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Bacteriophages assisted bacteria to facilitate soil multifunctionality under organochlorine pesticide contamination

Science China Technological Sciences 2024年第10期67卷 3116-3128页

作者： ZHAO DuoKai CHAO HuiZhen BALCAZAR Jose Luis WU ShiMao zheng xiaoxuan WU YunLing YUAN ShuJian SUN MingMing HU Feng Soil Ecology Lab Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource Utilization and Jiangsu Key Laboratory for Solid Organic Waste UtilizationNanjing Agriculture University J.F.Blumenbach Institute of Zoology and Anthropology University of G?ttingen Catalan Institute for Water Research (ICRA) University of Girona College of Environmental and Resource Sciences Zhejiang University

As the most abundant living entities in the environment, viruses have been well recognized as crucial members in sustaining biogeochemical cycling. However, the significance of viruses in soil ecosystem multifunctionality remains under-explored. In this study, we used metagenomics and meta-viromics analysis to investigate the role of soil viruses in soil ecosystem functions under heavy, light, and no organochlorine pesticides(OCPs) contamination. In the three types of soil samples collected, lightcontaminated soils supported the highest level of multifunctionality, followed by heavy-contaminated soils and clean ***, our results revealed a positive correlation between bacterial community evenness and multifunctionality index(p <0.05). Dominant bacterial species with biodegradation and stress resistance advantages exhibited higher abundance in OCPaffected soils, potentially playing a core functional supporting role. Furthermore, our results indicated that the species richness and diversity of bacteriophages were positively correlated with multifunctionality(p < 0.05) in OCP-affected soils. Bacteriophages in OCP-affected soils regulate host metabolism and enhance soil ecosystem multifunctionality by infecting functional bacterial hosts and encoding AMGs related to soil element cycling. Our findings emphasize the potential effect of phages on ecosystem multifunctionality in contaminated soil, suggesting that phages may serve as contributors to soil ecology beyond bacteria and other microorganisms. Therefore, in polluted or constrained soils, further research could potentially translate phage communities and related ecological processes into artificial methods for application in soil pollution remediation or ecological restoration.

关键词： soil ecosystem multifunctionality viruses auxiliary metabolic genes organochlorine pesticides contamination

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基于CDOM光谱特征的泥页岩产气特征评价

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地质科技通报 2024年第4期43卷 128-140页

作者：郑晓璇田继先田聪蒋峥文杨磊贺秋芳薛红蕾西南大学地理科学学院/岩溶环境重庆市重点实验室重庆400715 中国石油勘探开发研究院北京100083 中国石油青海油田公司勘探开发研究院甘肃敦煌736202 烟台市蓬莱区农业技术推广中心山东烟台265600

泥页岩中可溶有机质(DOM)组成和可降解性是影响生物气形成的重要因素,开发简便有效的方法来评估可溶有机质的组成、官能团特征和微生物活性等,可为泥页岩生物气田产气机制分析提供关键的基础信息。采集了柴达木盆地涩探1井1219~1309 m... 详细信息

泥页岩中可溶有机质(DOM)组成和可降解性是影响生物气形成的重要因素,开发简便有效的方法来评估可溶有机质的组成、官能团特征和微生物活性等,可为泥页岩生物气田产气机制分析提供关键的基础信息。采集了柴达木盆地涩探1井1219~1309 m泥质岩心,基于有色可溶有机质(CDOM)的三维荧光(EEM)和紫外可见吸收光谱特征,分析了可溶有机质的组分、官能团特征和易降解程度,了解了产甲烷菌可利用底物的分布情况。结果表明:涩探1井岩心有机质以易降解的类色氨酸荧光组分C1和C3为主,占比70.54%;荧光组分、荧光参数HIX、BIX和吸光系数E_(253)/E_(203)、SUVA_(254)共同指示1219~1222 m和1285~1301 m2个层位有机质腐殖化程度较低,芳香性较弱,为潜在的产气活跃层位。研究表明CDOM光谱可以作为分析泥页岩可溶有机质特征的有效方法,其结果反映了产甲烷菌可利用底物和微生物活性等特征,为烃源层系内生物产气预测提供有效的重要信息。

关键词：生物气可溶有机质(DOM) CDOM三维荧光光谱紫外-可见吸收光谱柴达木盆地泥页岩

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Sum Frequency Generation Vibrational Spectra of Perovskite Nanocrystals at the Single-Nanocrystal and Ensemble Levels

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Chinese Journal of Chemical Physics 2022年第5期35卷 738-746,I0001-I0003,I0011页

作者： Renlong Zhu Quanbing Pei Junjun Tan xiaoxuan zheng Shuji Ye Hefei National Research Center for Physical Sciences at the Microscale and Department of Chemical PhysicsUniversity of Science and Technology of ChinaHefei 230026China

Determination of molecular structures of organicinorganic hybrid perovskite(OIHP)nanocrystals at the single-nanocrystal and ensemble levels is essential to understanding the mechanisms responsible for their size-dependent optoelectronic properties and the nanocrystal assembling process,but its detection is still a bit *** this study,we demonstrate that femtosecond sum frequency generation(SFG)vibrational spectroscopy can provide a highly sensitive tool for probing the molecular structures of nanocrystals with a size comparable to the Bohr diameter(∼10 nm)at the single-nanocrystal *** SFG signals are monitored using the spectral features of the phenyl group in(RMBA)PbBr_(3) and(R-MBA)_(2)PbI_(4) nanocrystals(MBA:methyl-benzyl-ammonium).It is found that the SFG spectra exhibit a strong resonant peak at 3067±3 cm^(−1)(ν2 mode)and a weak shoulder peak at 3045±4 cm^(−1)(ν_(7a) mode)at the ensemble level,whereas a peak of theν2 mode and a peak at 3025±3 cm^(−1)(ν20b mode)at the single-nanocrystal *** nanocrystals at the single-nanocrystal level tend to lie down on the surface,but stand up as the ensemble number and the averaged sizes *** finding may provide valuable information on the structural origins for size-dependent photo-physical properties and photoluminescence blinking dynamics in nanocrystals.

关键词： Perovskite Single nanocrystal Sum frequency generation vibrational spectroscopy Size-dependent property

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HPLC法检测保健品口服液中的盐酸左旋咪唑

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生物化工 2024年第1期10卷 40-43页

作者：李晓茵韦林庄少珊黄丽芹吴淋富郑晓渲李聪聪汕尾市食品药品检验所广东汕尾516600 汕尾市高级技工学校广东汕尾516600 广东药科大学广东中山528458

目的:建立高效液相色谱法检测保健品口服液中盐酸左旋咪唑的方法。方法:采用C18-WR色谱柱(4.6 mm×250 mm,5μm),流动相为乙腈-0.05 mol/L磷酸二氢钾溶液(用三乙胺调节pH=7)(25∶75,体积比),流速1.0 mL/min,检测波长210 nm,柱温30℃,进... 详细信息

目的:建立高效液相色谱法检测保健品口服液中盐酸左旋咪唑的方法。方法:采用C18-WR色谱柱(4.6 mm×250 mm,5μm),流动相为乙腈-0.05 mol/L磷酸二氢钾溶液(用三乙胺调节pH=7)(25∶75,体积比),流速1.0 mL/min,检测波长210 nm,柱温30℃,进样量10μL。结果:盐酸左旋咪唑在8.634~86.340μg/mL时与峰面积线性关系良好(R=0.9997);低、中、高加标量对应的平均回收率分别为99.7%、99.2%和100.3%,RSD分别为1.40%、0.64%和0.78%,检测限为0.4317μg/mL。随机对市售16批样品进行检测,均未检出盐酸左旋咪唑。结论:该方法简便、快速、准确,可用于保健品口服液中非法添加盐酸左旋咪唑的检测。

关键词：保健品口服液盐酸左旋咪唑 HPLC法

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CXCL13 shapes tumor immune microenvironment in ovarian cancer with homologous recombination deficiency

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Genes & Diseases 2024年第5期11卷 48-50页

作者： Yue Ding zheng Ye Bo Ding Songwei Feng Furong Du Xuejiao Ma xiaoxuan Wang Yang Shen Department of Obstetrics and Gynaecology Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsu 210008China State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjingJiangsu 210096China State Key Laboratory of Translational Medicine and Innovative Drug Development Jiangsu Simcere Diagnostics Co.Ltd.NanjingJiangsu 210042China

Recently,immune checkpoint inhibitors(ICIs)and poly(ADP-ribose)polymerase inhibitors(PARPi)have played a pivotal role in prolonging the recurrence-free survival of patients with ovarian cancer(OC).1,2 Although PARPi have revolutionized the treatment of OC,the absence of reliable predictive biomarkers limits the broad application of ICIs for patients with homologous recombination(HR)deficiency(HRD).3 CXC-chemokine ligand 13(CXCL13)is a cytokine constitutively secreted in the stromal cells of the B-cell region of secondary lymphoid tissue.4 It exclusively binds to the chemokine receptor CXCR5,which is abundantly expressed in subsets of mature circulating B lymphocytes,follicular helper T cells,and skin-derived dendritic cells,and governs the migration of these cells into secondary lymphoid organs in response to the CXCL13 gradient.5 In this study,we aimed to elucidate the role of CXCL13 in shaping the tumor immune microenvironment(TIME)in HR-deficient OC and to explore its relationship with the cGAS-STING signaling pathway.

关键词： CXCL13 cancer organs

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Mannogalactoglucan from mushrooms protects pancreatic islets via restoring UPR and promotes insulin secretion in TIDM mice

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Food Science and Human Wellness 2024年第3期13卷 1390-1401页

作者： Ting Liu Si Chen Yunhe Qu Lujuan zheng xiaoxuan Yang Shuhan Men Yuanning Wang Hanrui Ma Yifa Zhou Yuying Fan Engineering Research Center of Glycoconjugates Ministry of EducationJilin Provincial Key Laboratory of Chemistry and Biology of Changbai Mountain Natural DrugsSchool of Life SciencesNortheast Normal UniversityChangchun 130024China

Type 1 diabetes mellitus(T1DM) lacks insulin secretion due to autoimmune deficiency of pancreaticβ-*** pancreatic islets and enhancing insulin secretion has been therapeutic *** is the main type of polysaccharide from natural mushroom,which has potential medicinal ***,the antidiabetic property of mannogalactoglucan in T1DM has not been fully *** this study,we obtained the neutral fraction of alkali-soluble Armillaria mellea polysaccharide(AAMP-N) with the structure of mannogalactoglucan from the fruiting body of *** and investigated the potential therapeutic value of AAMP-N in *** demonstrated that AAMP-N lowered blood glucose and improved diabetes symptoms in T1DM ***-N activated unfolded protein response(UPR) signaling pathway to maintain ER protein folding homeostasis and promote insulin secretion in *** that,AAMP-N promoted insulin synthesis via upregulating the expression of transcription factors,increased Ca^(2+) signals to stimulate intracellular insulin secretory vesicle transport via activating calcium/calmodulin-dependent kinase Ⅱ(CamkⅡ) and cAMP/PKA signals,and enhanced insulin secretory vesicle fusion with the plasma membrane via vesicle-associated membrane protein 2(VAMP2).Collectively,these studies demonstrated that the therapeutic potential of AAMP-N on pancreatic islets function,indicating that mannogalactoglucan could be natural nutraceutical used for the treatment of T1DM.

关键词： Mannogalactoglucan Mushroom Pancreatic islets Insulin secretion Insulin synthesis Unfolded protein response(UPR) Type 1 diabetes mellitus(T1DM)

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以中国式现代化全面推进中华民族伟大复兴的思考

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广东省社会主义学院学报 2022年第S01期 114-118页

作者：郑小璇揭阳市社会主义学院广东揭阳522000

新的时代新的征程,中国共产党在党的二十大报告中提出新的使命任务:以中国式现代化全面推进中华民族伟大复兴。要更好地朝着共同目标前进,需要深入理解党对中华民族伟大复兴这个初心使命的不断坚持,以及党在不同时代提出的不同的目标任... 详细信息

新的时代新的征程,中国共产党在党的二十大报告中提出新的使命任务:以中国式现代化全面推进中华民族伟大复兴。要更好地朝着共同目标前进,需要深入理解党对中华民族伟大复兴这个初心使命的不断坚持,以及党在不同时代提出的不同的目标任务。本文回到历史中去探寻民族复兴的形成与发展,总结习近平总书记的复兴观,辩证分析中国式现代化与民族复兴的关系。党用举旗定向为广大人民指明方面,而我们也用清晰的认识和坚定的信念跟随党的步伐循序渐进,共同实现中华民族伟大的复兴梦。

关键词：民族复兴二十大主题中国式现代化

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3'-Sialyllactose regulates glucose and lipid metabolic disorders via the gut–liver axis in mice fed a high-fat die

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Food Science and Human Wellness 2024年

作者： Wei Zhang Meizhen Zhu Kelsang Dekyi Linxi zheng Yichen Zhang Youping Lv Dongbei Guo xiaoxuan Chen Lili Pan Xinyue Wang Hongwei Li State Key Laboratory of Vaccines for Infectious Diseases， Xiang An Biomedicine Laboratory， School of Public Health， Xiamen University State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics，National Innovation Platform for Industry-Education Integration in Vaccine Research， Xiamen University Department of Nutrition， Zhongshan Hospital (Xiamen)， Fudan University Xiamen Clinical Research Center for Cancer Therapy

Recent research has indicated that sialic acid， such as free sialic acid (N-acetylneuraminic acid， Neu5Ac) and bound sialic acid (3'-sialyllactose， 3'-SL)， can ameliorate disorders associated with glycolipid metabolism， although the underlying mechanisms have yet to be determined. We examined the effects of 3'-SL on glycolipid metabolism in mice fed a high-fat diet. Male C57BL/6J mice were divided into six groups: two model control groups (normal and high-fat diets) and four intervention groups [Neu5Ac， and low-，moderate-， and high-dose 3'-SL]. After 8 weeks of continuous gavage intervention， mice in the 3'-SL intervention groups had lower body weight and total fat content; reduced fasting blood glucose， triglycerides， low-density lipoproteins and oxidized-low-density lipoproteins; and increased high-density lipoproteins，but no dosage-dependent of 3'-SL intervention was found， 3’-SL＿M intervention as optimal for further exploration. 3'-SL intervention could increase respiratory exchange ratio， energy expenditure， and amount of exercise performed. 3'-SL increased the colonic abundances of Akkermansia， Lactobacillus， and Bacteroides， and reduced those of Erysipelatoclostridium， Faecalibaculum， and Aldercreutzia. Changes were also observed in colonic metabolites， and liver gene transcript and metabolites， which were mainly enriched in bile secretion， taurine and hypotaurine metabolism， and insulin resistance. Additionally， 3'-SL was observed to regulate genes associated with physiological rhythms， including clock， per2， cry1， and bhihe41. Collectively， our findings indicate that 3'-SL can contribute to the prevention and control of disorders associated with glucose and lipid metabolism caused by high-fat diets. Compared with Neu5Ac， 3'-SL intervention can ameliorate intestinal flora disorders， enhance bile acid circulation， increase tissue energy expenditure， and reduce lipid synthesis， thereby promoting lipid-lowering effects mediated via the liver–gut axis， and can a

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科学论证在"基因的自由组合定律"复习课中的应用

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生物学通报 2022年第8期57卷 57-62页

作者：郑晓璇惠来慈云实验中学广东揭阳515200

引导学生根据资料分析推理得出主张,寻找证据捍卫主张、提出质疑并呈现证据进行辩驳论证,最终完善主张4大环节的论证模型对基因的自由组合定律2大核心概念进行论证,旨在通过论证过程使学生主动构建核心概念,发展其演绎与推理、分析与综... 详细信息

引导学生根据资料分析推理得出主张,寻找证据捍卫主张、提出质疑并呈现证据进行辩驳论证,最终完善主张4大环节的论证模型对基因的自由组合定律2大核心概念进行论证,旨在通过论证过程使学生主动构建核心概念,发展其演绎与推理、分析与综合、抽象与概括等科学思维以及科学探究能力,提高学生解决实际问题的能力,同时使学生更好地适应多变命题情境,提高复习效率.

关键词：论证模型自由组合定律科学思维科学探究实际问题

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基于CER框架的高考长句表达试题论证模型及其应用

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生物学教学 2022年第10期47卷 73-76页

作者：郑晓璇广东省揭阳市惠来慈云实验中学揭阳515200

对近几年高考长句表达试题进行整理分析归类,根据对学生在长句表达试题解答过程中常见的问题进行剖析,引用CER框架指导学生基于问题引导对试题进行论证推理,构建论证模型和规范作答,帮助学生攻克高考短板的同时,提升学生的逻辑推理能力... 详细信息

对近几年高考长句表达试题进行整理分析归类,根据对学生在长句表达试题解答过程中常见的问题进行剖析,引用CER框架指导学生基于问题引导对试题进行论证推理,构建论证模型和规范作答,帮助学生攻克高考短板的同时,提升学生的逻辑推理能力和科学表达能力。

关键词：长句表达试题 CER框架论证模型科学表达

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