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Journal of Environmental Sciences 2020年第1期32卷 194-204页

作者： Zhanwen Cheng xiaoxing liang Shaojun liang Nuoya Yin Francesco Faiola State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Enuironmental SciencesChinese Academy of SciencesBeijing 100085China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China

Air pollution has been linked to many health issues,including skin conditions,especially in children.Among all the atmospheric pollutants,ultrafine particles have been deemed very dangerous since they can readily penetrate the lungs and skin,and be absorbed into the bloodstream.Here,we employed a human embryonic stem cell(h ESC)-based differentiation system towards keratinocytes,to test the effects of ultrafine carbon particles,which mimic ambient ultrafine particles,at environment related concentrations.We found that10 ng/mL to 10μg/mL ultrafine carbon particles down-regulated the expression of the pluripotency marker SOX2 in h ESCs.Moreover,1μg/mL to 10μg/mL carbon particle treatments disrupted the keratinocyte differentiation,and up-regulated inflammationand psoriasis-related genes,such as IL-1β,IL-6,CXCL1,CXCL2,CXCL3,CCL20,CXCL8,and S100 A7 and S100 A9,respectively.Overall,our results provide a new insight into the potential developmental toxicity of atmospheric ultrafine particles.

关键词： Human embryonic stem cells(hESCs) Keratinocytes Ultrafine carbon particles Inflammation Psoriasis Developmental toxicity

Removal of dolomite and potassium feldspar from apatite using simultaneous flotation with a mixed cationic-anionic collector

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International Journal of Mining Science and Technology 2023年第6期33卷 783-791页

作者： Haoyong Yu Yangge Zhu liang Lu xiaoxing Hu Songqing Li State Key Laboratory of Mineral Processing Science and Technology BGRIMM Technology GroupBeijing 102628China

This study aims to investigate the effect of a cationic-anionic mixed collector(dodecyltrimethyl ammonium bromide/sodium oleate(DTAB/NaOL)on the selective separation of apatite,dolomite,and potassium feldspar.Herein,several experimental methods,including flotation experiments,zeta-potential detection,microcalorimetry detection,XPS analysis and FTIR measurements,were used.The flotation tests showed that dolomite and potassium feldspar can be successfully removed from apatite simultaneously when the molar ratio of DTAB to NaOL was 2:1 with pH 4.5.Zeta-potential and microcalorimetry detection suggested that NaOL and DTAB were adsorbed on the surface of dolomite and potassium feldspar respectively,and part of NaOL and DTAB formed co-adsorption on the surface of potassium feldspar to enhance the floatability of potassium feldspar.The XPS and FTIR spectra analysis demonstrated that the cationic collector,DTAB,was first adsorbed on the surface of potassium feldspar through electrostatic attraction in the DTAB/NaOL mixture system.Subsequently,the anionic NaOL collector and cationic DTAB collector form an electron neutralisation complex,thereby resulting in co-adsorption on the surface of potassium feldspar.NaOL was chemically reacted and adsorbed on dolomite surface,but almost no collector was adsorbed on apatite surface.Finally,the adsorption models of different collectors on mineral surface were obtained.

关键词： Flotation Mixed collectors Apatite Potassium feldspar Dolomite

Spatial density estimate of the snow leopard, Panthera uncia, in the Central Tibetan Plateau, China

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Integrative Zoology 2023年第4期18卷 677-687页

作者： xiaoxing BIAN Xuchang liang Byron WECKWORTH Dorje JYAL Vanessa HULL Le YANG School of Natural Resources and Environment University of FloridaGainesvilleUSA Department of Wildlife Ecology and Conservation University of FloridaGainesvilleUSA Wildlife Conservation Society China BeijingChina Panthera New YorkUSA Tibet Plateau Institute of Biology LhasaChina

Knowledge of large carnivore population abundance is essential for wildlife management and conservation,but these data are often difﬁcult to obtain in inherently low-density species.In particular,the snow leopard,Panthera uncia,an enigmatic cat occupying remote mountains in Central Asia,has received insufﬁcient assessments of its population abundance because of logistical and methodological challenges.Here,we aimed to develop a robust density estimation of snow leopards based on 81 days of camera trapping within a contiguous and previously un-surveyed 1950 km2 area of habitat on the Tibetan Plateau(Mayue Township,Shenzha County,Tibet Autonomous Region,China).By applying spatially explicit capture–recapture models,we produced an estimate of 1.40(95%CI:1.06–1.84)individuals per 100 km2.Results also suggested sex-speciﬁc variation in the range of movement around activity centers,with male(N=10,σ=4.02)movement considerably greater than female(N=8,σ=1.84)move-ment.Theﬁndings can serve as a reliable baseline reference for assessing the population trends of this endangered felid species with future estimates.This study will provide context to contribute toward a better understanding of ecological factors shaping the distribution and abundance of snow leopards and the related conservation measures needed to sustain their long-term survival on the Tibetan Plateau.

关键词： population density snow leopard spatial capture–recapture Tibetan Plateau

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富铼渣中铼浸出试验

有色金属（冶炼部分） 2024年第2期 107-110页

作者：张晓星鲁兴武殷勤生袁晶晶程亮李俞良白银有色集团股份有限公司甘肃白银730900 中南大学冶金与环境学院湖南长沙410083 白银市技术开发服务中心甘肃白银730900

针对富铼渣中成分多、金属赋存状态复杂的特点,采用控电位氧化浸出方法对富铼渣中的铼进行浸出试验,通过单因素试验确定了最优条件为氧化浸出电位700~750 mV、硫酸质量浓度15%、浸出温度70℃、浸出时间60 min,在此条件下铼浸出率为98.61... 详细信息

针对富铼渣中成分多、金属赋存状态复杂的特点,采用控电位氧化浸出方法对富铼渣中的铼进行浸出试验,通过单因素试验确定了最优条件为氧化浸出电位700~750 mV、硫酸质量浓度15%、浸出温度70℃、浸出时间60 min,在此条件下铼浸出率为98.612%,其他组分浸出率均高于90%。

关键词：富铼渣铼浸出氧化电位

Viral rebound and safety of nirmatrelvir/ritonavir for lung-transplant recipients infected with SARS-CoV-2

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Biosafety and Health 2023年第5期5卷 266-271页

作者： Hui Li Li Zhao Ke Huang xiaoxing Wang Fei Zhou Yiming Feng liang Ma Bin Cao Wenhui Chen Department of Pulmonary and Critical Care Medicine Center of Respiratory MedicineChina-Japan Friendship HospitalBeijing 100029China Institute of Respiratory Medicine Chinese Academy of Medical SciencesBeijing 100029China National Clinical Research Center for Respiratory Disease Beijing 100029China Department of Pharmacy China-Japan Friendship HospitalBeijing 100029China Clinical Laboratory China-Japan Friendship HospitalBeijing 100029China

Data on the viral rebound and safety of nirmatrelvir/ritonavir in lung transplant(LTx)recipients are limited.The study prospectively followed four LTx recipients.Clinical characteristics,viral RNA dynamic in throat swabs,and tacrolimus blood concentration were monitored regularly.All four LTx recipients,aged 35–74 years,were not vaccinated against severe acute respiratory syndrome coronavirus 2(SARS‐CoV‐2).They got coronavirus disease 2019(COVID‐19)after more than one week of admission during the era of Omicron.All cases received nirmatrelvir/ritonavir(NM/r)within two days of infection,and the relative viral RNA copies dropped quickly.Viral load rebound was observed in all four cases after discontinuation of the first five days of NM/r treatment.Three of them received another 5‐days antiviral therapy with NM/r.The duration of positive viral PCR testing was 25‐28 days.None of them progressed into severe or critical COVID‐19.Tacrolimus was stopped 12 h before NM/r and held during the 5‐day course of antiviral therapy.Blood concentration of tacrolimus were maintained at a baseline level during these five days.Tacrolimus was re‐initiated at its baseline daily dose 3‐4 days after NM/r therapy.However,during the second round of antiviral therapy with NM/r,the concentration of tacrolimus fluctuated wildly.In conclusion,the 5‐day course of NM/r treatment was not sufficient for LTx recipients and the viral rebound was common.More data are needed to clarify whether LTx recipients with SARS‐CoV‐2 viral rebound could benefit from additional treatment with NM/r.

关键词： SARS‐CoV‐2 Lung transplantation Nirmatrelvir/ritonavir

错配修复蛋白表达在胃癌中的临床病理特征及与Ki67、P53相关性的研究

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黑龙江医药科学 2024年第1期47卷 64-66,70页

作者：郝丽莉梁秀冰黄世勇黄小杏李江黄远涛曾庆苏阳江市人民医院病理科广东阳江529500

目的:探究93例胃癌患者中错配修复蛋白(MMR蛋白)的表达,并分析胃癌患者MMR蛋白表达缺失与其胃癌临床病理特征之间的联系以及其与Ki67和P53之间的相关性,以期为临床治疗提供理论依据。方法:采用免疫组织化学染色法测定93例胃癌组织4种MM... 详细信息

目的:探究93例胃癌患者中错配修复蛋白(MMR蛋白)的表达,并分析胃癌患者MMR蛋白表达缺失与其胃癌临床病理特征之间的联系以及其与Ki67和P53之间的相关性,以期为临床治疗提供理论依据。方法:采用免疫组织化学染色法测定93例胃癌组织4种MMR蛋白(MLH1、MSH2、MSH6和PMS2)的表达,分析临床病理特征和微卫星不稳定性(MSI)有无相关性,同时检测Ki67、P53蛋白,并分析与MSI的相关性。结果:在93例胃癌中dMMR组的缺失率达到27.96%,MLH1与PMS2均缺失20例。dMMR组胃癌中Ki67蛋白表达均≥30%,统计分析dMMR组与Ki67蛋白表达呈正相关(r=0.271,P<0.01),dMMR组与P53表达无相关性。结论:MLH1与PMS2在胃癌中有一定比例的成对缺失,dMMR组胃癌与年龄、性别、肿瘤大小、分化程度、肿瘤位置、TNM分期等均不相关,因MSI型胃癌中Ki67表达较高,进一步说明MSI与Ki67对评估胃癌的恶性程度有协同作用。

关键词： MMR蛋白胃癌免疫组织化学 Ki67 P53

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铜冶炼铼浸出渣中铋的浸出试验研究

甘肃冶金 2024年第1期46卷 64-66页

作者：鲁兴武殷勤生袁晶晶张晓星程亮李俞良西北矿冶研究院甘肃白银730900 白银有色集团股份有限公司甘肃白银730900 中南大学冶金与环境学院湖南长沙410083 白银市技术开发服务中心甘肃白银730900

采用盐酸对铼浸出渣浸出,考察了盐酸浓度、反应温度、搅拌强度、反应时间等因素对Bi浸出率的影响,得到了最有利条件下Bi浸出率,在最有利条件下,Bi的浸出率可以达到95%以上,最大限度实现了Bi的回收,效益明显。

关键词：铜冶炼铼浸出渣 Bi 浸出

Modeling and Analyzing Web Application with Aspect-Oriented Hierarchical Coloured Petri Nets

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China Communications 2016年第5期13卷 89-102页

作者： xiaoxing Sun Huiqun Yu Honghao liang Nianhua Yang Department of Computer Science and Engineering East China University of Science and Technology Department of System Technology East China University of Science and Technology Library Shanghai No NDA Smart Technology Co Ltd. School of Business Information Shanghai University of International Business and Economics

Aspect-oriented modeling can uncover potential design faults, yet most existing work fails to achieve both separation and composition in a natural and succinct way. This study presents an aspect-oriented modeling and analysis approach with hierarchical Coloured Petri Nets(HCPN). HCPN has sub-models and well-defined semantics combining a set of submodels. These two characteristics of HCPN are nicely integrated into aspect oriented modeling. Submodels are used to model aspects while the combination mechanism contributes to aspects weaving. Furthermore, the woven aspect oriented HCPN model can be simulated and analyzed by the CPN Tools. A systematic web application case study is conducted. The results show the system original properties are satisfied after weaving aspects and all design flaws are revealed. As such, the approach can support web application design and analysis in an aspect-oriented fashion concisely and effectively.

关键词： Web应用程序有色Petri网建模设计缺陷子模型 CPN 简洁模拟

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某锂云母粗精矿磁选再富集试验研究

现代矿业 2024年第2期40卷 176-178页

作者：邹伟民梅晓方邱振忠梁毅宏罗志勇陈笑星李宇宏江西永兴新能源科技有限公司江西省宜春市336300 赣州金环磁选科技装备股份有限公司江西省赣州市341000

江西某锂云母经浮选后粗精矿锂品位2.60%左右,产品竞争力较弱。为提高该锂云母精矿的市场竞争力,达到锂品位3.0%以上的要求,进行锂云母粗精矿磁选再富集试验。研究结果表明:在磨矿细度-0.074 mm65%、给矿浓度25%、磁介质棒直径3 mm、强... 详细信息

江西某锂云母经浮选后粗精矿锂品位2.60%左右,产品竞争力较弱。为提高该锂云母精矿的市场竞争力,达到锂品位3.0%以上的要求,进行锂云母粗精矿磁选再富集试验。研究结果表明:在磨矿细度-0.074 mm65%、给矿浓度25%、磁介质棒直径3 mm、强磁粗选1背景磁感应强度1.3T、强磁粗选2背景磁感应强度1.5 T的条件下,采用2次强磁粗选工艺流程,可获得锂品位3.03%、锂回收率82.03%的锂云母强磁选精矿;试验达到了对现场浮选精矿再富集的效果,可作为现场工艺改造的依据。

关键词：锂云母高梯度磁选再富集

CBX4 deletion promotes tumorigenesis under Kras^(G12D) background by inducing genomic instability

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Signal Transduction and Targeted Therapy 2023年第10期8卷 4877-4888页

作者： Fangzhen Chen Wulei Hou Xiangtian Yu Jing Wu Zhengda Li Jietian Xu Zimu Deng Gaobin Chen Bo Liu xiaoxing Yin Wei Yu Lei Zhang Guoliang Xu Hongbin Ji Chunmin liang Zuoyun Wang Department of Human Anatomy and Histoembryology School of Basic Medical Sciences and Shanghai Xuhui Central HospitalShanghai Medical CollegeFudan UniversityShanghai 200030China Shanghai Xuhui Central Hospital Zhongshan-Xuhui HospitalFudan UniversityShanghai 200031China Clinical Research Center Shanghai Jjiao Tong University Affliated Sixth People's HospitalShanghaiChina State Key Laboratory of Cell Biology CAS Center for Excellence in Molecular Cell ScienceShanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesShanghaiChina CAS Key Laboratory of Molecular Virology and Immunology Institute Pasteur of ShanghaiChinese Academy of SciencesShanghaiChina Department of General Surgery Jing'an District Central Hospital of ShanghaiFudan UniversityShanghaiChina Key Laboratory of Respiratory Disease People's Hospital of YangjiangYangjiangGuangdongChina

Chromobox protein homolog 4(CBX4)is a component of the Polycomb group(PcG)multiprotein Polycomb repressive complexes 1(PRC1),which is participated in several processes including growth,senescence,immunity,and tissue repair.CBX4 has been shown to have diverse,even opposite functions in different types of tissue and malignancy in previous studies.

关键词： immunity malignancy opposite