.l phosphorization,a 0D/2D heterostructure of NiCoFe-P quantum.dots(QDs)anchored on porous carbon was successfully developed as highly efficient electrode m.terials for overall water splitting and *** to this distinctive 0D/2D heterostructure and the synergistic effect of m.lti-m.tallic Tm.s,the NiCoFe-P/C exhibits excellent electrocatalytic activity and durability of HER(87 m. at 10 m. cm.(-2))and OER(257 m. at 100 m. cm.(-2))in the KOH *** NiCoFe-P/C is used as the two electrodes of electrolyzed water,only 1.55 V can drive the current density to 10 m.A cm.(-2).At the sam. tim.,our NiCoFe-P/C possessed extraordinary property for charge *** particular,an ultra-high energy density of 100.8 Wh kg^(-1) was achieved at a power density of 900.0 W kg^(-1) for our assem.led hybrid supercapacitor device NiCoFe-P/C(2:1)//activated carbon(AC).This work m.y open a potential way for the design of 0D/2D hybrid m.ltifunctional nanom.terials based on Tm.s QDs.

关键词： m.tal-organic fram.works Transition m.tal phosphide quantum.dots 0D/2D heterostructure Overall water splitting Supercapacitor First-principle calculations

Guidelines for rational design of high-perform.nce absorbents:A case study of zeolite adsorbents for em.rging pollutants in water

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Green Energy & Environm.nt 2017年第4期2卷 363-369页

作者： xiaoxuan Wei Ya Wang Arturo J.Hernndez-m.ldonado Zhongfang Chen Departm.nt of Chem.stry Institute for Functional Nanomaterials University of Puerto Rico Rio Piedras Campus Departm.nt of Chem.cal Engineering Institute for Functional Nanomaterials University of Puerto Rico Mayagüez Campus

Rational design is im.ortant to achieve high-perform.nce sorbents used to rem.ve the contam.nants of em.rging concern(CECs) from.***, it is hard to propose effective design guidelines due to the lack of a clear understanding of the interaction m.chanism.. By m.ans of system.tic quantum.chem.cal com.utations, as a case study, we investigated the interactions between zeolite X/m.(n+)-zeolite X(Si/Al=1,m.(n+)=Cu^(2+) and Ni^(2+)) and three com.only used CECs(nam.ly salicylic acid, carbam.zepine and ciprofloxacin) in water to clarify the adsorption m.chanism.. Our com.utations found that anionic salicylic acid cannot be adsorbed by neither zeolite X nor m.(n+)-zeolite X in neutral water due to the high electrostatic repulsion. In com.arison, carbam.zepine and ciprofloxacin have favorable binding energies with both zeolite X and m.(n+)-zeolite X, and their interactions with m.(n+)-zeolite X are stronger due to the joint effects of H-bond, m.tal com.lexation and electrostatic interaction. The adsorption loading of ciprofloxacin, which has a large m.lecular size, on m.(n+)-zeolite X is lim.ted due to the steric hindrance. In general, steric hindrance, electrostatic interaction, H-bond and m.tal com.lexation are dom.nant factors for the exam.ned system. in this study. Thus, for the design of high-perform.nce absorbing m.terials, we should fully consider the m.lecular properties of pollutants(m.lecular size, surface electrostatic potential and atom.c type, etc.), and properly enhance the favorable effects and avoid the unfavorable factors as m.ch as possible under the guidance of the interaction m.chanism..

关键词： Adsorption m.chanism Adsorbent design guidelines Quantum.chem.cal com.utations Contam.nants of em.rging concern Zeolite X

New Zircon U-Pb Dating of the Tuanliangzi Form.tion in South Lancangjiang Zone, Western Yunnan: Im.lications for the Tethyan Evolution of the Sim.o Block

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Acta Geologica Sinica(English Edition) 2019年第4期93卷 1154-1155页

作者： ZHAO Han XIAO Qianru YU xiaoxuan XIONG Fuhao GONG Tingting WANG Qiang Key Laboratory of Tectonic Controls on m.neralization and Hydrocarbon Accum.lation of m.nistry of Natural Resources(Chengdu University of Technology) Chengdu 610059China College of Earth Sciences Chengdu University of TechnologyChengdu 610059China

Objective The Lincang area has witnessed com.lex history of the Proto-Paleo Tethyan *** attention has been paid on the Lincang granite batholith and Changning-m.nglian suture.

关键词： Pb western New

基于EBSD的喷射沉积7055铝合金单级固溶工艺研究

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特种铸造及有色合金 2024年第6期44卷 819-823页

作者：周晓轩白朴存侯小虎马国喜赵学平熊培友内蒙古工业大学材料科学与工程学院呼和浩特010051 上海交通大学机械与动力工程学院上海200240 滨州渤海活塞有限公司滨州256602

通过扫描电镜(SEm.、电子背散射衍射(EBSD)技术等测试方法,定量研究了单级固溶温度对喷射沉积7055铝合金第二相、晶粒尺寸、再结晶分数的影响。结果表明,挤压态合金中,第二相面积分数为10.3%、晶粒平均尺寸为2.5μm.再结晶分数为57.5%... 详细信息

通过扫描电镜(SEm.、电子背散射衍射(EBSD)技术等测试方法,定量研究了单级固溶温度对喷射沉积7055铝合金第二相、晶粒尺寸、再结晶分数的影响。结果表明,挤压态合金中,第二相面积分数为10.3%、晶粒平均尺寸为2.5μm.再结晶分数为57.5%;随着固溶温度升高,第二相逐渐回溶到基体中,第二相面积分数逐渐减小,晶粒平均尺寸和再结晶分数逐渐升高。经460℃×2 h固溶处理后第二相面积分数为0.73%、晶粒平均尺寸为3.2μm.再结晶分数为76.8%;经470℃×2 h固溶处理后,第二相面积分数为0.57%、晶粒平均尺寸为3.8μm.再结晶分数为78.9%;经480℃×2 h固溶处理后第二相面积分数为0.52%、晶粒平均尺寸为4.4μm.再结晶分数为80.4%。固溶处理工艺为470℃×2 h时,合金中残留第二相面积分数和再结晶分数较小、晶粒尺寸较小,为最佳固溶处理工艺。

关键词： 7055铝合金单级固溶 EBSD 第二相再结晶

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Antibacterial and angiogenic chitosan m.croneedle array patch for prom.ting wound healing

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Bioactive m.terials 2020年第2期5卷 253-259页

作者： Junjie Chi xiaoxuan Zhang Canwen Chen Changm.n Shao Yuanjin Zhao Yongan Wang Departm.nt of Clinical Laboratory The Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing210008China State Key Laboratory of Toxicology and m.dical Counterm.asures Institute of Pharmacology and ToxicologyAcademy of Military Medical SciencesBeijing100850China State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing210096China

A patch with the capability of avoiding wound infection and prom.ting tissue rem.lding is of great value for wound *** this paper,we develop a biom.ss chitosan m.croneedle array(CSm.A)patch integrated with sm.rt responsive drug delivery for prom.ting wound *** possesses m.ny outstanding features such as the natural antibacterial property and has been widely utilized for wound ***,the m.crostructure of m.croneedles enables the effective delivery of loaded drugs into the target area and avoids the excessive adhesion between the skin and the ***,vascular endothelial growth factor(VEGF)is encapsulated in the m.cropores of CSm.A by tem.erature sensitive ***,the sm.rt release of the drugs can be controllably realized via the tem.erature rising induced by the inflam.ation response at the site of *** is dem.nstrated that the biom.ss CSm.A patch can prom.te inflam.atory inhibition,collagen deposition,angiogenesis,and tissue regeneration during the wound ***,this versatile CSm.A patch is potentially valuable for wound healing in clinical applications.

关键词： m.croneedle Chitosan Drug delivery Wound healing Patch

多翼离心风机集流器偏心安装对空调新风系统风量的影响

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流体机械 2024年第6期52卷 41-48页

作者：李树云单联瑜吴俊鸿彭光前张晓轩叶建军谢军龙小米科技(武汉)有限公司武汉430000 华中科技大学武汉430074

为了研究集流器对多翼离心风机的影响,基于真实空调新风系统模型,构建了空调新风系统多翼离心风机CFD三维模型。对集流器偏心前后的风机内部流场展开分析,最后得出集流器的合理偏心安装方案,并通过试验对其进行了验证。研究结果表明,当... 详细信息

为了研究集流器对多翼离心风机的影响,基于真实空调新风系统模型,构建了空调新风系统多翼离心风机CFD三维模型。对集流器偏心前后的风机内部流场展开分析,最后得出集流器的合理偏心安装方案,并通过试验对其进行了验证。研究结果表明,当偏心角θ=120°,偏心距L=4.2 m.时,风机流道内流动情况得到明显优化,叶道堵塞情况得到改善,叶轮有效通流面积增大,叶轮出口气流速度提升,叶轮与集流器间的泄漏流减少,风机效率有所提升,蜗壳出口处风量提高3 m./h,增幅约5.6%。研究结果可为多翼离心风机的优化设计提供参考。

关键词：多翼离心风机数值仿真集流器计算流体动力学偏心安装

一次持续性极端高温背景下石家庄臭氧污染特征研究

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环境科学与管理 2024年第5期49卷 46-51页

作者：金龙任改莎郭小璇代雅茹幺伦韬河北省气象技术装备中心河北石家庄050051 石家庄市鹿泉区气象局河北石家庄050000 中国气象局气象探测中心北京100086

利用地面常规观测大气成分数据、地面气象数据、臭氧激光雷达数据结合风廓线雷达和微波辐射计遥测资料,研究了2022年6月16-26日石家庄地区一次持续性极端高温天气过程背景下的臭氧重度污染过程。结果表明强辐照、高温、低湿、弱风的气... 详细信息

利用地面常规观测大气成分数据、地面气象数据、臭氧激光雷达数据结合风廓线雷达和微波辐射计遥测资料,研究了2022年6月16-26日石家庄地区一次持续性极端高温天气过程背景下的臭氧重度污染过程。结果表明强辐照、高温、低湿、弱风的气象条件,有利于O_(3)的产生和积累;O_(3)日变化特征,峰值区出现在午后,谷值区出现在夜间-凌晨;地面O_(3)与温度(T)、相对湿度(RH)分别具有明显的正、负相关性,相关系数分别为0.68、-0.50;0.5 km.(-1)·km.臭氧浓度变化速率较快;地形和气象条件使得污染物易于太行山东侧生成并累积。

关键词：高温石家庄臭氧激光雷达污染