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中国生理学会第24届全国会员代表大会暨生理学学术大会

作者：蒋斌 xiaoxiu tie Shuo Li 中山大学中山医学院生理学系

The functional maturation of visual cortex is sculpted by visual *** examine whether novel visual experience can trigger a new LTP（experience-induced synaptic strenghthening）in visual cortex,we induced LTP in layer 2/3 pyramidal cell by stimulation of layer 4 with a pairing protocol in visual cortex of mice which were treated in a different rearing *** can be induced in the pyramidal neurons in layer 2/3 of visual cortex by stimulating layer 4 around the age of P18-20 which is completely dependent on the activation of *** the dark rearing condition（DR）,LTP was enhanced which was also mediated by NMDARs,not m Glu R5 compared with the age-matched mice in normal rearing condition（NR）.Unexpectedly,LTP switched to LTD after 10-12 hour of light exposure for DR ***,by the same protocol,robust LTP was again induced at the presence of NMDA receptor inhibitor,*** at the presence of MPEP,an m Glu R5 antagonist,LTP was completely blocked,suggesting that the visual experience per se induces synaptic further strenghthening but instead this form of plasticity required the activation of metabotropic glutamate receptors（m Glu R5）.To examine the casual link between the loss of LTP and the upsurge of synaptic drive from layer 4 to layer 2/3 during the period of light exposure,the synaptic drive was evaluated by measuring the amplitude of stimulus-evoked miniature EPSC（m EPSCs）.The synaptic drive enhanced with the time of light exposure until it became the maximal when DR micewere exposed to light for 10-12 hour indicating that the switch of LTP to LTD corresponded to the increase of synaptic drive during light ***,LTP was blocked in the mice which were injected in vivo with CPP,an NMDARs antagonist just before light *** interestingly,m Glu R5-dependent LTP was induced only at the light exposure for 10-12 hour from DR mice,while ensuing light exposure restored NMDARs-dependent *** results suggested that short,novel v

关键词： LTP Visual cortex NMDA receptor mGluR Visual dperivation

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Hypocretin/orexin B potentiates the excitatory synaptic transmission to orexin-sensitive neurons in layer 6b of mouse visual cortex

Hypocretin/orexin B potentiates the excitatory synaptic tran...

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中国神经科学学会第十二届全国学术会议

作者： Mengyao Huang xiaoxiu tie Laijian Wang Bin Jiang Guangdong Province Key Laboratory of Brain Function and Disease Faculty of Forensic Medicine Zhongshan School of Medicine Sun Yat-sen University

Objective Some neurons in lateral hypothalamus release the peptides orexin A and B（also know as hypocretin 1 and 2）. As is evident from the pathological consequences of its absence in narcolepsy, orexin appears to be critical for the maintenance of wakefulness. Via diffuse projections through the brain, orexin-containing neurons in the hypothalamus may act on a number of wake-promoting systems. Indeed, the axons of these orexin-containing neurons project to the whole brain including visual cortex. It is reported that orexin can depolarize and excite some types of neurons, named as orexin-sensitive neuron in layer 6 b of visual cortex by the decrease of a potassium conductance. However, neurons in layer 6 b demonstrate the different cellular morphology and each neuron displays specific input and output connections as well as specialized local circuitry. Which cell types are sensitive to orexin and whether orexin mediates the synaptic transmission to these orexin-sensitive neurons in layer 6 b of visual cortex are unanswered. Methods Photomicrograph of biocytin-loaded cells from visual cortical slices was used for the cellular morphology of orexin-sensitive neurons. Wholecell EPSCs were recorded in orexin-sensitive neurons in layer 6 b evoked from layer 5 and orexin B was bath application to cortical slices. Results（1）: About 52% of pyramidal neuron and 45% of multipolar spiny neuron, but not other types of neurons in layer 6 b are sensitive to orexin B.（2） Orexin B induced an LTP-like enhancement of EPSCs recorded in these orexin-sensitive neurons in layer 6 b evoked from layer 5. This effect was blocked by orexin B receptor antagonist, by a phospholipase C inhibitor, and by Ca 2+ chelator, respectively. Conclusion In layer 6 b of mouse visual cortex, pyramidal neuron and multipolar spiny neuron are orexin-sensitive neurons and orexin B potentiates the excitatory synaptic transmission to these orexin-sensitive neurons.

关键词： Visual cortex Layer 6b Orexin B Orexin-sensitive neurons Excitatory synaptic transmission

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Emission patterns of biogenic volatile organic compounds from dominant forest species in Beijing, China

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Journal of Environmental Sciences 2020年第9期32卷 73-81页

作者： Xiaoxi Jing xiaoxiu Lun Chong Fan Weifang Ma College of Environmental Science and Engineering Beijing Forestry University Beijing 100083 China

Biogenic volatile organic compounds(BVOC s) have significant effects on atmospheric chemistry,ozone formation and secondary organic aerosol *** few investigations about BOVCs emissions in north China where is facing serious air pollution in recent years,emissions of various BVOCs from 24 dominant forest species in Beijing were measured from June to September in 2018,using a dynamic headspace sampling *** than one hundred BVOCs in the collected samples were identified by using an automatic thermal desorption-gas chromatography/mass spectrometry,and their emission rates based on leaf biomass were *** and monoterpenes were verified to be the dominant BVOCs emitted from the tree species,accounting for more than 50% of the total ***,broad-leaved species displayed high isoprene emission rates,especially the Platanus occidentalis(21.36μg/(g·hr)),Robinia pseudoacacia(11.55μg/(g·hr)),and Lonicera maackii(9.17μg/(g·hr)),while coniferous species emitted high rates of monoterpenes,such as Platycladus orientalis(27.18μg/(g·hr)),Pinus griffithii(23.11μg/(g·hr)),and Pinus armandii(7.42μg/(g·hr)).High emission rates of monoterpenes from the broad-leaved species of Buxus megistophylla(13.07μg/(g·hr)) and Ligustrum uicaryi(5.74μg/(g·hr)),and high isoprene emission rate from the coniferous tree of Taxus cuspidata(5.86μg/(g·hr)) were also *** emission rates of sesquiterpenes from each tree were usually 10-100 times smaller than those of isoprene and ***,relatively high emission rates of oxygenated volatile organic compounds and other alkenes than isoprene and monoterpenes were also found for several tree species.

关键词： pollution volatile forest

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Characteristic of organic aerosol in a remote area of Okinawa Island

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Journal of Environmental Sciences 2009年第10期21卷 1371-1377页

作者： LUN xiaoxiu TAKAMI Akinori MIYOSHI Takao HATAKEYAMA Shiro Beijing Forestry University Beijing 100083 China National Institute for Environmental Studies Tsukuba 305-8506 Japan Tokyo University of Agriculture and Technology Tokyo 183-8538 Japan

A continuous investigation of aerosol pollutants in Cape Hedo, Japan was conducted from October 2005 to August 2006 by Aerodyne aerosol mass spectrometer （AMS）. This article focused on the analysis of long-range transport of organic aerosol from continental origin to the remote island. Based on the transport distance and air mass origin, four main air mass origins were considered, including North China, South China, Japan and Korea. Although the mass concentration and air mass origin were quite different during study period, the mass spectrum and size distribution of organic matter and oxidized organics were similar, which showed uni-modal distribution with modal diameter of around 500 nm. The loss rate of organics was （5.15 ± 0.55） × 10^-6 s^-1 obtained by plotting the concentration against the transport time. Conversion rate of SO2 to sulfate and oxidation rate of organics were （1.07 ± 0.15） × 10^-5 and （1.09 ± 0.52） × 10^-6 s^-1, respectively.

关键词： long-range transport Okinawa organics loss rate

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CH_4 emission and conversion from A^2O and SBR processes in full-scale wastewater treatment plants

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Journal of Environmental Sciences 2014年第1期26卷 224-230页

作者： Yan Liu Xiang Cheng xiaoxiu Lun Dezhi Sun College of Environmental Science and Engineering Beijing Forestry University

Wastewater treatment systems are important anthropogenic sources of CH4 emission. A full-scale experiment was carried out to monitor the CH4 emission from anoxic/anaerobic/oxic process （A2O） and sequencing batch reactor （SBR） wastewater treatment plants （WWTPs） for one year from May 2011 to April 2012. The main emission unit of the A2O process was an oxic tank, accounting for 76.2% of CH4 emissions; the main emission unit of the SBR process was the feeding and aeration phase, accounting for 99.5% of CH4 emissions. CH4 can be produced in the anaerobic condition, such as in the primary settling tank and anaerobic tank of the A2O process. While CH4 can be consumed in anoxic denitrification or the aeration condition, such as in the anoxic tank and oxic tank of the A2O process and the feeding and aeration phase of the SBR process. The CH4 emission flux and the dissolved CH4 concentration rapidly decreased in the oxic tank of the A2O process. These metrics increased during the first half of the phase and then decreased during the latter half of the phase in the feeding and aeration phase of the SBR process. The CH4 oxidation rate ranged from 32.47% to 89.52% （mean： 67.96%） in the A2O process and from 12.65% to 88.31% （mean： 47.62%） in the SBR process. The mean CH4 emission factors were 0.182 g/ton of wastewater and 24.75 g CH4/（***） for the A2O process, and 0.457 g/ton of wastewater and 36.55 g CH4/（***） for the SBR process.

关键词： CH4 emission production and consumption wastewater treatment plant A2O SBR

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Reviews of emission of biogenic volatile organic compounds(BVOCs) in Asia

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Journal of Environmental Sciences 2020年第9期32卷 266-277页

作者： xiaoxiu Lun Ying Lin Fahe Chai Chong Fan Hong Li Junfeng Liu College of Environmental Science and Engineering Beijing Forestry UniversityBeijing 100083China State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing 100012China Research Center for Eco-Environmental Sciences Chinese Academy of SciencesBeijing 100085China

Biogenic volatile organic compounds(BVOCs) in the atmosphere play important roles in the formation of ground-level ozone and secondary organic aerosol(SOA) in global scale and also in regional scale under some condition due to their large amount and relatively higher *** places with high plant cover in the tropics and in China where air pollution is serious,the effect of BVOCs on ozone and secondary organic aerosols is *** present research aims to provide a comprehensive review about the emission rate,emission inventory, research methods,the influencing factors of BVOCs emissions,as well as their impacts on atmospheric environment quality and human health in recent years in Asia based on the summary and analysis of *** is suggested to use field direct measurement method to obtain the emission rate and model method to calculate the emission *** recommendations are given for future investigation and policy development on BVOCs emission.

关键词： BVOCs pollution volatile

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Estimation of PM_(10) in the trafc-related atmosphere for three road types in Beijing and Guangzhou, China

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Journal of Environmental Sciences 2014年第1期26卷 197-204页

作者： Yu Wang Jiong Li Xiang Cheng xiaoxiu Lun Dezhi Sun Xingzu Wang College of Environmental Science and Engineering Beijing Forestry University Beijing Northland Construction Engineering Co. Ltd

The levels of roadside PM10 in Beijing, China, were investigated in 2011 and 2012 on a seasonal basis to estimate the population exposure to particulates for three road types. The measurements of PM10 were also conducted in the southern Chinese megacity of Guangzhou for comparison purposes. The results showed that roadside PMlo in Beijing correlated strongly with the PM10 background in the urban atmosphere. The levels of PM10 in street canyons were markedly higher than those along the open roads and in crossroad areas because of limited ventilation. An elevation of PM10 was observed in April, which was possibly due to the sand storms that frequently occur in the spring. Based on these observations, roadside PM10 in Beijing could have multiple origins and was to some extent dispersion- governed. In Guangzhou, the roadside PM10 did not closely relate to the background values. The PM10 pollution was greatly affected by local traffic conditions. The simulation of PM10 for different road types was completed during the study period using the Motor Vehicle Emissions Factor Model （MOBILE6.2） as an emission model and the California Line Source Dispersion Model （CALINE4） and Operational Street Pollution Model （OSPM） as dispersion models. The MOBILE6.2/CALINE4 software package was demonstrated to be sufficient for the simulation of PM10 in the open roads and crossroad areas in both Beijing and Guangzhou, and the simulation results of roadside PM10 in the street canyons by the MOBILE6.2/OSPM package were in close agreement with those of the measurements.

关键词： roadside PM10 traffic volume open road crossroad street canyon

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Adsorption and biodegradation of three selected endocrine disrupting chemicals in river-based artificial groundwater recharge with reclaimed municipal wastewater

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Journal of Environmental Sciences 2015年第5期27卷 154-163页

作者： Weifang Ma Chao Nie Bin Chen Xiang Cheng xiaoxiu Lun Fangang Zeng College of Environmental Science and Engineering Beijing Forestry University School of Environment and Natural Resource Renmin University of China

Endocrine disrupting chemical（EDC） pollution in river-based artificial groundwater recharge using reclaimed municipal wastewater poses a potential threat to groundwater-based drinking water supplies in Beijing, China. Lab-scale leaching column experiments simulating recharge were conducted to study the adsorption, biodegradation, and transport characteristics of three selected EDCs： 17β-estradiol（E2）, 17α-ethinylestradiol（EE2） and bisphenol A（BPA）. The three recharge columns were operated under the conditions of continual sterilization recharge（CSR）, continual recharge（CR）, and wetting and drying alternative recharge（WDAR）. The results showed that the attenuation effect of the EDCs was in the order of WDAR 〉 CR 〉 CSR system and E2 〉 EE2 〉 BPA, which followed first-order kinetics. The EDC attenuation rate constants were 0.0783, 0.0505, and 0.0479 m-1 for E2, EE2 and BPA in the CR system, respectively. The removal rates of E2, EE2, and BPA in the CR system were 98%, 96% and 92%, which mainly depended on biodegradation and were affected by water *** the CR system, the concentrations of BPA, EE2, and E2 in soil were 4, 6 and 10 times higher than in the WDAR system, respectively. According to the DGGE fingerprints, the bacterial community in the bottom layer was more diverse than in the upper layer, which was related to the EDC concentrations in the water-soil system. The dominant group was found to be proteobacteria, including Betaproteobacteria and Alphaproteobacteria, suggesting that these microbes might play an important role in EDC degradation.

关键词： Endocrine disrupting chemicals Adsorption Biodegradation Artificial groundwater recharge Bacterial community

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Ecological-Based Mining:A Coal-Water-Thermal Collaborative Paradigm in Ecologically Fragile Areas in Western China

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Engineering 2024年第7期38卷 209-222页

作者： xiaoxiu Liu Yifan Zeng Qiang Wu Shihao Meng Jiyue Liang Zhuping Hou National Engineering Research Center of Coal Mine Water Hazard Controlling China University of Mining and TechnologyBeijing 100083China College of Geoscience and Surveying Engineering China University of Mining and TechnologyBeijing 100083China University of Mining and Technology(Beijing)Inner Mongolia Research Institute Ordos 017000China

A substantial reduction in groundwater level,exacerbated by coal mining activities,is intensifying water scarcity in western China’s ecologically fragile coal mining ***’s national strategic goal of achieving a carbon peak and carbon neutrality has made eco-friendly mining that prioritizes the protection and efficient use of water resources *** on the resource characteristics of mine water and heat hazards,an intensive coal-water-thermal collaborative co-mining paradigm for the duration of the mining process is *** integrated system for the production,supply,and storage of mining companion resources is achieved through technologies such as roof water inrush prevention and control,hydrothermal quality improvement,and deep-injection geological *** active preventive and control system achieved by adjusting the mining technology and a passive system centered on multiobjective drainage and grouting treatment are suggested,in accordance with the original geological characteristics and dynamic process of water *** implementing advanced multi-objective drainage,specifically designed to address the“skylight-type”water inrush mode in the Yulin mining area of Shaanxi Province,a substantial reduction of 50%in water drillings and inflow was achieved,leading to stabilized water conditions that effectively ensure subsequent safe coal *** integrated-energy complementary model that incorporates the clean production concept of heat utilization is also *** findings indicate a potential saving of 8419 t of standard coal by using water and air heat as an alternative heating source for the Xiaojihan coalmine,resulting in an impressive energy conservation of 50.2%and a notable 24.2%reduction in carbon *** ultra-deep sustained water injection of 100 m^(3)·h^(-1)in a single well would not rupture the formation or cause water leakage,and 7.87×10^(5)t of mine water could be effectively stored in the Liujiagou Formation,presenti

关键词： Dual carbon targets Coal-water-thermal co-mining Ecologically fragile areas Mine-water control Resource utilization

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Long-range transport of organic aerosol to Cape Hedo,Japan

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Particuology 2014年第2期12卷 35-41页

作者： xiaoxiu Lun Akinori Takami Weifang Ma Akio Shimono Shiro Hatakeyama Beijing Forestry University National Institute for Environmental Studies Onogawa 16-2Tsukuba 305-8506Japan Sanyu Plant Service Co. Ltd.Hashimotodai 1-8-21Kanagawa 229-1132Japan Tokyo University of Agriculture and Technology 3-8-IHarumi-choFuchu-shiTokyo 183-8538Japan

An investigation at Cape Hedo, Japan, from 2005 to 2006, focused on the long-range transport of organic aerosol （OA） from the Asian continent. An Aerodyne aerosol mass spectrometer was used to investigate the OA data collected over the study. OA concentrations were low from July to September and peaked during March and April. Based on air mass origins, four OA source regions were identified： northern China, southern China, Japan, and Korea. OA concentrations measured at Cape Hedo from the four sources did not exhibit large differences. Conversely, the frequencies of the air masses reaching Cape Hedo from the different regions varied considerably. Northern China was identified as the primary source of organic aerosols at Cape Hedo. Examination of variations in the ratio of m/z 44 to OA concentrations with transport time showed that OAs were partially oxidized during transport

关键词： Long-range transportOrganic aerosolSource contributionOkinawa

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